| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xue Liu, Shiyao Cui, Wenle Li, Hongqing Xie, Liangen Sh. Elucidation of the anti-colon cancer mechanism of Phellinus baumii polyphenol by an integrative approach of network pharmacology and experimental verification. International journal of biological macromolecules. 2023-10-14. PMID:37838121. |
finally, we determined the key regulatory proteins related to apoptosis and the cell cycle by western blot analysis, and proposed the potential mechanism by which pbp exerts an anti-colon cancer effect by inducing the caspase-dependent mitochondrial-mediated intrinsic apoptotic pathway and arresting the cell cycle in s phase in hct116 cells. |
2023-10-14 |
2023-11-08 |
human |
| Su-Ji Jeon, Eun-Young Choi, Eun-Ji Han, Sang-Woo Lee, Jun-Mo Moon, Soo-Hyun Jung, Ji-Youn Jun. Piperlongumine induces apoptosis via the MAPK pathway and ERK‑mediated autophagy in human melanoma cells. International journal of molecular medicine. vol 52. issue 6. 2023-10-13. PMID:37830157. |
pretreatment of a375p cells with the erk inhibitor pd98059 and the jnk inhibitor sp600125 followed by treatment with pl confirmed that apoptosis and autophagy were mediated via the mapk/erk pathway by western blot. |
2023-10-13 |
2023-10-15 |
human |
| Angqing Li, Junyi Zhang, Ke Chen, Jian Wang, Aman Xu, Zhengguang Wan. Donepezil attenuates inflammation and apoptosis in ulcerative colitis via regulating LRP1/AMPK/NF-κB signaling. Pathology international. 2023-10-13. PMID:37830504. |
apoptosis was estimated utilizing terminal deoxynucleotidyl transferase dutp nick-end labeling and western blot. |
2023-10-13 |
2023-10-15 |
mouse |
| Tingxiang Chen, Hongyu Chen, Yuedong Fu, Xuao Liu, Haosheng Huang, Zhijie Li, Shi L. The eNOS-induced leonurine's new role in improving the survival of random skin flap. International immunopharmacology. vol 124. issue Pt B. 2023-10-12. PMID:37827057. |
through immunohistochemistry and western blot, we proved that leo treatment can upregulate the level of angiogenesis, while leo treatment significantly reduced the expression levels of oxidative stress, apoptosis and inflammation. |
2023-10-12 |
2023-10-15 |
Not clear |
| Yi Luo, You-Zhi He, Yong-Fu Wang, Yu-Xia Xu, Li Yan. Adipose-derived mesenchymal stem cell exosomes ameliorate spinal cord injury in rats by activating the Nrf2/HO-1 pathway and regulating microglial polarization. Folia neuropathologica. vol 61. issue 3. 2023-10-11. PMID:37818693. |
motor function recovery was assessed on days 0, 7, 14, 21, and 28; histopathological changes and apoptosis levels in spinal cord tissues were observed by he staining and tunel staining; the levels of inflammatory cytokines tnf-a, il-6, and mcp-1 in spinal cord tissues were measured by elisa; the expression levels of inos, il-12, arg1, and mrc1 in spinal cord tissues were detected by qrt-pcr; and nrf2, ho-1, and nqo1 protein expression in spinal cord tissues were detected by western blot. |
2023-10-11 |
2023-10-15 |
rat |
| Juexing Li, Lei Zhou, Yuanliang Jiang, Hailan Gao, Tuersuntuoheti Maierhaba, Hui Gon. Long noncoding RNA RMRP ameliorates doxorubicin-induced apoptosis by interacting with PFN1 in a P53-Dependent manner. Molecular and cellular probes. 2023-10-11. PMID:37820747. |
the degree of apoptosis was detected by western blot and tunel staining. |
2023-10-11 |
2023-10-15 |
Not clear |
| Jianning Zeng, Hongyan Pei, Hong Wu, Weijia Chen, Rui Du, Zhongmei H. Palmatine attenuates LPS-induced neuroinflammation through the PI3K/Akt/NF-κB pathway. Journal of biochemical and molecular toxicology. 2023-10-10. PMID:37815058. |
