| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L B Wallnau, G D Bordash, P Cors. The effects of tryptophan and manipulations of serotonergic receptors on tonic immobility in chickens. Pharmacology, biochemistry, and behavior. vol 14. issue 4. 1981-07-20. PMID:7195035. |
this effect was reversed by quipazine, a 5-ht receptor agonist, and p-chloroamphetamine, a 5-ht releaser. |
1981-07-20 |
2023-08-12 |
Not clear |
| D Wallis, H Nas. Relative activities of substances related to 5-hydroxytryptamine as depolarizing agents of superior cervical ganglion cells. European journal of pharmacology. vol 70. issue 3. 1981-07-20. PMID:7227456. |
the results suggest that: (1) the optimal requirements for activating ganglionic 5-ht receptors are a hydroxyl group at position 5 on the indole nucleus and a side-chain bearing an ethylamine amino group; (2) methyl substituents around the terminal nitrogen atom are well tolerated and a quaternary nitrogen may increase activity at the 5-ht receptor; and (3) substitution of a methyl group at carbon atom 2 of the indole nucleus reduces activity. |
1981-07-20 |
2023-08-12 |
rabbit |
| E S Vizi, L G Hársing, G Zsill. Evidence of the modulatory role of serotonin in acetylcholine release from striatal interneurons. Brain research. vol 212. issue 1. 1981-07-09. PMID:7225867. |
l-(m-chlorophenyl)-piperazine, a pure serotonin receptor stimulant and d-fenfluramine, a serotonin releaser significantly reduced the release of acetylcholine evoked by ouabain. |
1981-07-09 |
2023-08-12 |
rat |
| S O Ogren, S B Ross, H Hall, A C Holm, A L Reny. The pharmacology of zimelidine: a 5-HT selective reuptake inhibitor. Acta psychiatrica Scandinavica. Supplementum. vol 290. 1981-06-13. PMID:6452789. |
in contrast to amitriptyline (ami) and mianserin (mian), zim only in extremely high doses displayed a 5-ht receptor blocking action in vitro and failed to block 5-ht mediated behaviour. |
1981-06-13 |
2023-08-12 |
mouse |
| G R Van Loon, A Shum, M J Sol. Decreased brain serotonin turnover after short term (two-hour) adrenalectomy in rats: a comparison of four turnover methods. Endocrinology. vol 108. issue 4. 1981-05-21. PMID:6258905. |
the adrenalectomy-induced decreases in brain 5ht turnover were also prevented by the administration of the serotonin receptor antagonist, pizotifen. |
1981-05-21 |
2023-08-12 |
rat |
| G R Van Loon, A Shum, M J Sol. Decreased brain serotonin turnover after short term (two-hour) adrenalectomy in rats: a comparison of four turnover methods. Endocrinology. vol 108. issue 4. 1981-05-21. PMID:6258905. |
in addition, serotonin receptor blockade with pizotifen inhibited the effect of corticosterone to normalize the adrenalectomy-induced changes in both the plasma acth concentration and brain 5ht turnover. |
1981-05-21 |
2023-08-12 |
rat |
| S R White, D Biege. Central serotonin receptor sensitivity in rats with experimental allergic encephalomyelitis. Research communications in chemical pathology and pharmacology. vol 30. issue 2. 1981-02-26. PMID:6969416. |
similarly, in urethane-anesthetized eae rats, serotonergically-evoked automatic swallowing activity was unchanged as judged by the effects of serotonin receptor agonists, and a serotonin precursor, a reuptake blocker and an antagonist. |
1981-02-26 |
2023-08-12 |
rat |
| A Pletscher, A Laubsche. Blood platelets as models for neurons: uses and limitations. Journal of neural transmission. Supplementum. issue 16. 1981-01-16. PMID:6933224. |
platelets show similarities with 5-hydroxytryptaminergic neurons with respect to (1) uptake kinetics of 5-hydroxytryptamine (5-ht) at the plasma membrane, (2) inhibitory effects of tricyclic antidepressants and neuroleptics on 5-ht uptake, (3) granular storage of 5-ht and possibly catecholamines, (4) action of drugs interfering with granular and possibly extragranular amine storage and (5) reaction of the 5-ht receptor at the plasma membrane to 5-ht agonists and antagonists. |
1981-01-16 |
2023-08-12 |
Not clear |
| E Müller-Schweinitze. The mechanism of ergometrine-induced coronary arterial spasm: in vitro studies on canine arteries. Journal of cardiovascular pharmacology. vol 2. issue 5. 1980-11-25. PMID:6157956. |
the use of the antagonists phentolamine, indoramine, pimozide, pizotifen, and methysergide provided evidence that ergometrine and 5-ht induce contraction of coronary arteries by stimulating the same type of 5-ht receptor, which, however, seems to be different from the 5-ht receptor present in basilar arteries. |
1980-11-25 |
2023-08-12 |
Not clear |
| R W Fuller, H D Snoddy, J A Clemen. Elevation of serum prolactin acutely after administration of p-chloroamphetamine in rats. Endocrine research communications. vol 7. issue 2. 1980-11-25. PMID:6447591. |
the effect was antagonized by pretreatment with p-chlorophenylalanine, an inhibitor of serotonin synethesis, or by metergoline, a serotonin receptor antagonist. |
1980-11-25 |
2023-08-12 |
rat |
