| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E J Homan, S Copinga, L Unelius, D M Jackson, H V Wikström, C J Gro. Synthesis and Pharmacology of the enantiomers of the potential atypical antipsychotic agents 5-OMe-BPAT and 5-OMe-(2,6-di-OMe)-BPAT. Bioorganic & medicinal chemistry. vol 7. issue 7. 1999-10-12. PMID:10465402. |
the optically pure enantiomers of the potential atypical antipsychotic agents 5-methoxy-2-[n-(2-benzamidoethyl)-n-n-propylamino]tetralin (5-ome-bpat, 5) and 5-methoxy-2-{n-[2-(2,6-dimethoxy)benzamidoethyl]-n-n-propylamino}t etralin [5-ome-(2,6-di-ome)-bpat, 6] were synthesized and evaluated for their in vitro binding affinities at alpha1-, alpha2-, and beta-adrenergic, muscarinic, dopamine d1, d2a, and d3, and serotonin 5-ht1a and 5-ht2 receptors. |
1999-10-12 |
2023-08-12 |
rat |
| E J Homan, S Copinga, L Unelius, D M Jackson, H V Wikström, C J Gro. Synthesis and Pharmacology of the enantiomers of the potential atypical antipsychotic agents 5-OMe-BPAT and 5-OMe-(2,6-di-OMe)-BPAT. Bioorganic & medicinal chemistry. vol 7. issue 7. 1999-10-12. PMID:10465402. |
(s)- and (r)-5 had high affinities for dopamine d2a, d3, and serotonin 5-ht1a receptors, moderate affinities for alpha1-adrenergic and serotonin 5-ht2 receptors, and no affinity (ki > 1000 nm) for the other receptor subtypes. |
1999-10-12 |
2023-08-12 |
rat |
| H H Berendsen, C L Broekkam. Antagonism of the 5-HT1A receptor stimulus in a conditioned taste aversion procedure. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 9. issue 4. 1999-09-03. PMID:10422896. |
the results suggest that the conditioned taste aversion induced by fluoxetine is not exclusively mediated by 5-ht1a receptors nor exclusively by 5-ht2 receptors. |
1999-09-03 |
2023-08-12 |
mouse |
| D G Rainni. Serotonergic modulation of neurotransmission in the rat basolateral amygdala. Journal of neurophysiology. vol 82. issue 1. 1999-08-10. PMID:10400936. |
the effect of 5-ht was mimicked by the 5-ht2 receptor agonist, alpha-methyl-5-hydroxytryptamine (alpha-methyl-5-ht), but not by the 5-ht1a receptor agonist, (+/-) 8-hydroxydipropylaminotetralin hydrobromide (8-oh-dpat), or the 5-ht1b agonist, cgs 12066a. |
1999-08-10 |
2023-08-12 |
rat |
| C Boast, A C Bartolomeo, H Morris, J A Moye. 5HT antagonists attenuate MK801-impaired radial arm maze performance in rats. Neurobiology of learning and memory. vol 71. issue 3. 1999-08-05. PMID:10196105. |
specifically, way-100635, a selective 5-ht1a receptor antagonist, buspirone, a 5-ht1a partial agonist, ritanserin, a 5-ht2 antagonist, and ondansetron, a 5-ht3 antagonist, were assessed. |
1999-08-05 |
2023-08-12 |
rat |
| A W Wilson, J C Neill, B Costal. An investigation into the effects of 5-HT agonists and receptor antagonists on ethanol self-administration in the rat. Alcohol (Fayetteville, N.Y.). vol 16. issue 3. 1999-05-24. PMID:9744857. |
these results demonstrate that, under the present experimental conditions, activation of central 5-ht1a, 5-ht1b, and 5-ht2 receptors reduced ethanol intake and reinforced behaviour in an operant paradigm. |
1999-05-24 |
2023-08-12 |
rat |
| W J McBride, T K L. Animal models of alcoholism: neurobiology of high alcohol-drinking behavior in rodents. Critical reviews in neurobiology. vol 12. issue 4. 1999-05-24. PMID:10348615. |
