| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G J Blatt, C M Fitzgerald, J T Guptill, A B Booker, T L Kemper, M L Bauma. Density and distribution of hippocampal neurotransmitter receptors in autism: an autoradiographic study. Journal of autism and developmental disorders. vol 31. issue 6. 2002-07-16. PMID:11814263. |
in contrast, the density and distribution of the other six receptors studied (3[h]-80h-dpat labeled 5-ht1a receptors, 3[h]-ketanserin labeled 5-ht2 receptors, 3[h]-pirenzepine labled m1 receptors, 3[h]-hemicholinium labeled high affinity choline uptake sites, 3[h]-mk801 labeled nmda receptors, and 3[h]-kainate labeled kainate receptors) in the hippocampus did not demonstrate any statistically significant differences in binding. |
2002-07-16 |
2023-08-12 |
Not clear |
| L Pinilla, L C González, M Tena-Sempere, E Aguila. Interactions between serotoninergic and aminoacidergic pathways in the control of PRL secretion in prepubertal male rats. Journal of physiology and biochemistry. vol 57. issue 3. 2002-07-12. PMID:11800286. |
for this purpose, 16 and 23-day old male rats were treated with 5-hydroxytryptophan (5-htp, precursor of serotonin synthesis) plus fluoxetine (blocker of serotonin reuptake), 8-oh-dpat (agonist of 5-ht1a receptors), doi and alpha-me-5-ht (agonists of 5-ht2 receptors), 1-phenylbiguanide (agonist of 5-ht3 receptors) alone or in combination with ampa (agonist of ampa receptors). |
2002-07-12 |
2023-08-12 |
rat |
| L Pinilla, L C González, M Tena-Sempere, E Aguila. Interactions between serotoninergic and aminoacidergic pathways in the control of PRL secretion in prepubertal male rats. Journal of physiology and biochemistry. vol 57. issue 3. 2002-07-12. PMID:11800286. |
the results obtained indicate that: (a) activation of 5-ht1a receptors stimulated prl secretion on day 16 and inhibited it on day 23; activation of 5-ht2 receptors stimulated prl secretion on days 16 and 23, whereas activation of 5-ht3 receptors inhibited prl release only on day 23; (b) activation of ampa receptors inhibited prl secretion on day 23, but not on day 16 and (c) a cross-talk is apparent between 5-ht2 and ampa receptors in the regulation of prl secretion, the stimulatory effect of doi being blocked by ampa. |
2002-07-12 |
2023-08-12 |
rat |
| Shitij Kapur, Robert A McClelland, Susan C VanderSpek, Marie-Louise G Wadenberg, Glen Baker, Jose Nobrega, Robert B Zipursky, Philip Seema. Increasing D2 affinity results in the loss of clozapine's atypical antipsychotic action. Neuroreport. vol 13. issue 6. 2002-06-26. PMID:11997696. |
to identify the critical mechanisms involved we synthesized an 8-c1 isomer of clozapine which showed an equivalent affinity to clozapine on multiple receptors (5-ht1a, 5-ht2, d1, d4, m1) but differed in having a 10-fold higher affinity at the dopamine d2/3 receptor. |
2002-06-26 |
2023-08-12 |
Not clear |
| William C de Groa. Influence of central serotonergic mechanisms on lower urinary tract function. Urology. vol 59. issue 5 Suppl 1. 2002-05-29. PMID:12007520. |
although there is some evidence in the rat for serotonergic facilitation of voiding, most experiments in rats and cats indicate that activation of the central serotonergic system by 5-ht reuptake inhibitors, as well as by 5-ht1a and 5-ht2 receptor agonists, depresses reflex bladder contractions and increases the bladder volume threshold for inducing micturition. |
2002-05-29 |
2023-08-12 |
rat |
| M Bauer, A Heinz, P C Whybro. Thyroid hormones, serotonin and mood: of synergy and significance in the adult brain. Molecular psychiatry. vol 7. issue 2. 2002-05-14. PMID:11840307. |
