| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rong-Jing Zhou, Xiong-Ying Xu, Bu-Xing Liu, Wen-Zhen Dai, Mei-Qin Cai, Chun-Feng Bai, Xian-Fei Zhang, Li-Min Wang, Li Lin, Shu-Zhen Jia, Wen-Hua Wan. Growth-inhibitory and chemosensitizing effects of microRNA-31 in human glioblastoma multiforme cells. International journal of molecular medicine. vol 36. issue 4. 2016-06-20. PMID:26310668. |
for this purpose, the human gbm cell lines, u251 and u87, were transfected with a mir-31 precursor (pre-mir-31), and cell proliferation, apoptosis and stat3 phosphorylation were then assessed. |
2016-06-20 |
2023-08-13 |
human |
| Rong-Jing Zhou, Xiong-Ying Xu, Bu-Xing Liu, Wen-Zhen Dai, Mei-Qin Cai, Chun-Feng Bai, Xian-Fei Zhang, Li-Min Wang, Li Lin, Shu-Zhen Jia, Wen-Hua Wan. Growth-inhibitory and chemosensitizing effects of microRNA-31 in human glioblastoma multiforme cells. International journal of molecular medicine. vol 36. issue 4. 2016-06-20. PMID:26310668. |
taken together, our results indicate that mir-31 triggers mitochondrial apoptosis and potentiates tmz cytotoxicity in gbm cells largely through the suppression of stat3 activation. |
2016-06-20 |
2023-08-13 |
human |
| Huan Yan, Bi-Ying Guo, Shu Zhan. Cancer-associated fibroblasts attenuate Cisplatin-induced apoptosis in ovarian cancer cells by promoting STAT3 signaling. Biochemical and biophysical research communications. vol 470. issue 4. 2016-06-20. PMID:26826383. |
cancer-associated fibroblasts attenuate cisplatin-induced apoptosis in ovarian cancer cells by promoting stat3 signaling. |
2016-06-20 |
2023-08-13 |
human |
| Huan Yan, Bi-Ying Guo, Shu Zhan. Cancer-associated fibroblasts attenuate Cisplatin-induced apoptosis in ovarian cancer cells by promoting STAT3 signaling. Biochemical and biophysical research communications. vol 470. issue 4. 2016-06-20. PMID:26826383. |
in conclusion, our data suggested that cafs could activate the anti-apoptotic stat3 signaling, thereby decrease the cisplatin-induced apoptosis and promote chemoresistance in ovarian cancer. |
2016-06-20 |
2023-08-13 |
human |
| Xian-Jie Zheng, Zhong-Xin Yang, Yan-Jun Dong, Guo-Yu Zhang, Ming-Fei Sun, Xiao-Kang An, Li-Hong Pan, Shuang-Lin Zhan. Downregulation of leptin inhibits growth and induces apoptosis of lung cancer cells via the Notch and JAK/STAT3 signaling pathways. Biology open. vol 5. issue 6. 2016-06-16. PMID:27185268. |
furthermore, gene silencing of notch signaling with notch-1 sirna or inhibition of jak/stat3 signaling by jsi-124, an inhibitor of stat3, resulted in proliferation inhibition and apoptosis induction in nsclc a549 cells. |
2016-06-16 |
2023-08-13 |
human |
| Wen Yue, Xi Zheng, Yong Lin, Chung S Yang, Qing Xu, Darren Carpizo, Huarong Huang, Robert S DiPaola, Xiang-Lin Ta. Metformin combined with aspirin significantly inhibit pancreatic cancer cell growth in vitro and in vivo by suppressing anti-apoptotic proteins Mcl-1 and Bcl-2. Oncotarget. vol 6. issue 25. 2016-06-15. PMID:26056043. |
herein, we evaluated the effects of metformin and aspirin, alone or in combination, on cell viability, migration, and apoptosis as well as the molecular changes in mtor, stat3 and apoptotic signaling pathways in panc-1 and bxpc3 cells. |
2016-06-15 |
2023-08-13 |
mouse |
| Wen Yue, Xi Zheng, Yong Lin, Chung S Yang, Qing Xu, Darren Carpizo, Huarong Huang, Robert S DiPaola, Xiang-Lin Ta. Metformin combined with aspirin significantly inhibit pancreatic cancer cell growth in vitro and in vivo by suppressing anti-apoptotic proteins Mcl-1 and Bcl-2. Oncotarget. vol 6. issue 25. 2016-06-15. PMID:26056043. |
metformin combined with aspirin significantly inhibited the phosphorylation of mtor and stat3, and induced apoptosis as measured by caspase-3 and parp cleavage. |
2016-06-15 |
2023-08-13 |
mouse |
