| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Poonam Yadav, Priyanshu Sharma, Neha Chetlangia, Priyadharshini Mayalagu, Devarajan Karunagara. Upregulation of miR-22-3p contributes to plumbagin-mediated inhibition of Wnt signaling in human colorectal cancer cells. Chemico-biological interactions. 2022-10-22. PMID:36272469. |
the present study revealed that alteration in mir-22-3p levels by plumbagin contributes to the induction of apoptosis and its inhibitory effects on wnt signaling and colony formation, thus providing a mechanistic basis behind its anti-cancer potential. |
2022-10-22 |
2023-08-14 |
human |
| Md Mominur Rahman, Md Taslim Sarker, Mst Afroza Alam Tumpa, Md Yamin, Tamanna Islam, Moon Nyeo Park, Md Rezaul Islam, Abdur Rauf, Rohit Sharma, Simona Cavalu, Bonglee Ki. Exploring the recent trends in perturbing the cellular signaling pathways in cancer by natural products. Frontiers in pharmacology. vol 13. 2022-09-26. PMID:36160435. |
these natural chemicals are known to affect numerous important cellular signaling pathways, such as nf-b, mapk, wnt, notch, akt, p53, ar, er, and many others, to cause cell death signals and induce apoptosis in pre-cancerous or cancer cells without harming normal cells. |
2022-09-26 |
2023-08-14 |
human |
| Negar Yadegar, Zahra Dadashi, Kimiya Shams, Mahdis Mohammadi, Mahya Abyar, Milad Rafa. The Prominent Role of miR-942 in Carcinogenesis of Tumors. Advanced biomedical research. vol 11. 2022-09-22. PMID:36133499. |
mir-942 is included in cell proliferation, migration, and invasion through cell cycle pathways, including pathways of transforming growth factor-beta signaling pathways, wnt pathway, jak/stat pathway, pi3k/akt pathway, apoptosis pathway, hippo signaling pathway, lectin pathway, interferon-gamma signaling, signaling by g-protein coupled receptor, developmental genes, nuclear factor-kappa b pathway, mesodermal commitment pathway, and t-cell receptor signaling in cancer. |
2022-09-22 |
2023-08-14 |
Not clear |
| Laleh Arzi, Homa Mollaei, Reyhane Hoshya. Countering Triple Negative Breast Cancer via Impeding Wnt/β-Catenin Signaling, a Phytotherapeutic Approach. Plants (Basel, Switzerland). vol 11. issue 17. 2022-09-09. PMID:36079579. |
these phytotherapy agents diminish proliferation, metastasis, breast cancer stem cell self-renewal and induce apoptosis in cell and animal models of tnbc through the down-expression of the downstream target genes of wnt signaling. |
2022-09-09 |
2023-08-14 |
Not clear |
| Dipen Desai, Rajkumar Londhe, Madhuri Chandane, Smita Kulkarn. Altered HIV-1 Viral Copy Number and Gene Expression Profiles of Peripheral (CEM CCR5+) and Mucosal (A3R5.7) T Cell Lines Co-Infected with HSV-2 In Vitro. Viruses. vol 14. issue 8. 2022-08-26. PMID:36016337. |
in both cell lines, it was observed that the wnt signaling, pi3 kinase, apoptosis, and t-cell activation pathways were negatively affected in co-infected cells. |
2022-08-26 |
2023-08-14 |
human |
| Mingqi Shen, Rongxiu Zheng, Xuan Ka. Neuroprotection of Bone Marrow-Derived Mesenchymal Stem Cell-Derived Extracellular Vesicle-Enclosed miR-410 Correlates with HDAC4 Knockdown in Hypoxic-Ischemic Brain Damage. Neurochemical research. 2022-08-26. PMID:36028735. |
treatment with mir-410-containing bmsc-evs improved learning and memory abilities of hibd mice while attenuating apoptosis by inactivating the wnt pathway via targeting hdac4. |
2022-08-26 |
2023-08-14 |
mouse |
| Vira Chumak, Katarzyna Sielatycka, Andrzej Ciechanowicz, Kamila Bujko, Mariusz Z Ratajczak, Magdalena Kuci. Proteomic Analysis of Murine Bone Marrow Very Small Embryonic-like Stem Cells at Steady-State Conditions and after In Vivo Stimulation by Nicotinamide and Follicle-Stimulating Factor Reflects their Germ-Lineage Origin and Multi Germ Layer Differentiation Potential. Stem cell reviews and reports. 2022-08-19. PMID:35986128. |