| J Koenig, M A Mayfield, R J Coppings, S M McCann, L Krulic. Role of central nervous system neurotransmitters in mediating the effects of morphine on growth hormone- and prolactin-secretion in the rat. Brain research. vol 197. issue 2. 1980-11-24. PMID:6105900. |
depletion of brain serotonin stores with p-chlorophenylalanine (300 mg/kg) or 5,7-dihydroxytryptamine or administration of serotonin receptor blocker, cyproheptadine (2.5 mg/kg), did not diminish the gh respnse to mor but it inhibited, or in the case of 5,7-dht treatment abolished the activation of prl secretion. |
1980-11-24 |
2023-08-12 |
rat |
| K Fuxe, S O Ogren, L F Agnati, K Andersson, H Hall, C Köhler, B Fredhol. Central monoamine synapses as sites of action for ergot drugs. Advances in biochemical psychopharmacology. vol 23. 1980-09-23. PMID:6104914. |
some ergot drugs also had affinity for 5-ht receptor binding sites, possibly reflecting a 5-ht agonistic action in some areas, as shown in behavioral studies. |
1980-09-23 |
2023-08-12 |
rat |
| R Samanin, T Mennini, A Ferraris, C Bendotti, F Borsin. Hyper- and hyposensitivity of central serotonin receptors:[3H]serotonin binding and functional studies in the rat. Brain research. vol 189. issue 2. 1980-07-12. PMID:7189434. |
the data show that central 5-ht receptor numbers and sensitivity may change after repeated treatments with drugs acting on brain serotonin. |
1980-07-12 |
2023-08-12 |
rat |
| E Chung Hwang, M H Van Woer. Comparative effects of substituted phenylethylamines on brain serotonergic mechanisms. The Journal of pharmacology and experimental therapeutics. vol 213. issue 2. 1980-06-27. PMID:6965983. |
a series of substituted phenylethylamines were examined for their relative potencies to 1) release and inhibit accumulation of labeled serotonin in brain synaptosomes, 2) compete with serotonin receptor binding and 3) induce the "serotonin syndrome" in mice. |
1980-06-27 |
2023-08-12 |
mouse |
| E Chung Hwang, M H Van Woer. Comparative effects of substituted phenylethylamines on brain serotonergic mechanisms. The Journal of pharmacology and experimental therapeutics. vol 213. issue 2. 1980-06-27. PMID:6965983. |
in general, the relative potencies of the phenylethylamine derivatives to produce the serotonin syndrome did not correlates well with their effects on synaptosomal uptake or release of serotonin or serotonin receptor binding. |
1980-06-27 |
2023-08-12 |
mouse |
| J R Fozard, A T Mobarok Ali, G Newgros. Blockade of serotonin receptors on autonomic neurones by (-)-cocaine and some related compounds. European journal of pharmacology. vol 59. issue 3-4. 1980-04-26. PMID:527645. |
selective blockade of 5-ht neuronal responses is a property shared by several structural analogues of (--)-cocaine and (+)-pseudococaine; nor-(--)-cocaine proved the most potent of these, being active at a concentration of 2 x 10(-8) m. these data indicate that (--)-cocaine and several of its derivatives inhibit 5-ht stimulation of both adrenergic and cholinergic autonomic neurones through competition with the agonist at serotonin receptor sties. |
1980-04-26 |
2023-08-11 |
rabbit |
| N Weiner, C Martin, W Wesemann, P Riedere. Effects of post-mortem storage on synaptic 5-HT binding and uptake in mammalian brain. Journal of neural transmission. vol 46. issue 3. 1980-04-17. PMID:528997. |
freezing at --80 degrees c of whole brain or of isolated membranes did not affect 5-ht receptor interaction.--the capacity of specific 5-ht binding to membranes isolated from human post-mortem brain was comparable to that found with synaptic membranes from rat brain. |
1980-04-17 |
2023-08-11 |
human |
| L Pawłowski, J Ruczyńska, E Wojtasi. An evidence for the central serotoninergic activity of viloxazine. Polish journal of pharmacology and pharmacy. vol 31. issue 4. 1980-03-17. PMID:523336. |
this effect of viloxazine was inhibited by serotonin receptor blockers, cyproheptadine, danitracen and metergoline, and by serotonin uptake blocking agents imipramine and clomipramine. |
1980-03-17 |
2023-08-11 |
rat |
| S O Ogren, K Fuxe, L F Agnati, J A Gustafsson, G Jonsson, A C Hol. Reevaluation of the indoleamine hypothesis of depression. Evidence for a reduction of functional activity of central 5-HT systems by antidepressant drugs. Journal of neural transmission. vol 46. issue 2. 1980-02-15. PMID:574536. |
a number of antidepressant drugs such as amitriptyline, nortriptyline, mianserine, doxepine, nomifensine and dibenzepine appear to possess marked 5-ht receptor blocking activity at some type of 5-ht receptors in brain. |
1980-02-15 |
2023-08-11 |
mouse |
| S O Ogren, K Fuxe, L F Agnati, J A Gustafsson, G Jonsson, A C Hol. Reevaluation of the indoleamine hypothesis of depression. Evidence for a reduction of functional activity of central 5-HT systems by antidepressant drugs. Journal of neural transmission. vol 46. issue 2. 1980-02-15. PMID:574536. |
new antidepressant drugs such as zimelidine, which specifically inhibit 5-ht reuptake and do not block 5-ht receptor sites, may after chronic treatment also reduce the functional activity of 5-ht systems by producing adaptive changes in postsynaptic 5-ht mechanisms. |
1980-02-15 |
2023-08-11 |
mouse |