| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Schreiber, K Opitz, T Glaser, J De Vr. Ipsapirone and 8-OH-DPAT reduce ethanol preference in rats: involvement of presynaptic 5-HT1A receptors. Psychopharmacology. vol 112. issue 1. 1995-03-29. PMID:7870997. |
local application of 8-oh-dpat (10 micrograms, 0.5 microliters) into the dorsal raphe nucleus (drn, a brain area rich in somatodendritic 5-ht1a autoreceptors), reduced the etoh preference significantly as compared to the saline injection in the same animal (-12%, 8:00-12:00 p.m.). |
1995-03-29 |
2023-08-12 |
rat |
| S M Tejani-Butt, D M Labo. Time course of the effects of adrenalectomy and corticosterone replacement on 5-HT1A receptors and 5-HT uptake sites in the hippocampus and dorsal raphe nucleus of the rat brain: an autoradiographic analysis. Psychopharmacology. vol 113. issue 3-4. 1995-03-20. PMID:7862863. |
time course of the effects of adrenalectomy and corticosterone replacement on 5-ht1a receptors and 5-ht uptake sites in the hippocampus and dorsal raphe nucleus of the rat brain: an autoradiographic analysis. |
1995-03-20 |
2023-08-12 |
rat |
| T Jolas, R Schreiber, A M Laporte, M Chastanet, J De Vry, T Glaser, J Adrien, M Hamo. Are postsynaptic 5-HT1A receptors involved in the anxiolytic effects of 5-HT1A receptor agonists and in their inhibitory effects on the firing of serotonergic neurons in the rat? The Journal of pharmacology and experimental therapeutics. vol 272. issue 2. 1995-03-15. PMID:7853210. |
previous studies have shown that injection of 5-hydroxytryptamine (serotonin) receptor agonists in the dorsal raphe nucleus (drn) to stimulate somatodendritic 5-ht1a autoreceptors or in the hippocampus to stimulate postsynaptic 5-ht1a receptors, induces anxiolytic-like effects in the rat. |
1995-03-15 |
2023-08-12 |
rat |
| H H Berendsen, F G Bourgondien, C L Broekkam. Role of dorsal and median raphe nuclei in lower lip retraction in rats. European journal of pharmacology. vol 263. issue 3. 1995-03-03. PMID:7843270. |
the results suggest that lower lip retraction is mediated by 5-ht1a receptors in the median rather than in the dorsal raphe nucleus. |
1995-03-03 |
2023-08-12 |
rat |
| L Arborelius, B B Höök, U Hacksell, T H Svensso. The 5-HT1A receptor antagonist (S)-UH-301 blocks the qR)-8-OH-DPAT-induced inhibition of serotonergic dorsal raphe cell firing in the rat. Journal of neural transmission. General section. vol 96. issue 3. 1995-02-23. PMID:7826569. |
the 5-ht1a receptor antagonist (s)-uh-301 blocks the qr)-8-oh-dpat-induced inhibition of serotonergic dorsal raphe cell firing in the rat. |
1995-02-23 |
2023-08-12 |
rat |
| D M Tomkins, E M Sellers, P J Fletche. Median and dorsal raphe injections of the 5-HT1A agonist, 8-OH-DPAT, and the GABAA agonist, muscimol, increase voluntary ethanol intake in Wistar rats. Neuropharmacology. vol 33. issue 3-4. 1994-12-30. PMID:7984273. |
median and dorsal raphe injections of the 5-ht1a agonist, 8-oh-dpat, and the gabaa agonist, muscimol, increase voluntary ethanol intake in wistar rats. |
1994-12-30 |
2023-08-12 |
rat |
| H Gozlan, A M Laporte, S Thibault, L E Schechter, F Bolaños, M Hamo. Differential effects of N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) on various 5-HT receptor binding sites in the rat brain. Neuropharmacology. vol 33. issue 3-4. 1994-12-30. PMID:7984280. |
analyses of the time-course recovery of respective binding sites after eedq administration showed that the turnover rate of 5-ht1a sites did not significantly differ in the dorsal raphe nucleus and in various forebrain areas (hippocampus, septum, cerebral cortex; half-life: approximately 4 days), but was lower than that of cortical 5-ht2a sites (half-life: 2.9 days). |
1994-12-30 |
2023-08-12 |
rat |
| M R Pranzatelli, M M Durkin, A I Barka. Quantitative autoradiography of 5-hydroxytryptamine1A binding sites in rats with chronic neonatal 5,7-dihydroxytryptamine lesions. Brain research. Developmental brain research. vol 80. issue 1-2. 1994-12-20. PMID:7955334. |
5-ht1a binding was significantly decreased (-87%) in the dorsal raphe after i.c.-made 5,7-dht lesions. |
1994-12-20 |
2023-08-12 |
rat |
| M R Pranzatelli, M M Durkin, A I Barka. Quantitative autoradiography of 5-hydroxytryptamine1A binding sites in rats with chronic neonatal 5,7-dihydroxytryptamine lesions. Brain research. Developmental brain research. vol 80. issue 1-2. 1994-12-20. PMID:7955334. |
injection compared to controls, but rather a 246% increase in area of 5-ht1a binding extending from the dorsal raphe was observed. |
1994-12-20 |
2023-08-12 |
rat |
| M R Pranzatelli, M M Durkin, A I Barka. Quantitative autoradiography of 5-hydroxytryptamine1A binding sites in rats with chronic neonatal 5,7-dihydroxytryptamine lesions. Brain research. Developmental brain research. vol 80. issue 1-2. 1994-12-20. PMID:7955334. |
these changes in 5-ht1a binding sites in the dorsal raphe in the chronic phase of 5,7-dht lesions may contribute to the different behavioral consequences of the route of neonatal 5,7-dht injection. |
1994-12-20 |
2023-08-12 |
