| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Jolas, S Haj-Dahmane, E J Kidd, X Langlois, L Lanfumey, C M Fattaccini, V Vantalon, A M Laporte, J Adrien, H Gozla. Central pre- and postsynaptic 5-HT1A receptors in rats treated chronically with a novel antidepressant, cericlamine. The Journal of pharmacology and experimental therapeutics. vol 268. issue 3. 1994-04-25. PMID:8138956. |
in contrast, in vitro and in vivo electrophysiological recordings of serotoninergic neurons in the dorsal raphe nucleus revealed a clearcut functional desensitization of somatodendritic 5-ht1a autoreceptors. |
1994-04-25 |
2023-08-12 |
rat |
| T Jolas, S Haj-Dahmane, E J Kidd, X Langlois, L Lanfumey, C M Fattaccini, V Vantalon, A M Laporte, J Adrien, H Gozla. Central pre- and postsynaptic 5-HT1A receptors in rats treated chronically with a novel antidepressant, cericlamine. The Journal of pharmacology and experimental therapeutics. vol 268. issue 3. 1994-04-25. PMID:8138956. |
these data support the idea that postsynaptic (in the hippocampus) and somatodendritic (in the dorsal raphe nucleus) 5-ht1a receptors are differently regulated in the rat brain, because only the latter receptors desensitized after a long-term blockade of serotonin reuptake by cericlamine. |
1994-04-25 |
2023-08-12 |
rat |
| M C Boadle-Biber, V B Singh, K C Corley, T H Phan, R P Dilt. Evidence that corticotropin-releasing factor within the extended amygdala mediates the activation of tryptophan hydroxylase produced by sound stress in the rat. Brain research. vol 628. issue 1-2. 1994-03-23. PMID:7508808. |
additionally, the 5-ht1a agonist, gepirone, given either systemically (10 mg/kg) or intracerebrally into the region of the dorsal raphe (14 micrograms), blocked the tryptophan hydroxylase response to crf. |
1994-03-23 |
2023-08-12 |
rat |
| M J Millan, H Canton, A Gobert, F Lejeune, J M Rivet, K Bervoets, M Brocco, P Widdowson, T Mennini, V Audino. Novel benzodioxopiperazines acting as antagonists at postsynaptic 5-HT1A receptors and as agonists at 5-HT1A autoreceptors: a comparative pharmacological characterization with proposed 5-HT1A antagonists. The Journal of pharmacology and experimental therapeutics. vol 268. issue 1. 1994-03-10. PMID:8301575. |
at 5-ht1a autoreceptors, s 14489, s 15535 and s 15931 acted as agonists in inhibiting striatal 5-hydroxytryptophan accumulation (0.16-2.5 mg/kg, s.c.) and in abolishing the electrical activity of the dorsal raphe nucleus (0.005-0.100 mg/kg, i.v.). |
1994-03-10 |
2023-08-12 |
Not clear |
| R Schreiber, J De Vr. Neuronal circuits involved in the anxiolytic effects of the 5-HT1A receptor agonists 8-OH-DPAT ipsapirone and buspirone in the rat. European journal of pharmacology. vol 249. issue 3. 1994-02-24. PMID:7904566. |
in rats, the 5-ht1a receptor full agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) and the 5-ht1a receptor partial agonists ipsapirone and buspirone dose dependently and completely inhibited shock-induced ultrasonic vocalization after systemic injection and after microinjection into the dorsal raphe nucleus, a brain region rich in somatodendritic 5-ht1a receptors. |
1994-02-24 |
2023-08-12 |
rat |
| R Schreiber, J De Vr. Neuronal circuits involved in the anxiolytic effects of the 5-HT1A receptor agonists 8-OH-DPAT ipsapirone and buspirone in the rat. European journal of pharmacology. vol 249. issue 3. 1994-02-24. PMID:7904566. |
or dorsal raphe nucleus) and 8-oh-dpat (dorsal raphe nucleus) retained their ability to inhibit ultrasonic vocalization and, in non-lesioned rats, bilateral injection of ipsapirone, buspirone and 8-oh-dpat into the dorsal hippocampus and the amygdala - two brain regions rich in postsynaptic 5-ht1a receptors - also inhibited ultrasonic vocalization. |
