| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| José-Ángel García-Pedraza, Mónica García, María-Luisa Martín, Asunción Morá. 5-HT1D receptor inhibits renal sympathetic neurotransmission by nitric oxide pathway in anesthetized rats. Vascular pharmacology. vol 72. 2016-05-19. PMID:26003124. |
bolus of agonists α-methyl-5-ht (5-ht2), 1-pbg (5-ht3), cisapride (5-ht4), as-19 (5-ht7), cgs-12066b (5-ht1b) or 8-oh-dpat (5-ht1a) (0.0125μg/kg each). |
2016-05-19 |
2023-08-13 |
rat |
| Saki Shimizu, Yuto Mizuguchi, Akira Sobue, Mai Fujiwara, Tomoki Morimoto, Yukihiro Ohn. Interaction between anti-Alzheimer and antipsychotic drugs in modulating extrapyramidal motor disorders in mice. Journal of pharmacological sciences. vol 127. issue 4. 2016-03-14. PMID:25850380. |
in addition, the bradykinesia potentiation by galantamine was significantly reduced by (±)-8-hydroxy-2-(di-n-propylamino)-tetralin (a 5-ht1a agonist), ritanserin (a 5-ht2 antagonist), and sb-258585 (a 5-ht6 antagonist). |
2016-03-14 |
2023-08-13 |
mouse |
| Małgorzata Zygmunt, Grażyna Chłoń-Rzepa, Jacek Sap. THE EFFECT OF SEROTONIN 5-HT1A, 5-HT2 RECEPTOR LIGANDS, KETOPROFEN AND THEIR COMBINATION IN MODELS OF INDUCED PAIN IN MICE. Acta poloniae pharmaceutica. vol 72. issue 3. 2016-01-11. PMID:26642666. |
the effect of serotonin 5-ht1a, 5-ht2 receptor ligands, ketoprofen and their combination in models of induced pain in mice. |
2016-01-11 |
2023-08-13 |
mouse |
| Fatima M Nathan, Satoshi Ogawa, Ishwar S Parha. Kisspeptin1 modulates odorant-evoked fear response via two serotonin receptor subtypes (5-HT1A and 5-HT2) in zebrafish. Journal of neurochemistry. vol 133. issue 6. 2015-09-02. PMID:25818845. |
blockade of the 5-ht1a receptor utilizing way 100635 (0.28 mg/kg) and the 5-ht1 and 5-ht2 receptor utilizing methysergide (92.79 mg/kg) produced increased as-evoked fear responses that were unable to be overcome even during the recovery period. |
2015-09-02 |
2023-08-13 |
zebrafish |
| Michelle R Lofwall, Paul A Nuzzo, Charles Campbell, Sharon L Wals. Aripiprazole effects on self-administration and pharmacodynamics of intravenous cocaine and cigarette smoking in humans. Experimental and clinical psychopharmacology. vol 22. issue 3. 2015-01-26. PMID:24467369. |
aripiprazole is a partial agonist at dopamine (d2) and serotonin (5-ht1a) receptors and 5-ht2 antagonist. |
2015-01-26 |
2023-08-12 |
human |
| Tamara Romón, Anna M Planas, Albert Adel. Blockade of MK-801-induced heat shock protein 72/73 in rat brain by antipsychotic and monoaminergic agents targeting D2, 5-HT1A, 5-HT2A and α1-adrenergic receptors. CNS & neurological disorders drug targets. vol 13. issue 1. 2014-10-08. PMID:24040788. |
in addition, antagonism at dopamine d2 (raclopride), 5-ht2 (m100907) and α1- adrenoceptors (prazosin) as well as agonism at 5-ht1a receptors (bay x 3702) also diminished the mk-801-induced number of cells labeled with hsp72/73. |
2014-10-08 |
2023-08-12 |
rat |
| Tamara Romón, Anna M Planas, Albert Adel. Blockade of MK-801-induced heat shock protein 72/73 in rat brain by antipsychotic and monoaminergic agents targeting D2, 5-HT1A, 5-HT2A and α1-adrenergic receptors. CNS & neurological disorders drug targets. vol 13. issue 1. 2014-10-08. PMID:24040788. |
the results suggest that the efficacy of atypical antipsychotic drugs in the clinic may result from a combined effect on 5-ht2, 5-ht1a and α1-adrenergic receptors added to the classical dopamine d2 receptor antagonism. |
2014-10-08 |
2023-08-12 |
rat |
