| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaokui Yu, Li He, Peng Cao, Qiang Y. Eriocalyxin B Inhibits STAT3 Signaling by Covalently Targeting STAT3 and Blocking Phosphorylation and Activation of STAT3. PloS one. vol 10. issue 5. 2016-04-27. PMID:26010889. |
these data strongly suggest that eb directly targets stat3 through a covalent linkage to inhibit the phosphorylation and activation of stat3 and induces apoptosis of stat3-dependent tumor cells. |
2016-04-27 |
2023-08-13 |
Not clear |
| Ning Wu, Jia Liu, Xiangzhong Zhao, Zhiyong Yan, Bo Jiang, Lijun Wang, Shousong Cao, Dayong Shi, Xiukun Li. Cardamonin induces apoptosis by suppressing STAT3 signaling pathway in glioblastoma stem cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 36. issue 12. 2016-04-26. PMID:26150336. |
cardamonin induces apoptosis by suppressing stat3 signaling pathway in glioblastoma stem cells. |
2016-04-26 |
2023-08-13 |
mouse |
| Ning Wu, Jia Liu, Xiangzhong Zhao, Zhiyong Yan, Bo Jiang, Lijun Wang, Shousong Cao, Dayong Shi, Xiukun Li. Cardamonin induces apoptosis by suppressing STAT3 signaling pathway in glioblastoma stem cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 36. issue 12. 2016-04-26. PMID:26150336. |
in the present study, we investigated the effects of cardamonin (3,4,2,4-tetrahydroxychalcone) on the self-renewal and apoptosis of gscs, and if its action is associated with signal transducer and activator of transcription 3 (stat3) pathway. |
2016-04-26 |
2023-08-13 |
mouse |
| Jijun You, Xuejun He, Haibing Ding, Tingrong Zhan. BRMS1 regulates apoptosis in non-small cell lung cancer cells. Cell biochemistry and biophysics. vol 71. issue 1. 2016-04-25. PMID:25182004. |
we identified that brms1 regulate apoptosis in nsclc cells by modulating stat3 activation. |
2016-04-25 |
2023-08-13 |
human |
| Jijun You, Xuejun He, Haibing Ding, Tingrong Zhan. BRMS1 regulates apoptosis in non-small cell lung cancer cells. Cell biochemistry and biophysics. vol 71. issue 1. 2016-04-25. PMID:25182004. |
taken together, our results show that brms1 sensitizes nsclc cells to apoptosis through stat3 signaling pathway, suggesting a potential role of brms1 in regulating nsclc apoptosis and metastasis. |
2016-04-25 |
2023-08-13 |
human |
| Concetta Paola Ilisso, Luigi Sapio, Donatella Delle Cave, Michela Illiano, Annamaria Spina, Giovanna Cacciapuoti, Silvio Naviglio, Marina Porcell. S-Adenosylmethionine Affects ERK1/2 and Stat3 Pathways and Induces Apotosis in Osteosarcoma Cells. Journal of cellular physiology. vol 231. issue 2. 2016-04-22. PMID:26174106. |
altogether, our data enforce the evidence of adomet acting as a biomolecule with antiproliferative action in osteosarcoma cells, capable of down-regulating erk1/2 and stat3 pathways leading to cell cycle inhibition and apoptosis, and provide a rationale for the possible use of adomet in osteosarcoma therapy. |
2016-04-22 |
2023-08-13 |
Not clear |
| Takanobu Nagata, Hideo Yasukawa, Sachiko Kyogoku, Toyoharu Oba, Jinya Takahashi, Shoichiro Nohara, Tomoko Minami, Kazutoshi Mawatari, Yusuke Sugi, Koutatsu Shimozono, Sylvain Pradervand, Masahiko Hoshijima, Hiroki Aoki, Yoshihiro Fukumoto, Tsutomu Imaizum. Cardiac-Specific SOCS3 Deletion Prevents In Vivo Myocardial Ischemia Reperfusion Injury through Sustained Activation of Cardioprotective Signaling Molecules. PloS one. vol 10. issue 5. 2016-04-21. PMID:26010537. |
