| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xinyan Li, Yuanyuan Han, Guimiao Li, Yingze Zhang, Juan Wang, Chen Fen. Role of Wnt signaling pathway in joint development and cartilage degeneration. Frontiers in cell and developmental biology. vol 11. 2023-06-27. PMID:37363728. |
excessive mechanical load activates wnt pathway in chondrocytes, resulting in chondrocyte apoptosis, matrix destruction and other osteoarthritis-related changes. |
2023-06-27 |
2023-08-14 |
Not clear |
| Dong-Ni Liu, Man Liu, Shan-Shan Zhang, Yu-Fu Shang, Wen-Fang Zhang, Fu-Hang Song, Hua-Wei Zhang, Guan-Hua Du, Yue-Hua Wan. Chrysomycin A Regulates Proliferation and Apoptosis of Neuroglioma Cells via the Akt/GSK-3β Signaling Pathway In Vivo and In Vitro. Marine drugs. vol 21. issue 6. 2023-06-27. PMID:37367654. |
the results showed that chr-a treatment significantly inhibits glioblastoma progression in xenografted hairless mice, and enrichment analysis suggested that apoptosis, pi3k-akt and wnt signaling pathways were involved in the possible mechanisms. |
2023-06-27 |
2023-08-14 |
mouse |
| Eric Mayo. Neurotrophic effects of intermittent fasting, calorie restriction and exercise: a review and annotated bibliography. Frontiers in aging. vol 4. 2023-06-19. PMID:37334045. |
the most researched signaling pathways (pi3k, akt, mtor, ampk, gsk3β, ulk, mapk, pgc-1α, nf-κb, sirtuins, notch, sonic hedgehog and wnt) and processes (e.g., anti-inflammation, autophagy, apoptosis) that support or thwart neuroprotection, synaptic plasticity and neurogenesis are then briefly presented. |
2023-06-19 |
2023-08-14 |
Not clear |
| Yan Zhuang, Chunlan Ning, Pengfei Liu, Yanpeng Zhao, Yue Li, Zhenchi Ma, Luling Shan, Yingzhe Piao, Peng Zhao, Xun Ji. LSM12 facilitates the progression of colorectal cancer by activating the WNT/CTNNB1 signaling pathway. Oncology research. vol 30. issue 6. 2023-06-12. PMID:37303493. |
lsm12 is involved in the proliferation, invasion, and apoptosis of crc cells, similar to the function of wnt signaling in crc. |
2023-06-12 |
2023-08-14 |
Not clear |
| Lin Wang, Qinghua Jiang, Siyu Chen, Siyi Wang, Jingyi Lu, Xun Gao, Dongfang Zhang, Xin Ji. Natural epidithiodiketopiperazine alkaloids as potential anticancer agents: Recent mechanisms of action, structural modification, and synthetic strategies. Bioorganic chemistry. vol 137. 2023-06-05. PMID:37276722. |
owing to their privileged sulfur units and intriguing architectural structures, etp alkaloids exhibit excellent anticancer activities by regulating multiple cancer proteins/signaling pathways, including hif-1, nf-κb, notch, wnt, and pi3k/akt/mtor, or by inducing cell-cycle arrest, apoptosis, and autophagy. |
2023-06-05 |
2023-08-14 |
Not clear |
| Pratibha Pandey, Fahad Khan, Min Choi, Sujeet Kumar Singh, Han Na Kang, Moon Nyeo Park, Seong-Gyu Ko, Sanjeev Kumar Sahu, Rupa Mazumder, Bonglee Ki. Review deciphering potent therapeutic approaches targeting Notch signaling pathway in breast cancer. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 164. 2023-06-02. PMID:37267635. |
these substances are effective against several signaling pathways, particularly the cell death pathways (apoptosis and autophagy) and embryonic developmental pathways (notch, wnt, and hedgehog pathways). |
2023-06-02 |
2023-08-14 |
Not clear |
| Yi Bai, Jinyun He, Yanquan Ma, He Liang, Ming Li, Yan W. Identification of DNA repair gene signature and potential molecular subtypes in hepatocellular carcinoma. Frontiers in oncology. vol 13. 2023-06-01. PMID:37260986. |
gene set enrichment analysis (gsea) revealed that in the high-risk group, apoptosis, cell cycle, mapk, mtor, and wnt cascades were highly enriched. |
2023-06-01 |
2023-08-14 |
Not clear |
