| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L J Dupont, J L Pype, M G Demedts, P De Leyn, G Deneffe, G M Verlede. The effects of 8-hydroxy-2-(di-n-propylamino)tetralin on the cholinergic contraction in guinea pig and human airways in vitro. American journal of respiratory and critical care medicine. vol 158. issue 5 Pt 1. 1998-12-18. PMID:9817696. |
pretreatment with ketanserin (10 microm), a 5-ht2 antagonist, tropisetron (1 microm), a 5-ht3/4 antagonist, sdz 216-525 (1 to 10 microm) and pindobind (10 microm), both selective 5-ht1a antagonists, or capsaicin (10 microm), which depletes sensory nerves from neuropeptides, had no effect on the inhibition of the cholinergic contraction by 8-oh-dpat (10 to 30 microm). |
1998-12-18 |
2023-08-12 |
human |
| L L Hwang, N J Du. 5-Hydroxytryptamine responses in immature rat rostral ventrolateral medulla neurons in vitro. Journal of neurophysiology. vol 80. issue 3. 1998-12-03. PMID:9744919. |
the 5-ht1a antagonist pindobind-5-ht1a (pbd; 1-3 microm) and the 5-ht2/5-ht1 receptor antagonist spiperone (1-10 microm) suppressed 5-hth and the hyperpolarizing phase of biphasic responses; the 5-ht2 receptor antagonist ketanserin (3 microm) was without significant effect. |
1998-12-03 |
2023-08-12 |
rat |
| L L Hwang, N J Du. 5-Hydroxytryptamine responses in immature rat rostral ventrolateral medulla neurons in vitro. Journal of neurophysiology. vol 80. issue 3. 1998-12-03. PMID:9744919. |
the present study shows that, in the immature rat rvlm neurons, 5-ht causes a slow hyperpolarization and depolarization probably by interacting with 5-ht1a and 5-ht2 receptors, which are g-proteins coupled. |
1998-12-03 |
2023-08-12 |
rat |
| J S Silvestre, J M Palacios, A G Fernandez, M F O'Neil. Comparison of effects of a range of 5-HT receptor modulators on consumption and preference for a sweetened ethanol solution in rats. Journal of psychopharmacology (Oxford, England). vol 12. issue 2. 1998-11-06. PMID:9694030. |
these studies thus confirm the potential for decreasing ethanol consumption and ethanol preference of 5-ht1a agonists and 5-ht3 antagonists, but failed to find any selective effects for agents acting at 5-ht1b or 5-ht2 receptors. |
1998-11-06 |
2023-08-12 |
rat |
| b' S Ruotsalainen, E MacDonald, E Koivisto, R Stefanski, A Haapalinna, P Riekkinen, J Sirvi\\xc3\\xb. 5-HT1A receptor agonist (8-OH-DPAT) and 5-HT2 receptor agonist (DOI) disrupt the non-cognitive performance of rats in a working memory task. Journal of psychopharmacology (Oxford, England). vol 12. issue 2. 1998-11-06. PMID:9694031.' |
5-ht1a receptor agonist (8-oh-dpat) and 5-ht2 receptor agonist (doi) disrupt the non-cognitive performance of rats in a working memory task. |
1998-11-06 |
2023-08-12 |
rat |
| b' S Ruotsalainen, E MacDonald, E Koivisto, R Stefanski, A Haapalinna, P Riekkinen, J Sirvi\\xc3\\xb. 5-HT1A receptor agonist (8-OH-DPAT) and 5-HT2 receptor agonist (DOI) disrupt the non-cognitive performance of rats in a working memory task. Journal of psychopharmacology (Oxford, England). vol 12. issue 2. 1998-11-06. PMID:9694031.' |
the present study investigated the role of 5 -ht1a and 5 -ht2 receptors in the execution of a working memory task (delayed non-matching to position, dnmtp) by assessing the influence of 8-oh-dpat (5-ht1a receptor agonist) and doi (5-ht2 receptor agonist) on the performance of rats lesioned with 5,7-dihydroxytryptamine (5,7-dht) and their controls. |
1998-11-06 |
2023-08-12 |
rat |
| D J Bootle, J J Adcock, A G Ramag. The role of central 5-HT receptors in the bronchoconstriction evoked by inhaled capsaicin in anaesthetised guinea-pigs. Neuropharmacology. vol 37. issue 2. 1998-10-01. PMID:9680249. |
the effects of intracisternal (i.c) injections of the 5-ht1a receptor agonists, buspirone and 8-oh-dpat, and the antagonists way-100635; and (-)-pindolol, the 5-ht1b/1d receptor agonist sumatriptan and antagonist gr127935, the 5-ht2 receptor agonist doi and the antagonist cinanserin, the 5-ht3 receptor antagonist granisetron, the alpha-adrenoceptor agonist clonidine and the antagonist idazoxan, the d2 receptor antagonists (-)-sulpiride and the 5-ht uptake inhibitor fluoxetine on capsaicin-evoked increase in tracheal inflation pressure (bronchoconstriction) were investigated in alpha-chloralose anaesthetised, neuromuscularly blocked, artificially ventilated guinea-pigs. |
