Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Xuan Wang, Johanna Breuer, Stephan Garbe, Frank Giordano, Peter Brossart, Georg Feldmann, Savita Bish. Triple Blockade of Oncogenic RAS Signaling Using KRAS and MEK Inhibitors in Combination with Irradiation in Pancreatic Cancer. International journal of molecular sciences. vol 25. issue 11. 2024-06-19. PMID:38892436. |
underlying pathophysiological mechanisms were examined by using western blot analyses, apoptosis assay, and ras activation assay. |
2024-06-19 |
2024-06-21 |
human |
Yinwen Hong, Xueliang Sun, Lijuan L. Loureirin B inhibits Cervical Cancer Development by Blocking PI3K/AKT Signaling Pathway: Network Pharmacology Analysis and Experimental Validation. Applied biochemistry and biotechnology. 2024-06-18. PMID:38888697. |
cell cycle and apoptosis were detected by flow cytometry and western blot. |
2024-06-18 |
2024-06-21 |
Not clear |
Qian Zhang, Dengfeng Che. Validating linalool as a potential drug for breast cancer treatment based on machine learning and molecular docking. Drug development research. vol 85. issue 4. 2024-06-16. PMID:38879780. |
cell counting kit 8 (cck-8, edu, transwell, flow cytometry, and western blot assay were used to analyze cell activity, apoptosis, cell cycle and protein expression. |
2024-06-16 |
2024-06-18 |
human |
Fang He, Juan Yu, Sha Ma, Weiqing Zhao, Qi Wang, Haitao He, Mingxing Zhang, Juan Wang, Zhixiang L. MiR-34a promotes mitochondrial pathway of apoptosis in human salivary gland epithelial cells by activating NF-κB signaling. Archives of biochemistry and biophysics. 2024-06-16. PMID:38880321. |
immunohistochemistry, he staining, cck-8, tunel assay, flow cytometry, immunofluorescence and western blot were used to investigate the effects of mir-34a on nf-κb signaling and mitochondrial pathway of apoptosis in hsge cells. |
2024-06-16 |
2024-06-19 |
mouse |
Dan Wang, Zhiqiang Lin, Yiqing Zhou, Meixia Su, Haiwang Zhang, Lixia Yu, Minghui L. Atractylenolide I ameliorates sepsis-induced cardiomyocyte injury by inhibiting macrophage polarization through the modulation of the PARP1/NLRP3 signaling pathway. Tissue & cell. vol 89. 2024-06-15. PMID:38878655. |
the apoptosis of h9c2 cells was detected using flow cytometry and western blot. |
2024-06-15 |
2024-06-18 |
Not clear |
Na Ning, Xiangyang Li, Yi Nan, Guoqing Chen, Shicong Huang, Yuhua Du, Qian Gu, Weiqiang Li, Ling Yua. Molecular mechanism of Saikosaponin-d in the treatment of gastric cancer based on network pharmacology and in vitro experimental verification. Naunyn-Schmiedeberg's archives of pharmacology. 2024-06-12. PMID:38864908. |
finally, in vitro cellular experiments including cell viability, apoptosis, cell scratch, transwell invasion, transwell migration, qrt-pcr, and western blot were conducted to verify these findings of network pharmacology. |
2024-06-12 |
2024-06-14 |
Not clear |
Harika Atmaca, Suleyman Ilhan, Çisil Çamli Pulat, Buse Aysen Dundar, Metin Zor. Evaluation of Novel Spiro-pyrrolopyridazine Derivatives as Anticancer Compounds: In Vitro Selective Cytotoxicity, Induction of Apoptosis, EGFR Inhibitory Activity, and Molecular Docking Analysis. ACS omega. vol 9. issue 22. 2024-06-10. PMID:38854531. |
flow cytometry and western blot (wb) analyses were conducted for apoptosis detection. |
2024-06-10 |
2024-06-14 |
Not clear |
