| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J H Jacoby, R F Thomas, J J Poulakos, A Siege. Studies on tryptophan accumulation in brain during methiothepin-induced enhancement of 5-hydroxyindole synthesis. Naunyn-Schmiedeberg's archives of pharmacology. vol 307. issue 2. 1979-11-29. PMID:481614. |
the elevation of brain tryptophan, 5-hydroxytryptophan and 5-hydroxyindoles (serotonin + 5-hydroxyindole acetic acid) that results from a tryptophan load is potentiated by prior administration of methiothepin, a serotonin receptor antagonist. |
1979-11-29 |
2023-08-11 |
rat |
| C L Williams, J S Rosenblatt, W G Hal. Inhibition of suckling in weaning-age rats: a possible serotonergic mechanism. Journal of comparative and physiological psychology. vol 93. issue 3. 1979-11-21. PMID:479391. |
it was found that (a) methysergide, a serotonin (5-ht) receptor blocker, reinstated suckling behavior in pups 15 days of age and older but had no effect on the suckling of 10-day old pups, (b) quipazine, a 5-ht receptor agonist, inhibited suckling of pups 10 days of age and older, (c) methysergide pretreatment blocked the quipazine inhibition of suckling, and (d) metergoline, another 5-ht blocker, also stimulated suckling, and fenfluramine, a 5-ht releaser, blocked suckling in deprived pups. |
1979-11-21 |
2023-08-11 |
rat |
| P Steigrad, I Tobler, P G Waser, A A Borbél. Effect of p-chlorophenylalanine on cerebral serotonin binding, serotonin concentration and motor activity in the rat. Naunyn-Schmiedeberg's archives of pharmacology. vol 305. issue 2. 1979-03-24. PMID:153478. |
it is concluded that the initial pcpa-induced decrease in kd was due to a reduced competition for binding sites by the endogenous 5-ht, whereas the increase of bmax after a prolonged 5-ht depletion may reflect a 5-ht receptor supersensitivity. |
1979-03-24 |
2023-08-11 |
rat |
| E Müller-Schweinitze. Studies on the 5-HT receptor in vascular smooth muscle. Research and clinical studies in headache. vol 6. 1979-02-23. PMID:725257. |
bc-105 was nearly equipotent in antagonizing responses to 5-ht, e and dhe suggesting that both ergot alkaloids act as noncompetitive dualists at the 5-ht receptor. |
1979-02-23 |
2023-08-11 |
cattle |
| J E Blundel. Is there a role for serotonin (5-hydroxytryptamine) in feeding? International journal of obesity. vol 1. issue 1. 1979-01-26. PMID:361584. |
in general, treatments and procedures believed to lead to an increased availability of 5-ht in the synaptic cleft or which directly activate 5-ht receptors reduce food consumption, while procedures which either directly or indirectly decrease 5-ht receptor activation bring about the opposite effect. |
1979-01-26 |
2023-08-11 |
Not clear |
| J F Deakin, A R Gree. The effects of putative 5-hydroxytryptamine antagonists on the behaviour produced by administration of tranylcypromine and L-tryptophan or tranylcypromine and L-DOPA to rats. British journal of pharmacology. vol 64. issue 2. 1979-01-26. PMID:708990. |
3 none of the putative 5-ht receptor antagonists affected brain 5-ht turnover as assessed by rate of accumulation of 5-ht following monoamine oxidase inhibition with tranylcypromine. |
1979-01-26 |
2023-08-11 |
rat |
| J F Deakin, A R Gree. The effects of putative 5-hydroxytryptamine antagonists on the behaviour produced by administration of tranylcypromine and L-tryptophan or tranylcypromine and L-DOPA to rats. British journal of pharmacology. vol 64. issue 2. 1979-01-26. PMID:708990. |
the behavioural response to the putative 5-ht receptor agonist, 5-methoxy n,n-dimethyltryptamine (2 mg/kg), was potentiated in these animals suggesting that 5-ht receptors become supersensitive on denervation, and that some components of the behavioural syndrome are mediated by spinal cord 5-ht receptors. |
1979-01-26 |
2023-08-11 |
rat |
| L Edvinsson, J E Hardeb. Demonstration of 5-hydroxytryptamine receptors through inhibition by methergoline in cat pial arteries in vitro. British journal of pharmacology. vol 64. issue 2. 1979-01-26. PMID:708997. |
1 in an attempt to characterize further the nature of the 5-hydroxytryptamine (5-ht)-induced contraction of intracranial vessels, cat's middle cerebral artery was exposed to this amine and the specific 5-ht receptor antagonist, methergoline, under standardized conditions in vitro. |
1979-01-26 |
2023-08-11 |
cat |
| G Jonsson, T Pollare, H Hallman, C Sach. Developmental plasticity of central serotonin neurons after 5,7-dihydroxytryptamine treatment. Annals of the New York Academy of Sciences. vol 305. 1978-12-27. PMID:280250. |
studies of the postsynaptic 5-ht receptor in vitro with [3h]-5-ht and [3h]lsd binding indicate that this receptor develops independently of presynaptic 5-ht nerve terminals. |
1978-12-27 |
2023-08-11 |
rat |
| M O Carruba, G Nisticò, G Gargiul. Effect of central nervous system-acting drugs after selective destruction by neurotoxins of 5-hydroxytryptamine fibers in the brain. Annals of the New York Academy of Sciences. vol 305. 1978-12-27. PMID:309299. |
