| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mengwei Wang, Ping Zhang, Zeyu Li, Yu Yan, Xin Cheng, Guang Wang, Xuesong Yan. Different cellular mechanisms from low- and high-dose zinc oxide nanoparticles-induced heart tube malformation during embryogenesis. Nanotoxicology. 2022-09-22. PMID:36137004. |
during early cardiogenesis, zno nps exposure increased the chance of heart tube malformation, while precardiac cell apoptosis rises in the phenotype of closure defect and bifida. |
2022-09-22 |
2023-08-14 |
human |
| Mengwei Wang, Ping Zhang, Zeyu Li, Yu Yan, Xin Cheng, Guang Wang, Xuesong Yan. Different cellular mechanisms from low- and high-dose zinc oxide nanoparticles-induced heart tube malformation during embryogenesis. Nanotoxicology. 2022-09-22. PMID:36137004. |
apart from cell apoptosis, high-dose zno nps exposure led to massive programmed necrosis, and further experiments verified that ferroptosis remained primarily in zno nps-induced programmed necrosis. |
2022-09-22 |
2023-08-14 |
human |
| Liying Dong, Shutao Wang, Lin Zhang, Dongmei Liu, Hong Yo. DBDPE and ZnO NPs synergistically induce neurotoxicity of SK-N-SH cells and activate mitochondrial apoptosis signaling pathway and Nrf2-mediated antioxidant pathway. Journal of hazardous materials. vol 441. 2022-09-09. PMID:36084461. |
dbdpe and zno nps synergistically induce neurotoxicity of sk-n-sh cells and activate mitochondrial apoptosis signaling pathway and nrf2-mediated antioxidant pathway. |
2022-09-09 |
2023-08-14 |
human |
| Liying Dong, Shutao Wang, Lin Zhang, Dongmei Liu, Hong Yo. DBDPE and ZnO NPs synergistically induce neurotoxicity of SK-N-SH cells and activate mitochondrial apoptosis signaling pathway and Nrf2-mediated antioxidant pathway. Journal of hazardous materials. vol 441. 2022-09-09. PMID:36084461. |
moreover, dbdpe and zno nps caused apoptosis by disrupting mitochondrial kinetic homeostasis, reducing mitochondrial membrane potential (mmp), increasing cytochrome c release and regulating bax/bcl-2 and caspase-3 mrna and protein expression. |
2022-09-09 |
2023-08-14 |
human |
| Armina Shirangi, Fatemeh Mottaghitalab, Sajad Dinarvand, Fatemeh Atyab. Theranostic silk sericin/SPION nanoparticles for targeted delivery of ROR1 siRNA: Synthesis, characterization, diagnosis and anticancer effect on triple-negative breast cancer. International journal of biological macromolecules. 2022-09-09. PMID:36084874. |
the apoptosis study showed significant death of mda-mb-231 cells after 24 h treatment with the prepared nps. |
2022-09-09 |
2023-08-14 |
mouse |
| Jiangnan Yi, Yuanliang Li, Qianying Mai, Yaxuan Li, Yingying Lin, Xiaoshan Weng, Zhu Ai, Mingze Li, Peng Shang, Mujahid Iqbal, Khalid Mehmood, Yung-Fu Chang, Zhaoxin Tang, Hui Zhang, Ying L. Hepatotoxicity and the role of the gut-liver axis in dogs after oral administration of zinc oxide nanoparticles. Metallomics : integrated biometal science. 2022-09-04. PMID:36057841. |
results showed that zno nps significantly inhibited the hepatocyte apoptosis via cytc pathway and promoted the autophagy via activating mtor/atg5 pathway. |
2022-09-04 |
2023-08-14 |
Not clear |
| Liyao Zhang, Peijie Huang, Shubin Huang, Tao Wang, Shufeng Chen, Zhihao Chen, Yi Zhou, Linghao Qi. Development of ligand modified erythrocyte coated polydopamine nanomedicine to codeliver chemotherapeutic agent and oxygen for chemo-photothermal synergistic cancer therapy. International journal of pharmaceutics. 2022-09-04. PMID:36058410. |
moreover, dppr nps could be effectively internalized into tumor cells and destroyed the intracellular redox balance to mediate cell apoptosis. |
