| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jin-Zi Chen, Xyu-Yan Li, Dong-Mei Liu, Shu-Ting Long, Yong-Mei Li, Hong-Bing Che. [Effects of ZnO nanoparticles on proliferation and apoptosis of human lung epithelial BEAS-2B cells]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 38. issue 5. 2023-04-23. PMID:37088749. |
to investigate the effects of zno nanoparticles (zno nps) on proliferation and apoptosis of human lung epithelial cells beas-2b and its molecular mechanisms. |
2023-04-23 |
2023-08-14 |
human |
| Ruikun Lin, Lei Zhang, Biwei Ye, Yanan Wang, Yi-Dong Li, Hsu Jason, Wenzhen Liu, Ping Hu, Jincan Chen, Zhe-Sheng Chen, Zhuo Che. A multi-functional nano-system combining PI3K-110α/β inhibitor overcomes P-glycoprotein mediated MDR and improves anti-cancer efficiency. Cancer letters. 2023-04-22. PMID:37086953. |
in-vitro experiments indicated that pbdf nps greatly enhanced uptake of dox, improved the activity to reverse mdr, inhibited the cell proliferation, and induced s-phase arrest and apoptosis in kb-c2 cells, as compared with free dox combining free bay-1082439. |
2023-04-22 |
2023-08-14 |
mouse |
| Tian-Tian Zhao, Tian-Jiao Zhou, Chen Zhang, Ying-Xuan Liu, Wen-Jia Wang, Chengjun Li, Lei Xing, Hu-Lin Jian. Hypoxia Inhibitor Combined with Chemotherapeutic Agents for Antitumor and Antimetastatic Efficacy against Osteosarcoma. Molecular pharmaceutics. 2023-04-12. PMID:37042832. |
compared with free dox, abz combined with dox can increase intracellular reactive oxygen species (ros) and induce more tumor cell apoptosis; therefore, ad@plga-peg nps produced more mitochondria-mediated oxidative stress and better apoptosis efficiency. |
2023-04-12 |
2023-08-14 |
Not clear |
| Senthilkumar Thirumurugan, Pranjyan Dash, Xinrui Liu, Yuan-Yun Tseng, Jui-Hua Chung, Yunqian Li, Gang Zhao, Chingpo Lin, Yu-Chien Lin, Ren-Jei Chun. Angiopep-2-conjugated FeTi@Au core-shell nanoparticles for tumor targeted dual-mode magnetic resonance imaging and hyperthermic glioma therapy. Nanomedicine : nanotechnology, biology, and medicine. 2023-04-12. PMID:37044193. |
effective targeted delivery of feti@au-ang nps was demonstrated in vitro by improved transport and cellular uptake, and increased apoptosis in glioma cells (c6) compared with normal fibroblast cells (l929). |
2023-04-12 |
2023-08-14 |
mouse |
| Lipeng Qiu, Junze Wang, Mariana Conceição, Shenhuan Liu, Meiyang Yang, Weijun Chen, Miaomiao Long, Xian Cheng, Matthew J A Wood, Jinghua Che. Tumor-targeted glycogen nanoparticles loaded with hemin and glucose oxidase to promote tumor synergistic therapy. International journal of biological macromolecules. 2023-04-09. PMID:37031790. |
the nps could efficiently produce reactive oxygen species in tumor cells, resulting in a decrease in the mitochondrial membrane potential and apoptosis of tumor cells. |
2023-04-09 |
2023-08-14 |
Not clear |
| Xiang Sun, Rui Zhao, Eryong Zhao, Qing Wang, Wenqin Lian, Jian Xion. Targeting CD44-positive ovarian cancers via engineered paclitaxel prodrug nanoparticles for enhanced chemotherapeutic efficacy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 154. 2023-03-21. PMID:36942600. |
further studies indicated that ha-coated nanodrugs (ha-pla-ptx nps) could preferentially accumulate in the cd44-expressing skov3 cells, which induced elevated cytotoxicity, reduced cell proliferation, and increased cell apoptosis. |
2023-03-21 |
2023-08-14 |
human |
| Sha Yang, Bin Sun, Fen Liu, Na Li, Minghui Wang, Peixian Wu, Gui-Long Wu, Huilong Fang, Yuxuan He, Wei Zhou, Hao Xiao, Xiaofeng Tan, Li Tang, Shoujun Zhu, Qinglai Yan. NIR-II Imaging-Guided Mitochondrial-Targeting Organic Nanoparticles for Multimodal Synergistic Tumor Therapy. Small (Weinheim an der Bergstrasse, Germany). 2023-03-21. PMID:36942859. |
after 808 nm irradiation, the mitochondrial localization of fe-t nps generated reactive oxygen species (ros), and hyperthermia, leading to mitochondrial dysfunction, photoinductive apoptosis, and immunogenic cell death (icd). |
2023-03-21 |
2023-08-14 |
Not clear |
