| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ye Zhang, Peng Lu, Huaping Du, Lifei Zhan. LINK-A lncRNA Promotes Proliferation and Inhibits Apoptosis of Mantle Cell Lymphoma Cell by Upregulating Survivin. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-03-22. PMID:30636001. |
link-a lncrna shrna and expression vector were transfected into cells of human mantle cell lymphoma cell lines, followed by detection of cell proliferation, cell apoptosis, and survivin expression by cell proliferation assay, cell apoptosis assay, and western blot analysis, respectively. |
2019-03-22 |
2023-08-13 |
human |
| Ke-Feng Zhai, Hong Duan, Cai-Yue Cui, Yu-Yao Cao, Jia-Li Si, Hui-Jiao Yang, Yong-Chao Wang, Wen-Gen Cao, Gui-Zhen Gao, Zhao-Jun We. Liquiritin from Glycyrrhiza uralensis Attenuating Rheumatoid Arthritis via Reducing Inflammation, Suppressing Angiogenesis, and Inhibiting MAPK Signaling Pathway. Journal of agricultural and food chemistry. vol 67. issue 10. 2019-03-22. PMID:30785275. |
an mtt assay, hoechst 33342 staining, jc-1 staining, and western blot were used to check the viability, cell apoptosis, mitochondrial membrane potential changes, and the expression of related proteins, respectively. |
2019-03-22 |
2023-08-13 |
Not clear |
| H Ramamoorthy, P Abraham, B Isaac, D Selvakuma. Mitochondrial pathway of apoptosis and necrosis contribute to tenofovir disoproxil fumarate-induced renal damage in rats. Human & experimental toxicology. vol 38. issue 3. 2019-03-19. PMID:30326737. |
apoptosis was detected by terminal deoxynucleotidyl transferase biotin-deoxyuridine triphosphate nick end-labelling (tunel) assay and caspase 3 activity and protein expression; mitochondrial pathway of apoptosis by cyt c release; and parp activation by immunofluorescence, immunohistochemistry and western blot techniques. |
2019-03-19 |
2023-08-13 |
human |
| Wen Zhu, Xue-Rui Wang, Si-Qi Du, Chao-Qun Yan, Na-Na Yang, Lu-Lu Lin, Guang-Xia Shi, Cun-Zhi Li. Anti-oxidative and Anti-apoptotic Effects of Acupuncture: Role of Thioredoxin-1 in the Hippocampus of Vascular Dementia Rats. Neuroscience. vol 379. 2019-03-18. PMID:29592844. |
the protein and mrna levels of trx-1 and trxr-1, the activity of trxr-1 as well as the phosphorylation of the apoptosis signal-regulating kinase 1 (ask1)-c-jun n-terminal kinase (jnk)/p38 pathway were measured by western blot, real-time pcr analysis, trxr-1 activity analysis and immunofluorescence (if) staining respectively. |
2019-03-18 |
2023-08-13 |
rat |
| Hao Wu, Chao Zeng, Yiwang Ye, Jixian Liu, Zhimin Mu, Yuancai Xie, Baokun Chen, Qiaohong Nong, Da W. Exosomes from Irradiated Nonsmall Cell Lung Cancer Cells Reduced Sensitivity of Recipient Cells to Anaplastic Lymphoma Kinase Inhibitors. Molecular pharmaceutics. vol 15. issue 5. 2019-03-18. PMID:29595984. |
western blot, flow cytometry, mtt, and xenograft were employed to respectively assess activation of the alk pathway, apoptosis, cell viability, and tumor growth. |
2019-03-18 |
2023-08-13 |
mouse |
| Yue Guo, Fang Wang, Haopeng Li, Hui Liang, Yuhuan Li, Zhengchao Gao, Xijing H. Metformin Protects Against Spinal Cord Injury by Regulating Autophagy via the mTOR Signaling Pathway. Neurochemical research. vol 43. issue 5. 2019-03-18. PMID:29728793. |
western blot and immunofluorescent analysis revealed that mammalian target of rapamycin (mtor) and p70s6 kinase (p70s6k) decreased, while the expression of autophagy markers increased and apoptosis markers declined in animals treated with metformin following sci. |
2019-03-18 |
2023-08-13 |
rat |
| Shuyun Ma, Xiaohong Deng, Yang Yang, Qingqing Zhang, Ting Zhou, Zi Li. The lncRNA LINC00675 regulates cell proliferation, migration, and invasion by affecting Wnt/β-catenin signaling in cervical cancer. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 108. 2019-03-18. PMID:30372871. |