Sijin Chen, Rong Qin, Zhibo Zhang, Xirui Fan, Lifang Zhou, Hui Wan. HSP70 protects against acute pancreatitis-elicited intestinal barrier damage in rats. Clinics and research in hepatology and gastroenterology. vol 48. issue 7. 2024-06-08. PMID:38810880. |
tunel assay and western blot were used to detect apoptosis. |
2024-06-08 |
2024-06-11 |
rat |
Shuyang Zhang, Yanwen Xu, Chenyang Zhang Junior, Xiao Chen, Jiayan Zh. Dang-Gui-Si-Ni decoction facilitates wound healing in diabetic foot ulcers by regulating expression of AGEs/RAGE/TGF-β/Smad2/3. Archives of dermatological research. vol 316. issue 7. 2024-06-07. PMID:38847916. |
cell viability by cck8, migration ability by cell scratch, apoptosis by flow cytometry, and ages/rage/tgf-β/smad2/3 expression by western blot were measured. |
2024-06-07 |
2024-06-10 |
human |
Zhongbo Yin, Xuedong Zhang, Xiao Sun, Yunlong Huo, Nan Ji, Keyan Che. Mogrol-mediated enhancement of radiotherapy sensitivity in non-small cell lung cancer: a mechanistic study. American journal of physiology. Cell physiology. vol 326. issue 6. 2024-06-06. PMID:38682239. |
cck-8, clonogenic, flow cytometry, tunel, and western blot assays evaluated mogrol and radiation effects on nsclc viability and apoptosis. |
2024-06-06 |
2024-06-08 |
mouse |
Hantao Ye, Tingwen Cai, Yang Shen, Lin Zhao, Haojie Zhang, Jianxin Yang, Feida Li, Jiaoxiang Chen, Xiaolong Shu. MST1 knockdown inhibits osteoarthritis progression through Parkin-mediated mitophagy and Nrf2/NF-κB signalling pathway. Journal of cellular and molecular medicine. vol 28. issue 11. 2024-06-06. PMID:38842136. |
western blot, elisa and if were used to analyse the expression of inflammation, extracellular matrix (ecm) degradation, apoptosis and mitophagy-associated proteins. |
2024-06-06 |
2024-06-08 |
Not clear |
Xiaodong Zhang, Yanzhang Yang, Xinyi Ma, Huijuan Cao, Yingjie Su. Probiotics relieve perioperative postoperative cognitive dysfunction induced by cardiopulmonary bypass through the kynurenine metabolic pathway. Scientific reports. vol 14. issue 1. 2024-06-04. PMID:38834581. |
neuronal apoptosis was detected by tdt-mediated dutp nick end-labeling (tunel) staining and western blot. |
2024-06-04 |
2024-06-07 |
rat |
Changtao Wan, Chuancai Liang, Hao Pen. Omaveloxolone ameliorates glucocorticoid-induced osteonecrosis of the femoral head by promoting osteogenesis and angiogenesis. Biochemical and biophysical research communications. vol 723. 2024-06-02. PMID:38824808. |
the in vitro environment of sonfh cells was simulated by inducing human bone marrow mesenchymal stem cells (hbmscs) and human umbilical vein endothelial cells (huvecs) using dexamethasone (dex).various assays, including cck-8, alizarin red staining, western blot, qpcr, immunofluorescence, flow cytometry, and tunnel, were employed to assess cell viability, sting/nf-κb signaling pathway-related proteins, hbmscs osteogenesis, huvecs migration, angiogenesis, and apoptosis. |
2024-06-02 |
2024-06-05 |
human |
Jiangpeng Lin, Riken Chen, Huizhao Liao, Yuzhuo Zhang, Zhenzhen Zheng, Cheng Hon. Mechanisms of cordycepin in the treatment of pulmonary arterial hypertension in rats based on metabonomics and transcriptomics. Scientific reports. vol 14. issue 1. 2024-05-30. PMID:38816406. |
evaluations included hematoxylin and eosin staining for pulmonary vascular remodeling, cck-8 assay, edu, and tunel kits for cell viability, proliferation, and apoptosis, respectively, and western blot for protein expression. |