in socs3-cko mice, stat3, akt, and erk1/2 phosphorylation was sustained, myocardial apoptosis was prevented, and the expression of anti-apoptotic bcl-2 family member myeloid cell leukemia-1 (mcl-1) was augmented. |
2016-04-21 |
2023-08-13 |
mouse |
| Aiping Shi, Jie Dong, Susan Hilsenbeck, Lirong Bi, Hong Zhang, Yi L. The Status of STAT3 and STAT5 in Human Breast Atypical Ductal Hyperplasia. PloS one. vol 10. issue 7. 2016-04-18. PMID:26146825. |
signal transducer and activation of transcription factors (stat3 and stat5) play important roles in breast epithelial cell differentiation, proliferation, and apoptosis. |
2016-04-18 |
2023-08-13 |
human |
| Xiaoli Yao, Hua Liu, Xinghua Zhang, Liang Zhang, Xiang Li, Changhua Wang, Shengrong Su. Cell Surface GRP78 Accelerated Breast Cancer Cell Proliferation and Migration by Activating STAT3. PloS one. vol 10. issue 5. 2016-04-13. PMID:25973748. |
furthermore, genetic and pharmacological inhibition of stat3 reversed the impacts of grp78 on cell proliferation, apoptosis, and migration. |
2016-04-13 |
2023-08-13 |
human |
| X Song, C T Wang, X H Gen. MicroRNA-29a promotes apoptosis of monocytes by targeting STAT3 during sepsis. Genetics and molecular research : GMR. vol 14. issue 4. 2016-04-13. PMID:26535690. |
microrna-29a promotes apoptosis of monocytes by targeting stat3 during sepsis. |
2016-04-13 |
2023-08-13 |
human |
| C Liu, L-H Dai, D-Q Dou, L-Q Ma, Y-X Su. A natural food sweetener with anti-pancreatic cancer properties. Oncogenesis. vol 5. 2016-04-12. PMID:27065453. |
herein, we found that mogroside v possesses tumor growth inhibitory activity in in vitro and in vivo models of pancreatic cancer by promoting apoptosis and cell cycle arrest of pancreatic cancer cells (panc-1 cells), which may in part be mediated through regulating the stat3 signaling pathway. |
2016-04-12 |
2023-08-13 |
mouse |
| W-J Teng, P Chen, F-Y Zhu, K Di, C Zhou, J Zhuang, X-J Cao, J Yang, L-J Deng, C-G Su. Effect of Rhizoma paridis total saponins on apoptosis of colorectal cancer cells and imbalance of the JAK/STAT3 molecular pathway induced by IL-6 suppression. Genetics and molecular research : GMR. vol 14. issue 2. 2016-04-11. PMID:26125778. |
we determined whether rpts influences the interleukin-6 (il-6)/janus kinase (jak)-signal transducer and activator of transcription-3 (stat3) apoptosis molecular pathway and looked for colon cancer-related signal transduction pathways or targets inducing apoptosis. |
2016-04-11 |
2023-08-13 |
Not clear |
| E Yu Moskaleva, V G Perevozchikova, A S Zhirnik, S E Severi. [Molecular mechanisms of niclosamide antitumor activity]. Biomeditsinskaia khimiia. vol 61. issue 6. 2016-04-08. PMID:26716739. |
niclosamide not only inhibits the wnt/β-catenin, mtorc1, stat3, nf-κb and notch signaling pathways, but also targets mitochondria in cancer cells to induce growth inhibition and apoptosis. |
2016-04-08 |
2023-08-13 |
mouse |
| C F Chang, J Yang, W M Zhao, Y Li, P J Guo, M H Li, Y Zhou, C S X. Gene expression profiling analysis of 5-hydroxytryptamine signaling pathway in rat regenerating liver and different types of liver cells. Genetics and molecular research : GMR. vol 14. issue 2. 2016-04-05. PMID:25966107. |