| Irina Kiprianova, Janina Remy, Nelli Milosch, Isabelle V Mohrenz, Volker Seifert, Achim Aigner, Donat Köge. Sorafenib Sensitizes Glioma Cells to the BH3 Mimetic ABT-737 by Targeting MCL1 in a STAT3-Dependent Manner. Neoplasia (New York, N.Y.). vol 17. issue 7. 2016-06-09. PMID:26297434. |
the oncogenic transcription factor signal transducer and activator of transcription 3 (stat3) is overactivated in malignant glioma and plays a key role in promoting cell survival, thereby increasing the acquired apoptosis resistance of these tumors. |
2016-06-09 |
2023-08-13 |
Not clear |
| Irina Kiprianova, Janina Remy, Nelli Milosch, Isabelle V Mohrenz, Volker Seifert, Achim Aigner, Donat Köge. Sorafenib Sensitizes Glioma Cells to the BH3 Mimetic ABT-737 by Targeting MCL1 in a STAT3-Dependent Manner. Neoplasia (New York, N.Y.). vol 17. issue 7. 2016-06-09. PMID:26297434. |
they also suggest that targeting stat3 in combination with inducers of the intrinsic pathway of apoptosis may be a promising novel strategy for the treatment of malignant glioma. |
2016-06-09 |
2023-08-13 |
Not clear |
| Minhua Hu, Wenfeng Ye, Jiaming Li, Peng Zhou, Zhaoxin Chu, Weijun Huan. The salicylanilide derivatives inhibit signal transducer and activator of transcription 3 pathways in A549 lung cancer cells. Anti-cancer drugs. vol 27. issue 1. 2016-05-31. PMID:26469835. |
these studies further validate stat3 as a drug discovery target and provide evidence that pharmacological agents that can selectively reduce the phospho-stat3 levels in human cancer cells result in tumor apoptosis and growth inhibition. |
2016-05-31 |
2023-08-13 |
human |
| Ya-Ju Hsieh, Sung-Pin Tseng, Yu-Hsuan Kuo, Tain-Lu Cheng, Chiao-Yu Chiang, Yew-Min Tzeng, Wan-Chi Tsa. Ovatodiolide of Anisomeles indica Exerts the Anticancer Potential on Pancreatic Cancer Cell Lines through STAT3 and NF-κB Regulation. Evidence-based complementary and alternative medicine : eCAM. vol 2016. 2016-05-31. PMID:27242913. |
these results demonstrated that ov could potentially inhibit mia-paca2 cancer cells proliferation and induce apoptosis through modulation of nf-κb and stat3 pathway. |
2016-05-31 |
2023-08-13 |
Not clear |
| Muhammad Khan, Amara Maryam, Javed Iqbal Qazi, Tonghui M. Targeting Apoptosis and Multiple Signaling Pathways with Icariside II in Cancer Cells. International journal of biological sciences. vol 11. issue 9. 2016-05-27. PMID:26221076. |
icariside ii has been found to induce apoptosis in various human cancer cell lines of different origin by targeting multiple signaling pathways including stat3, pi3k/akt, mapk/erk, cox-2/pge2 and β-catenin which are frequently deregulated in cancers, suggesting that this collective activity rather than just a single effect may play an important role in developing icariside ii into a potential lead compound for anticancer therapy. |
2016-05-27 |
2023-08-13 |
human |
| Ji Hoon Jung, Miyong Yun, Eun-Jeong Choo, Sun-Hee Kim, Myoung-Seok Jeong, Deok-Beom Jung, Hyemin Lee, Eun-Ok Kim, Nobuo Kato, Bonglee Kim, Sanjay K Srivastava, Kunihiro Kaihatsu, Sung-Hoon Ki. A derivative of epigallocatechin-3-gallate induces apoptosis via SHP-1-mediated suppression of BCR-ABL and STAT3 signalling in chronic myelogenous leukaemia. British journal of pharmacology. vol 172. issue 14. 2016-05-17. PMID:25825203. |
a derivative of epigallocatechin-3-gallate induces apoptosis via shp-1-mediated suppression of bcr-abl and stat3 signalling in chronic myelogenous leukaemia. |
2016-05-17 |
2023-08-13 |
Not clear |
| Napapan Kangwan, Yoon-Jae Kim, Young-Min Han, Migyeong Jeong, Jong-Min Park, Ki-Baik Hah. Concerted actions of ameliorated colitis, aberrant crypt foci inhibition and 15-hydroxyprostaglandin dehydrogenase induction by sonic hedgehog inhibitor led to prevention of colitis-associated cancer. International journal of cancer. vol 138. issue 6. 2016-05-13. PMID:26476372. |
