| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K A Cunningham, J M Lakosk. The interaction of cocaine with serotonin dorsal raphe neurons. Single-unit extracellular recording studies. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 3. issue 1. 1990-04-05. PMID:2137698. |
cocaine potently inhibits the spontaneous activity of dorsal raphe serotonin (5-hydroxytryptamine [5-ht] neurons which possess impulse-modulating receptors of the 5-ht1a subtype. |
1990-04-05 |
2023-08-11 |
rat |
| P H Hutson, G S Sarna, M T O'Connell, G Curzo. Hippocampal 5-HT synthesis and release in vivo is decreased by infusion of 8-OHDPAT into the nucleus raphe dorsalis. Neuroscience letters. vol 100. issue 1-3. 1989-09-15. PMID:2474776. |
infusion of the serotonin-1a (5-ht1a) agonist, 8-hydroxy-2-di(n-propylamino)tetralin (8-ohdpat) (0.5, 1.0 and 2.0 micrograms) into the dorsal raphe, decreased extracellular 5-ht as measured by dialysis in the ventral hippocampus and also decreased 5-ht synthesis in both the hippocampus and the rest of the brain as measured by 5-hydroxytryptophan (5-htp) accumulation following decarboxylase inhibition by nsd 1015. |
1989-09-15 |
2023-08-11 |
Not clear |
| V Hillegaart, S Hjort. Median raphe, but not dorsal raphe, application of the 5-HT1A agonist 8-OH-DPAT stimulates rat motor activity. European journal of pharmacology. vol 160. issue 2. 1989-09-15. PMID:2527161. |
median raphe, but not dorsal raphe, application of the 5-ht1a agonist 8-oh-dpat stimulates rat motor activity. |
1989-09-15 |
2023-08-11 |
rat |
| T Sharp, S R Bramwell, D Clark, D G Grahame-Smit. In vivo measurement of extracellular 5-hydroxytryptamine in hippocampus of the anaesthetized rat using microdialysis: changes in relation to 5-hydroxytryptaminergic neuronal activity. Journal of neurochemistry. vol 53. issue 1. 1989-07-13. PMID:2470860. |
injection of the 5-ht1a agonist 8-hydroxy-2-(di-n-propylamino)tetralin (0.5 and 2.5 micrograms) into the dorsal raphe nucleus caused a dose-related fall in hippocampal output of 5-ht compared to saline-injected controls. |
1989-07-13 |
2023-08-11 |
rat |
| P Blier, S Steinberg, Y Chaput, C de Montign. Electrophysiological assessment of putative antagonists of 5-hydroxytryptamine receptors: a single-cell study in the rat dorsal raphe nucleus. Canadian journal of physiology and pharmacology. vol 67. issue 2. 1989-06-09. PMID:2523754. |
the intravenous administration of low doses of lysergic acid diethylamide (lsd) or of the selective 5-hydroxytryptamine1a (5-ht1a) receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) depresses the firing activity of dorsal raphe 5-ht-containing neurons, presumably via the activation of 5-ht1a receptors. |
1989-06-09 |
2023-08-11 |
rat |
| P Blier, C de Montign. Modification of 5-HT neuron properties by sustained administration of the 5-HT1A agonist gepirone: electrophysiological studies in the rat brain. Synapse (New York, N.Y.). vol 1. issue 5. 1989-02-23. PMID:2905533. |
the sustained administration of the 5-ht1a agonist gepirone (15 mg/kg/day, s.c.) in the rat produced an initial decrease of the firing activity of dorsal raphe 5-ht neurons which was followed by a progressive recovery to normal after 14 days of treatment. |
1989-02-23 |
2023-08-11 |
rat |
| J S Sprouse, G K Aghajania. Electrophysiological responses of serotoninergic dorsal raphe neurons to 5-HT1A and 5-HT1B agonists. Synapse (New York, N.Y.). vol 1. issue 1. 1989-02-21. PMID:3505364. |
electrophysiological responses of serotoninergic dorsal raphe neurons to 5-ht1a and 5-ht1b agonists. |
1989-02-21 |
2023-08-11 |
rat |
| J S Sprouse, G K Aghajania. Electrophysiological responses of serotoninergic dorsal raphe neurons to 5-HT1A and 5-HT1B agonists. Synapse (New York, N.Y.). vol 1. issue 1. 1989-02-21. PMID:3505364. |
a direct comparison was made of the effects of serotonin 5-ht1a and 5-ht1b selective compounds on the spontaneous firing rate of dorsal raphe serotoninergic neurons in chloral-hydrate-anesthetized rats. |
1989-02-21 |
2023-08-11 |
rat |
| J S Sprouse, G K Aghajania. Electrophysiological responses of serotoninergic dorsal raphe neurons to 5-HT1A and 5-HT1B agonists. Synapse (New York, N.Y.). vol 1. issue 1. 1989-02-21. PMID:3505364. |
in intracellular studies, ipsapirone and ly 165163, when added to the media bathing brain slices, mimicked the actions of 5-ht in hyperpolarizing dorsal raphe cell membranes and decreasing input resistance; however, the maximal effects of the 5-ht1a compounds on these membrane properties exceeded those of 5-ht. |
1989-02-21 |
2023-08-11 |
rat |
| J S Sprouse, G K Aghajania. Electrophysiological responses of serotoninergic dorsal raphe neurons to 5-HT1A and 5-HT1B agonists. Synapse (New York, N.Y.). vol 1. issue 1. 1989-02-21. PMID:3505364. |