thus it is postulated that one mechanism, among others, through which exogenous thyroid hormones may exert their modulatory effects in affective illness is via an increase in serotonergic neurotransmission, specifically by reducing the sensitivity of 5-ht1a autoreceptors in the raphe area, and by increasing 5-ht2 receptor sensitivity. |
2002-05-14 |
2023-08-12 |
Not clear |
| R M Craven, D G Grahame-Smith, N R Newberr. 5-HT1A and 5-HT2 receptors differentially regulate the excitability of 5-HT-containing neurones of the guinea pig dorsal raphe nucleus in vitro. Brain research. vol 899. issue 1-2. 2002-04-02. PMID:11311877. |
5-ht1a and 5-ht2 receptors differentially regulate the excitability of 5-ht-containing neurones of the guinea pig dorsal raphe nucleus in vitro. |
2002-04-02 |
2023-08-12 |
rat |
| C Belzung, A M Le Guisquet, S Barreau, F Calatayu. An investigation of the mechanisms responsible for acute fluoxetine-induced anxiogenic-like effects in mice. Behavioural pharmacology. vol 12. issue 3. 2002-01-25. PMID:11485052. |
the drugs used included the benzodiazepine diazepam, the 5-ht1a receptor partial agonist buspirone, the 5-ht1a receptor antagonists pindolol and way-100635, the non-selective 5-ht2 receptor antagonists methiothepin, mianserin and ritanserin, the non-selective dopamine (da) receptor antagonist haloperidol, the d1 antagonist sch23390, the selective d2 antagonist raclopride, the d2/3 agonist quinelorane, the cholecystokininb (cck(b)) receptor antagonist ly 288513, and the corticotropin-releasing factor1 (crf1) receptor antagonist cp-154,526. |
2002-01-25 |
2023-08-12 |
mouse |
| C Belzung, A M Le Guisquet, S Barreau, F Calatayu. An investigation of the mechanisms responsible for acute fluoxetine-induced anxiogenic-like effects in mice. Behavioural pharmacology. vol 12. issue 3. 2002-01-25. PMID:11485052. |
taken together, these results suggest that dopaminergic mechanisms may underlie, at least in part, the behavioral effects of fluoxetine in the free-exploration test, whereas 5-ht1a 5-ht2, cck(b) and crf1 receptors may not be involved primarily in these effects. |
2002-01-25 |
2023-08-12 |
mouse |
| P Olausson, P Akesson, J A Engel, B Söderpal. Effects of 5-HT1A and 5-HT2 receptor agonists on the behavioral and neurochemical consequences of repeated nicotine treatment. European journal of pharmacology. vol 420. issue 1. 2001-08-30. PMID:11412838. |
effects of 5-ht1a and 5-ht2 receptor agonists on the behavioral and neurochemical consequences of repeated nicotine treatment. |
2001-08-30 |
2023-08-12 |
rat |
| P Olausson, P Akesson, J A Engel, B Söderpal. Effects of 5-HT1A and 5-HT2 receptor agonists on the behavioral and neurochemical consequences of repeated nicotine treatment. European journal of pharmacology. vol 420. issue 1. 2001-08-30. PMID:11412838. |
taken together, these findings suggest that the 5-ht1a and the 5-ht2 receptor subtypes are differentially involved in the effects of repeated nicotine on locomotor sensitization, behavioral inhibition and mesolimbic dopamine neurochemistry. |
2001-08-30 |
2023-08-12 |
rat |
| P Blier, F V Abbot. Putative mechanisms of action of antidepressant drugs in affective and anxiety disorders and pain. Journal of psychiatry & neuroscience : JPN. vol 26. issue 1. 2001-03-15. PMID:11212592. |
in major depression, an increase in 5-ht1a transmission is thought to be a crucial determinant of the antidepressant response, whereas an enhancement of 5-ht2 transmission in the orbitofrontal cortex may mediate the therapeutic effect of 5-ht reuptake inhibitors in obsessive-compulsive disorder (ocd). |
2001-03-15 |
2023-08-12 |
Not clear |
| A Siddiqui, K Kotecha, A M Salicioni, V Kalia, J F Murray, C A Wilso. Serotonin inhibits luteinizing hormone release via 5-HT1A receptors in the zona incerta of ovariectomised, anaesthetised rats primed with steroids. Neuroendocrinology. vol 72. issue 5. 2001-01-25. PMID:11124584. |