1998-10-01 |
2023-08-12 |
Not clear |
| F Navas, F L Tang, L T Schaller, M H Norma. Analogues of the potential antipsychotic agent 1192U90: amide modifications. Bioorganic & medicinal chemistry. vol 6. issue 6. 1998-09-29. PMID:9681147. |
analogues of 2-amino-n-(4-(4-(1,2-benzisothiazol-3-yl)-l-piperazinyl) -butyl)benzamide hydrochloride (1192u90) were prepared and evaluated in receptor binding assays for the dopamine d2, serotonin 5-ht1a, and serotonin 5-ht2 receptors. |
1998-09-29 |
2023-08-12 |
Not clear |
| H Schwörer, G Ramador. Autoreceptors can modulate 5-hydroxytryptamine release from porcine and human small intestine in vitro. Naunyn-Schmiedeberg's archives of pharmacology. vol 357. issue 5. 1998-09-28. PMID:9650808. |
the 5-ht1a receptor agonist (+)-8-hydroxy-dipropylaminotetralin (8-oh-dpat, 1 micromol/l) and the 5-ht2 receptor agonist alpha-methyl-5-ht (1 micromol/l) increased 5-ht release by 40% in about 60% of the human preparations. |
1998-09-28 |
2023-08-12 |
human |
| M Zivin, L Sprah, D Ske. Antiparkinsonian potential of interaction of LEK-8829 with bromocriptine. European journal of pharmacology. vol 349. issue 2-3. 1998-09-23. PMID:9671092. |
the ergoline derivative, lek-8829 (9,10-didehydro-n-methyl-(2-propynyl)-6-methyl-8-aminomethylerg oline), has been proposed as a potential atypical antipsychotic drug with antagonistic actions at dopamine d2 and serotonin 5-ht2 and 5-ht1a receptors (krisch et al., 1994, 1996). |
1998-09-23 |
2023-08-12 |
rat |
| M Balcells-Olivero, M S Cousins, L S Seide. Holtzman and Harlan Sprague-Dawley rats: differences in DRL 72-sec performance and 8-hydroxy-di-propylamino tetralin-induced hypothermia. The Journal of pharmacology and experimental therapeutics. vol 286. issue 2. 1998-09-02. PMID:9694929. |
a dose-response determination for the tricyclic antidepressants, imipramine and desipramine, the selective serotonin (5-hydroxytryptamine; 5-ht) reuptake inhibitor, fluoxetine, the 5-ht2 receptor antagonist, ketanserin, the 5-ht1a receptor agonist, (+/-)8-hydroxy-di-propylamino tetralin (8-oh-dpat) and the dopamine releasing compound, amphetamine, were assessed in both rat stocks. |
1998-09-02 |
2023-08-12 |
rat |
| E J Pappert, C G Goetz, G T Stebbins, M Belden, P M Carve. 5-Hydroxytryptophan-induced myoclonus in guinea pigs: mediation through 5-HT1/2 receptor subtypes. European journal of pharmacology. vol 347. issue 1. 1998-09-01. PMID:9650847. |
guinea pigs were pre-treated with carbidopa (50 mg) followed by one of eight 5-ht antagonists: (-)-n-tert-butyl-3-[4-(2-methoxyphenyl) piperazin-1-yl]-2-phenyl propionamide ((-)-way 100135) (5-ht1a), n-[2-[4-(2-methoxyphenyl)-1-piperazinyl]-ethyl]-n-(2-pyridyl)-cy clohexancarboxamide (way 100635) (5-ht1a), methiothepin mesylate (5-ht1/2), mesulergine hydrochloride (5-ht2a/2c), n[4-methoxy-3-(4-methyl-l-piperazinyl)phenyl]-2'-methyl-4'-(5-methyl-1,2 ,4-oxadizol-3-yl) (gr 127935) (5-ht1d), trans-4-[(3z)3-(2-dimethylaminoethyl)oxyimino-3(2-fluorop hen yl) propen-1-yl]phenol, hemifumarate (sr 46349) (5-ht2), ondansetron hydrochloride (5-ht3), and [1-[2-[methylsulphonyl)amino]ethyl]-4-piperidinyl]methyl-5-fluoro-2-meth oxy-1h-indole-3-carboxylate (gr 125487) (5-ht4). |
1998-09-01 |
2023-08-12 |
Not clear |
| M Santiago, E R Matarredona, A Machado, J Can. Influence of serotoninergic drugs on in vivo dopamine extracellular output in rat striatum. Journal of neuroscience research. vol 52. issue 5. 1998-08-21. PMID:9632315. |
the following serotoninergic drugs were perfused in the absence or presence of nomifensine (5 microm) or tetrodotoxin (ttx; 2 microm): clomipramine (10, 500 and 1,000 microm), a selective 5-ht reuptake inhibitor; 8-oh-dpat (50 and 500 microm), a 5-ht1a receptor agonist; and alpha-methyl-5-ht (1, 5 and 50 microm), a 5-ht2 receptor agonist. |
1998-08-21 |
2023-08-12 |