he staining and niss staining were performed on brain tissue sections to observe morphological lesions and apoptosis; serum was examined for inflammatory factors tnf-α, il-6, and il-1β; western blot was performed to detect the protein expression. |
2023-10-10 |
2023-10-15 |
mouse |
| Jun Chen, Kaixin Zhang, Yi Yang, Jianqiang W. MiR-204-5p regulates HUVEC cell inflammation and apoptosis by targeting P4HB. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 9. 2023-10-09. PMID:37807312. |
apoptosis was assayed by flow cytometry, western blot and western blot. |
2023-10-09 |
2023-10-15 |
human |
| Qianwen Zhang, Yiyu He, Hao Xu, Yuqiao Zeng, Li Wang, Zengxi Xue, Qingyun Sun, Likun Wan. MicroRNA-181a-5p alleviates acute liver failure in mice by inhibiting HMGB1. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 9. 2023-10-09. PMID:37807324. |
the expression of caspase 3 was detected as the marker of cell apoptosis in alf by immunohistochemistry and western blot. |
2023-10-09 |
2023-10-15 |
mouse |
| Yujia Sun, Tianqi Zhao, Yaoyao Ma, Xinyi Wu, Shuangfeng Chu, Zhangping Yan. Multiple roles of LncRNA-BMNCR on cell proliferation and apoptosis by targeting miR-145/CBFB axis in BMECs. The veterinary quarterly. 2023-10-09. PMID:37807922. |
in bovine mammary epithelial cells, we preformed loss of function experiments to detect changes in cytokine, proliferation and apoptosis by qrt-pcr, western blot, flow cytometry and edu staining. |
2023-10-09 |
2023-10-15 |
cattle |
| Nan Nan, Xiao-Li DU, Miao Chen, Jia-Qi Lu. [Qirong Tablets inhibits apoptosis of ovarian granulosa cells via PI3K/Akt/ HIF-1 signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 17. 2023-10-06. PMID:37802816. |
terminal deoxynucleotidyl transferase-mediated dutp nick end labeling(tunel) assay was used to detect the apoptosis of granulosa cells, and western blot to determine the expression levels of b-cell lymphoma-2(bcl-2), bcl-2-associated x protein(bax), caspase-3, pi3k, akt, and hif-1. |
2023-10-06 |
2023-10-15 |
mouse |
| Hefei Huang, Tianlun Wang, Luopei Wang, Yan Huang, Weili Li, Jin'e Wang, Yuanlang Hu, Zhiyong Zho. Saponins of Panax japonicus ameliorates cardiac aging phenotype in aging rats by enhancing basal autophagy through AMPK/mTOR/ULK1 pathway. Experimental gerontology. 2023-10-05. PMID:37797916. |
tunel kit was used to detect apoptosis level of cardiomyocyte, and western blot was used to evaluate autophagy-related proteins as well as ampk/mtor/ulk1 pathway-related markers. |
2023-10-05 |
2023-10-07 |
mouse |
| Shi-Wei Liu, Jia-Qiang Luo, Liang-Yu Zhao, Ning-Jing Ou, Chao-Yang, Yu-Xiang Zhang, Hao-Wei Bai, Hong-Fang Sun, Jian-Xiong Zhang, Chen-Cheng Yao, Peng Li, Ru-Hui Tian, Zheng Li, Zi-Jue Zh. scRNA-seq reveals that origin recognition complex subunit 6 regulates mouse spermatogonial cell proliferation and apoptosis via activation of Wnt/β-catenin signaling. Asian journal of andrology. 2023-10-03. PMID:37788012. |
subsequently, 5-ethynyl-2-deoxyuridine (edu) and terminal deoxynucleotidyl transferase dutp nick end labeling (tunel) assays, flow cytometry, and western blot were used to evaluate its effects on proliferation and apoptosis. |
2023-10-03 |
2023-10-07 |
mouse |
| Gui-Hong Zhang, Kai Ling Chin, Shi-Yan Yan, Rahmawati Par. Antioxioxidant and antiapoptotic effects of Thymosin β4 in Aβ-induced SH-SY5Y cells via the 5-HTR1A/ERK axis. PloS one. vol 18. issue 10. 2023-10-03. PMID:37788276. |
we performed western blot and flow cytometry to study the apoptosis and standard kits to measure the oxidative stress-associated biomarkers. |
2023-10-03 |