| Riza Serttas, Suat Erdoga. Pretreatment of prostate cancer cells with salinomycin and Wnt inhibitor increases the efficacy of cabazitaxel by inducing apoptosis and decreasing cancer stem cells. Medical oncology (Northwood, London, England). vol 40. issue 7. 2023-06-01. PMID:37264204. |
pretreatment of prostate cancer cells with salinomycin and wnt inhibitor increases the efficacy of cabazitaxel by inducing apoptosis and decreasing cancer stem cells. |
2023-06-01 |
2023-08-14 |
human |
| Huibin Zhang, Jinglin Wang, Fan Xie, Yangguang Liu, Mengyao Qiu, Zheng Han, Yueyun Ding, Xianrui Zheng, Zongjun Yin, Xiaodong Zhan. Identification of microRNAs implicated in modulating resveratrol-induced apoptosis in porcine granulosa cells. Frontiers in cell and developmental biology. vol 11. 2023-05-30. PMID:37250898. |
in the high vs. con group, rsv functions were associated with metabolic processes and responses to stimuli, while the pathways were related to pi3k24, akt, wnt, and apoptosis. |
2023-05-30 |
2023-08-14 |
Not clear |
| Zhiyong Ren, Liguo Tang, Zhonghua Ding, Jun Song, Hailiang Zheng, Dongzhu L. Dried root of Rehmannia glutinosa extracts prevents steroid-induced avascular necrosis of femoral head by activating the wingless-type (Wnt)/β-catenin signal pathway. Toxicon : official journal of the International Society on Toxinology. 2023-05-26. PMID:37236550. |
furthermore, dkk-1, an inhibitor of the wingless-type (wnt)/β-catenin signaling pathway, reversed the effect of drge on cell apoptosis and alp activity in cells treated with dex. |
2023-05-26 |
2023-08-14 |
rat |
| Farzaneh Zarghampoor, Behnaz Valibeigi, Abbas Behzad-Behbahan. The molecular characteristics of colorectal cancer: Impact of Ibuprofen and hyperthermia. Molecular biology research communications. vol 12. issue 1. 2023-05-18. PMID:37201032. |
this study investigated the effects of hyperthermia and ibuprofen on human colorectal adenocarcinoma cells (ht-29) viability, proliferation, and gene expression related to tumor suppression, wnt signaling pathways, proliferation, and apoptosis the cells were exposed to hyperthermia at 42 or 43°c for 3 hours or ibuprofen at different concentrations (700-1500 μm), and the effects were analyzed through mtt assay, trypan blue staining, and quantitative real-time pcr. |
2023-05-18 |
2023-08-14 |
human |
| Farzaneh Zarghampoor, Behnaz Valibeigi, Abbas Behzad-Behbahan. The molecular characteristics of colorectal cancer: Impact of Ibuprofen and hyperthermia. Molecular biology research communications. vol 12. issue 1. 2023-05-18. PMID:37201032. |
the study used quantitative real-time pcr (qrt-pcr) to evaluate the effect of hyperthermia and ibuprofen on the expression of various genes associated with tumor suppression, proliferation, wnt signaling pathway, and apoptosis. |
2023-05-18 |
2023-08-14 |
human |
| Luyang Wang, Anning Du, Yan Lu, Yunxi Zhao, Ming Qiu, Zhenyang Su, Huanyu Shu, Hui Shen, Wei Sun, Xiangqing Kon. Peptidase Inhibitor 16 Attenuates Left Ventricular Injury and Remodeling After Myocardial Infarction by Inhibiting the HDAC1-Wnt3a-β-Catenin Signaling Axis. Journal of the American Heart Association. 2023-05-09. PMID:37158154. |
pi16 also inhibited hdac1 (class i histone deacetylase) expression, and overexpression hdac1 abolished the inhibition of apoptosis and wnt signaling of pi16. |
2023-05-09 |
2023-08-14 |
mouse |
| Guang Yang, Yunbiao He, Yingxing Chen, Zhihan Huang, Jieqiong Huang, Xinyi Ren, Shihai Xu, Ping L. Antitumor activity of galaxamide involved in cell apoptosis and stemness by inhibiting Wnt/β-catenin pathway in cervical cancer. Drug development research. 2023-05-08. PMID:37154105. |
it was found galaxamide significantly inhibited cell growth, colony formation, migration, and invasion and induced cell apoptosis by inhibiting the wnt signaling pathway in hela cells. |
2023-05-08 |