1994-02-24 |
2023-08-12 |
rat |
| L Lanfumey, S Haj-Dahmane, M Hamo. Further assessment of the antagonist properties of the novel and selective 5-HT1A receptor ligands (+)-WAY 100 135 and SDZ 216-525. European journal of pharmacology. vol 249. issue 1. 1994-02-14. PMID:8282017. |
the higher potency of the latter compound was also noted at the level of presynaptic 5-ht1a receptors where both (+)-way 100 135 and sdz 216-525 prevented the negative influence of 5-ht1a receptor agonists (8-oh-dpat, flesinoxan or lesopitron) on the nerve impulse flow within dorsal raphe nucleus 5-ht neurones in brain stem slices. |
1994-02-14 |
2023-08-12 |
rat |
| N J Penington, J S Kelly, A P Fo. Whole-cell recordings of inwardly rectifying K+ currents activated by 5-HT1A receptors on dorsal raphe neurones of the adult rat. The Journal of physiology. vol 469. 1994-01-31. PMID:8271204. |
whole-cell recordings of inwardly rectifying k+ currents activated by 5-ht1a receptors on dorsal raphe neurones of the adult rat. |
1994-01-31 |
2023-08-12 |
rat |
| F Lejeune, J M Rivet, A Gobert, H Canton, M J Milla. WAY 100,135 and (-)-tertatolol act as antagonists at both 5-HT1A autoreceptors and postsynaptic 5-HT1A receptors in vivo. European journal of pharmacology. vol 240. issue 2-3. 1994-01-03. PMID:8243546. |
the firing rate of dorsal raphe neurones, which bear inhibitory 5-ht1a autoreceptors, was reduced by s 14671 whereas it was not affected by way 100,135 and was increased by (-)-tertatolol. |
1994-01-03 |
2023-08-12 |
Not clear |
| R F Cox, E Meller, B L Waszcza. Electrophysiological evidence for a large receptor reserve for inhibition of dorsal raphe neuronal firing by 5-HT1A agonists. Synapse (New York, N.Y.). vol 14. issue 4. 1994-01-03. PMID:8248853. |
electrophysiological evidence for a large receptor reserve for inhibition of dorsal raphe neuronal firing by 5-ht1a agonists. |
1994-01-03 |
2023-08-12 |
rat |
| R F Cox, E Meller, B L Waszcza. Electrophysiological evidence for a large receptor reserve for inhibition of dorsal raphe neuronal firing by 5-HT1A agonists. Synapse (New York, N.Y.). vol 14. issue 4. 1994-01-03. PMID:8248853. |
the current studies were undertaken to determine if the above drugs exhibit similar relative efficacies and receptor reserves in an electrophysiological model of 5-ht1a receptor activation, i.e., the inhibition of dorsal raphe cell firing. |
1994-01-03 |
2023-08-12 |
rat |
| M Briley, C More. Neurobiological mechanisms involved in antidepressant therapies. Clinical neuropharmacology. vol 16. issue 5. 1993-12-22. PMID:8221701. |
the firing rate of dorsal raphe serotonergic neurons is under the control of somatodendritic 5-hydroxytryptamine 1a (5-ht1a) autoreceptors, the release of serotonin from nerve terminals is under the control of 5-ht autoreceptors (5-ht1b subtype in rodents, 5-ht1d in other species), whereas the control of the activity of tryptophan hydroxylase, the rate-limiting enzyme of serotonin synthesis, is complex, involving 5-ht1a but possibly other 5-ht receptors including the 5-ht1b/d subtype. |
1993-12-22 |
2023-08-12 |
Not clear |
| K Gołembiowska, K Wedzon. Enhancement by ipsapirone of dopamine release in the rat striatum. Polish journal of pharmacology. vol 45. issue 3. 1993-12-13. PMID:7693136. |
it is postulated that ipsa increases the release of da from nigrostriatal terminals via activation of striatal 5-ht1a receptors in a manner independent of the activation of 5-ht1a receptors in the dorsal raphe nuclei. |
1993-12-13 |
2023-08-12 |
rat |