2024-05-30 |
2024-06-02 |
rat |
Li Chen, Ya-Jun Zhang, Hong-Wen Qin, Wu-Jing Hu, Yan-Jiao Liu, Guo-Sheng Xiao, Hui-Hui DU, Dong-Lin Yan. [Study on mechanism of inhibiting proliferation of head and neck cancer cells by citral, active ingredient of lemon essential oil]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 9. 2024-05-30. PMID:38812137. |
the cell cycle arrest and apoptosis induction of head and neck cancer cells by citral were evaluated by flow cytometry, and western blot was used to detect the effect of citral on the expression levels of cell cycle-and apoptosis-related proteins in head and neck cancer cells. |
2024-05-30 |
2024-06-17 |
Not clear |
Chang-Long Fu, Yan-Ming Lin, Hai-Shui Tu, Jin-Xia Ye, Yan-Feng Huang, De-Zun Ma, Chun-Song Zhen. [Mechanism of Tougu Xiaotong Capsules in delaying degeneration of osteoarthritis by regulating cholesterol metabolism in chondrocytes through lncRNA MALAT1]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 7. 2024-05-30. PMID:38812190. |
western blot results showed that compared with the model group, protein expressions of abca1, apoa1, lxrβ, chop, and caspase-3 in the tgxtc group were significantly decreased, after lncrna malat1 knockdown, the regulation and apoptosis of abca1, apoa1, lxrβ, chop, and caspase-3 in tg-induced mouse chondrocytes were weakened by tgxtc. |
2024-05-30 |
2024-06-08 |
mouse |
Jun-Yu He, Jia-Xin Yang, Shi-Ying Qin, Jing-Qi Zheng, Yi-Ran Guo, Tian-Xing M. [Exploration of mechanism of total triterpenoids from fruits of Chaenomeles speciosa against senescent GES-1 cells induced by D-galactose based on Gln/GLS1/α-KG metabolic axis and mitochondrial apoptosis signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 8. 2024-05-30. PMID:38812238. |
the mrna and protein expressions of gls1 and the related genes of the mitochondrial apoptosis signaling pathway were measured by real-time fluorescence quantitative pcr and western blot. |
2024-05-30 |
2024-06-08 |
Not clear |
Tairan Zhang, Xidong Wan. Modafinil lightens apoptosis and inflammatory response in hepatic ischemia-reperfusion injury through inactivation of TLR9/Myd88/p38 signaling. Drug development research. vol 85. issue 4. 2024-05-30. PMID:38812444. |
terminal-deoxynucleoitidyl transferase-mediated nick end labeling assay and western blot appraised apoptosis. |
2024-05-30 |
2024-06-08 |
mouse |
Hui Wang, Xiaopei Yan, Li X. [Aloperine suppresses TLR4/NF-κB/NLRP3 signaling to ameliorate cigarette smoke-induced injury to human bronchial epithelial cells]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 40. issue 5. 2024-05-25. PMID:38790097. |
cell apoptosis was evaluated using the terminal-deoxynucleotidyl transferase-mediated dutp-biotin nick end labeling assay (tunel) and western blot analysis. |
2024-05-25 |
2024-05-27 |
human |
Tingting Xua. Tripartite Motif-containing Protein 11 Silencing Inhibits Proliferation and Glycolysis and Promotes Apoptosis of Esophageal Squamous Cell Carcinoma Cells by Inactivating Signal Transduction and Activation of Transcription Factor 3/c-Myc Signaling. Journal of physiological investigation. vol 67. issue 1. 2024-05-23. PMID:38780271. |
in addition, western blot was employed to detect the expression of proteins related to apoptosis, glycolysis, and stat3/c-myc signaling. |
2024-05-23 |
2024-05-27 |
human |