| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G S Allen, C J Gross, L M Henderson, S N Cho. Cerebral arterial spasm. Part 4: in vitro effects of temperature, serotonin analogues, large nonphysiological concentrations of serotonin, and extracellular calcium and magnesium on serotonin-induced contractions of the canine basilar artery. Journal of neurosurgery. vol 44. issue 5. 1976-07-06. PMID:1262918. |
cumulative log-dose response curves for analogues of serotonin demonstrated a high degree of specificity for the serotonin receptor and large nonphysiological concentrations of serotonin caused relaxation of the contracted artery. |
1976-07-06 |
2023-08-11 |
Not clear |
| J P Evans, D G Grahame-Smith, A R Green, A F Tordof. Electroconvulsive shock increases the behavioural responses of rats to brain 5-hydroxytryptamine accumulation and central nervous system stimulant drugs. British journal of pharmacology. vol 56. issue 2. 1976-06-02. PMID:3248. |
4 the hyperactivity following administration of the 5-ht agonist 5-methoxy n,n-dimethyltryptamine was enhanced by repeated (10 day) ecs, suggesting altered post-synaptic responses to 5-ht receptor stimulation. |
1976-06-02 |
2023-08-11 |
rat |
| K Fuxe, L F Agnati, U Ungersted. The effect of mepiprazole on central monoamine neurons. Evidence for increased 5-hydroxytryptamine and dopamine receptor activity. European journal of pharmacology. vol 35. issue 1. 1976-06-02. PMID:943291. |
the extensor hindlimb reflex, which is dependent on 5-ht receptor activity, was only increased with higher doses (2.5-10 mg/kg), suggesting that the spinal 5-ht nerve terminals are less sensitive to the releasing action of pap. |
1976-06-02 |
2023-08-11 |
rat |
| A Seiger, L Olson, L O Farneb. Brain tissue transplanted to the anterior chamber of the eye. 4. Drug-modulated transmitter release in central monoamine nerve terminals lacking normal postsynaptic receptors. Cell and tissue research. vol 165. issue 2. 1976-04-10. PMID:174817. |
the 5-ht receptor stimulating agent ergocornine tended to reduce the stimulation-induced release of 3h-5-ht from central 5-ht fibers on the iris. |
1976-04-10 |
2023-08-11 |
rat |
| W B Mendelson, L S Jacobs, J D Reichman, E Othmer, P E Cryer, B Trivedi, W H Daughada. Suppression of sleep-related prolactin secretion and enhancement of sleep-related growth hormone secretion. The Journal of clinical investigation. vol 56. issue 3. 1975-12-04. PMID:1159082. |
it seems likely from these data that the role of serotonin in the control of prolactin secretion is relatively more important, since serotonin receptor blockade dramatically reduced sleep-related prolactin secretion. |
1975-12-04 |
2023-08-11 |
Not clear |
| R A O'Brien, M Boublik, S Specto. Immunopharmacological studies using 5-hydroxytryptamine antibody. The Journal of pharmacology and experimental therapeutics. vol 194. issue 1. 1975-10-30. PMID:1151746. |
the antibody was capable of effectively competing with 5-ht receptor sites for free molecules of 5-ht. |
1975-10-30 |
2023-08-11 |
Not clear |
| H Corrodi, L O Farnebo, K Fuxe, B Hamberge. Effect of ergot drugs on central 5-hydroxytryptamine neurons: evidence for 5-hydroxytryptamine release or 5-hydroxytryptamine receptor stimulation. European journal of pharmacology. vol 30. issue 2. 1975-07-28. PMID:1173234. |
it was found that ergocornine increased the 5-ht receptor activity independent of presynaptic 5-ht stores and that it didnot have any effects on uptake, retention and spontaneous overflow of 3-h-5-ht in vitro but reduced the fiedl stimulation-induced release of 3-h-5-ht in vitro. |
1975-07-28 |
2023-08-11 |
rat |
| H Corrodi, L O Farnebo, K Fuxe, B Hamberge. Effect of ergot drugs on central 5-hydroxytryptamine neurons: evidence for 5-hydroxytryptamine release or 5-hydroxytryptamine receptor stimulation. European journal of pharmacology. vol 30. issue 2. 1975-07-28. PMID:1173234. |
mpme, on the other hand, seems to increase 5-ht receptor release of 5-ht stores, mainly from extragranular sites. |
1975-07-28 |
2023-08-11 |
rat |
| H Corrodi, L O Farnebo, K Fuxe, B Hamberge. Effect of ergot drugs on central 5-hydroxytryptamine neurons: evidence for 5-hydroxytryptamine release or 5-hydroxytryptamine receptor stimulation. European journal of pharmacology. vol 30. issue 2. 1975-07-28. PMID:1173234. |
it is suggested that mpme is a releaser of extragranular 5-ht stores leading to increased 5-ht receptor activity and reduction of 5-ht turnover in the same way as indicated for ergocornine. |
1975-07-28 |
2023-08-11 |
rat |
| P B Bradley, I Brigg. Further studies on the mode of action of psychotomimetic drugs: antagonism of the excitatory actions of 5-hydroxytryptamine by methylated derivatives of tryptamine. British journal of pharmacology. vol 50. issue 3. 1974-11-08. PMID:4277490. |
it therefore seems that the 5-ht mimicking actions are unlikely to be due to release of 5-ht, but are due to direct actions on 5-ht receptors.6 the evidence presented supports the hypothesis that lsd-like psychotomimetics act by an antagonism of 5-ht in the lower brain stem, and is not compatible with the suggestion that the psychotomimetic action of these drugs is related to 5-ht receptor stimulation. |
1974-11-08 |
2023-08-11 |
rat |
| D A Coo. Blockade by phenoxybenzamine of the contractor response produced by agonists in the isolated ileum of the guinea-pig. British journal of pharmacology. vol 43. issue 1. 1972-03-30. PMID:4400182. |
in the case of the contraction induced by 5-ht, phenoxybenzamine probably interferes with the 5-ht receptor responsible for neuronal release of acetycholine. |
1972-03-30 |
2023-08-11 |
Not clear |