| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R F Walke. Melatonin:serotonin interaction during termination of the LH surge in rats. Progress in clinical and biological research. vol 92. 1982-10-21. PMID:7202213. |
furthermore, the effects of melatonin and methiothepin, a serotonin receptor antagonist, on hypothalamic serotonin metabolism were comparable, and opposite from quipazine. |
1982-10-21 |
2023-08-12 |
rat |
| C Fornal, M Radulovack. Methysergide blocks the sleep suppressant action of quipazine in rats. Psychopharmacology. vol 76. issue 3. 1982-09-24. PMID:6808546. |
the aim of the present study was to examine the effect of methysergide, a 5-hydroxytryptamine (5-ht) receptor antagonist, on the sleep suppression produced by the 5-ht receptor agonist, quipazine. |
1982-09-24 |
2023-08-12 |
rat |
| J A Russell, M L Gilberstadt, M S Rohrbac. Constrictor effect of cotton bract extract on isolated canine airways. The American review of respiratory disease. vol 125. issue 6. 1982-08-07. PMID:7091879. |
we conclude that cotton bracts contain a potent 5-ht receptor agonist that appears to be distinct from 5-ht. |
1982-08-07 |
2023-08-12 |
Not clear |
| R J Barrett, M A Blackshear, E Sanders-Bus. Discriminative stimulus properties of L-5-hydroxytryptophan: behavioral evidence for multiple serotonin receptors. Psychopharmacology. vol 76. issue 1. 1982-07-19. PMID:6805004. |
further evidence for the involvement of 5-ht receptor stimulation in mediating the discrimination was that pretreatment with fluoxetine, a highly specific 5-ht uptake inhibitor, markedly potentiated the cue. |
1982-07-19 |
2023-08-12 |
rat |
| E Chung Hwang, M H Van Woer. p,p'-DDT-induced alterations in brain serotonin metabolism. Neurotoxicology. vol 2. issue 4. 1982-07-08. PMID:6176920. |
p,p'-ddt had no effect on the transport of 5-hydroxyindoleacetic acid out of the central nervous system, serotonin uptake and release from nerve terminals, or serotonin receptor binding in the brain. |
1982-07-08 |
2023-08-12 |
rat |
| A Biegon, B S McEwe. Modulation by estradiol of serotonin receptors in brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 2. issue 2. 1982-05-21. PMID:7199565. |
estrogens were found to exert a biphasic effect on the density of serotonin receptors in the female rat brain: an acute reduction in serotonin receptor density throughout the brain is followed 48 to 72 hr later by a selective increase in those brain regions known to contain estrogen receptors--hypothalamus, preoptic area, and amygdala. |
1982-05-21 |
2023-08-12 |
rat |
| R Takahashi, T Tateishi, H Yoshida, H Nagayama, K H Tachik. Serotonin metabolism of animal model of depression. Advances in experimental medicine and biology. vol 133. 1982-02-12. PMID:6172020. |
all results presented here would indicate that serotonin plays an important role in animal behavior such as locomotor depression and that, taking into consideration the effects of antidepressants on 5-ht receptor activity as well as recent biochemical findings of human depression, some forms of human depression could be induced by a cerebral serotonergic receptor hyperactivity contrary to a conventional theory of serotonin deficiency in the synaptic cleft in the brain. |
1982-02-12 |
2023-08-12 |
human |
| S R Coughlin, M A Moskowitz, H N Antoniades, L Levin. Serotonin receptor-mediated stimulation of bovine smooth muscle cell prostacyclin synthesis and its modulation by platelet-derived growth factor. Proceedings of the National Academy of Sciences of the United States of America. vol 78. issue 11. 1982-02-12. PMID:7031670. |
an increase in prostacyclin synthesis was elicited by the addition of a serotonin agonist, quipazine (1 microm and above), and antagonized by the serotonin receptor blockers cyproheptadine, methysergide, or methiothepin but not by other aminergic receptor-blocking drugs (e.g., phentolamine or propranolol). |
1982-02-12 |
2023-08-12 |
cattle |
