| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Meng Qin, Yun Luo, Xiang-bao Meng, Min Wang, Hong-wei Wang, Shi-yu Song, Jing-xue Ye, Rui-le Pan, Fan Yao, Ping Wu, Gui-bo Sun, Xiao-bo Su. Myricitrin attenuates endothelial cell apoptosis to prevent atherosclerosis: An insight into PI3K/Akt activation and STAT3 signaling pathways. Vascular pharmacology. vol 70. 2016-03-04. PMID:25849952. |
treatment with myricitrin significantly attenuated ox-ldl-induced endothelial cell apoptosis by inhibiting lox-1 expression and by increasing the activation of the stat3 and pi3k/akt/enos signaling pathways. |
2016-03-04 |
2023-08-13 |
mouse |
| Zhongmian Zhang, Ping Liu, Jian Wang, Tianxiao Gong, Fang Zhang, Jun Ma, Na Ha. Ubiquitin-conjugating enzyme E2C regulates apoptosis-dependent tumor progression of non-small cell lung cancer via ERK pathway. Medical oncology (Northwood, London, England). vol 32. issue 5. 2016-03-02. PMID:25832867. |
furthermore, ube2c could regulate phospho-erk1/2 level but not stat3, yap, or akt pathway, which was accompanied with the classic function of erk pathway in cell growth and apoptosis. |
2016-03-02 |
2023-08-13 |
human |
| Qiang Meng, Xinli Chen, Changyuan Wang, Qi Liu, Huijun Sun, Pengyuan Sun, Xiaokui Huo, Zhihao Liu, Kexin Li. Protective effects of alisol B 23-acetate from edible botanical Rhizoma alismatis against carbon tetrachloride-induced hepatotoxicity in mice. Food & function. vol 6. issue 4. 2016-03-01. PMID:25747392. |
in addition, ab23a induced the expression of stat3 phosphorylation, and stat3 target genes bcl-xl and socs3, resulting in decreased hepatocyte apoptosis. |
2016-03-01 |
2023-08-13 |
mouse |
| Xin-Hong Wang, Ming-Na Liu, Ping Huang, Jun Xu, Ai-Yun Liu, Jing Chen, Cheng-Qian Lv, Rui-Ling X. Simultaneous silencing of β-catenin and signal transducer and activator of transcription 3 synergistically induces apoptosis and inhibits cell proliferation in HepG2 liver cancer cells. Molecular medicine reports. vol 12. issue 2. 2016-03-01. PMID:25845340. |
following sirna transfection, β-catenin and stat3 protein levels decreased at 72 h. hepg2 cell growth inhibition and early apoptosis in the β-catenin and stat3 sirna co-transfection group were significantly greater than those in the groups transfected with β-catenin or stat3 sirna alone. |
2016-03-01 |
2023-08-13 |
Not clear |
| Xin-Hong Wang, Ming-Na Liu, Ping Huang, Jun Xu, Ai-Yun Liu, Jing Chen, Cheng-Qian Lv, Rui-Ling X. Simultaneous silencing of β-catenin and signal transducer and activator of transcription 3 synergistically induces apoptosis and inhibits cell proliferation in HepG2 liver cancer cells. Molecular medicine reports. vol 12. issue 2. 2016-03-01. PMID:25845340. |
simultaneous silencing of β-catenin and stat3 using sirnas resulted in an enhanced loss of cell viability and induction of apoptosis in hepg2 liver cancer cells, suggesting that these genes are promising targets for the further preclinical and clinical development of anti-cancer therapeutic strategies, which target several cancer signaling pathways simultaneously. |
2016-03-01 |
2023-08-13 |
Not clear |
| Na Zhou, Yizhuang Zhang, Xuehui Zhang, Zhen Lei, Ruobi Hu, Hui Li, Yiqing Mao, Xi Wang, David M Irwin, Gang Niu, Huanran Ta. Exposure of tumor-associated macrophages to apoptotic MCF-7 cells promotes breast cancer growth and metastasis. International journal of molecular sciences. vol 16. issue 6. 2016-02-29. PMID:26016502. |
our results indicate that when cancer cells endure chemotherapy induced apoptosis, macrophages in their microenvironment can then activate cancer stem cells to promote cancer growth and metastasis by secreting il-6, which activates stat3 phosphorylation to regulate the transcription of its downstream target genes. |
2016-02-29 |
2023-08-13 |
mouse |
