| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Almas Jabeen, Nadeem Ahmad, Khalid Raz. Global Gene Expression and Docking Profiling of COVID-19 Infection. Frontiers in genetics. vol 13. 2022-04-28. PMID:35480316. |
the functional changes are mainly associated with these pathways tnf, cytokine, nf-kb, tlr, tcr, bcr, foxo, and tgf signaling pathways are among them and there are additional pathways such as hippo signaling, apoptosis, estrogen signaling, regulating pluropotency of stem cells, erbb, wnt, p53, camp, mapk, pi3k-akt, oxidative phosphorylation, protein processing in endoplasmic reticulum, prolactin signaling, adipocytokine, neurotrophine signaling, and longevity regulating pathways. |
2022-04-28 |
2023-08-13 |
Not clear |
| Chiami Moyama, Mitsugu Fujita, Shota Ando, Keiko Taniguchi, Hiromi Ii, Seisuke Tanigawa, Naoya Hashimoto, Susumu Nakat. Stat5b inhibition blocks proliferation and tumorigenicity of glioblastoma stem cells derived from a American journal of cancer research. vol 12. issue 3. 2022-04-12. PMID:35411230. |
previous studies have shown that expression of leucine-rich repeat-containing g-protein coupled receptor 5 (lgr5), a wnt pathway-related stem cell marker, correlates with a poor prognosis in gbm, and its knockdown in gscs induces apoptosis accompanied with downregulation of signal transducer and activator of transcription 5b (stat5b). |
2022-04-12 |
2023-08-13 |
Not clear |
| Pedro E Lázaro-Mixteco, José M González-Coronel, Laura Hernández-Padilla, Lorena Martínez-Alcantar, Enrique Martínez-Carranza, Jesús Salvador López-Bucio, Ángel A Guevara-García, Jesús Campos-Garcí. Transcriptomics Reveals the Mevalonate and Cholesterol Pathways Blocking as Part of the Bacterial Cyclodipeptides Cytotoxic Effects in HeLa Cells of Human Cervix Adenocarcinoma. Frontiers in oncology. vol 12. 2022-04-01. PMID:35359411. |
bioinformatics confirmed the impact of cdps in the differential expression of genes from signal transduction pathways such as pi3k-akt, mtor, foxo, wnt, mapk, p53, tgf-β, notch, apoptosis, emt, and csc. |
2022-04-01 |
2023-08-13 |
human |
| Pallavi Goel, Shivani Malpotra, Songyukta Shyam, Deepak Kumar, Manoj Kumar Singh, Prabhat Palt. Global MicroRNA Expression Profiling of Buffalo ( Genes. vol 13. issue 3. 2022-03-25. PMID:35328007. |
the major pathways related to embryonic development, such as the wnt signaling pathway, the apoptosis signaling pathway, the fgf signaling pathway, the p53 pathway, etc., were found to be affected in cloned relative to ivf embryos. |
2022-03-25 |
2023-08-13 |
Not clear |
| Yi Yang, Limei Wang, Caijun Zhang, Yuqian Guo, Jintao Li, Chao Wu, Jianlin Jiao, Hong Zhen. Ginsenoside Rg1 improves Alzheimer's disease by regulating oxidative stress, apoptosis and neuroinflammation through Wnt/GSK-3β/β-catenin signaling pathway. Chemical biology & drug design. 2022-03-21. PMID:35313087. |
however, the mechanism of how rg1 mediates the wnt signaling pathway and improves cognitive function by regulating oxidative stress, apoptosis and neuroinflammation is still unclear. |
2022-03-21 |
2023-08-13 |
cat |
| Souvick Roy, Yinghui Zhao, Yate-Ching Yuan, Ajay Goe. Metformin and ICG-001 Act Synergistically to Abrogate Cancer Stem Cells-Mediated Chemoresistance in Colorectal Cancer by Promoting Apoptosis and Autophagy. Cancers. vol 14. issue 5. 2022-03-10. PMID:35267590. |
accordingly, selective targeting of wnt signaling using icg-001 along with metformin abrogated csc-mediated chemoresistance by decreasing the expression of csc markers and promoting autophagy and apoptosis in a synergistic manner. |
2022-03-10 |
2023-08-13 |
Not clear |
| Sheetu, Tapan Behl, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Saurabh Bhatia, Ahmed Al-Harassi, Simona Bungau, Ebrahim Mostafav. Possible Role of Wnt Signaling Pathway in Diabetic Retinopathy. Current drug targets. 2022-03-02. PMID:35232336. |