| C De Montign. Enhancement of the 5-HT neurotransmission by antidepressant treatments. Journal de physiologie. vol 77. issue 2-3. 1981-12-22. PMID:6270317. |
however, chronic administration of a new antidepressant drug, zimelidine, a potent and long-lasting 5-ht uptake blocker, fails to modify 5-ht receptor sensitivity. |
1981-12-22 |
2023-08-12 |
human |
| R D Myer. Serotonin and thermoregulation: old and new views. Journal de physiologie. vol 77. issue 2-3. 1981-12-22. PMID:6793718. |
new observations are described which show that 5-ht may elicit a fall in temperature as a result of the: (1) overloading of 5-ht receptor sites in the anterior hypothalamus; and/or (2) occupation by 5-ht of either noradrenergic or dopaminergic receptors, or both classes of catecholamine receptors which are believed to mediate the hypothalamic pathways for heat loss. |
1981-12-22 |
2023-08-12 |
rat |
| G Fillion, M P Fillion, J C Roussell. [Increase in binding affinity of the 5-HT receptor and decrease in 5-HT sensitive adenylate cyclase activity following prolonged exposure to 5-HT (author's transl)]. Journal de physiologie. vol 77. issue 2-3. 1981-12-22. PMID:7288651. |
[increase in binding affinity of the 5-ht receptor and decrease in 5-ht sensitive adenylate cyclase activity following prolonged exposure to 5-ht (author's transl)]. |
1981-12-22 |
2023-08-12 |
Not clear |
| L Noreika, G Pastor, J Liebma. Delayed emergence of antidepressant efficacy following withdrawal in olfactory bulbectomized rats. Pharmacology, biochemistry, and behavior. vol 15. issue 3. 1981-12-22. PMID:7291242. |
the olfactory bulbectomy syndrome may reflect functional serotonin deficiency, which would be ameliorated through antidepressant-induced alterations in serotonin receptor sensitivity. |
1981-12-22 |
2023-08-12 |
rat |
| M O Carruba, G B Picotti, M Calogero, J Negreanu, P Mantegazz. Hyperthermic responses to direct and indirect 5-HT agonists in rabbits following induction of 5-HT receptor supersensitivity by pharmacological manipulations which either reduce or leave unmodified brain 5-HT stores. Pharmacological research communications. vol 13. issue 8. 1981-12-15. PMID:6457307. |
hyperthermic responses to direct and indirect 5-ht agonists in rabbits following induction of 5-ht receptor supersensitivity by pharmacological manipulations which either reduce or leave unmodified brain 5-ht stores. |
1981-12-15 |
2023-08-12 |
Not clear |
| H Nagayama, J N Hingtgen, M H Apriso. Postsynaptic action by four antidepressive drugs in an animal model of depression. Pharmacology, biochemistry, and behavior. vol 15. issue 1. 1981-12-15. PMID:6974869. |
since acute pretreatment with comparable clinical doses of the antidepressive drugs, mianserin, amitriptyline, imipramine, or iprindole, resulted in blockade of the 5-htp induced depression by 70, 50, 40, and 20% respectively, these drugs can act as antagonists of 5-ht at the postsynaptic serotonin receptor. |
1981-12-15 |
2023-08-12 |
rat |
| C Singleton, C A Marsde. Circadian variation in the head twitch response produced by 5-methoxy-N1,N1-dimethyltryptamine and p-chloroamphetamine in the mouse. Psychopharmacology. vol 74. issue 2. 1981-10-29. PMID:6168003. |
mice maintained on a 12-h light-dark cycle showed a maximum response to the direct 5-ht receptor agonist 5-meodmt (5 mg/kg iv) towards the end of the dark period, when the 5-ht level was at its lowest. |
1981-10-29 |
2023-08-12 |
mouse |
| C Singleton, C A Marsde. Circadian variation in the head twitch response produced by 5-methoxy-N1,N1-dimethyltryptamine and p-chloroamphetamine in the mouse. Psychopharmacology. vol 74. issue 2. 1981-10-29. PMID:6168003. |
it is concluded that 5-ht receptor response shows a circadian rhythm related to both pre-synaptic availability of 5-ht and post-synaptic receptor sensitivity. |
1981-10-29 |
2023-08-12 |
mouse |
| A R Green, J E Hall, A R Ree. A behavioural and biochemical study in rats of 5-hydroxytryptamine receptor agonists and antagonists, with observations on structure-activity requirements for the agonists. British journal of pharmacology. vol 73. issue 3. 1981-09-25. PMID:6166345. |