2022-09-04 |
2023-08-14 |
Not clear |
| Jiang Ni, Yuanyuan Mi, Bei Wang, Yuting Zhu, Yang Ding, Yongjuan Ding, Xia L. Naturally Equipped Urinary Exosomes Coated Poly (2-ethyl-2-oxazoline)-Poly (D, L-lactide) Nanocarriers for the Pre-Clinical Translation of Breast Cancer. Bioengineering (Basel, Switzerland). vol 9. issue 8. 2022-08-25. PMID:36004889. |
in vitro experiments revealed that uepp-d nps exhibited significantly improved cellular uptake, cytotoxicity, and apoptosis in mcf-7 cell lines as compared to dox-loaded peoz-pla nanoparticles (pp-d nps) and free dox. |
2022-08-25 |
2023-08-14 |
mouse |
| Quan Wang, Hongshu Jing, Jun Lin, Zhihua Wu, Yu Tian, Ke Gong, Qianqian Guo, Xupeng Yang, Liting Wang, Zhaojun Li, Yourong Dua. Programmed prodrug breaking the feedback regulation of P-selectin in plaque inflammation for atherosclerotic therapy. Biomaterials. 2022-08-24. PMID:36002347. |
functionally, li nps could interfere with p-selectin in the inflammatory process, such as inhibiting macrophage adhesion, reducing the secretion of inflammatory factors, and inducing macrophage apoptosis. |
2022-08-24 |
2023-08-14 |
mouse |
| Murat Doga. Assessment of mechanism involved in the apoptotic and anti-cancer activity of Quercetin and Quercetin-loaded chitosan nanoparticles. Medical oncology (Northwood, London, England). vol 39. issue 11. 2022-08-23. PMID:35999475. |
overall, quercetin and quercetin-loaded chitosan nps caused significant cytotoxicity in sh-sy5y cells via producing oxidative stress, dna damage, and eventually apoptosis. |
2022-08-23 |
2023-08-14 |
Not clear |
| Jun Yang, Jieqiong Lin, Xianxiang Chen, Liyuan Rong, Mingyue Shen, Yuanxing Wang, Jianhua Xi. Mesona chinensis polysaccharide/zein nanoparticles to improve the bioaccesibility and in vitro bioactivities of curcumin. Carbohydrate polymers. vol 295. 2022-08-21. PMID:35989015. |
studies on in vitro antitumor activity of zmc nps showed that they could enter hepatocellular carcinoma cells, induce cell apoptosis, promote ros production, and alter mitochondrial membrane potential, showing higher in vitro antitumor activity compared to free curcumin. |
2022-08-21 |
2023-08-14 |
Not clear |
| Pengxiao Li, Xiaoyuan Guo, Ting Liu, Qing Liu, Jie Yang, Guoyun Li. Evaluation of Hepatoprotective Effects of Piperlongumine Derivative PL 1-3-Loaded Albumin Nanoparticles on Lipopolysaccharide/d-Galactosamine-Induced Acute Liver Injury in Mice. Molecular pharmaceutics. 2022-08-16. PMID:35971845. |
1-3 nps treatment can inhibit inflammation, oxidative stress, and apoptosis via the downregulation of nf-κb signaling pathways, the activation of nrf2/ho-1 signaling pathways, and the inhibition of expression of bax and caspase 3 proteins. |
2022-08-16 |
2023-08-14 |
mouse |
| Xingyu Nan, Xingkun Jin, Yu Song, Kaimin Zhou, Yukai Qin, Qun Wang, Weiwei L. Effect of polystyrene nanoplastics on cell apoptosis, glucose metabolism, and antibacterial immunity of Eriocheir sinensis. Environmental pollution (Barking, Essex : 1987). 2022-08-16. PMID:35973454. |
this study aimed to investigate the effects of ps nps on apoptosis and glucose metabolism in chinese mitten crabs, and whether ps nps could synergistically affect the antibacterial immunity of crabs. |
2022-08-16 |
2023-08-14 |
Not clear |
| Xingyu Nan, Xingkun Jin, Yu Song, Kaimin Zhou, Yukai Qin, Qun Wang, Weiwei L. Effect of polystyrene nanoplastics on cell apoptosis, glucose metabolism, and antibacterial immunity of Eriocheir sinensis. Environmental pollution (Barking, Essex : 1987). 2022-08-16. PMID:35973454. |