| Tomohisa Mori, Naoki Uzawa, Haruyo Kazawa, Hirohiko Watanabe, Ayano Mochizuki, Masahiro Shibasaki, Kazumi Yoshizawa, Kimio Higashiyama, Tsutomu Suzuk. Differential substitution for the discriminative stimulus effects of 3,4-methylenedioxymethamphetamine and methylphenidate in rats. The Journal of pharmacology and experimental therapeutics. vol 350. issue 2. 2014-08-26. PMID:24917544. |
on the other hand, serotonin (5-ht) receptor agonists 5-ht1a and 5-ht2 fully substituted for the discriminative stimulus effects of mdma. |
2014-08-26 |
2023-08-13 |
rat |
| Naoki Hiramatsu, Yukio Ago, Shigeru Hasebe, Akira Nishimura, Kazuya Mori, Kazuhiro Takuma, Toshio Matsud. Synergistic effect of 5-HT1A and σ1 receptor activation on prefrontal dopaminergic transmission under circulating steroid deficiency. Neuropharmacology. vol 75. 2014-08-19. PMID:23851260. |
this enhancement of da release was blocked by way100635 (a 5-ht1a receptor antagonist), but not by ritanserin (a 5-ht2 receptor antagonist), azasetron (a 5-ht3 receptor antagonist) or sb269970 (a 5-ht7 receptor antagonist). |
2014-08-19 |
2023-08-12 |
mouse |
| Carla S Lima, Ana C Dutra-Tavares, Fernanda Nunes, André L Nunes-Freitas, Anderson Ribeiro-Carvalho, Cláudio C Filgueiras, Alex C Manhães, Armando Meyer, Yael Abreu-Villaç. Methamidophos exposure during the early postnatal period of mice: immediate and late-emergent effects on the cholinergic and serotonergic systems and behavior. Toxicological sciences : an official journal of the Society of Toxicology. vol 134. issue 1. 2014-01-28. PMID:23596261. |
at pn63, in the brainstem, there was a decrease in choline transporter, a female-only decrease in 5ht1a and a male-only increase in 5ht2 receptor binding. |
2014-01-28 |
2023-08-12 |
mouse |
| W J Xu, Y Zhao, F Q Huo, J Q Du, J S Tan. Involvement of ventrolateral orbital cortex 5-HT 1-7 receptors in 5-HT induced depression of spared nerve injury allodynia. Neuroscience. vol 238. 2013-10-17. PMID:23485814. |
microinjection of selective 5-ht1a, 5-ht2, 5-ht3, 5-ht4, 5-ht5a, 5-ht6 and 5-ht7 receptor antagonists, 1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl] piperazine hydrobromide (nan-190) (10μg), cyproheptadine (50ng), granisetron hydrochloride (granisetron) (10μg), 1-[2-[(methylsulfonyl)-amino]ethyl]-4-piperidinyl]methyl1-methyl-1h-indole-3-carboxylate (gr113808) (5μg), sb699551 dihydrochloride (sb699551) (10μg), sb258585 dihydrochloride (sb258585) (2μg) or sb269970 hydrochloride (sb269970) (10μg) into the vlo 5-min prior to 5-ht (10μg) injection, all antagonized the 5-ht-induced inhibition of allodynia. |
2013-10-17 |
2023-08-12 |
rat |
| Andrea E Corcoran, George B Richerson, Michael B Harri. Serotonergic mechanisms are necessary for central respiratory chemoresponsiveness in situ. Respiratory physiology & neurobiology. vol 186. issue 2. 2013-09-20. PMID:23454177. |
hypercapnic responses were also assessed during exposure to ketanserin (5-ht2 receptor antagonist), and 8-oh-dpat (inhibiting 5-ht neurons via 5-ht1a autoreceptors). |
2013-09-20 |
2023-08-12 |
rat |
| Jocelien D A Olivier, Christiaan H Vinkers, Berend Olivie. The role of the serotonergic and GABA system in translational approaches in drug discovery for anxiety disorders. Frontiers in pharmacology. vol 4. 2013-06-20. PMID:23781201. |
in this review, we illustrate the complex interplay between genes and environment in anxiety processes by reviewing preclinical and clinical studies on the serotonin transporter (5-htt), 5-ht1a receptor, 5-ht2 receptor, and gabaa receptor. |
2013-06-20 |
2023-08-12 |
human |