2023-10-07 |
Not clear |
| Xu-Hui Li, Li Liu, Wen-Zhong W. Trans-Anethole Alleviates DSS-Induced Ulcerative Colitis by Remodeling the Intestinal Flora to Regulate Immunity and Bile Acid Metabolism. Mediators of inflammation. vol 2023. 2023-10-02. PMID:37780399. |
to observe the effect of ta on the colon tissue, various investigations were performed, including western blot and immunohistochemistry for intestinal barrier protein expression, tunel staining for apoptosis, western blot, and elisa for inflammation level, flow cytometry for th17/treg, lc-ms for blood bile acid content, gc-ms for blood fatty acid content, and 16s rna for intestinal contents. |
2023-10-02 |
2023-10-07 |
mouse |
| Yaobo Yang, Zhaoyong Yan, Yang Jiao, Weihao Yang, Qi Cui, Sipan Che. Family with sequence similarity 111 member B contributes to tumor growth and metastasis by mediating cell proliferation, invasion, and EMT via transforming acidic coiled-coil protein 3/PI3K/AKT signaling pathway in hepatocellular carcinoma. Environmental toxicology. 2023-10-02. PMID:37782700. |
the impact of fam111b on proliferation, invasion, apoptosis and emt of hcc cells were detected by cck-8, transwell, flow cytometry and western blot assays. |
2023-10-02 |
2023-10-07 |
mouse |
| Jian-Lan Huang, Li Liang, Pei-En Xie, Wei-Liang Sun, Li Wang, Zheng-Wen Ca. Cucurbitacin B induces apoptosis in colorectal cells through reactive oxygen species generation and endoplasmic reticulum stress pathways. Experimental and therapeutic medicine. vol 26. issue 4. 2023-09-27. PMID:37753296. |
subsequently, the appropriate cub concentration (5 µm) was selected for treatment of crc cells for 48 h. western blot analysis was used to measure the expression levels of ers-related proteins, flow cytometry was used to evaluate apoptosis, the dichlorodihydrofluorescein diacetate fluorescent probe was used to detect reactive oxygen species (ros) production, and the relationship between ros and ers was determined by western blot analysis. |
2023-09-27 |
2023-10-07 |
Not clear |
| Shaoyi Qiao, Wuhe Zhang, Yao Jiang, Yansheng S. Sennoside A induces autophagic death of prostate cancer via inactivation of PI3K/AKT/mTOR axis. Journal of molecular histology. 2023-09-23. PMID:37740843. |
the effects of sa on growth, apoptosis, and autophagy were determined through cck-8, hoechst stain, flow cytometry, western blot, and immunofluorescence examinations. |
2023-09-23 |
2023-10-07 |
mouse |
| Jing Zhang, Qingbo Zhao, Zhihui Xue, Siyi Zhang, Zeyu Ren, Shaokui Chen, Ao Zhou, Hongbo Chen, Yulan Li. Deoxynivalenol induces endoplasmic reticulum stress-associated apoptosis via the IRE1/JNK/CHOP pathway in porcine alveolar macrophage 3D4/21 cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023-09-22. PMID:37739053. |
our subsequent validation via qpcr and western blot analyses confirmed the attenuation of grp78 and bcl-2, coupled with the upregulation of ire1, chop, jnk, p-jnk, and bax in don-induced cells, indicating the instigation of er stress-associated apoptosis by don. |
2023-09-22 |
2023-10-07 |
Not clear |
| Feng Guo, Yang Luo, GuangYao Ye, WeiJun Tan. Circular RNA METTL15/miR-374a-5p/ESCO2 axis induces colorectal cancer development. Acta biochimica Polonica. 2023-09-16. PMID:37715994. |
cell proliferation was detected by cck-8 and colony formation tests, cell apoptosis and cell cycle were detected by flow cytometry, cell migration and invasion were detected by transwell assay, and protein expression of ki-67, e-cadherin, n-cadherin, and cleaved caspase-3 was detected by western blot. |
2023-09-16 |
2023-10-07 |
Not clear |