the rna sequencing data showed that after hemocytes endocytosed nps, apoptosis and glucose metabolism-related gene expression was significantly induced, resulting in abnormal cell apoptosis and a glucose metabolism disorder. |
2022-08-16 |
2023-08-14 |
Not clear |
| Xingyu Nan, Xingkun Jin, Yu Song, Kaimin Zhou, Yukai Qin, Qun Wang, Weiwei L. Effect of polystyrene nanoplastics on cell apoptosis, glucose metabolism, and antibacterial immunity of Eriocheir sinensis. Environmental pollution (Barking, Essex : 1987). 2022-08-16. PMID:35973454. |
in summary, nps could be endocytosed by crab hemocytes, which adversely affected the cell apoptosis, glucose metabolism, and antibacterial immunity of eriocheir sinensis. |
2022-08-16 |
2023-08-14 |
Not clear |
| Sayanta Dutta, Pratik Chakraborty, Susmita Basak, Sumit Ghosh, Noyel Ghosh, Sharmistha Chatterjee, Saikat Dewanjee, Parames C Si. Synthesis, characterization, and evaluation of in vitro cytotoxicity and in vivo antitumor activity of asiatic acid-loaded poly lactic-co-glycolic acid nanoparticles: A strategy of treating breast cancer. Life sciences. 2022-08-12. PMID:35961595. |
immunoblotting showed that aa-plga nps elicited an intrinsic pathway of apoptosis in mcf-7 cells. |
2022-08-12 |
2023-08-14 |
mouse |
| Madhu Gupta, Vikas Sharma, Kalicharan Sharma, Anoop Kumar, Ajay Sharma, Imran Kazmi, Fahad A Al-Abbasi, Sami I Alzarea, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Sachin Kumar Singh, Gaurav Gupta, Keshav Raj Paudel, Philip M Hansbro, Kamal Du. A kNGR Peptide-Tethered Lipid-Polymer Hybrid Nanocarrier-Based Synergistic Approach for Effective Tumor Therapy: Development, Characterization, Ex-Vivo, and In-Vivo Assessment. Pharmaceutics. vol 14. issue 7. 2022-07-27. PMID:35890297. |
the results support that, compared to other nps, plns-kngr-nps are highly cytotoxic, owing to higher apoptosis and intracellular uptake. |
2022-07-27 |
2023-08-14 |
mouse |
| Jiacui Liu, Ping Wang, Ben Huang, Qingyuan Cheng, Yiping Duan, Liangyue Chen, Tiantian Ma, Cuiwen Zhu, Dongxu Li, Wei Fan, Mingxia Y. Effective suppression of triple negative breast cancer by paclitaxel nanoparticles conjugated with transmembrane TNF-α monoclonal antibody. International journal of pharmaceutics. 2022-07-08. PMID:35803533. |
tmtnf-α mab-ptx nps exerts anti-tumor effects via promoting apoptosis and regulating mitogen-activated protein kinase (mapk), phosphatidylinositol 3-kinase (pi3k) / protein kinase b (akt)/ mammalian target of rapamycin (mtor) cascade, as well as amp-activated protein kinase (ampk) and nuclear factor kappa-b (nf-κb) pathways. |
2022-07-08 |
2023-08-14 |
mouse |
| Ehab Tousson, Sarah Alashmouni, Afaf El-Atrash, Doaa M El-Gharbaw. The potential curative role of Avena sativa extract against oxidative stress, DNA damage and apoptosis induced by acute hepatotoxicity of silver nanoparticles in rats. Environmental toxicology. 2022-06-29. PMID:35765203. |
the goal of this study was to investigate if avena sativa (avs) extract could ameliorate ag nps toxicity-induced alterations in liver structure and function, dna damage, apoptosis, and oxidative stress. |
2022-06-29 |
2023-08-14 |
rat |
| Zhuojia Xu, Aihua Qu, Hongyu Zhang, Weiwei Wang, Changlong Hao, Meiru Lu, Baimei Shi, Liguang Xu, Maozhong Sun, Chuanlai Xu, Hua Kuan. Photoinduced elimination of senescent microglia cells Chemical science. vol 13. issue 22. 2022-06-27. PMID:35756519. |
in this study, chiral gold nanoparticles (nps) with different helical directions were synthesized to selectively induce the apoptosis of senescent cells under light illumination. |
2022-06-27 |
2023-08-14 |
Not clear |