linc00675 expression was determined by quantitative real-time polymerase chain reaction; cell proliferation, migration and invasion were determined by cell counting kit-8, transwell migration, and invasion assays, respectively; cell apoptosis was measured by flow cytometry; protein levels were measured by western blot assay. |
2019-03-18 |
2023-08-13 |
Not clear |
| Weichao Zhao, Nan Hu, Dexin Ding, Dingxin Long, Sheng Li, Guangyue Li, Hui Zhan. Developmental toxicity and apoptosis in zebrafish embryos induced by low-dose γ-ray irradiation. Environmental science and pollution research international. vol 26. issue 4. 2019-03-18. PMID:30539402. |
in this paper, the developmental toxicity and apoptosis in zebrafish (danio rerio) embryos induced by 0.01, 0.05, and 0.10-gy γ-ray irradiation were investigated and verified by single cell gel electrophoresis, acridine orange staining, flow cytometry, transmission electron microscopy, digital gene expression sequencing, and western blot analysis. |
2019-03-18 |
2023-08-13 |
zebrafish |
| Elisa Landucci, Irene L Llorente, Berta Anuncibay-Soto, Domenico E Pellegrini-Giampietro, Arsenio Fernández-Lópe. Bicuculline Reverts the Neuroprotective Effects of Meloxicam in an Oxygen and Glucose Deprivation (OGD) Model of Organotypic Hippocampal Slice Cultures. Neuroscience. vol 386. 2019-03-11. PMID:29949743. |
western blot assays were performed to measure levels of cleaved and non-cleaved caspase-3 to quantify apoptosis, while levels of grp78, grp94 and phosphorylated eif2α were used to detect unfolded protein response (upr). |
2019-03-11 |
2023-08-13 |
rat |
| Bo Xu, An-Ming Zhang, Fang Li, Miao Cui, Ji Han, Qin Ca. XZ-1 regulates cell apoptosis of gastric epithelial dysplasia via NF-κB/p53/Ki67 signaling pathway. Bioscience reports. vol 38. issue 3. 2019-03-08. PMID:29588340. |
specimens taken from the pyloric area of the stomachs from rats in each group were subjected to hematoxylin and eosin (h&e) staining for pathological examination, tunel staining for apoptosis detection, and western blot analysis for apoptosis-related proteins. |
2019-03-08 |
2023-08-13 |
rat |
| Chao Liu, Min Jian, Hong Qi, Wei-Zheng Ma. MicroRNA 495 Inhibits Proliferation and Metastasis and Promotes Apoptosis by Targeting Twist1 in Gastric Cancer Cells. Oncology research. vol 27. issue 3. 2019-03-08. PMID:29615148. |
the expressions of mir-495, cell viability, migration, apoptosis, and apoptosis-related factors were examined by qrt-pcr, trypan blue staining, transwell, flow cytometry, and western blot, respectively. |
2019-03-08 |
2023-08-13 |
Not clear |
| Xiaoqi Zhang, Hao Feng, Juan Du, Jing Sun, Dongfang Li, Tomoka Hasegawa, Norio Amizuka, Minqi L. Aspirin promotes apoptosis and inhibits proliferation by blocking G0/G1 into S phase in rheumatoid arthritis fibroblast-like synoviocytes via downregulation of JAK/STAT3 and NF-κB signaling pathway. International journal of molecular medicine. vol 42. issue 6. 2019-03-06. PMID:30221683. |
apoptosis and cell cycle‑associated proteins (bcl‑2, bax, prap1, cyclin d1, p21), as well as the key proteins and their phosphorylation levels of the nf‑κb and jak/stat3 signaling pathways, were detected via western blot analysis. |
2019-03-06 |
2023-08-13 |
Not clear |
| Yanlin Tan, Xingwang Yao, Zhehao Dai, Yunhua Wang, Guohua L. Bone morphogenetic protein 2 alleviated intervertebral disc degeneration through mediating the degradation of ECM and apoptosis of nucleus pulposus cells via the PI3K/Akt pathway. International journal of molecular medicine. vol 43. issue 1. 2019-03-05. PMID:30387830. |