in summary, dorsal raphe 5-ht neurons appear highly responsive to 5-ht1a, but not to 5-ht1b compounds; these findings are discussed with regard to the 5-ht receptor subtypes as candidates for the somatodendritic autoreceptor of dorsal raphe neurons. |
1989-02-21 |
2023-08-11 |
rat |
| J S Sprouse, G K Aghajania. Responses of hippocampal pyramidal cells to putative serotonin 5-HT1A and 5-HT1B agonists: a comparative study with dorsal raphe neurons. Neuropharmacology. vol 27. issue 7. 1988-10-24. PMID:2901680. |
responses of hippocampal pyramidal cells to putative serotonin 5-ht1a and 5-ht1b agonists: a comparative study with dorsal raphe neurons. |
1988-10-24 |
2023-08-11 |
rat |
| J S Sprouse, G K Aghajania. Responses of hippocampal pyramidal cells to putative serotonin 5-HT1A and 5-HT1B agonists: a comparative study with dorsal raphe neurons. Neuropharmacology. vol 27. issue 7. 1988-10-24. PMID:2901680. |
in summary, the inability of ca1 pyramidal cells to distinguish the actions of 5-ht1a and 5-ht1b ligands is in sharp contrast to the striking differences observed for these compounds with dorsal raphe neurons. |
1988-10-24 |
2023-08-11 |
rat |
| J S Sprouse, G K Aghajania. Responses of hippocampal pyramidal cells to putative serotonin 5-HT1A and 5-HT1B agonists: a comparative study with dorsal raphe neurons. Neuropharmacology. vol 27. issue 7. 1988-10-24. PMID:2901680. |
consistent with these findings is the idea that 5-ht1a compounds are full agonists on dorsal raphe neurons but only partial agonists on pyramidal cells. |
1988-10-24 |
2023-08-11 |
rat |
| J T Lum, M F Pierce. Electrophysiological evidence that spiperone is an antagonist of 5-HT1A receptors in the dorsal raphe nucleus. European journal of pharmacology. vol 149. issue 1-2. 1988-08-31. PMID:2969339. |
electrophysiological evidence that spiperone is an antagonist of 5-ht1a receptors in the dorsal raphe nucleus. |
1988-08-31 |
2023-08-11 |
Not clear |
| J T Lum, M F Pierce. Electrophysiological evidence that spiperone is an antagonist of 5-HT1A receptors in the dorsal raphe nucleus. European journal of pharmacology. vol 149. issue 1-2. 1988-08-31. PMID:2969339. |
the neuroleptic spiperone, which binds to 5-ht1a, 5-ht2 and dopamine (da) receptors, was studied for its effects on serotonin (5-ht) and da neurons in dorsal raphe nucleus and substantia nigra pars compacta, respectively. |
1988-08-31 |
2023-08-11 |
Not clear |
| J T Lum, M F Pierce. Electrophysiological evidence that spiperone is an antagonist of 5-HT1A receptors in the dorsal raphe nucleus. European journal of pharmacology. vol 149. issue 1-2. 1988-08-31. PMID:2969339. |
spiperone, but not ly53837 (a 5-ht2 antagonist), antagonized the inhibition induced by 5-ht1a agonists 8-hydroxy-dipropylaminotetralin (8-oh-dpat) and buspirone in the dorsal raphe nucleus. |
1988-08-31 |
2023-08-11 |
Not clear |
| J T Lum, M F Pierce. Electrophysiological evidence that spiperone is an antagonist of 5-HT1A receptors in the dorsal raphe nucleus. European journal of pharmacology. vol 149. issue 1-2. 1988-08-31. PMID:2969339. |
it is concluded that spiperone is an antagonist of 5-ht1a receptors in the dorsal raphe nucleus. |
1988-08-31 |
2023-08-11 |
Not clear |
| D Vergé, G Daval, M Marcinkiewicz, A Patey, S el Mestikawy, H Gozlan, M Hamo. Quantitative autoradiography of multiple 5-HT1 receptor subtypes in the brain of control or 5,7-dihydroxytryptamine-treated rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 6. issue 12. 1987-02-10. PMID:2947981. |
the selective degeneration of serotoninergic neurons produced by an intracerebral injection of 5,7-dihydroxytryptamine was associated only with a significant loss of 5-ht1a binding to the dorsal raphe nucleus (-60%) and of 5-ht1b binding to the substantia nigra (-37%). |
1987-02-10 |
2023-08-11 |
rat |
| J S Sprouse, G K Aghajania. (-)-Propranolol blocks the inhibition of serotonergic dorsal raphe cell firing by 5-HT1A selective agonists. European journal of pharmacology. vol 128. issue 3. 1987-01-27. PMID:2878817. |
(-)-propranolol blocks the inhibition of serotonergic dorsal raphe cell firing by 5-ht1a selective agonists. |
1987-01-27 |
2023-08-11 |
Not clear |
| J S Sprouse, G K Aghajania. (-)-Propranolol blocks the inhibition of serotonergic dorsal raphe cell firing by 5-HT1A selective agonists. European journal of pharmacology. vol 128. issue 3. 1987-01-27. PMID:2878817. |
however, (-)-propranolol was a relatively weak antagonist of 5-ht itself, suggesting that the endogenous neurotransmitter may have actions on dorsal raphe neurons in addition to those mediated by 5-ht1a receptors. |
1987-01-27 |
2023-08-11 |
Not clear |