| Nadine Wittkopf, Geethanjali Pickert, Ulrike Billmeier, Mousumi Mahapatro, Stefan Wirtz, Eva Martini, Moritz Leppkes, Markus Friedrich Neurath, Christoph Becke. Activation of intestinal epithelial Stat3 orchestrates tissue defense during gastrointestinal infection. PloS one. vol 10. issue 3. 2016-02-25. PMID:25799189. |
stat3 concerts the host response to bacterial infection by controlling bacterial growth and suppression of apoptosis to maintain intestinal epithelial barrier function. |
2016-02-25 |
2023-08-13 |
mouse |
| Jun-Ru Liu, Wen-Juan Wu, Shu-Xia Liu, Lian-Fu Zuo, Yuan Wang, Jian-Zhu Yang, Yue-Min Na. Nimesulide inhibits the growth of human esophageal carcinoma cells by inactivating the JAK2/STAT3 pathway. Pathology, research and practice. vol 211. issue 6. 2016-02-22. PMID:25724470. |
nimesulide downregulated the phosphorylation levels of jak2 and stat3, and jak2 inhibition by ag490 significantly augmented both nimesulide-induced apoptosis and the downregulation of cox-2 and survivin (p<0.05). |
2016-02-22 |
2023-08-13 |
mouse |
| Tian-xiao Wang, Xiao-yan Shi, Yue Cong, Zhong-qing Zhang, Ying-hua Li. [Prosapogenin A inhibits cell growth of MCF7 via downregulating STAT3 and glycometabolism-related gene]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 48. issue 9. 2016-02-02. PMID:24358789. |
the results suggested that psa could inhibit cell growth and promote cell apoptosis of mcf7 via inhibition of stat3 and glycometabolism-related gene. |
2016-02-02 |
2023-08-12 |
Not clear |
| Y J Tang, Z L Sun, W G Wu, J Xing, Y F He, D M Xin, P Ha. Inhibitor of signal transducer and activator of transcription 3 (STAT3) suppresses ovarian cancer growth, migration and invasion and enhances the effect of cisplatin in vitro. Genetics and molecular research : GMR. vol 14. issue 1. 2016-01-27. PMID:25867391. |
in conclusion, inhibition of stat3 may suppress the proliferation, migration and invasion, induce apoptosis and enhance the chemosensitivity of ovarian cancer cells, indicating that stat3 is a new therapeutic target of ovarian cancer. |
2016-01-27 |
2023-08-13 |
Not clear |
| Moon Kyung Joo, Jong-Jae Park, Sung Ho Kim, Hyo Soon Yoo, Beom Jae Lee, Hoon Jai Chun, Sang Woo Lee, Young-Tae Ba. Antitumorigenic effect of plumbagin by induction of SH2-containing protein tyrosine phosphatase 1 in human gastric cancer cells. International journal of oncology. vol 46. issue 6. 2016-01-26. PMID:25815436. |
collectively, our findings suggest that plumbagin is a potential regulator of cellular growth, migration, invasion and apoptosis by inhibiting both constitutive and inducible stat3 activity through induction of shp1 in gastric cancer cells. |
2016-01-26 |
2023-08-13 |
human |
| Rong Tian, You Li, Mei Ga. Shikonin causes cell-cycle arrest and induces apoptosis by regulating the EGFR-NF-κB signalling pathway in human epidermoid carcinoma A431 cells. Bioscience reports. vol 35. issue 2. 2016-01-25. PMID:25720435. |
then, the nf-κb inhibitors such as bay11-7082, sn50, helenalin and the egfr inhibitor ag1478 and its downstream inhibitor such as pi3k inhibitor ly294002 and stat3 inhibitor stattic dramatically blocked egf-reversed decreases in cell viability and increases in apoptosis induced by shikonin. |
2016-01-25 |
2023-08-13 |
human |
| Meixian Xiang, Hanwen Su, Zongguo Hong, Tianming Yang, Guangwen Sh. Chemical composition of total flavonoids from Polygonum amplexicaule and their pro-apoptotic effect on hepatocellular carcinoma cells: Potential roles of suppressing STAT3 signaling. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 80. 2016-01-25. PMID:25754378. |
suppressing stat3 signaling is implicated in tfpa-mediated hcc cell apoptosis. |
2016-01-25 |
2023-08-13 |
mouse |
| Sichu Liu, Qi Shen, Yu Chen, Chengwu Zeng, Changshu Cao, Lijian Yang, Shaohua Chen, Xiuli Wu, Bo Li, Yangqiu L. Alteration of gene expression profile following PPP2R5C knockdown may be associated with proliferation suppression and increased apoptosis of K562 cells. Journal of hematology & oncology. vol 8. 2016-01-19. PMID:25888193. |