among inflammatory mediators, significantly decreased levels of il-6 and tnf-α, regulated with repressed nf-κb and stat3, were prominent with shh inhibitor, whereas significant inductions of apoptosis were noted with shh inhibitors. |
2016-05-13 |
2023-08-13 |
mouse |
| Napapan Kangwan, Yoon-Jae Kim, Young-Min Han, Migyeong Jeong, Jong-Min Park, Ki-Baik Hah. Concerted actions of ameliorated colitis, aberrant crypt foci inhibition and 15-hydroxyprostaglandin dehydrogenase induction by sonic hedgehog inhibitor led to prevention of colitis-associated cancer. International journal of cancer. vol 138. issue 6. 2016-05-13. PMID:26476372. |
in conclusion, shh inhibitors significantly prevented cac covering either ameliorating oncogenic inflammation or suppressing tumor proliferation, especially supported with significant inhibition of il-6 and stat3 signaling, 15-pgdh preservation and apoptosis induction. |
2016-05-13 |
2023-08-13 |
mouse |
| Jean-René Pallandre, Christophe Borg, Didier Rognan, Thibault Boibessot, Vincent Luzet, Semen Yesylevskyy, Christophe Ramseyer, Marc Pudl. Novel aminotetrazole derivatives as selective STAT3 non-peptide inhibitors. European journal of medicinal chemistry. vol 103. 2016-05-09. PMID:26352675. |
in this context, the selectivity of inhibitors against the stat1 transcription factor is crucial as stat3 and stat1 play opposite roles in the apoptosis of tumor cells and polarization of the immune response. |
2016-05-09 |
2023-08-13 |
Not clear |
| Weiliang Jiang, Senlin Zhao, Ling Xu, Yingying Lu, Zhanjun Lu, Congying Chen, Jianbo Ni, Rong Wan, Lijuan Yan. The inhibitory effects of xanthohumol, a prenylated chalcone derived from hops, on cell growth and tumorigenesis in human pancreatic cancer. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 73. 2016-05-02. PMID:26211581. |
xn treatment was found to induce cell cycle arrest and apoptosis of pc cells (panc-1, bxpc-3) by inhibiting phosphorylation of signal transducer and activator of transcription 3 (stat3) and expression of its downstream targeted genes cyclind1, survivin, and bcl-xl at the messenger rna level, which involved in regulation of apoptosis and the cell cycle. |
2016-05-02 |
2023-08-13 |
human |
| Elena Ciaglia, Giovanni Torelli, Simona Pisanti, Paola Picardi, Alba D'Alessandro, Chiara Laezza, Anna Maria Malfitano, Donatella Fiore, Antonio Christian Pagano Zottola, Maria Chiara Proto, Giuseppe Catapano, Patrizia Gazzerro, Maurizio Bifulc. Cannabinoid receptor CB1 regulates STAT3 activity and its expression dictates the responsiveness to SR141716 treatment in human glioma patients' cells. Oncotarget. vol 6. issue 17. 2016-04-29. PMID:26008966. |
functional studies, using u251mg glioma cells and primary tumor cell lines derived from glioma patients expressing different levels of cb1, highlighted sr141716 efficacy in inducing apoptosis via g1 phase stasis and block of tgf-β1 secretion through a mechanism that involves stat3 inhibition. |
2016-04-29 |
2023-08-13 |
human |
| Xiaokui Yu, Li He, Peng Cao, Qiang Y. Eriocalyxin B Inhibits STAT3 Signaling by Covalently Targeting STAT3 and Blocking Phosphorylation and Activation of STAT3. PloS one. vol 10. issue 5. 2016-04-27. PMID:26010889. |
activated stat3 plays an important role in oncogenesis by stimulating cell proliferation and resisting apoptosis. |
2016-04-27 |
2023-08-13 |
Not clear |
| Xiaokui Yu, Li He, Peng Cao, Qiang Y. Eriocalyxin B Inhibits STAT3 Signaling by Covalently Targeting STAT3 and Blocking Phosphorylation and Activation of STAT3. PloS one. vol 10. issue 5. 2016-04-27. PMID:26010889. |
eb selectively inhibited constitutive as well as il-6-induced phosphorylation of stat3 and induced apoptosis of stat3-dependent tumor cells. |
2016-04-27 |
2023-08-13 |
Not clear |