| Karin Fromell, Ulrika Johansson, Sophia Abadgar, Pauline Bourzeix, Lovisa Lundholm, Karine Elih. The effect of airborne Palladium nanoparticles on human lung cells, endothelium and blood - A combinatory approach using three in vitro models. Toxicology in vitro : an international journal published in association with BIBRA. 2023-03-17. PMID:36931534. |
in the endothelial cell model, pd nps induced apoptosis, but not to the same extent as the most aggressive types of nps such as tio |
2023-03-17 |
2023-08-14 |
human |
| Yaqin Tu, Wei Zhang, Guorun Fan, Chenming Zou, Jie Zhang, Nan Wu, Jiahui Ding, Wen Qing Zou, Hongjun Xiao, Songwei Ta. Paclitaxel-loaded ROS-responsive nanoparticles for head and neck cancer therapy. Drug delivery. vol 30. issue 1. 2023-03-14. PMID:36916054. |
compared to ptx, ptx-loaded nanoparticles (ptx@tpgs-pbte nps) showed enhanced cytotoxicity and higher level of apoptosis toward squamous cell carcinoma (scc-7) cells. |
2023-03-14 |
2023-08-14 |
Not clear |
| Thi-Luu Ho, Chinmaya Mutalik, Lekshmi Rethi, Huynh-Ngoc Truc Nguyen, Pei-Ru Jheng, Chin-Chean Wong, Tzu-Sen Yang, Thi Thuy Nguyen, Bradley W Mansel, Chen-An Wang, Er-Yuan Chuan. Cancer-targeted fucoidan‑iron oxide nanoparticles for synergistic chemotherapy/chemodynamic theranostics through amplification of P-selectin and oxidative stress. International journal of biological macromolecules. 2023-03-04. PMID:36870633. |
moreover, fu-io nps induced efficient apoptosis of lung cancer cells, and thus offer significant anti-cancer functions by potential chemotherapeutic-cdt. |
2023-03-04 |
2023-08-14 |
Not clear |
| Liangliang Xiang, Yun Li, Xinyu Gu, Shujie Li, Junwei Li, Jinlong Li, Yongxiang Y. Nucleolin recognizing silica nanoparticles inhibit cell proliferation by activating the Bax/Bcl-2/caspase-3 signalling pathway to induce apoptosis in liver cancer. Frontiers in pharmacology. vol 14. 2023-02-27. PMID:36843953. |
in addition, atp-msn (ict@fitc) nps can not only inhibit cell proliferation but also improve the level of ros while activating the bax/bcl-2/caspase-3 signalling pathway to induce apoptosis |
2023-02-27 |
2023-08-14 |
Not clear |
| b' Peter Tak\\xc3\\xa1\\xc4\\x8d, Radka Michalkov\\xc3\\xa1, Martina \\xc4\\x8ci\\xc5\\xbem\\xc3\\xa1rikov\\xc3\\xa1, Zdenka Bedlovi\\xc4\\x8dov\\xc3\\xa1, \\xc4\\xbdudmila Bal\\xc3\\xa1\\xc5\\xbeov\\xc3\\xa1, Gabriela Tak\\xc3\\xa1\\xc4\\x8dov\\xc3\\xa. The Role of Silver Nanoparticles in the Diagnosis and Treatment of Cancer: Are There Any Perspectives for the Future? Life (Basel, Switzerland). vol 13. issue 2. 2023-02-25. PMID:36836823.' |
it has been documented that, in cancer cells, nps promote reactive oxygen species (ros) production, induce cell cycle arrest and apoptosis, activate er (endoplasmic reticulum) stress, modulate various signaling pathways, etc. |
2023-02-25 |
2023-08-14 |
Not clear |
| Junyu Chen, Liucheng Mao, Yuming Jiang, Huihui Liu, Xiao Wang, Lingwei Meng, Qiuyao Du, Jing Han, Liuying He, Hongye Huang, Yawei Wang, Caiqiao Xiong, Yen Wei, Zongxiu Ni. Revealing the In Situ Behavior of Aggregation-Induced Emission Nanoparticles and Their Biometabolic Effects via Mass Spectrometry Imaging. ACS nano. 2023-02-21. PMID:36802559. |
moreover, spatial-selective metabolic changes upon nps mediated photodynamic therapy was identified, which enables understanding of the nps induced apoptosis in the process of cancer therapy. |
2023-02-21 |
2023-08-14 |
Not clear |
| Nasrin Ziamajidi, Sajedeh Daei, Maryam Khajvand-Abedini, Roghayeh Abbasalipourkabir, Alireza Nouria. Vitamins A, C, and E Exert Anti-apoptotic Function in the Testis of Rats After Exposure to Zinc Oxide Nanoparticles. Chonnam medical journal. vol 59. issue 1. 2023-02-16. PMID:36794239. |
to this aim, a population of 54 healthy, male wistar rats were used in this work and then assigned into nine groups of 6 rats as g1: control 1 (water); g2: control 2 (olive oil); g3: va (1000 iu/kg), g4: vc (200 mg/kg), g5: ve (100 iu/kg), g6: zno nps exposed animals (200 mg/kg); and g7, 8 and 9: zno nps-exposed animals that were pre-treated with either va, c, or e. apoptosis rates were estimated by measuring the level of apoptotic regulatory markers including bcl-2-associated x (bax) and b-cell lymphoma protein 2 (bcl-2) using western blotting and qrt-pcr assays. |
2023-02-16 |
