| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lina Shan, Bingjun Bai, Yiming Lv, Binbin Xie, Xuefeng Huang, Hongbo Zh. Lobaplatin suppresses proliferation and peritoneal metastasis of colorectal cancer in a preclinical model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 108. 2019-02-28. PMID:30243080. |
flow cytometry and western blot analysis confirmed that lobaplatin affected crc cells by inducing apoptosis and modulating the caspase family. |
2019-02-28 |
2023-08-13 |
mouse |
| Chih-Chung Feng, Po-Hsiang Liao, Hsiang-I Tsai, Shiu-Min Cheng, Liang-Yo Yang, Vijaya PadmaViswanadha, Lung-Fa Pan, Ray-Jade Chen, Jeng-Fan Lo, Chih-Yang Huan. Tumorous imaginal disc 1 (TID1) inhibits isoproterenol-induced cardiac hypertrophy and apoptosis by regulating c-terminus of hsc70-interacting protein (CHIP) mediated degradation of Gαs. International journal of medical sciences. vol 15. issue 13. 2019-02-26. PMID:30443176. |
h9c2 cells were pretreated tid1 before iso-induced hypertrophy and apoptosis and then evaluated by ihc, tunel assay, ifc, co-ip, and western blot. |
2019-02-26 |
2023-08-13 |
human |
| Xiao Liang, Shumao Xu, Jun Zhang, Jing Li, Qi She. Cascade Amplifiers of Intracellular Reactive Oxygen Species Based on Mitochondria-Targeted Core-Shell ZnO-TPP@D/H Nanorods for Breast Cancer Therapy. ACS applied materials & interfaces. vol 10. issue 45. 2019-02-25. PMID:30339356. |
western blot demonstrated that zno-tpp@d/h nrs dramatically induced cell apoptosis in 4t1 cells. |
2019-02-25 |
2023-08-13 |
Not clear |
| Dalin Sun, Weihang Dong, Baofang Jin, Guanghui Chen, Bin Cai, Weimin Deng, Yugui Cui, Yihan Ji. Mechanisms of Yangjing Capsule in Leydig Cell Apoptosis and Testosterone Synthesis via Promoting StAR Expression. Biological & pharmaceutical bulletin. vol 41. issue 9. 2019-02-20. PMID:29984732. |
leydig tumor cells (mltc-1) were cultured and treated with yc, and immunofluorescence assay was performed to examine the expression of star; furthermore, luciferase reporter assay was conducted to evaluate the impact of yc on star promoter; next, mltc-1 cells were treated with star small interfering rna (sirna), and flow cytometry was carried out to examine the effect of star sirna on the apoptosis of the cells; furthermore, quantitative (q)rt-pcr and western blot methods was used to determine the expression of star and apoptosis related molecules bcl-2, bax and caspase-3 on both mrna and protein levels in different groups; finally the secretion of testosterone in different groups was examined by radioimmunoassay. |
2019-02-20 |
2023-08-13 |
Not clear |
| Leila Shahriyary, Gholamhossein Riazi, Mohammad Reza Lornejad, Mansoureh Ghezlou, Bahareh Bigdeli, Behdad Delavari, Fatemeh Mamashli, Shayan Abbasi, Jamshid Davoodi, Ali Akbar Sabour. Effect of glycated insulin on the blood-brain barrier permeability: An in vitro study. Archives of biochemistry and biophysics. vol 647. 2019-02-18. PMID:29444458. |
apoptosis induction was determined and confirmed by flow cytometry and western blot analyses, respectively. |
2019-02-18 |
2023-08-13 |
Not clear |
| Fan Zhang, Hui-Zeng Lv, Ji-Ming Liu, Xiao-Yong Ye, Cun-Chuan Wan. UNBS5162 inhibits colon cancer growth via suppression of PI3K/Akt signaling pathway. Medecine sciences : M/S. vol 34 Focus issue F1. 2019-02-13. PMID:30403183. |
in addition, annexin v-fitc/pi assay and western blot analysis were performed to detect whether unbs5162 could induce cell apoptosis. |
2019-02-13 |
2023-08-13 |
Not clear |
| Xinrui Zhao, Lidong Liu, Rui Li, Xuan Wei, Wenqing Luan, Peishu Liu, Jing Zha. Hypoxia-Inducible Factor 1-α (HIF-1α) Induces Apoptosis of Human Uterosacral Ligament Fibroblasts Through the Death Receptor and Mitochondrial Pathways. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2019-02-13. PMID:30504760. |
