| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hui Huang, Jinju Xue, Jiaxuan Zheng, Haiquan Tian, Yehan Fang, Wei Wang, Guangji Wang, Dan Hou, Jianping Li. Bioinformatic analysis of the gene expression profile in muscle atrophy after spinal cord injury. Scientific reports. vol 11. issue 1. 2021-11-13. PMID:34754020. |
in the pathway network analysis, the 10 most important pathways were citrate cycle (tca cycle), pyruvate metabolism, mapk signalling pathway, fatty acid degradation, propanoate metabolism, apoptosis, focal adhesion, synthesis and degradation of ketone bodies, wnt signalling, and cancer pathways. |
2021-11-13 |
2023-08-13 |
rat |
| Zuo-Long Wu, Qi-Qi Xie, Tai-Cong Liu, Xing Yang, Guang-Zhi Zhang, Hai-Hong Zhan. Role of the Wnt pathway in the formation, development, and degeneration of intervertebral discs. Pathology, research and practice. vol 220. 2021-11-09. PMID:33647863. |
however, the activation of the wnt pathway after birth promotes ivd cell senescence, apoptosis, and degradation of the extracellular matrix and induces the production of inflammatory factors, thereby accelerating the ivdd process. |
2021-11-09 |
2023-08-13 |
Not clear |
| Hafid O Al-Hassi, Oliver Ng, Rayko Evstatiev, Manel Mangalika, Natalie Worton, Manuela Jambrich, Vineeta Khare, Oliver Phipps, Barrie Keeler, Christoph Gasche, Austin G Acheson, Matthew J Brooke. Intravenous iron is non-inferior to oral iron regarding cell growth and iron metabolism in colorectal cancer associated with iron-deficiency anaemia. Scientific reports. vol 11. issue 1. 2021-11-03. PMID:34211054. |
paired (normal and tumour tissues) samples were compared for expression of iron loading, iron transporters, proliferation, apoptosis and wnt signalling using immunohistochemistry and rt-pcr. |
2021-11-03 |
2023-08-13 |
Not clear |
| Yifeng Yan, Liang Ren, Yan Liu, Liang Li. Long non-coding RNA CRNDE as potential biomarkers facilitate inflammation and apoptosis in alcoholic liver disease. Aging. vol 13. issue 19. 2021-11-03. PMID:34633988. |
kyoto encyclopedia of genes and genomes pathways analysis revealed higher crnde can activate mapk signaling pathway, apoptosis, wnt signaling pathway, and hematopoietic cell lineage. |
2021-11-03 |
2023-08-13 |
mouse |
| Jin-Shuo Tang, Zhong-Sheng Zhou, Jian-Lin Xiao, Zhong-Li Gao, Jian-Lin Zu. [Research progression in the pathogenesis of osteoarthritis]. Zhongguo gu shang = China journal of orthopaedics and traumatology. vol 34. issue 10. 2021-11-03. PMID:34726030. |
what's more, signaling pathways such as stromal cell derived factor-1 (sdf-1) and wnt, chondrocytic senescence and the senescence-associated secretory phenotype (sasp), chondrocyte apoptosis and autophagy, and estrogen all play significant roles in oa pathogenesis. |
2021-11-03 |
2023-08-13 |
Not clear |
| Vikas Yadav, Njainday Jobe, Lubna Mehdawi, Tommy Andersso. Targeting Oncogenic WNT Signalling with WNT Signalling-Derived Peptides. Handbook of experimental pharmacology. vol 269. 2021-11-02. PMID:34455485. |
investigations of how wnt signalling affects carcinogenesis and cancer progression have revealed that it has essential roles in the regulation of proliferation, apoptosis, and cancer stemness and in angiogenesis and metastasis. |
2021-11-02 |
2023-08-13 |
Not clear |
| Sijing Li, Xiaohui Wei, Jinyong He, Quanquan Cao, Danyu Du, Xiaoman Zhan, Yuqi Zeng, Shengtao Yuan, Li Su. The comprehensive landscape of miR-34a in cancer research. Cancer metastasis reviews. vol 40. issue 3. 2021-11-01. PMID:33959850. |
also, the targets are implicated in critical signaling pathways, such as mapk, notch, wnt, pi3k/akt, p53, and ras, as well as apoptosis, cell cycle, and emt-related pathways. |