2023-08-14 |
mouse |
| Guang Yang, Yunbiao He, Yingxing Chen, Zhihan Huang, Jieqiong Huang, Xinyi Ren, Shihai Xu, Ping L. Antitumor activity of galaxamide involved in cell apoptosis and stemness by inhibiting Wnt/β-catenin pathway in cervical cancer. Drug development research. 2023-05-08. PMID:37154105. |
our results provide evidence that suppression of stemness by downregulating the wnt signaling pathway is the molecular mechanism by which galaxamide effectively inhibits cell growth and induces apoptosis in cervical cancer cells. |
2023-05-08 |
2023-08-14 |
mouse |
| Juanjuan Li, Juntao Zhang, Yalin Zhang, Yujie Zhuang, Penghui Yan, Jin Zhou, Saina Hu, Lixin Deng, Zhiping Zhan. The effect of 1,25-dihydroxyvitamin D3 on the Wnt signaling pathway in bovine intestinal epithelial cells is mediated by the DKK2 (dickkopf2) Wnt antagonist. The Journal of steroid biochemistry and molecular biology. 2023-05-06. PMID:37149202. |
the potential mechanism of action was investigated after knockdown and overexpression of the wnt pathway inhibitor, dkk2, in intestinal epithelial cells by observing the effects of 1,25(oh)2d3 on proliferation, apoptosis, pluripotency and the expression of genes related to the wnt/β-catenin signaling pathway. |
2023-05-06 |
2023-08-14 |
cattle |
| Xian Lin, Jian Chen, Xin Li, Dong Chen, Kaixuan Luo, Yongxing Deng, Dinghua Yang, Zunnan Huang, Cheng Ta. Dimeric oxyberberine CT4-1 targets LINC02331 to induce cytotoxicity and inhibit chemoresistance via suppressing Wnt/β-catenin signaling in hepatocellular carcinoma. Archives of toxicology. 2023-04-30. PMID:37120773. |
rna sequencing analyses verified the involvement of ct4-1-affected differential expression genes in dysregulated pathways and processes, including wnt, dna damage repair, cell cycle, dna replication, apoptosis, and cell adhesion molecules. |
2023-04-30 |
2023-08-14 |
mouse |
| Ghada M H Abdel-Salam, Hanan H Afifi, Mohamed S Abdel-Hamid, Nermeen E B Ahmed, Mohamed B Taher, Ghada El-Kamah, Holger Thiele, Peter N Nürnberg, Hanno J Bol. Expanding the phenotypic spectrum and clinical severity associated with WLS gene. Journal of human genetics. 2023-04-27. PMID:37106064. |
wls (wnt ligand secretion mediator or wntless) orchestrates the secretion of all wnt proteins, a family of evolutionary conserved proteins, involved in wnt signaling pathway that has many essential biological functions including the regulation of development, cell proliferation, migration and apoptosis. |
2023-04-27 |
2023-08-14 |
Not clear |
| Xueying Shao, Yuanjun Zhang, Yuan Li. Cyclic stretch-regulated wound healing. Biophysical journal. 2023-04-26. PMID:37098651. |
specifically, a great diversity of cellular responses (1-4) have been reported, including 1) re-alignment of cells, associated with the remodeling of cellular stress fibers and focal adhesions; 2) altered cell proliferation or apoptosis; 3) migration of cells driven by stretch-triggered formation of lamellipodia; 4) secretion of extracellular matrix (ecm) proteins that are critical for tissue remodeling; 5) activation of mitogen-activated protein kinase (mapk), nuclear factor-kappa b (nf-kb) and wnt signaling pathways; and 6) upregulation of genes involved in cell adhesion and inflammation. |
2023-04-26 |
2023-08-14 |
Not clear |
| Zahra Nasrpour Navaei, Negin Taghehchian, Amir Sadra Zangouei, Mohammad Reza Abbaszadegan, Meysam Moghbel. MicroRNA-506 as a tumor suppressor in anaplastic thyroid carcinoma by regulation of WNT and NOTCH signaling pathways. Iranian journal of basic medical sciences. vol 26. issue 5. 2023-04-13. PMID:37051101. |
we assessed the role of mir-506 in the regulation of cell migration, apoptosis, and drug resistance via notch and wnt pathways in atc cells. |
2023-04-13 |
2023-08-14 |
Not clear |