systemic administration of agents that (1) increase synaptic levels of serotonin (5-ht) or dopamine (da); (2) activate 5-ht1a, 5-ht2, d2, d3, or gaba(a) receptors; or (3) block opioid and 5-ht3 receptors decrease ethanol intake in most animal models. |
1999-05-24 |
2023-08-12 |
rat |
| J L Evende. The pharmacology of impulsive behaviour in rats IV: the effects of selective serotonergic agents on a paced fixed consecutive number schedule. Psychopharmacology. vol 140. issue 3. 1999-04-21. PMID:9877012. |
these results suggest that stimulation of 5-ht1a receptors reduces impulsivity, whereas stimulation of 5-ht2 receptors increases it. |
1999-04-21 |
2023-08-12 |
rat |
| J Watson, S Brough, M C Coldwell, T Gager, M Ho, A J Hunter, J Jerman, D N Middlemiss, G J Riley, A M Brow. Functional effects of the muscarinic receptor agonist, xanomeline, at 5-HT1 and 5-HT2 receptors. British journal of pharmacology. vol 125. issue 7. 1999-04-01. PMID:9884068. |
these studies indicate that xanomeline is a potent agonist at 5-ht1a and 5-ht1b receptors and an antagonist at 5-ht2 receptor subtypes. |
1999-04-01 |
2023-08-12 |
human |
| F G Graeff, C F Netto, H Zangross. The elevated T-maze as an experimental model of anxiety. Neuroscience and biobehavioral reviews. vol 23. issue 2. 1999-03-29. PMID:9884116. |
the anxiolytic agents diazepam (benzodiazepine), buspirone and ipsapirone (5-ht1a agonists) as well as ritanserin (5-ht2 antagonist) selectively impaired inhibitory avoidance while leaving one-way escape unchanged. |
1999-03-29 |
2023-08-12 |
rat |
| A Menese. Physiological, pathophysiological and therapeutic roles of 5-HT systems in learning and memory. Reviews in the neurosciences. vol 9. issue 4. 1999-03-23. PMID:9886142. |
for instance, when pre- vs post-training administration of 5-ht1a agonist, 5-ht2 antagonists and 5-ht4 agonists have been compared contrasting findings were reported in aversive and appetitive learning tasks. |
1999-03-23 |
2023-08-12 |
Not clear |
| A Menese. Physiological, pathophysiological and therapeutic roles of 5-HT systems in learning and memory. Reviews in the neurosciences. vol 9. issue 4. 1999-03-23. PMID:9886142. |
emerging evidence also indicates that 5-ht1a and 5-ht4 receptor agonists, as well as, 5-ht1a antagonists, 5-ht2 antagonists, 5-ht3 antagonists and 5-ht uptake inhibitors may have therapeutic utility in the treatment of alzheimer's disease and amnesia. |
1999-03-23 |
2023-08-12 |
Not clear |
| P Rogu. [Pharmacological approach to failures of antidepressant treatment]. L'Encephale. vol 24. issue 6. 1999-03-11. PMID:9949941. |
one original and most promising strategy for developing new antidepressants that are more efficient and better tolerated involves antagonizing both alpha 2-noradrenergic and 5ht2 and 5ht3 serotonergic receptors, without blocking 5ht1a serotonergic receptors. |
1999-03-11 |
2023-08-12 |
Not clear |
| K Krebs-Thomson, M A Geye. Evidence for a functional interaction between 5-HT1A and 5-HT2 receptors in rats. Psychopharmacology. vol 140. issue 1. 1999-02-25. PMID:9862404. |
evidence of a functional interaction between serotonin 5-ht1a and 5-ht2 receptor subtypes has been compromised by incomplete experimental designs and conflicting data. |
