| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aziz Zaanan, Koichi Okamoto, Hisato Kawakami, Khashayarsha Khazaie, Shengbing Huang, Frank A Sinicrop. The Mutant KRAS Gene Up-regulates BCL-XL Protein via STAT3 to Confer Apoptosis Resistance That Is Reversed by BIM Protein Induction and BCL-XL Antagonism. The Journal of biological chemistry. vol 290. issue 39. 2015-12-17. PMID:26245900. |
the mutant kras gene up-regulates bcl-xl protein via stat3 to confer apoptosis resistance that is reversed by bim protein induction and bcl-xl antagonism. |
2015-12-17 |
2023-08-13 |
Not clear |
| Aziz Zaanan, Koichi Okamoto, Hisato Kawakami, Khashayarsha Khazaie, Shengbing Huang, Frank A Sinicrop. The Mutant KRAS Gene Up-regulates BCL-XL Protein via STAT3 to Confer Apoptosis Resistance That Is Reversed by BIM Protein Induction and BCL-XL Antagonism. The Journal of biological chemistry. vol 290. issue 39. 2015-12-17. PMID:26245900. |
these data suggest that bcl-xl up-regulation by stat3 contributes to mutant kras-mediated apoptosis resistance. |
2015-12-17 |
2023-08-13 |
Not clear |
| Zhan Zhang, Xiaoqian Yang, Linlin Zhang, Zhenfeng Duan, Liting Jia, Peng Wang, Ying Shi, Ying Li, Junjun Ga. Decreased expression and activation of Stat3 in severe preeclampsia. Journal of molecular histology. vol 46. issue 2. 2015-12-14. PMID:25752465. |
decreased stat3 expression and activation may play an important role in the pathogenesis of pe through regulation of the transcription of the stat3 targeted genes survivin and mmp-2 to modulate apoptosis and invasion of placental trophoblastic cells. |
2015-12-14 |
2023-08-13 |
Not clear |
| Muthu K Shanmugam, Peramaiyan Rajendran, Feng Li, Chulwon Kim, Sakshi Sikka, Kodappully Sivaraman Siveen, Alan Prem Kumar, Kwang Seok Ahn, Gautam Seth. Abrogation of STAT3 signaling cascade by zerumbone inhibits proliferation and induces apoptosis in renal cell carcinoma xenograft mouse model. Molecular carcinogenesis. vol 54. issue 10. 2015-12-07. PMID:24797723. |
abrogation of stat3 signaling cascade by zerumbone inhibits proliferation and induces apoptosis in renal cell carcinoma xenograft mouse model. |
2015-12-07 |
2023-08-13 |
mouse |
| Muthu K Shanmugam, Peramaiyan Rajendran, Feng Li, Chulwon Kim, Sakshi Sikka, Kodappully Sivaraman Siveen, Alan Prem Kumar, Kwang Seok Ahn, Gautam Seth. Abrogation of STAT3 signaling cascade by zerumbone inhibits proliferation and induces apoptosis in renal cell carcinoma xenograft mouse model. Molecular carcinogenesis. vol 54. issue 10. 2015-12-07. PMID:24797723. |
the pharmacological effect of zerumbone on stat3 activation, associated protein kinases and phosphatase, and apoptosis was investigated using both rcc cell lines and xenograft mouse model. |
2015-12-07 |
2023-08-13 |
mouse |
| Yonghua Bao, Zhiguo Chen, Yongchen Guo, Yansheng Feng, Zexin Li, Wenliang Han, Jianguo Wang, Weixing Zhao, Yunjuan Jiao, Kai Li, Qian Wang, Jiaqi Wang, Huijuan Zhang, Liang Wang, Wancai Yan. Tumor suppressor microRNA-27a in colorectal carcinogenesis and progression by targeting SGPP1 and Smad2. PloS one. vol 9. issue 8. 2015-11-23. PMID:25166914. |
taken together, this study has revealed mir-27a as a tumor suppressor and has identified sgpp1 and smad2 as novel targets of mir-27a, linking to stat3 for regulating cancer cell proliferation, apoptosis and migration in colorectal cancer. |
2015-11-23 |
2023-08-13 |
mouse |
| Izabella T Silva, Annelise Carvalho, Karen L Lang, Sabine E Dudek, Dörthe Masemann, Fernando J Durán, Miguel S B Caro, Ulf R Rapp, Viktor Wixler, Eloir P Schenkel, Cláudia M O Simões, Stephan Ludwi. In vitro and in vivo antitumor activity of a novel semisynthetic derivative of cucurbitacin B. PloS one. vol 10. issue 2. 2015-11-20. PMID:25674792. |