the wnt protein ligands family influences various processes; this ensures the cells are able to interact and co-ordinate various mobile functions, including cell growth, division, survival, apoptosis, migration, and cell destiny. |
2022-03-02 |
2023-08-13 |
Not clear |
| Robert Kleszcz, Jarosław Paluszcza. The Wnt Signaling Pathway Inhibitors Improve the Therapeutic Activity of Glycolysis Modulators against Tongue Cancer Cells. International journal of molecular sciences. vol 23. issue 3. 2022-02-15. PMID:35163171. |
the aim of this study was to evaluate the effects of the combinatorial use of glycolysis and wnt signaling inhibitors on viability, cytotoxicity, apoptosis induction, cell cycle distribution and the glycolytic activity of tongue carcinoma cells. |
2022-02-15 |
2023-08-13 |
Not clear |
| Zuo-Long Wu, Ya-Jun Chen, Guang-Zhi Zhang, Qi-Qi Xie, Ke-Ping Wang, Xin Yang, Tai-Cong Liu, Zhi-Qiang Wang, Guang-Hai Zhao, Hai-Hong Zhan. SKI knockdown suppresses apoptosis and extracellular matrix degradation of nucleus pulposus cells via inhibition of the Wnt/β-catenin pathway and ameliorates disc degeneration. Apoptosis : an international journal on programmed cell death. 2022-02-11. PMID:35147801. |
this study aimed to determine the effects of ski on interleukin (il)-1β-induced apoptosis of nucleus pulposus (np) cells, intervertebral disc degeneration (idd), and the wnt signaling pathway. |
2022-02-11 |
2023-08-13 |
human |
| Austin Armstrong, Ashok Mandala, Milan Malhotra, Jaya P Gnana-Prakasa. Canonical Wnt Signaling in the Pathology of Iron Overload-Induced Oxidative Stress and Age-Related Diseases. Oxidative medicine and cellular longevity. vol 2022. 2022-02-04. PMID:35116092. |
canonical wnt signaling is an evolutionarily conserved signaling pathway that regulates many cellular functions including cell proliferation, apoptosis, cell migration, and stem cell renewal. |
2022-02-04 |
2023-08-13 |
Not clear |
| Yuanshan Han, Yang Yang, Sanqian Huang, Lei Yao, Lile W. The miR-34a/WNT7B modulates the sensitivity of cholangiocarcinoma cells to p53-mediated photodynamic therapy toxicity. Biochemical and biophysical research communications. vol 591. 2022-01-09. PMID:34999254. |
in cholangiocarcinoma cells, pdt treatment inhibited wnt signaling, suppressed cell viability, and enhanced cell apoptosis. |
2022-01-09 |
2023-08-13 |
Not clear |
| Yuanshan Han, Yang Yang, Sanqian Huang, Lei Yao, Lile W. The miR-34a/WNT7B modulates the sensitivity of cholangiocarcinoma cells to p53-mediated photodynamic therapy toxicity. Biochemical and biophysical research communications. vol 591. 2022-01-09. PMID:34999254. |
under pdt treatment, wnt7b knockdown inhibited the wnt signaling and cell viability, and promoted cell apoptosis, while mir-34a-5p suppression showed the opposite trends; wnt7b knockdown partially attenuated mir-34a-5p inhibition effects on pdt-treated cholangiocarcinoma cells. |
2022-01-09 |
2023-08-13 |
Not clear |
| Shanshan Liu, Wenjuan Tian, Burong L. Integrative bioinformatics analysis the clinical value of KMT5A in different subtypes of lung cancer. Computational biology and chemistry. vol 96. 2021-12-11. PMID:34894606. |
luad was differentially enriched with apoptosis, cancer pathway, vascular endothelial growth factor signaling pathway and wnt signaling pathway. |
2021-12-11 |
2023-08-13 |
Not clear |
| Rui Zhang, Shuai Yu, Qiaoyan Shen, Wenxu Zhao, Juqing Zhang, Xiaolong Wu, Zhenshuo Zhu, Xiaojie Wu, Na Li, Sha Peng, Jinlian Hu. AXIN2 Reduces the Survival of Porcine Induced Pluripotent Stem Cells (piPSCs). International journal of molecular sciences. vol 22. issue 23. 2021-12-10. PMID:34884759. |
we found that (1) overexpression of the porcine axin2 gene significantly reduced survival and negatively impacted the pluripotency of pipscs, and (2) knockdown of axin2, a negative effector of the wnt signaling pathway, enhanced the expression of genes involved in cell cycle but reduced the expression of genes related to cell differentiation, death, and apoptosis. |
2021-12-10 |
2023-08-13 |