cell apoptosis and expression of apoptosis-associated proteins and collagen type i alpha 1 (col1a1) were measured by flow cytometry, tunel and western blot, respectively. |
2019-02-13 |
2023-08-13 |
human |
| Zhen Mu, Qing Su. Cantharidin inhibits melanoma cell proliferation via the miR‑21‑mediated PTEN pathway. Molecular medicine reports. vol 18. issue 5. 2019-02-12. PMID:30221692. |
furthermore, ctd treatment could induce a375 cell apoptosis, as detected by annexin v‑fluorescein isothiocyanate/propidium iodide staining and western blot analysis. |
2019-02-12 |
2023-08-13 |
human |
| Yinqiang Xin, Peiling Ben, Qi Wang, Yanyan Zhu, Zhimin Yin, Lan Lu. Theanine, an antitumor promoter, induces apoptosis of tumor cells via the mitochondrial pathway. Molecular medicine reports. vol 18. issue 5. 2019-02-12. PMID:30221698. |
further experiments demonstrated that theanine caused hepg2 cell apoptosis through the mitochondrial pathway, with a loss of membrane potential and the release of apoptosis‑inducing factor, endonuclease g and cytochrome c. western blot analysis and caspase activity detection also revealed that caspase‑9 and caspase‑3 were activated, whereas caspase‑8 remained inactive. |
2019-02-12 |
2023-08-13 |
human |
| Zhengpeng Zeng, Shenghua Sun, Lihua Xi. [Effect of miR-21 on autophagy, proliferation and apoptosis of macrophages induced by cigarette smoke extract]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 43. issue 12. 2019-02-11. PMID:30643042. |
the effects of mir-21 inhibitor on macrophage autophagy, proliferation and apoptosis were detected by western blot, mtt assay and flow cytometry.
results: compared with the control group, the levels of mir-21 and autophagy in the cse group were significantly increased (both p<0.05). |
2019-02-11 |
2023-08-13 |
Not clear |
| Xing-He Wang, Wei Li, Xing-Hui Wang, Mei-Yu Han, Ishfaq Muhammad, Xiu-Ying Zhang, Xiao-Qi Sun, Xiao-Xu Cu. Water-soluble substances of wheat: a potential preventer of aflatoxin B1-induced liver damage in broilers. Poultry science. vol 98. issue 1. 2019-02-06. PMID:30107611. |
the hallmarks of hepatocellular autophagy, apoptosis, and inflammation were measured by western blot and real-time polymerase chain reaction. |
2019-02-06 |
2023-08-13 |
chicken |
| Wenxian Jiang, Rongshen Wang, Di Liu, Min Zuo, Chunzhen Zhao, Tianliang Zhang, Wanzhong L. Protective Effects of Kaempferitrin on Advanced Glycation End Products Induce Mesangial Cell Apoptosis and Oxidative Stress. International journal of molecular sciences. vol 19. issue 11. 2019-02-05. PMID:30373106. |
hoechst 33258 and annexin v and propidium iodide (pi) double staining were performed to observe the apoptosis states in gmcs, whereas apoptosis and protective mechanism in age-induced gmcs were investigated by western blot. |
2019-02-05 |
2023-08-13 |
rat |
| He Zhang, Qingli Shang, Jianbin An, Caixia Wang, Jingxue M. Crocetin inhibits PDGF-BB-induced proliferation and migration of retinal pigment epithelial cells. European journal of pharmacology. vol 842. 2019-02-04. PMID:30395849. |
the levels of main regulatory proteins for apoptosis and the pdgf-bb-induced signaling pathway were determined by western blot analysis. |
2019-02-04 |
2023-08-13 |
Not clear |
| Zefei Wang, Chunzhi Yu, Hong Wan. HOXA5 inhibits the proliferation and induces the apoptosis of cervical cancer cells via regulation of protein kinase B and p27. Oncology reports. vol 41. issue 2. 2019-02-04. PMID:30483748. |
additionally, significant elevation of akt activation measured by western blot analysis abrogated the effect of hoxa5 on caspase‑3 activity, cell apoptosis, proliferation, invasion and cell viability. |