since identical behavioral, electrocortical, and body temperature effects have been observed after 5-ht or 5,6-dht infusion into the third ventricle of fowl, it may be concluded that 5,6-dht behaves also as a central 5-ht receptor agonist. |
1978-12-27 |
2023-08-11 |
Not clear |
| R S Sloviter, E G Drust, J D Conno. Specificity of a rat behavioral model for serotonin receptor activation. The Journal of pharmacology and experimental therapeutics. vol 206. issue 2. 1978-10-27. PMID:682117. |
depletion of catecholamines by alpha-methyl-p-tyrosine, or depletion of 5-ht by either p-chlorophenylalanine or 5,7-dihydroxytryptamine, did not prevent the syndrome caused by 5-methoxy-n,n-dimethyltryptamine, a 5-ht receptor agonist. |
1978-10-27 |
2023-08-11 |
rat |
| J S Meyer, N S Buckholtz, W O Bogga. Serotonergic stimulation of pituitary-adrenal activity in the mouse. Neuroendocrinology. vol 26. issue 5. 1978-10-18. PMID:150549. |
corticosterone (cs) responses to 5-htp were uninfluenced by pretreatment with a tryptophan hydroxylase inhibitor, p-chlorophenylalanine (pcpa), but were significantly potentiated by a serotonin (5-ht) reuptake inhibitor (lilly 110140), attenuated by two 5-ht receptor blockers, cyproheptadine and methergoline, and almost completely abolished by 2 extracerebral aromatic l-amino acid decarboxylase inhibitors, mk 486 and a low dose of ro 4-4602. |
1978-10-18 |
2023-08-11 |
mouse |
| T O De Roij, J Frens, F Woutersen-Van-Nijnanten, M Vianen-Meijerin. Comparison of the thermoregulatory responses to intracerebroventricularly injected dopamine, noradrenaline and 5-hydroxytryptamine in the goat. European journal of pharmacology. vol 49. issue 4. 1978-09-25. PMID:668811. |
the thermoregulatory responses to dopamine (da), noradrenaline (na) and 5-hydroxytryptamine (5-ht), injected into the third cerebral ventricle of goats at 20 degrees c ambient temperature (ta) or during cold exposure, were compared before and after pretreatment with the da receptor blocker haloperidol or the 5-ht receptor blocker methysergide. |
1978-09-25 |
2023-08-11 |
Not clear |
| E Friedman, G A Lambert, E Buchweit. 2,5-Dimethoxy-4-methylamphetamine (DOM)- a central component of its cardiovascular effects in rats; involvement of serotonin. European journal of pharmacology. vol 49. issue 2. 1978-08-14. PMID:26578. |
tachyphylaxis may be the result of irreversible binding of dom to 5-ht receptors or to 5-ht receptor densensitization. |
1978-08-14 |
2023-08-11 |
rat |
| S Bourgoin, F Artaud, J Bockaert, F Héry, J Glowinski, M Hamo. Paradoxical decrease of brain 5-HT turnover by metergoline, a central 5-HT receptor blocker. Naunyn-Schmiedeberg's archives of pharmacology. vol 302. issue 3. 1978-08-14. PMID:662027. |
paradoxical decrease of brain 5-ht turnover by metergoline, a central 5-ht receptor blocker. |
1978-08-14 |
2023-08-11 |
rat |
| K Golembiowska-Nikitin, G Wiszniowska, J Marcha. The effect of serotonin receptor blocking agents--cyproheptadine and danitracen--on serotonin turnover in the rat brain. Polish journal of pharmacology and pharmacy. vol 29. issue 5. 1978-02-18. PMID:145590. |
the effect of serotonin receptor blocking agents--cyproheptadine and danitracen--on serotonin turnover in the rat brain. |
1978-02-18 |
2023-08-11 |
rat |
| H Y Meltzer, R G Fessler, M Simonovic, J Doherty, V S Fan. Lysergic acid diethylamide: evidence for stimulation of pituitary dopamine receptors. Psychopharmacology. vol 54. issue 1. 1977-11-30. PMID:143671. |
lsd was more potent than methysergide, a serotonin receptor blocker, in lowering plasma prl levels and more potent than apomorphine, a known direct acting dopamine agonist, in blocking the increase in plasma prl produced by quipazine, a 5-ht agonist. |
1977-11-30 |
2023-08-11 |
rat |
| J B Malick, E Doren, A Barnet. Quipazine-induced head-twitch in mice. Pharmacology, biochemistry, and behavior. vol 6. issue 3. 1977-06-22. PMID:140381. |
the present studies suggest that quipazine influences serotonin receptors in the brain to produce head-twitch by two mechanisms of action: (1) by direct serotonin receptor activation, and (2) indirectly by causing a release of endogenous serotonin. |
1977-06-22 |
2023-08-11 |
mouse |
| A R Gree. Repeated chlorpromazine administration increases a behavioural response of rats to 5-hydroxytryptamine receptor stimulation. British journal of pharmacology. vol 59. issue 2. 1977-04-15. PMID:264797. |
it is suggested therefore that the enhanced behavioural response to 5-ht receptor stimulation following repeated chlorpromazine administration may be because this drug blocks 5-ht receptors. |
1977-04-15 |
2023-08-11 |
rat |
| G F Oksenkry. [Effect of D-, M- and T-antagonists of serotonin on its absorption by human thrombocytes]. Biulleten' eksperimental'noi biologii i meditsiny. vol 82. issue 9. 1977-01-25. PMID:990460. |
it is supposed that "serotonin" centre of the membrane carrier participating in the process of transmembrane serotonin transport was not identical to any definite type of serotonin receptor. |
1977-01-25 |
2023-08-11 |
human |