Not clear |
| Zhu Yue Lin, Qu Zhen Yun, Liu Wu, Tian Wen Zhang, Tang Ze Ya. Pharmacological basis and new insights of deguelin concerning its anticancer effects. Pharmacological research. vol 174. 2021-12-07. PMID:34644595. |
it possesses the inhibition of cancer cell proliferation by inducing apoptosis through regulating the phosphoinositide 3-kinase/protein kinase b (pi3k/akt) signaling pathway, the nf-κb signaling pathway, the wnt signaling pathway, the adenosine 5'-monophosphate (amp)-activated protein kinase (ampk) signaling pathway and epidermal growth factor receptor (egfr) signaling, activating the p38 mitogen-activated protein kinase (mapk) pathway, repression of bmi1, targeting cyclooxygenase-2 (cox-2), targeting galectin-1, promotion of glycogen synthase kinase-3β (gsk3β)/fbw7-mediated mcl-1 destabilization and targeting mitochondria via down-regulating hexokinases ii-mediated glycolysis, puma-mediation, which are some crucial molecules which modulate closely cancer cell growth and metastasis. |
2021-12-07 |
2023-08-13 |
Not clear |
| Md Sahab Uddin, Md Tanvir Kabir, Mst Marium Begum, Md Siddiqul Islam, Tapan Behl, Ghulam Md Ashra. Exploring the Role of CLU in the Pathogenesis of Alzheimer's Disease. Neurotoxicity research. vol 39. issue 6. 2021-12-03. PMID:32820456. |
growing evidence indicates that clu plays roles in ad pathogenesis via various processes, including aggregation and clearance of aβ, neuroinflammation, lipid metabolism, wnt signaling, copper homeostasis, and regulation of neuronal cell cycle and apoptosis. |
2021-12-03 |
2023-08-13 |
Not clear |
| Bahar Degirmenci, Cansu Dincer, Habibe Cansu Demirel, Linda Berkova, Andreas E Moor, Abdullah Kahraman, George Hausmann, Michel Aguet, Nurcan Tuncbag, Tomas Valenta, Konrad Basle. Epithelial Wnt secretion drives the progression of inflammation-induced colon carcinoma in murine model. iScience. vol 24. issue 12. 2021-12-03. PMID:34849464. |
genetically blocking wnt secretion from epithelial cells of such tumors results in apoptosis, reduced expression of colon cancer markers, followed by enhanced tumor differentiation. |
2021-12-03 |
2023-08-13 |
Not clear |
| Seisuke Tanigawa, Mitsugu Fujita, Chiami Moyama, Shota Ando, Hiromi Ii, Yasushi Kojima, Teruaki Fujishita, Masahiro Aoki, Hayato Takeuchi, Takumi Yamanaka, Yoshinobu Takahashi, Naoya Hashimoto, Susumu Nakat. Inhibition of Gli2 suppresses tumorigenicity in glioblastoma stem cells derived from a de novo murine brain cancer model. Cancer gene therapy. vol 28. issue 12. 2021-12-02. PMID:33414520. |
gli2 knockdown using lentiviral-mediated shrna downregulated hedgehog-related and wnt signaling pathway-related genes, including lgr5; suppressed tumor cell proliferation and invasion capacity; and induced apoptosis. |
2021-12-02 |
2023-08-13 |
mouse |
| Cheng-Xian Song, Sheng-Yao Liu, Wen-Ting Zhu, Shao-Yong Xu, Guo-Xin N. Excessive mechanical stretch‑mediated osteoblasts promote the catabolism and apoptosis of chondrocytes via the Wnt/β‑catenin signaling pathway. Molecular medicine reports. vol 24. issue 2. 2021-11-17. PMID:34165157. |
in the co‑culture model, the results indicated that excessive mechanically stretched osteoblasts induced the catabolism and apoptosis of chondrocytes, which was partly inhibited by wnt inhibitor xav‑939. |
2021-11-17 |
2023-08-13 |
rat |
| Peng An, Jianxiao Xing, Aihong Peng, Xincheng Zhao, Wenjuan Chang, Nannan Liang, Yue Cao, Juan Li, Junqin Li, Ruixia Hou, Xinhua Li, Kaiming Zhan. The regulation of dermal mesenchymal stem cells on keratinocytes apoptosis. Cell and tissue banking. vol 22. issue 1. 2021-11-15. PMID:32990869. |
moreover, 33 genes with the function of induced cell apoptosis were highly expressed in dmscs, including insulin-like growth factor-binding protein 4 (2828.13), igfbp7 (1805.69), cathepsin d (1694.34), cathepsin b (ctsb, 1641.40) and dickkopf wnt signaling pathway inhibitor 1 (dkk1, 384.79). |
2021-11-15 |
2023-08-13 |
Not clear |