based on the gene expression profiles of the 8 types of liver cells, 5-hydroxytryptamine promoted hepatocyte proliferation through the ras and stat3 signaling pathways, proliferation and differentiation of sinusoidal endothelial cells through the stat3 signaling pathway, and proliferation and apoptosis of pit cells through the akt3 signaling pathway. |
2016-04-05 |
2023-08-13 |
rat |
| Hephzibah Rani S Tagaram, Dhimant Desai, Guangfu Li, Dai Liu, C Bart Rountree, Kavitha Gowda, Arthur Berg, Shantu Amin, Kevin F Staveley-O'Carroll, Eric T Kimch. A Selenium Containing Inhibitor for the Treatment of Hepatocellular Cancer. Pharmaceuticals (Basel, Switzerland). vol 9. issue 2. 2016-03-30. PMID:27023566. |
pbise promoted apoptosis by inhibiting pi3k, mapk, and stat3 signaling with significant reduction in the tumor sizes (p < 0.007). |
2016-03-30 |
2023-08-13 |
mouse |
| Suresh V Kuchipud. The Complex Role of STAT3 in Viral Infections. Journal of immunology research. vol 2015. 2016-03-24. PMID:26199948. |
signal transducer and activators of transcription-3 (stat3) regulates diverse biological functions including cell growth, differentiation, and apoptosis. |
2016-03-24 |
2023-08-13 |
Not clear |
| Hye-Sook Seo, Jin Mo Ku, Han-Seok Choi, Jong-Kyu Woo, Bo-Hyoung Jang, Hoyeon Go, Yong Cheol Shin, Seong-Gyu K. Apigenin induces caspase-dependent apoptosis by inhibiting signal transducer and activator of transcription 3 signaling in HER2-overexpressing SKBR3 breast cancer cells. Molecular medicine reports. vol 12. issue 2. 2016-03-10. PMID:25936427. |
therefore, these results suggested that apigenin induced apoptosis via the inhibition of stat3 signaling in skbr3 cells. |
2016-03-10 |
2023-08-13 |
human |
| Samson Jamesdanie. Downstream targets of Lmo4 are modulated by cisplatin in the inner ear of Wistar rats. PloS one. vol 9. issue 12. 2016-03-09. PMID:25501662. |
these results suggest that cisplatin-induced decreases in the cochlear lmo4 upon nitration, and associated modulation in the cochlear expression of its binding partners esr1 and jak1, probably facilitates the repression of stat3, a downstream target of lmo4 implicated in drug mediated apoptosis. |
2016-03-09 |
2023-08-13 |
rat |
| San-Qiang Li, Sha Zhu, Hong-Mei Han, Hua-Jie Lu, Hong-Ye Men. IL-6 trans-signaling plays important protective roles in acute liver injury induced by acetaminophen in mice. Journal of biochemical and molecular toxicology. vol 29. issue 6. 2016-03-08. PMID:25914167. |
blockade of il-6 trans-signaling during aap-induced liver injury remarkably increased the levels of serum aspartate aminotransferase and alanine aminotransferase; lowered the level of serum sil-6r; aggravated liver injury; inhibited the expression of phosphorylation of stat3 (pstat3), proliferating cell nuclear antigen, vascular endothelial growth factor, and glycogen synthesis; and induced the expression of caspase3, cytochrome p450 2e1 (cyp2e1), and hepatocyte apoptosis in the liver of mice. |
2016-03-08 |
2023-08-13 |
mouse |
| Meng Qin, Yun Luo, Xiang-bao Meng, Min Wang, Hong-wei Wang, Shi-yu Song, Jing-xue Ye, Rui-le Pan, Fan Yao, Ping Wu, Gui-bo Sun, Xiao-bo Su. Myricitrin attenuates endothelial cell apoptosis to prevent atherosclerosis: An insight into PI3K/Akt activation and STAT3 signaling pathways. Vascular pharmacology. vol 70. 2016-03-04. PMID:25849952. |
myricitrin attenuates endothelial cell apoptosis to prevent atherosclerosis: an insight into pi3k/akt activation and stat3 signaling pathways. |
2016-03-04 |
2023-08-13 |
mouse |