dace arrested the cell cycle of lung epithelial cells at the g2/m phase and induced cell apoptosis by interfering with egfr activation and its downstream signaling, including akt, erk, and stat3. |
2015-11-20 |
2023-08-13 |
mouse |
| Qiaoyan Cai, Jiumao Lin, Lihui Wei, Ling Zhang, Lili Wang, Youzhi Zhan, Jianwei Zeng, Wei Xu, Aling Shen, Zhenfeng Hong, Jun Pen. Hedyotis diffusa Willd inhibits colorectal cancer growth in vivo via inhibition of STAT3 signaling pathway. International journal of molecular sciences. vol 13. issue 5. 2015-10-26. PMID:22754353. |
in addition, eehdw treatment suppressed stat3 phosphorylation in tumor tissues, which in turn resulted in the promotion of cancer cell apoptosis and inhibition of proliferation. |
2015-10-26 |
2023-08-12 |
mouse |
| Devan Prabhavathy, Bandaru Niranjana Prabhakar, Devarajan Karunagara. HPV16 E2-mediated potentiation of NF-κB activation induced by TNF-α involves parallel activation of STAT3 with a reduction in E2-induced apoptosis. Molecular and cellular biochemistry. vol 394. issue 1-2. 2015-10-26. PMID:24833467. |
hpv16 e2-mediated potentiation of nf-κb activation induced by tnf-α involves parallel activation of stat3 with a reduction in e2-induced apoptosis. |
2015-10-26 |
2023-08-13 |
human |
| Devan Prabhavathy, Bandaru Niranjana Prabhakar, Devarajan Karunagara. HPV16 E2-mediated potentiation of NF-κB activation induced by TNF-α involves parallel activation of STAT3 with a reduction in E2-induced apoptosis. Molecular and cellular biochemistry. vol 394. issue 1-2. 2015-10-26. PMID:24833467. |
inhibition of stat3 activation enhanced e2-induced apoptosis, whereas parallel activation of nf-κb and stat3 by the combined action of e2 and tnf-α increased the expression of their common targets, cyclin-d1, c-myc, survivin, and bcl-2, leading to a decrease in e2-induced apoptosis (viability and cell cycle). |
2015-10-26 |
2023-08-13 |
human |
| Yubao Zhang, Xia Ren, Meiyan Shi, Zheng Jiang, Hengxiao Wang, Qinghong Su, Qinglin Liu, Gang Li, Guosheng Jian. Downregulation of STAT3 and activation of MAPK are involved in the induction of apoptosis by HNK in glioblastoma cell line U87. Oncology reports. vol 32. issue 5. 2015-10-26. PMID:25175884. |
downregulation of stat3 and activation of mapk are involved in the induction of apoptosis by hnk in glioblastoma cell line u87. |
2015-10-26 |
2023-08-13 |
human |
| Yubao Zhang, Xia Ren, Meiyan Shi, Zheng Jiang, Hengxiao Wang, Qinghong Su, Qinglin Liu, Gang Li, Guosheng Jian. Downregulation of STAT3 and activation of MAPK are involved in the induction of apoptosis by HNK in glioblastoma cell line U87. Oncology reports. vol 32. issue 5. 2015-10-26. PMID:25175884. |
moreover, the inhibition of stat3 signaling, erk1/2 as well as activation of the p38 mapk signaling pathway may be involved in apoptosis induced by hnk in u87 cells. |
2015-10-26 |
2023-08-13 |
human |
| Chengsheng Wu, Ommoleila Molavi, Haifeng Zhang, Nidhi Gupta, Abdulraheem Alshareef, Kathleen M Bone, Keshav Gopal, Fang Wu, Jamie T Lewis, Donna N Douglas, Norman M Kneteman, Raymond La. STAT1 is phosphorylated and downregulated by the oncogenic tyrosine kinase NPM-ALK in ALK-positive anaplastic large-cell lymphoma. Blood. vol 126. issue 3. 2015-10-19. PMID:25921060. |
the importance of the stat1/stat3 functional interaction was further highlighted by the observation that short interfering rna knockdown of stat1 significantly decreased apoptosis induced by stat3 inhibition. |
2015-10-19 |
2023-08-13 |
Not clear |
| Jiumao Lin, Jianheng Zhou, Xiaoyong Zhong, Zhenfeng Hong, Jun Pen. Inhibition of the signal transducer and activator of transcription 3 signaling pathway by Qianliening capsules suppresses the growth and induces the apoptosis of human prostate cells. Molecular medicine reports. vol 11. issue 3. 2015-10-09. PMID:25394909. |