1999-02-25 |
2023-08-12 |
rat |
| J Yamada, Y Sugimoto, T Noma, T Yoshikaw. Effects of the non-selective 5-HT receptor agonist, 5-carboxamidotryptamine, on plasma glucose levels in rats. European journal of pharmacology. vol 359. issue 1. 1999-02-08. PMID:9831297. |
these results indicate that 5-ct-induced hyperglycemia is elicited by facilitation of adrenaline release from the adrenal gland and that 5-ct-induced hyperglycemia is mediated by the 5-ht7 receptor unrelated to 5-ht1a, 5-ht1b, 5-ht2, 5-ht3, 5-ht4 or 5-ht5 receptors. |
1999-02-08 |
2023-08-12 |
rat |
| P Rogu. [Pharmacological management of failure of treatment with antidepressants]. Presse medicale (Paris, France : 1983). vol 27. issue 40. 1999-02-01. PMID:9922801. |
one original and most promising strategy for developing new antidepressants that are more efficient and better tolerated involves antagonizing both alpha 2-noradrenergic and 5ht2 and 5ht3 serotonergic receptors, without blocking 5ht1a serotonergic receptors. |
1999-02-01 |
2023-08-12 |
Not clear |
| J Yamada, Y Sugimoto, T Yoshikaw. p-Chloroamphetamine, a serotonin-releasing drug, elicited in rats a hyperglycemia mediated by the 5-HT1A and 5-HT2B/2C receptors. European journal of pharmacology. vol 359. issue 2-3. 1999-01-21. PMID:9832390. |
p-chloroamphetamine-induced hyperglycemia was prevented by methysergide, which blocks the 5-ht1 and 5-ht2 receptor, the 5-ht1a/1b/2c receptor antagonist, (-)-propranolol, the selective 5-ht1a receptor antagonist, 4-(2'-methoxyphenyl-1-[2'-n-2"pyridinyl)-p-iodobenzamido]-ethyl-pi perazine (p-mppi), the 5-ht2a/2b/2c receptor antagonists, ritanserin and 4-isopropyl-7-methyl-9-(2-hydroxy-1-methyl-propoxycarbonyl)-4,6a,7 ,8,9,10,10a-octahydro-indolo[4,3-fg]quinolone maleate(ly 53857). |
1999-01-21 |
2023-08-12 |
rat |
| S Croul, A Radzievsky, A Sverstiuk, M Murra. NK1, NMDA, 5HT1a, and 5HT2 receptor binding sites in the rat lumbar spinal cord: modulation following sciatic nerve crush. Experimental neurology. vol 154. issue 1. 1999-01-19. PMID:9875269. |
nk1, nmda, 5ht1a, and 5ht2 receptor binding sites in the rat lumbar spinal cord: modulation following sciatic nerve crush. |
1999-01-19 |
2023-08-12 |
rat |
| S Croul, A Radzievsky, A Sverstiuk, M Murra. NK1, NMDA, 5HT1a, and 5HT2 receptor binding sites in the rat lumbar spinal cord: modulation following sciatic nerve crush. Experimental neurology. vol 154. issue 1. 1999-01-19. PMID:9875269. |
quantitative receptor binding autoradiography was used to study the nk1, nmda, 5ht1a, and 5ht2 receptor binding densities in the adult rat lumbar spinal cord from 3 days to 20 weeks following a unilateral crush lesion of the sciatic nerve. |
1999-01-19 |
2023-08-12 |
rat |
| G Vitale, L A Pini, A Ottani, M Sandrin. Effect of acetylsalicylic acid on formalin test and on serotonin system in the rat brain. General pharmacology. vol 31. issue 5. 1998-12-23. PMID:9809474. |
increased serotonin (5-ht) content in rat brain but did not modify the number or the affinity of 5-ht1a receptors in the pons and the cerebral cortex, whereas the number of cortical 5-ht2 receptors decreased significantly. |
1998-12-23 |
2023-08-12 |
rat |