2019-02-04 |
2023-08-13 |
Not clear |
| Beibei Zhang, Jin Xu, Zhe Quan, Miao Qian, Wei Liu, Wanfang Zheng, Fang Yin, Jiru Du, Yuanting Zhi, Ningjing Son. Klotho Protein Protects Human Keratinocytes from UVB-Induced Damage Possibly by Reducing Expression and Nuclear Translocation of NF-κB. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2019-02-01. PMID:30481165. |
the effects of exposure to uvb radiation on the human keratinocyte hacat cells, including cell growth, apoptosis, and changes of selected biomarkers, were measured by cck-8, flow cytometry, quantitative real-time pcr, and western blot analysis. |
2019-02-01 |
2023-08-13 |
human |
| W Cheng, Y Q Feng, J Ren, D Jing, C Wan. Anti-tumor role of Bacillus subtilis fmbJ-derived fengycin on human colon cancer HT29 cell line. Neoplasma. vol 63. issue 2. 2019-01-28. PMID:26774143. |
western blot analysis showed that after being treated with fengycin, bax, caspase-3, and caspase-6 expressions were increased, however, bcl-2, and cdk4/cyclin d1 expressions were decreased (p<0.05).our study suggested that fengycin may play certain inhibit roles in the development and progression of colon cancer through involving in the cell apoptosis and cell cycle processes by targeting the bax/bcl-2 pathway. |
2019-01-28 |
2023-08-13 |
human |
| Aruo Nan, Yangyang Jia, Xin Li, Meiling Liu, Nan Zhang, Lijian Chen, Ti Yang, Yiqin Xu, Xin Dai, Ying Cheng, Zhenzhong Liu, Yihui Ling, Yiguo Jian. Editor's Highlight: lncRNAL20992 Regulates Apoptotic Proteins to Promote Lead-Induced Neuronal Apoptosis. Toxicological sciences : an official journal of the Society of Toxicology. vol 161. issue 1. 2019-01-28. PMID:29029323. |
silencing lncrnal20992 revealed its significant functions involved in promoting cell apoptosis and inhibiting cell proliferation according to cell-counting kit-8, edu assay, terminal deoxynucleotidyl transferase dutp nick-end labeling, and western blot. |
2019-01-28 |
2023-08-13 |
human |
| Hai Liu, Xuanxuan Wang, Aihua Huang, Huaping Gao, Yikan Sun, Tingting Jiang, Liming Shi, Xianjie Wu, Qinghua Dong, Xiaonan Su. Silencing Artemis Enhances Colorectal Cancer Cell Sensitivity to DNA-Damaging Agents. Oncology research. vol 27. issue 1. 2019-01-28. PMID:29426373. |
induced by dna-damaging agents, delayed dna repair kinetics was found by the γ-h2ax foci assay, and a significantly increased cell apoptosis occurred in the artemis knockdown rko cells through apoptosis detection methods and western blot. |
2019-01-28 |
2023-08-13 |
human |
| Daniel Ngabire, Yeong-Ae Seong, Maheshkumar Prakash Patil, Irvine Niyonizigiye, Yong Bae Seo, Gun-Do Ki. Induction of apoptosis and G1 phase cell cycle arrest by Aster incisus in AGS gastric adenocarcinoma cells. International journal of oncology. vol 53. issue 5. 2019-01-28. PMID:30226597. |
the results of western blot analysis indicated that aie increased the expression of pro-apoptotic proteins, particularly bid, bad, bak, cytochrome c, apoptosis inducing factor (aif), cleaved caspase‑3, -8 and -9 and cleaved poly(adp-ribose) polymerase (parp). |
2019-01-28 |
2023-08-13 |
human |
| Zongmeng Zhang, Jie Chen, Fanghui Chen, Daolun Yu, Rui Li, Chenglong Lv, Haosen Wang, Honglin Li, Jun Li, Yafei Ca. Tauroursodeoxycholic acid alleviates secondary injury in the spinal cord via up-regulation of CIBZ gene. Cell stress & chaperones. vol 23. issue 4. 2019-01-25. PMID:29151236. |
traumatic sci mice were intraperitoneally injected with tudca, and the effects were evaluated based on motor function assessment, histopathology, apoptosis detection, qrt-pcr, and western blot at different time periods. |
2019-01-25 |
2023-08-13 |
mouse |