| C M Contreras, M L Marván, A Muñoz-Ménde. Clomipramine increases the responsiveness of raphe-cortical neurons in the rat. Neuropsychobiology. vol 27. issue 4. 1993-12-03. PMID:8232839. |
the cerebral cortex of the rat possesses 5-ht1a receptor subtype; however, whether the activation of this receptor by dorsal raphe nucleus stimulation produces a similar action on neuronal cortical firing as antidepressants acting on serotonin (5-ht) function is unknown. |
1993-12-03 |
2023-08-12 |
rat |
| J Mos, B Olivier, M Poth, R Van Oorschot, H Van Ake. The effects of dorsal raphe administration of eltoprazine, TFMPP and 8-OH-DPAT on resident intruder aggression in the rat. European journal of pharmacology. vol 238. issue 2-3. 1993-11-09. PMID:8405111. |
to evaluate the role of somatodendritic 5-ht1a receptors in the mediation of aggressive behaviour, eltoprazine, tfmpp (1-(3-trifluoromethylphenyl)piperazine hydrochloride) and 8-oh-dpat (8-hydroxy-2-(di-n-propylamino)tetralin) were administered locally into the dorsal raphe nucleus of rats. |
1993-11-09 |
2023-08-12 |
rat |
| H Sommermeyer, R Schreiber, J M Greuel, J De Vry, T Glase. Anxiolytic effects of the 5-HT1A receptor agonist ipsapirone in the rat: neurobiological correlates. European journal of pharmacology. vol 240. issue 1. 1993-11-02. PMID:7691626. |
it is concluded that ipsapirone exhibits its anxiolytic effects, at least partially, by stimulating presynaptic somatodendritic 5-ht1a receptors in the brain stem raphe nuclei (i.e., the dorsal raphe), resulting in attenuation of presynaptic cell firing and subsequent inhibition of serotonergic neurotransmission in the limbic system (i.e., the hippocampus). |
1993-11-02 |
2023-08-12 |
rat |
| J S Sprouse, D R McCarty, M W Dudle. Apparent regional differences in 5-HT1A binding may reflect [3H]8-OH-DPAT labeling of serotonin uptake sites. Brain research. vol 617. issue 1. 1993-10-15. PMID:8374738. |
the binding of [3h]8-oh-dpat and [3h]paroxetine to 5-ht1a and 5-ht uptake sites (respectively) was examined in membranes prepared from bovine dorsal raphe and hippocampus. |
1993-10-15 |
2023-08-12 |
cattle |
| J S Sprouse, D R McCarty, M W Dudle. Apparent regional differences in 5-HT1A binding may reflect [3H]8-OH-DPAT labeling of serotonin uptake sites. Brain research. vol 617. issue 1. 1993-10-15. PMID:8374738. |
competition studies with mdl 73,005ef, a selective 5-ht1a ligand, revealed a high and a low affinity site in the dorsal raphe, but only the high affinity component in hippocampal membranes. |
1993-10-15 |
2023-08-12 |
cattle |
| T Jolas, S Haj-Dahmane, L Lanfumey, C M Fattaccini, E J Kidd, J Adrien, H Gozlan, B Guardiola-Lemaitre, M Hamo. (-)Tertatolol is a potent antagonist at pre- and postsynaptic serotonin 5-HT1A receptors in the rat brain. Naunyn-Schmiedeberg's archives of pharmacology. vol 347. issue 5. 1993-08-05. PMID:7686633. |
), (-)tertatolol prevented the inhibitory effects of the 5-ht1a receptor agonists 8-oh-dpat, ipsapirone and lesopitron on the firing rate of serotoninergic neurones within the dorsal raphe nucleus. |
1993-08-05 |
2023-08-12 |
rat |
| T Jolas, S Haj-Dahmane, L Lanfumey, C M Fattaccini, E J Kidd, J Adrien, H Gozlan, B Guardiola-Lemaitre, M Hamo. (-)Tertatolol is a potent antagonist at pre- and postsynaptic serotonin 5-HT1A receptors in the rat brain. Naunyn-Schmiedeberg's archives of pharmacology. vol 347. issue 5. 1993-08-05. PMID:7686633. |
these data indicate that (-)tertatolol is a potent competitive antagonist at both pre (in the dorsal raphe nucleus)-and post (in the hippocampus)-synaptic 5-ht1a receptors in the rat brain. |
1993-08-05 |
2023-08-12 |
rat |