2023-08-14 |
rat |
| Sajmina Khatun, Monika Pebam, Chandra Lekha Putta, Aravind Kumar Renga. Camptothecin loaded casein nanosystem for tuning the therapeutic efficacy against highly metastatic triple-negative breast cancer cells. Biomaterials science. 2023-02-13. PMID:36779378. |
enhanced uptake of ccs nps in zebrafish embryos and 4t1 cells, cancer cell toxicity of nearly 80-85%, sub-cellular mitochondrial localization, alterations of mitochondrial membrane potential, lysosomal localization, and reactive oxygen species generation that causes cancer cell apoptosis have been observed. |
2023-02-13 |
2023-08-14 |
zebrafish |
| Jingtong Zhao, Xupeng Mu, Xuejia Hou, Xiaowen Zhang, Ping Li, Jinlan Jian. Synergistic treatment of osteosarcoma with biomimetic nanoparticles transporting doxorubicin and siRNA. Frontiers in oncology. vol 13. 2023-02-09. PMID:36756155. |
to make chemotherapy safer and more effective for osteosarcoma patients, biomimetic nanoparticles (nps) camouflaged by mesenchymal stem cell membranes (mscms) were synthesized to induce osteosarcoma cell apoptosis by co-delivering the anticancer drug doxorubicin hydrochloride(dox) and a small interfering rna (sirna). |
2023-02-09 |
2023-08-14 |
Not clear |
| Sitong Liu, Chen Zhang, Yuanyuan Zhou, Fang Zhang, Xiaohui Duan, Yang Liu, Xibang Zhao, Jie Liu, Xintao Shuai, Jiali Wang, Zhong Ca. MRI-visible mesoporous polydopamine nanoparticles with enhanced antioxidant capacity for osteoarthritis therapy. Biomaterials. vol 295. 2023-02-09. PMID:36758340. |
a series of in vitro studies showed that the sustained release of dex from damm nps suppressed synovial inflammation and simultaneously inhibited toll-like receptor 3 (tlr-3) production in chondrocytes, contributing to prevention of chondrocyte apoptosis through the inflammatory factor-dependent tlr-3/nf-κb signaling pathway via modulation of macrophage-chondrocyte crosstalk. |
2023-02-09 |
2023-08-14 |
mouse |
| Yi Yan, An Lu, Yun Dou, Zhen Zhang, Xiang-Yu Wang, Lin Zhai, Li-Ya Ai, Ming-Ze Du, Lin-Xia Jiang, Yuan-Jun Zhu, Yu-Jie Shi, Xiao-Yan Liu, Dong Jiang, Jian-Cheng Wan. Nanomedicines Reprogram Synovial Macrophages by Scavenging Nitric Oxide and Silencing CA9 in Progressive Osteoarthritis. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2023-02-07. PMID:36748885. |
in vitro experiments demonstrate that these nps can significantly scavenge intracellular no similar to the levels as those in the normal group and downregulate the expression levels of ca9 mrna (≈90%), thereby repolarizing the m1 macrophages into the m2 phenotype and increasing the expression levels of pro-chondrogenic tgf-β1 mrna (≈1.3-fold), and inhibiting chondrocyte apoptosis. |
2023-02-07 |
2023-08-14 |
mouse |
| Jing Li, Yi-Fei Wang, Zi-Chun Shen, Qi Zou, Xiao-Fan Lin, Xiao-Yin Wan. Recent developments on natural polysaccharides as potential anti-gastric cancer substance: Structural feature and bioactivity. International journal of biological macromolecules. 2023-01-27. PMID:36706878. |
nps exhibited anti-gc activities in cell and animal experiments as well as clinical trials, and the mechanisms might be anti-proliferation, inducing apoptosis, anti-metastasis and anti-invasion, inducing autophagy, boosting immunity, anti-angiogenesis, reducing drug resistance, anti-angiogenesis, improving antioxidant level and changing metabolites. |
2023-01-27 |
2023-08-14 |
human |
| Shenglong Xia, Zimo Liu, Jieru Cai, Huiming Ren, Qi Li, Hongfang Zhang, Jing Yue, Quan Zhou, Tianhua Zhou, Liangjing Wang, Xiangrui Liu, Xuefei Zho. Liver fibrosis therapy based on biomimetic nanoparticles which deplete activated hepatic stellate cells. Journal of controlled release : official journal of the Controlled Release Society. 2023-01-24. PMID:36693527. |
non-coated nps loaded with atra) only showed the ability to induce apoptosis and decrease the α-sma expression in ahscs, respectively, tm-atra/nps induced both apoptosis and quiescence in ahscs, ultimately leading to improved fibrosis amelioration in both carbon tetrachloride-induced and methionine and choline deficient l-amino acid diet induced liver fibrosis mouse models. |
2023-01-24 |
2023-08-14 |
mouse |