2021-11-01 |
2023-08-13 |
human |
| Retraction. Journal of cellular biochemistry. vol 122 Suppl 1. 2021-11-01. PMID:34191356. |
retraction: "microrna-539 promotes osteoblast proliferation and differentiation and osteoclast apoptosis through the axna-dependent wnt signaling pathway in osteoporotic rats," by xiong-bai zhu, wen-jun lin, chen lv, lu wang, zheng-xiang huang, sheng-wu yang, xin chen, j cell biochem. |
2021-11-01 |
2023-08-13 |
rat |
| Y Taank, N Agnihotr. Understanding the regulation of β-catenin expression and activity in colorectal cancer carcinogenesis: beyond destruction complex. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. vol 23. issue 12. 2021-11-01. PMID:34426910. |
the well-known potential of targeting the canonical wnt signaling pathway for the treatment of crc is largely attributed to the ability of this pathway to regulate various cellular processes such as cell proliferation, metastasis, drug resistance, immune response, apoptosis, and cellular metabolism. |
2021-11-01 |
2023-08-13 |
Not clear |
| Zongbing You, Daniel Saims, Shaoqiong Chen, Zhaocheng Zhang, Denis C Guttridge, Kun-Liang Guan, Ormond A MacDougald, Anthony M C Brown, Gerard Evan, Jan Kitajewski, Cun-Yu Wan. Correction: Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis. The Journal of cell biology. vol 220. issue 5. 2021-10-30. PMID:33830173. |
correction: wnt signaling promotes oncogenic transformation by inhibiting c-myc-induced apoptosis. |
2021-10-30 |
2023-08-13 |
Not clear |
| Zhanpeng Guo, Mina Huang, Yajiang Yuan, Yue Guo, Changwei Song, Hongyu Wang, Xiaoqian Dan. Nischarin downregulation attenuates cell injury induced by oxidative stress via Wnt signaling. Neuroreport. vol 31. issue 17. 2021-10-26. PMID:33075003. |
moreover, inhibition of the wnt pathway further decreased the cell viability and promoted the cell apoptosis induced by h2o2 in pc12 cells. |
2021-10-26 |
2023-08-13 |
rat |
| Qiang Shao, Stephanie D Byrum, Linley E Moreland, Samuel G Mackintosh, Aarthi Kannan, Zhenyu Lin, Michael Morgan, Brendan C Stack, Lynn A Cornelius, Alan J Tackett, Ling Ga. A Proteomic Study of Human Merkel Cell Carcinoma. Journal of proteomics & bioinformatics. vol 6. 2021-10-21. PMID:25284964. |
further analysis of significantly over-expressed proteins suggested the involvement of mapk, pi3k/akt/mtor, wnt, and apoptosis signaling pathways. |
2021-10-21 |
2023-08-13 |
human |
| Qiang Zuo, Yunsheng Ou, Shenxi Zhong, Haoyang Yu, Fangbiao Zhan, Muzi Zhan. Targeting GRP78 enhances the sensitivity of HOS osteosarcoma cells to pyropheophorbide-α methyl ester-mediated photodynamic therapy via the Wnt/β-catenin signaling pathway. Acta biochimica et biophysica Sinica. vol 53. issue 10. 2021-10-15. PMID:34494093. |
apoptosis and reactive oxygen species (ros) levels were detected by hoechst staining and flow cytometry, cell viability was detected by cell counting kit-8 assay, grp78 protein fluorescence intensity was detected by immunofluorescence, and apoptosis-related proteins, cell proliferation-related proteins, and wnt pathway-related proteins were detected by western blot. |
2021-10-15 |
2023-08-13 |
human |
| Yayu Wang, Ya Chen, Mulian Cao, Xiaoqiang Wang, Guiling Wang, Jiale L. Identification of wnt2 in the pearl mussel Hyriopsis cumingii and its role in innate immunity and gonadal development. Fish & shellfish immunology. vol 118. 2021-10-11. PMID:34438059. |
wnt2 is a significant factor in the wnt signaling pathway, which is associated with a variety of physiological activities, including inflammatory response, cell apoptosis, reproductive system development, and cell differentiation. |
2021-10-11 |
2023-08-13 |
Not clear |