these results suggested that qc effectively inhibited the proliferation and promoted the apoptosis of human prostate cells via modulation of the stat3 signaling pathway and its target genes, which is likely to be one of the mechanisms underlying its activity in bph treatment. |
2015-10-09 |
2023-08-13 |
human |
| Marisa Granato, Barbara Chiozzi, Maria Rosaria Filardi, Lavinia Vittoria Lotti, Livia Di Renzo, Alberto Faggioni, Mara Ciron. Tyrosine kinase inhibitor tyrphostin AG490 triggers both apoptosis and autophagy by reducing HSF1 and Mcl-1 in PEL cells. Cancer letters. vol 366. issue 2. 2015-10-08. PMID:26184999. |
these results suggest that stat3 inhibition, by down-regulating the expression of hsf1/hsp70, reduces mcl-1 and leads to both apoptosis and autophagy induction in pel cells. |
2015-10-08 |
2023-08-13 |
Not clear |
| Ivan Quetier, Nicolas Brezillon, Julien Revaud, James Ahodantin, Lucie DaSilva, Patrick Soussan, Dina Kremsdor. C-terminal-truncated hepatitis B virus X protein enhances the development of diethylnitrosamine-induced hepatocellular carcinogenesis. The Journal of general virology. vol 96. issue Pt 3. 2015-09-30. PMID:25519169. |
furthermore, during den-induced initiation of hcc, ct-hbx- and fl-hbx-transgenic mice showed higher expression of il-6, tnf-α and il-1β transcripts, activation of stat3, erk and jnk proteins and an increase in cell apoptosis. |
2015-09-30 |
2023-08-13 |
mouse |
| Di Xiang, Yunsheng Yuan, Li Chen, Xin Liu, Chandra Belani, Hua Chen. Niclosamide, an anti-helminthic molecule, downregulates the retroviral oncoprotein Tax and pro-survival Bcl-2 proteins in HTLV-1-transformed T lymphocytes. Biochemical and biophysical research communications. vol 464. issue 1. 2015-09-30. PMID:26116531. |
since tax, stat3 and mcl-1 are crucial molecules for promoting survival and growth of htlv-1-transformed t cells, our findings demonstrate a novel mechanism of niclosamide in inducing tax degradation and downregulating various cellular pro-survival molecules, thereby promoting apoptosis of htlv-1-associated leukemia cells. |
2015-09-30 |
2023-08-13 |
human |
| Kang Lu, Na Chen, Xiang-xiang Zhou, Xue-ling Ge, Li-li Feng, Pei-pei Li, Xin-yu Li, Ling-yun Geng, Xin Wan. The STAT3 inhibitor WP1066 synergizes with vorinostat to induce apoptosis of mantle cell lymphoma cells. Biochemical and biophysical research communications. vol 464. issue 1. 2015-09-30. PMID:26116769. |
the stat3 inhibitor wp1066 synergizes with vorinostat to induce apoptosis of mantle cell lymphoma cells. |
2015-09-30 |
2023-08-13 |
Not clear |
| Min-Beom Kim, Chulwon Kim, Won-Seok Chung, Jae-Heung Cho, Dongwoo Nam, Sung-Hoon Kim, Kwang Seok Ah. The hydrolysed products of iridoid glycosides can enhance imatinib mesylate-induced apoptosis in human myeloid leukaemia cells. Phytotherapy research : PTR. vol 29. issue 3. 2015-09-29. PMID:25583173. |
using several leukaemia cell lines, the effect of the hydrolysed-catalpol (h-catalpol) and hydrolysed-aucubin (h-aucubin) products on the stat3 signalling pathway, inhibition of bcr-abl activation, cellular proliferation and potentiation of imatinib mesylate-induced apoptosis was investigated. |
2015-09-29 |
2023-08-13 |
human |
| Min-Beom Kim, Chulwon Kim, Won-Seok Chung, Jae-Heung Cho, Dongwoo Nam, Sung-Hoon Kim, Kwang Seok Ah. The hydrolysed products of iridoid glycosides can enhance imatinib mesylate-induced apoptosis in human myeloid leukaemia cells. Phytotherapy research : PTR. vol 29. issue 3. 2015-09-29. PMID:25583173. |
indeed, h-catalpol and h-aucubin down-regulated bcr-abl phosphorylation and inhibited constitutive stat3 activation through abrogating upstream jak2 and c-src and constitutive stat5 activation leading to apoptosis through caspase-3 activation. |
2015-09-29 |
2023-08-13 |
human |