rat |
| M T Hsieh, C R Wu, C C Hsie. Ameliorating effect of p-hydroxybenzyl alcohol on cycloheximide-induced impairment of passive avoidance response in rats: interactions with compounds acting at 5-HT1A and 5-HT2 receptors. Pharmacology, biochemistry, and behavior. vol 60. issue 2. 1998-08-17. PMID:9632215. |
ameliorating effect of p-hydroxybenzyl alcohol on cycloheximide-induced impairment of passive avoidance response in rats: interactions with compounds acting at 5-ht1a and 5-ht2 receptors. |
1998-08-17 |
2023-08-12 |
rat |
| M T Hsieh, C R Wu, C C Hsie. Ameliorating effect of p-hydroxybenzyl alcohol on cycloheximide-induced impairment of passive avoidance response in rats: interactions with compounds acting at 5-HT1A and 5-HT2 receptors. Pharmacology, biochemistry, and behavior. vol 60. issue 2. 1998-08-17. PMID:9632215. |
furthermore, the counteractive effect was also inhibited by the 5-ht1a receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) and the 5-ht2 receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2 aminopropane [(+/-)-doi], but potentiated by the 5-ht1 receptor antagonist (+/-)-pindolol and the 5-ht2 receptor antagonist ritanserin. |
1998-08-17 |
2023-08-12 |
rat |
| M T Hsieh, C R Wu, C C Hsie. Ameliorating effect of p-hydroxybenzyl alcohol on cycloheximide-induced impairment of passive avoidance response in rats: interactions with compounds acting at 5-HT1A and 5-HT2 receptors. Pharmacology, biochemistry, and behavior. vol 60. issue 2. 1998-08-17. PMID:9632215. |
there results suggest that the beneficial effect of hba on cxm-induced impairment is amplified by treatment with serotonergic receptor antagonists but reduced by serotonergic 5-ht1a and 5-ht2 receptor agonists, and insensitive to cholinergic manipulations. |
1998-08-17 |
2023-08-12 |
rat |
| M T Lin, H J Tsay, W H Su, F Y Chue. Changes in extracellular serotonin in rat hypothalamus affect thermoregulatory function. The American journal of physiology. vol 274. issue 5. 1998-06-24. PMID:9644038. |
the results indicate that elevating the 5-ht levels in the hypothalamus activates postsynaptic 5-ht2 receptors and results in hyperthermic effects, whereas stimulation of presynaptic 5-ht1a receptors in the hypothalamus reduces the endogenous 5-ht release and results in hypothermic effects. |
1998-06-24 |
2023-08-12 |
rat |
| R H Alper, D L Nelso. Characterization of 5-HT1A receptor-mediated [35S]GTPgammaS binding in rat hippocampal membranes. European journal of pharmacology. vol 343. issue 2-3. 1998-06-09. PMID:9570480. |
neither the 5-ht2 receptor agonist [(+/-)1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane hcl] (doi) nor the 5-ht1a receptor antagonists way 100,635 (n-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-n-(2-pyridinyl) cyclohexanecarboxamide trihydrochloride) and spiperone altered basal gtpgammas binding. |
1998-06-09 |
2023-08-12 |
rat |
| A Szabó, B L Butz, R H Alpe. Further characterization of forebrain serotonin receptors mediating tachycardia in conscious rats. Brain research bulletin. vol 45. issue 6. 1998-06-08. PMID:9566502. |
the present studies were designed to characterize: (1) the requirement of the 5-ht1a receptor agonist r(+)-8-hydroxy-2-(di-n-propylamino) tetralin [r(+)8-oh-dpat]-induced tachycardia on the integrity of serotonergic innervation of the preoptic area, (2) the ability of the 5-ht1a receptor partial agonist buspirone to elicit cardiovascular responses when microinjected into the preoptic area, (3) the role of 5-ht2 and 5-ht3 receptors in the preoptic area in cardiovascular regulation, and (4) the site specificity of the tachycardia produced by r(+)8-oh-dpat. |
1998-06-08 |
2023-08-12 |
rat |
| A Szabó, B L Butz, R H Alpe. Further characterization of forebrain serotonin receptors mediating tachycardia in conscious rats. Brain research bulletin. vol 45. issue 6. 1998-06-08. PMID:9566502. |
the data suggest that activation of 5-ht1a receptors, but not 5-ht2 or 5-ht3 receptors, within or very near the preoptic area increases blood pressure and heart rate in conscious rats. |
1998-06-08 |
2023-08-12 |
rat |