in contrast, cypropheptadine, cinanserin and mianserin had no effects on the behaviour.3 similar findings were obtained when the behaviours were elicited by administration of tranylcypromine (10 mg/kg) followed by the putative 5-ht receptor agonist, 5-methoxy-n,n-dimethyltryptamine (5-meodmt) (2 mg/kg).4 when the behaviours were elicited by the putative 5-ht receptor agonist, quipazine (50 mg/kg), all the drugs effectively inhibited head weaving and forepaw treading.5 when the dose of cypropheptadine was doubled to 20 mg/kg an inhibition of the tranylcypromine/l-tryptophan induced behaviours was seen.6 methiothepin produced a marked inhibition of apomorphine-induced locomotor activity whilst all the others enhanced this response, suggesting that only methiothepin inhibits the 5-ht behaviours by dopamine antagonism and that the increased reactivity seen following tranylcypromine/l-tryptophan after pretreatment with methysergide or methergoline might be due to enhanced dopamine function.7 pretreatment with p-chlorophenylalanine resulted in enhanced behavioural responses to both 5-meodmt and quipazine.8 both methergoline and methiothepin decreased the rate of 5-ht synthesis in whole brain but not spinal cord and methergoline decreased spinal cord 5-hiaa concentration. |
1981-09-25 |
2023-08-12 |
rat |
| A R Green, J E Hall, A R Ree. A behavioural and biochemical study in rats of 5-hydroxytryptamine receptor agonists and antagonists, with observations on structure-activity requirements for the agonists. British journal of pharmacology. vol 73. issue 3. 1981-09-25. PMID:6166345. |
none of the other drugs had any significant effects on the concentration of 5-ht, 5-hiaa or 5-ht synthesis rate in brain or spinal cord.9 experiments with compounds structurally related to quipazine and with molecular models suggested that quipazine produces behavioural changes probably by stimulating the 5-ht receptor in a similar way to 5-ht but that it would bind weakly, in agreement with ligand-receptor binding studies.10 it is suggested, therefore, that cyproheptadine, cinanserin and mianserin fail to inhibit 5-ht and 5-meodmt-induced behaviours because they are weak antagonists whilst they are able to inhibit the same behaviours induced by quipazine because it is a weak agonist.11 these data indicate that extreme care should be taken in accepting or rejecting 5-ht as a mediator of behaviours or of other responses unless several antagonists or agonists have been examined. |
1981-09-25 |
2023-08-12 |
rat |
| H L Nash, D I Walli. Effects of divalent cations on responses of a sympathetic ganglion to 5-hydroxytryptamine and 1,1-dimethyl-4-phenyl piperazinium. British journal of pharmacology. vol 73. issue 3. 1981-09-25. PMID:6265020. |
in ca/mg-free solutions, 5-ht depolarizations were potentiated but no significant shift in the curve was observed.6 it is suggested that divalent cations modulate the coupling between 5-ht receptor and ion channel, an increase in [ca(2+)](o) reducing the coupling or stabilizing the ion channel in the closed conformation. |
1981-09-25 |
2023-08-12 |
Not clear |
| M Hamon, D L Nelson, A Herbet, J Bockaert, J Glowinsk. Characteristics of serotonin receptors in the rat brain. Monographs in neural sciences. vol 7. 1981-07-23. PMID:7231436. |
indeed, several observations strongly suggested that the high affinity binding site for 3h-5-ht did not correspond to the 5-ht receptor coupled to adenylate cyclase in synaptic membranes: 1) the apparent affinity of the 5-ht-sensitive adenylate cyclase for 5-ht was about 300 times lower (kd = 0.5 microm) than that of the specific 3h-5-ht binding site; 2)the ontogenic evolutions of 3h-5-ht binding and 5-ht-sensitive adenylate cyclase were not parallel, notably in the hippocampus; 3) they were differently affected by several drugs. |
1981-07-23 |
2023-08-12 |
rat |