| Wenqing Liang, Xiaozhen Chen, Songou Zhang, Jian Fang, Meikai Chen, Yifan Xu, Xuerong Che. Mesenchymal stem cells as a double-edged sword in tumor growth: focusing on MSC-derived cytokines. Cellular & molecular biology letters. vol 26. issue 1. 2021-10-06. PMID:33472580. |
however, other studies have shown that mscs suppress tumor growth by suppressing angiogenesis, incrementing inflammatory infiltration, apoptosis and cell cycle arrest, and inhibiting the akt and wnt signaling pathways. |
2021-10-06 |
2023-08-13 |
Not clear |
| Yan Fang, Zhitang Chang, Zhicheng Xu, Jing Hu, Haiwen Zhou, Songping Yu, Xuan Wa. Osteoglycin silencing exerts inhibitory effects on myocardial fibrosis and epithelial/endothelial-mesenchymal transformation in a mouse model of myocarditis. BioFactors (Oxford, England). vol 46. issue 6. 2021-10-01. PMID:33141515. |
expression of ogn and wnt signaling pathway-related factors were measured by reverse transcription quantitative polymerase chain reaction and western blot assay, cell viability by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, and cell cycle distribution and apoptosis by flow cytometry. |
2021-10-01 |
2023-08-13 |
mouse |
| Yan Fang, Zhitang Chang, Zhicheng Xu, Jing Hu, Haiwen Zhou, Songping Yu, Xuan Wa. Osteoglycin silencing exerts inhibitory effects on myocardial fibrosis and epithelial/endothelial-mesenchymal transformation in a mouse model of myocarditis. BioFactors (Oxford, England). vol 46. issue 6. 2021-10-01. PMID:33141515. |
loss function assays showed reduced levels of ogn, β-catenin, lrp6, tgf-β1, twist, fsp-1, α-sma and higher levels of e-cadherin and ve-cadherin, together with decreased proliferation rate, as well as increased apoptosis rate, indicating that the wnt signaling pathway, proliferation were inhibited while apoptosis was enhanced with upon gene silencing. |
2021-10-01 |
2023-08-13 |
mouse |
| Yan Fang, Zhitang Chang, Zhicheng Xu, Jing Hu, Haiwen Zhou, Songping Yu, Xuan Wa. Osteoglycin silencing exerts inhibitory effects on myocardial fibrosis and epithelial/endothelial-mesenchymal transformation in a mouse model of myocarditis. BioFactors (Oxford, England). vol 46. issue 6. 2021-10-01. PMID:33141515. |
coherently, depletion of ogn inhibits myocardial fibroblasts proliferation and emt/endmt while facilitating myocardial fibroblasts apoptosis in myocarditis through the wnt signaling pathway, thus serving as an intervention target for the molecular treatment of myocarditis. |
2021-10-01 |
2023-08-13 |
mouse |
| Anuradha Kirtonia, Milad Ashrafizadeh, Ali Zarrabi, Kiavash Hushmandi, Amirhossein Zabolian, Atefe K Bejandi, Reshma Rani, Amit K Pandey, Prakash Baligar, Vinit Kumar, Bhudev C Das, Manoj Gar. Long noncoding RNAs: A novel insight in the leukemogenesis and drug resistance in acute myeloid leukemia. Journal of cellular physiology. 2021-09-30. PMID:34569616. |
we discuss the significant role of lncrnas in the proliferation, survival, differentiation, leukemic stem cells in aml and their involvement in different molecular pathways (insulin-like growth factor type i receptor, flt3, c-kit, wnt, phosphatidylinositol 3-kinase/protein kinase-b, micrornas), and associated mechanisms such as autophagy, apoptosis, and glucose metabolism. |
2021-09-30 |
2023-08-13 |
human |
| Wei Li, Huiping Ma, Minglei Li. Cell Proliferation and Apoptosis-Related Genes Affect the Development of Human Nasopharyngeal Carcinoma Through PI3K/AKT Signaling Pathway. Molecular biotechnology. vol 63. issue 11. 2021-09-29. PMID:34236626. |
at the same time, they mainly affect the proliferation and apoptosis of npc cells through pi3k-akt signaling pathway, nf-kappa b signaling pathway and wnt signaling pathway. |
2021-09-29 |
2023-08-13 |
human |