we propose that the mechanism for proliferation inhibition and increased apoptosis of k562 cells following ppp2r5c suppression may be related to the alteration of expression profiles of braf, akt2, akt3, nfkb2 and stat3 genes. |
2016-01-19 |
2023-08-13 |
Not clear |
| Xiaoyun Dai, Kwang Seok Ahn, Chulwon Kim, Kodappully Sivaraman Siveen, Tina H Ong, Muthu K Shanmugam, Feng Li, Jizhong Shi, Alan Prem Kumar, Ling Zhi Wang, Boon Cher Goh, Junji Magae, Kam M Hui, Gautam Seth. Ascochlorin, an isoprenoid antibiotic inhibits growth and invasion of hepatocellular carcinoma by targeting STAT3 signaling cascade through the induction of PIAS3. Molecular oncology. vol 9. issue 4. 2016-01-05. PMID:25624051. |
deletion of pias3 gene by sirna abolished the ability of asc to inhibit stat3 activation and induce apoptosis in hcc cells. |
2016-01-05 |
2023-08-13 |
mouse |
| Matteo Santoni, Francesco Massari, Marzia Del Re, Chiara Ciccarese, Francesco Piva, Giovanni Principato, Rodolfo Montironi, Daniele Santini, Romano Danesi, Giampaolo Tortora, Stefano Cascin. Investigational therapies targeting signal transducer and activator of transcription 3 for the treatment of cancer. Expert opinion on investigational drugs. vol 24. issue 6. 2016-01-04. PMID:25746129. |
signal transducer and activator of transcription 3 (stat3) mediates the expression of a variety of genes in response to cell stimuli and thus plays a key role in several cellular processes such as cell growth and apoptosis. |
2016-01-04 |
2023-08-13 |
Not clear |
| Changxiao Ye, Wei Zhao, Minghui Li, Junlong Zhuang, Xiang Yan, Qun Lu, Cunjie Chang, Xiaojing Huang, Ji Zhou, Bingxian Xie, Zhen Zhang, Xin Yao, Jun Yan, Hongqian Gu. δ-tocotrienol induces human bladder cancer cell growth arrest, apoptosis and chemosensitization through inhibition of STAT3 pathway. PloS one. vol 10. issue 4. 2016-01-04. PMID:25849286. |
δ-tocotrienol induces human bladder cancer cell growth arrest, apoptosis and chemosensitization through inhibition of stat3 pathway. |
2016-01-04 |
2023-08-13 |
human |
| Alejandro D Hofmann, Toshiaki Takahashi, Johannes Duess, Jan-Hendrik Gosemann, Prem Pur. Increased expression of activated pSTAT3 and PIM-1 in the pulmonary vasculature of experimental congenital diaphragmatic hernia. Journal of pediatric surgery. vol 50. issue 6. 2015-12-28. PMID:25812446. |
in human ph activated stat3 (pstat3) was shown to directly trigger expression of the provirus integration site for moloney murine leukemia virus (pim-1), which promotes proliferation and resistance to apoptosis in smcs. |
2015-12-28 |
2023-08-13 |
human |
| Miyong Yun, Duckgue Lee, Moon-Nyeo Park, Eun-Ok Kim, Eun Jung Sohn, Byung-Mog Kwon, Sung-Hoon Ki. Cinnamaldehyde derivative (CB-PIC) sensitizes chemo-resistant cancer cells to drug-induced apoptosis via suppression of MDR1 and its upstream STAT3 and AKT signalling. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 35. issue 5. 2015-12-28. PMID:25833196. |
cinnamaldehyde derivative (cb-pic) sensitizes chemo-resistant cancer cells to drug-induced apoptosis via suppression of mdr1 and its upstream stat3 and akt signalling. |
2015-12-28 |
2023-08-13 |
Not clear |
| Hongsheng Lu, Xuequan Cao, Qi Chen, Lanxi Chen, Lili Chen, Meifu Ga. The expression and role of MEKK3 in renal clear cell carcinoma. Anatomical record (Hoboken, N.J. : 2007). vol 298. issue 4. 2015-12-17. PMID:25388155. |
to explore the relationship between mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase 3(mekk3) and cell apoptosis, clinicopathology, and prognosis, we characterize the expression of mekk3, survivin and stat3 in renal clear cell carcinoma (rccc). |
2015-12-17 |
2023-08-13 |
Not clear |