we have identified several go biological processes regulating development, organogenesis, gene expression, signal transduction, wnt signaling, insulin signaling, cytoskeleton organization, cell adhesion, inhibiting apoptosis, responses to extra- and intracellular stimuli, protein transport and stabilization, protein phosphorylation and ubiquitination, dna repair, immune response, and regulation of circadian rhythm. |
2022-08-19 |
2023-08-14 |
Not clear |
| Runzi Zheng, Yanghuan Zhang, Ke Zhang, Yang Yuan, Shuting Jia, Jing Li. The Complement System, Aging, and Aging-Related Diseases. International journal of molecular sciences. vol 23. issue 15. 2022-08-12. PMID:35955822. |
complement plays a role in inflammatory processes, metabolism, apoptosis, mitochondrial function, and wnt signaling pathways. |
2022-08-12 |
2023-08-14 |
Not clear |
| Fan-Chi Chang, Chia-Hao Liu, An-Jie Luo, Thomas Tao-Min Huang, Ming-Hsuan Tsai, Yu-Jhen Chen, Chun-Fu Lai, Chih-Kang Chiang, Tzu-Hung Lin, Wen-Chih Chiang, Yung-Ming Chen, Tzong-Shinn Chu, Shuei-Liong Li. Angiopoietin-2 inhibition attenuates kidney fibrosis by hindering chemokine C-C motif ligand 2 expression and apoptosis of endothelial cells. Kidney international. 2022-08-07. PMID:35934136. |
mechanistically, angiopoietin-1 reduced ccl2-activated macrophage migration and protected endothelial cells against cell apoptosis induced by angiopoietin-2 and wnt ligands. |
2022-08-07 |
2023-08-14 |
mouse |
| Shimin Xu, Yuezhong Li, Junshan Zhang, Zhiwei L. LINC01116 regulates the proliferation and apoptosis of nucleus pulposus cells through miR-9-5p-mediated ZIC5 and the Wnt pathway and affects the progression of intervertebral disc degeneration. Current stem cell research & therapy. 2022-08-05. PMID:35927800. |
linc01116 regulates the proliferation and apoptosis of nucleus pulposus cells through mir-9-5p-mediated zic5 and the wnt pathway and affects the progression of intervertebral disc degeneration. |
2022-08-05 |
2023-08-14 |
Not clear |
| Fatemeh Tavakkoli, Mukesh Damala, Madhuri Amulya Koduri, Abhilash Gangadharan, Amit K Rai, Debasis Dash, Sayan Basu, Vivek Sing. Transcriptomic Profiling of Human Limbus-Derived Stromal/Mesenchymal Stem Cells-Novel Mechanistic Insights into the Pathways Involved in Corneal Wound Healing. International journal of molecular sciences. vol 23. issue 15. 2022-07-28. PMID:35897793. |
these degs were involved in wnt, tgf-β signaling pathways, and 16 other biological processes, including apoptosis, cell motility, tissue remodeling, and stem cell maintenance, etc. |
2022-07-28 |
2023-08-14 |
human |
| Concetta Scimone, Simona Alibrandi, Luigi Donato, Concetta Alafaci, Antonino Germanò, Sergio L Vinci, Rosalia D'Angelo, Antonina Sidot. Editome landscape of CCM-derived endothelial cells. RNA biology. vol 19. issue 1. 2022-06-30. PMID:35771000. |
with a whole transcriptome-based variant calling pipeline, we identified differential edited genes in ccm-ecs that were enriched in pathways related to angiogenesis, apoptosis and cell survival, inflammation and, in particular, to thrombin signalling mediated by protease-activated receptors and non-canonical wnt signalling. |
2022-06-30 |
2023-08-14 |
human |
| Pnina Fishma. Drugs Targeting the A3 Adenosine Receptor: Human Clinical Study Data. Molecules (Basel, Switzerland). vol 27. issue 12. 2022-06-24. PMID:35744805. |
both induce apoptosis of cancer and inflammatory cells via a molecular mechanism entailing deregulation of the wnt and the nf-κb signaling pathways. |
2022-06-24 |
2023-08-14 |
human |