in addition, the levels of phosphorylation of phosphoinositide 3‑kinase (pi3k) and protein kinase b (akt), and the levels of apoptosis‑associated proteins and apoptosis ratio of np cells were also determined by western blot analysis and flow cytometry, respectively. |
2019-03-05 |
2023-08-13 |
human |
| Sheng Zhao, Wei Li, Fan Cheng, Ting Rao, Weimin Yu, Yuan Ruan, Run Yuan, Xiaobing Yao, Jinzhuo Nin. High-pressure carbon dioxide pneumoperitoneum induces oxidative stress and mitochondria-associated apoptotic pathway in rabbit kidneys with severe hydronephrosis. International journal of molecular medicine. vol 43. issue 1. 2019-03-05. PMID:30431064. |
activation of apoptosis was analyzed by western blot analysis of b‑cell lymphoma 2 (bcl‑2), bcl‑2‑associated x protein (bax), cytochrome c (cyt c), caspase‑3 and caspase‑9 levels. |
2019-03-05 |
2023-08-13 |
rabbit |
| Ying Xu, Bing Shu, Ye Tian, Guangxi Wang, Yongjun Wang, Jinwu Wang, Yufeng Don. Oleanolic acid induces osteosarcoma cell apoptosis by inhibition of Notch signaling. Molecular carcinogenesis. vol 57. issue 7. 2019-03-04. PMID:29566282. |
western blot analysis and a mitochondrial membrane potential assay demonstrated that oa functions through the mitochondrial apoptosis pathway. |
2019-03-04 |
2023-08-13 |
human |
| In Hwan Tae, Eun Young Park, Prasanta Dey, Ji Yeon Son, Seok-Yong Lee, Jee H Jung, Saloni Saloni, Mi-Hyun Kim, Hyung Sik Ki. Novel SIRT1 inhibitor 15-deoxy-Δ12,14-prostaglandin J2 and its derivatives exhibit anticancer activity through apoptotic or autophagic cell death pathways in SKOV3 cells. International journal of oncology. vol 53. issue 6. 2019-03-04. PMID:30221742. |
cell cycle arrest, apoptosis and autophagy were determined using flow cytometry or western blot analysis. |
2019-03-04 |
2023-08-13 |
Not clear |
| Zhenlan Du, Haidong Zhang, Qiang Chen, Yongfeng Gao, Baoliang Su. Intranasal Calcitonin Gene-Related Peptide Protects Against Focal Cerebral Ischemic Injury in Rats Through the Wnt/β-Catenin Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2019-03-04. PMID:30531687. |
cell counting kit-8 assay, colony formation assay, cell cycle assay, apoptosis assay, western blot assay, and top/fop assay were used to investigate the role of cgrp in normal human astrocytes (nha) cells. |
2019-03-04 |
2023-08-13 |
human |
| Yan Ma, Xiaojing Ji. Polydatin Alleviates Radiation-Induced Testes Injury by Scavenging ROS and Inhibiting Apoptosis Pathways. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2019-03-04. PMID:30539937. |
elisa assay was used to measure the level of inflammatory cytokines, and apoptosis proteins were detected by western blot assay. |
2019-03-04 |
2023-08-13 |
mouse |
| Yanting Chai, Ke Xiang, Yezi Wu, Te Zhang, Ying Liu, Xuewen Liu, Weiguo Zhen, Yuan S. Cucurbitacin B Inhibits the Hippo-YAP Signaling Pathway and Exerts Anticancer Activity in Colorectal Cancer Cells. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2019-03-04. PMID:30566960. |
western blot and real-time pcr were used to investigate the expression of apoptosis and hippo-yap signaling pathway proteins. |
2019-03-04 |
2023-08-13 |
Not clear |
| Jiayu Lin, Qingyan Cai, Bo Liang, Lizhen Wu, Yong Zhuang, Yuanfang He, Wanrong Li. Berberine, a Traditional Chinese Medicine, Reduces Inflammation in Adipose Tissue, Polarizes M2 Macrophages, and Increases Energy Expenditure in Mice Fed a High-Fat Diet. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-03-04. PMID:30606998. |
the expression of pro-inflammatory cytokines, apoptosis genes, thermogenic genes (including ucp1), and ire1α, were investigated using immunohistochemistry, western blot, and quantitative reverse transcription polymerase chain reaction (qrt-pcr), in white and brown adipose tissue. |
2019-03-04 |
2023-08-13 |
mouse |