this effect was mimicked by 2 microg/side 8-oh-dpat, a 5-ht1a agonist, but not by doi, a 5-ht2 agonist, bmy7378, a presynaptic 5-ht1a agonist or mcpp, a 2b & 2c agonist. |
2001-01-25 |
2023-08-12 |
rat |
| B Scatton, D J Sange. Pharmacological and molecular targets in the search for novel antipsychotics. Behavioural pharmacology. vol 11. issue 3-4. 2000-12-14. PMID:11103879. |
much of this effort is directed towards compounds which, in addition to blocking dopamine receptors, also act on other neurotransmitter receptors such as 5-ht2, 5-ht1a and alpha2-adrenergic receptors. |
2000-12-14 |
2023-08-12 |
Not clear |
| I D Hentall, P J Kurle, T R Whit. Correlations between serotonin level and single-cell firing in the rat's nucleus raphe magnus. Neuroscience. vol 95. issue 4. 2000-03-21. PMID:10682715. |
the released serotonin could contribute to the inhibition of off(m) cells and excitation of on(m) cells by noxious stimulation, since inhibitory 5-ht1a receptors and excitatory 5-ht2 receptors, respectively, have previously been shown to dominate their serotonergic responses. |
2000-03-21 |
2023-08-12 |
rat |
| M P Arolfo, B A McMille. Effects of amperozide and tiospirone, atypical antipsychotic 5-HT2 drugs, on food-reinforced behavior in rats. Physiology & behavior. vol 68. issue 1-2. 2000-01-31. PMID:10627067. |
tiospirone (tsp) is a 5-ht2 receptor antagonist with affinity for d2, 5-ht1a, and 5-ht7, and sigma receptors, which can decrease consumption of ethanol while increasing food intake. |
2000-01-31 |
2023-08-12 |
rat |
| T Yamaguchi, T Nagasawa, M Satoh, Y Kuraish. Itch-associated response induced by intradermal serotonin through 5-HT2 receptors in mice. Neuroscience research. vol 35. issue 2. 2000-01-21. PMID:10616911. |
scratching was also elicited by the 5-ht2 receptor agonist alpha-methylserotonin, but not by the 5-ht1a receptor agonist r(+)-8-hydroxy-n,n-dipropyl-2-aminotetralin nor the 5-ht3 receptor agonists 2-methylserotonin and 1-phenylbiganide. |
2000-01-21 |
2023-08-12 |
mouse |
| L J Dupont, J L Pype, C J Meade, P DeLeyn, G Deneffe, M G Demedts, G M Verlede. Epinastine (WAL 801CL) inhibits the electrical field stimulation-induced cholinergic contraction in guinea pig and human airways in vitro. The European respiratory journal. vol 14. issue 5. 2000-01-07. PMID:10596692. |
pretreatment with tropisetron (5-ht3/4 antagonist), ketanserin (5-ht2 antagonist), sdz216-525 (5-ht1a antagonist) or phentolamine (alpha-adrenergic antagonist) had no effect. |
2000-01-07 |
2023-08-12 |
human |
| A H Herremans, J A van der Heyden, M van Drimmelen, B Olivie. The 5-HT1A receptor agonist flesinoxan shares discriminative stimulus properties with some 5-HT2 receptor antagonists. Pharmacology, biochemistry, and behavior. vol 64. issue 2. 1999-12-20. PMID:10515319. |
the 5-ht2 receptor antagonist mianserin (ed50 = 4.8 mg/kg) fully substituted for flesinoxan, whereas ketanserin, ritanserin, mesulergine, and sb200646a substituted only partially, suggesting an interaction between 5-ht1a and 5-ht2 receptors. |
1999-12-20 |
2023-08-12 |
Not clear |
| J S Sprouse, L S Reynolds, J P Braselton, H Rollema, S H Zor. Comparison of the novel antipsychotic ziprasidone with clozapine and olanzapine: inhibition of dorsal raphe cell firing and the role of 5-HT1A receptor activation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 21. issue 5. 1999-11-15. PMID:10516958. |
ziprasidone is a novel antipsychotic agent which binds with high affinity to 5-ht1a receptors (ki = 3.4 nm), in addition to 5-ht1d, 5-ht2, and d2 sites. |
1999-11-15 |
2023-08-12 |
rat |