| Nan Xing, Xianli Meng, Shaohui Wan. Isobavachalcone: A comprehensive review of its plant sources, pharmacokinetics, toxicity, pharmacological activities and related molecular mechanisms. Phytotherapy research : PTR. 2022-06-10. PMID:35684981. |
mechanically, ibc can induce the production of reactive oxygen species (ros), inhibit akt, erk, and wnt pathways, and promote apoptosis of cancer cells through mitochondrial or endoplasmic reticulum pathways. |
2022-06-10 |
2023-08-14 |
Not clear |
| Zhizhun Mo, Zhongyi Zeng, Yuxiang Liu, Linsheng Zeng, Jiansong Fang, Yinzhong M. Activation of Wnt/Beta-Catenin Signaling Pathway as a Promising Therapeutic Candidate for Cerebral Ischemia/Reperfusion Injury. Frontiers in pharmacology. vol 13. 2022-06-07. PMID:35668927. |
recently, abnormal wnt signaling activity has been observed in ischemic stroke, which is accompanied by massive blood-brain barrier (bbb) disruption, neuronal apoptosis, and neuroinflammation within the central nervous system (cns). |
2022-06-07 |
2023-08-14 |
Not clear |
| Sheema Hashem, Tayyiba Akbar Ali, Sabah Akhtar, Sabah Nisar, Geetanjali Sageena, Shahid Ali, Sharefa Al-Mannai, Lubna Therachiyil, Rashid Mir, Imadeldin Elfaki, Mohammad Muzaffar Mir, Farrukh Jamal, Tariq Masoodi, Shahab Uddin, Mayank Singh, Mohammad Haris, Muzafar Macha, Ajaz A Bha. Targeting cancer signaling pathways by natural products: Exploring promising anti-cancer agents. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 150. 2022-06-05. PMID:35658225. |
these compounds are effective against several signaling pathways, mainly cell death pathways (apoptosis and autophagy) and embryonic developmental pathways (notch pathway, wnt pathway, and hedgehog pathway). |
2022-06-05 |
2023-08-14 |
Not clear |
| Huali Huang, Wenjing Chen, Jiefu Lu, Shiyu Zhang, Xuelian Xiang, Xianmo Wang, Guodu Tan. Circ_0000284 Promoted Acute Pancreatitis Progression through the Regulation of miR-10a-5p/Wnt/β-Catenin Pathway. Chemistry & biodiversity. 2022-05-17. PMID:35581162. |
knockdown of circ_0000284 could decrease apoptosis and inflammation in caerulein-induced ar42j cells, which was attenuated by mir-10a-5p inhibition or wnt signaling pathway antagonist dickkopf-related protein 1 (dkk1). |
2022-05-17 |
2023-08-13 |
rat |
| Olivia L Sniezek, Arianna Anzmann, Nanami Senoo, Grant Butschek, Steven Claypool, Hilary Verno. Investigating Mitochondrial Dysfunction in Barth Syndrome. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35556725. |
rnaseq identified dysregulation in pathways regulated by parl and pgam5 including wnt signaling, apoptosis, and autophagy in the undifferentiated state, with differentiated cell types highlighting pathways such as glucose metabolism and response to cellular stimuli. |
2022-05-13 |
2023-08-13 |
Not clear |
| Fanzhi Kong, Wei Ran, Ning Jiang, Shize Li, Dongjie Zhang, Dongbo Su. Identification and characterization of differentially expressed miRNAs in HepG2 cells under normoxic and hypoxic conditions. RSC advances. vol 9. issue 29. 2022-05-06. PMID:35516357. |
among the environmental information processing, certain pathways associated with cell proliferation and apoptosis, such as the hippo signalling pathway, wnt signalling pathway, mapk signalling pathway and jak-stat signaling pathways, represented potential factors in the response to hypoxia treatment. |
2022-05-06 |
2023-08-13 |
human |
| Fabiola Pacheco Valencia, Amanda F Marino, Christos Noutsos, Kinning Poo. Concentration-dependent change in hypothalamic neuronal transcriptome by the dietary fatty acids: oleic and palmitic acids. The Journal of nutritional biochemistry. 2022-05-02. PMID:35500830. |
the enriched signaling pathways include wnt, integrin, pdgf, and apoptosis, in addition to endocrine function signaling pathways cckr and gnrh. |
2022-05-02 |
2023-08-13 |
Not clear |