| Nagahisa Okamoto, Kota Sakamoto, Maki Yamad. Transient serotonin syndrome by concurrent use of electroconvulsive therapy and selective serotonin reuptake inhibitor: a case report and review of the literature. Case reports in psychiatry. vol 2012. 2012-12-06. PMID:23213590. |
the serotonin syndrome, which is characterized by psychiatric, autonomic nervous and neurological symptoms, is considered to be caused by excessive stimulation of the 5-ht1a and 5-ht2 receptors in the gray matter and spinal cord of the central nervous system, after the start of dosing or increase of the dose of a serotoninergic drug. |
2012-12-06 |
2023-08-12 |
Not clear |
| Bibiana M Gay, Marina Prigol, André L Stein, Cristina W Nogueir. Antidepressant-like pharmacological profile of 3-(4-fluorophenylselenyl)-2,5-diphenylselenophene: Involvement of serotonergic system. Neuropharmacology. vol 59. issue 3. 2010-10-14. PMID:20488195. |
in the fst was prevented by pretreatment of mice with pcpa (100 mg/kg, i.p., once a day for 4 consecutive days, an inhibitor of 5-ht synthesis), way 100635 (0.1 mg/kg, s.c., a selective 5-ht1a receptor antagonist), ritanserin (1 mg/kg, i.p., a 5-ht2 receptor antagonist) or ondansetron (1 mg/kg, i.p., a 5-ht3 receptor antagonist). |
2010-10-14 |
2023-08-12 |
mouse |
| Araceli Sánchez-López, David Centurión, Jair Lozano-Cuenca, Enriqueta Muñoz-Islas, Luis E Cobos-Puc, Carlos M Villaló. [Role of serotonin receptors in vascular tone in the pithed rat]. Archivos de cardiologia de Mexico. vol 79 Suppl 2. 2010-06-03. PMID:20361490. |
thus, 5-ht-induced sympatho-inhibition has been shown to be: (i) unaffected by physiological saline or by the selective antagonists ritanserin (5-ht2), mdl72222 (5-ht3) or tropisetron (5-ht3/4); (ii) blocked by methysergide, a non-selective 5-ht1/2 receptor antagonist; and (iii) potently mimicked by 5-carboxamidotryptamine (5-ct), a non-selective 5-ht1 receptor agonist, as well as by the selective agonists 8-oh-dpat (5-ht1a), indorenate (5-ht1a), cp93,129 (5-ht1b), and sumatriptan (5-ht1b/1d). |
2010-06-03 |
2023-08-12 |
rat |
| S Pasquier de Franclieu, C Germain, F Petitjea. [Aripiprazole induced Parkinsonism: A case report]. L'Encephale. vol 35. issue 5. 2010-02-01. PMID:19853725. |
it is a high-affinity partial agonist at the dopamine d2 and serotonin 5-ht1a receptors and an antagonist at serotonin 5-ht2 receptors. |
2010-02-01 |
2023-08-12 |
Not clear |
| Theodore A Slotkin, Nicola Wrench, Ian T Ryde, T Leon Lassiter, Edward D Levin, Frederic J Seidle. Neonatal parathion exposure disrupts serotonin and dopamine synaptic function in rat brain regions: modulation by a high-fat diet in adulthood. Neurotoxicology and teratology. vol 31. issue 6. 2010-01-07. PMID:19616088. |
in addition, we monitored 5ht1a and 5ht2 receptor binding and the concentration of 5ht presynaptic transporters. |
2010-01-07 |
2023-08-12 |
rat |
| G Troy Smith, Nicole Comb. Serotonergic activation of 5HT1A and 5HT2 receptors modulates sexually dimorphic communication signals in the weakly electric fish Apteronotus leptorhynchus. Hormones and behavior. vol 54. issue 1. 2008-11-18. PMID:18336816. |
serotonergic activation of 5ht1a and 5ht2 receptors modulates sexually dimorphic communication signals in the weakly electric fish apteronotus leptorhynchus. |
2008-11-18 |
2023-08-12 |
Not clear |
| T B Nucci, L G S Branco, L H Gargaglion. 5-HT1A, but not 5-HT2 and 5-HT7, receptors in the nucleus raphe magnus modulate hypoxia-induced hyperpnoea. Acta physiologica (Oxford, England). vol 193. issue 4. 2008-08-20. PMID:18363900. |
5-ht1a, but not 5-ht2 and 5-ht7, receptors in the nucleus raphe magnus modulate hypoxia-induced hyperpnoea. |
2008-08-20 |
2023-08-12 |
Not clear |