rat |
| C A Fornal, W J Litto, C W Metzler, F Marrosu, K Tada, B L Jacob. Single-unit responses of serotonergic dorsal raphe neurons to 5-HT1A agonist and antagonist drug administration in behaving cats. The Journal of pharmacology and experimental therapeutics. vol 270. issue 3. 1994-11-07. PMID:7932189. |
single-unit responses of serotonergic dorsal raphe neurons to 5-ht1a agonist and antagonist drug administration in behaving cats. |
1994-11-07 |
2023-08-12 |
Not clear |
| C A Fornal, W J Litto, C W Metzler, F Marrosu, K Tada, B L Jacob. Single-unit responses of serotonergic dorsal raphe neurons to 5-HT1A agonist and antagonist drug administration in behaving cats. The Journal of pharmacology and experimental therapeutics. vol 270. issue 3. 1994-11-07. PMID:7932189. |
these results confirm the marked sensitivity of serotonergic dorsal raphe nucleus neurons to selective 5-ht1a agonist compounds in unanesthetized animals and suggest that 5-ht1a somatodendritic autoreceptors exert a tonic inhibitory influence on the firing rate of these neurons during periods of behavioral activation, but not during periods of behavioral quiescence. |
1994-11-07 |
2023-08-12 |
Not clear |
| C A Fornal, F Marrosu, C W Metzler, K Tada, B L Jacob. Effects of the putative 5-hydroxytryptamine1A antagonists BMY 7378, NAN 190 and (-)-propranolol on serotonergic dorsal raphe unit activity in behaving cats. The Journal of pharmacology and experimental therapeutics. vol 270. issue 3. 1994-11-07. PMID:7932190. |
the present study examines the effects of three other putative 5-ht1a antagonists (bmy 7378 (8-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro [4,5]decane-7,9-dione), nan 190 [1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl]piperazine) and (-)-propranolol) on the single-unit activity of serotonergic neurons recorded in the dorsal raphe nucleus of free-moving cats. |
1994-11-07 |
2023-08-12 |
Not clear |
| J G Hensler, R C Ferry, D M Labow, G B Kovachich, A Fraze. Quantitative autoradiography of the serotonin transporter to assess the distribution of serotonergic projections from the dorsal raphe nucleus. Synapse (New York, N.Y.). vol 17. issue 1. 1994-08-23. PMID:8042142. |
within the dorsal raphe nucleus the binding of 3h-cn-imi was compared in adjacent coronal sections of rat brain to the binding of 3h-dpat to 5-ht1a receptors, which have a known somatodendritic localization. |
1994-08-23 |
2023-08-12 |
rat |
| S Haj-Dahmane, T Jolas, A M Laporte, H Gozlan, A J Farré, M Hamon, L Lanfume. Interactions of lesopitron (E-4424) with central 5-HT1A receptors: in vitro and in vivo studies in the rat. European journal of pharmacology. vol 255. issue 1-3. 1994-08-08. PMID:8026543. |
as previously shown for agonists acting at the somato-dendritic 5-ht1a autoreceptors in the dorsal raphe nucleus, lesopitron inhibited the firing of serotoninergic neurons both in vitro (in brainstem slices, ic50 = 120 nm) and in vivo (in chloral hydrate-anaesthetized rats, id50 = 35 micrograms/kg i.v. |
1994-08-08 |
2023-08-12 |
mouse |
| P W Burnet, D Michelson, M A Smith, P W Gold, E M Sternber. The effect of chronic imipramine administration on the densities of 5-HT1A and 5-HT2 receptors and the abundances of 5-HT receptor and transporter mRNA in the cortex, hippocampus and dorsal raphe of three strains of rat. Brain research. vol 638. issue 1-2. 1994-07-07. PMID:8199869. |
the effect of chronic imipramine administration on the densities of 5-ht1a and 5-ht2 receptors and the abundances of 5-ht receptor and transporter mrna in the cortex, hippocampus and dorsal raphe of three strains of rat. |
1994-07-07 |
2023-08-12 |
rat |
| P W Burnet, D Michelson, M A Smith, P W Gold, E M Sternber. The effect of chronic imipramine administration on the densities of 5-HT1A and 5-HT2 receptors and the abundances of 5-HT receptor and transporter mRNA in the cortex, hippocampus and dorsal raphe of three strains of rat. Brain research. vol 638. issue 1-2. 1994-07-07. PMID:8199869. |
to further characterize these strains, we investigated the effect of chronic (8 wk) imipramine administration (5 mg/kg/day) on 5-ht1a and 5-ht2 receptor densities and mrna in the cortex and hippocampus and 5-ht transporter mrna in the dorsal raphe of lew/n, hsd, and f344/n rats, using quantitative autoradiography and in situ hybridization histochemistry. |
1994-07-07 |
2023-08-12 |
rat |
| P W Burnet, D Michelson, M A Smith, P W Gold, E M Sternber. The effect of chronic imipramine administration on the densities of 5-HT1A and 5-HT2 receptors and the abundances of 5-HT receptor and transporter mRNA in the cortex, hippocampus and dorsal raphe of three strains of rat. Brain research. vol 638. issue 1-2. 1994-07-07. PMID:8199869. |
finally, 5-ht1a receptor densities and the abundance of mrnas encoding the 5-ht1a receptor and 5-ht transporter in the dorsal raphe remained unaltered after imipramine administration in all three strains. |
1994-07-07 |
2023-08-12 |
rat |
| M K Mundey, A Fletcher, C A Marsde. Effect of the putative 5-HT1A antagonists WAY100135 and SDZ 216-525 on 5-HT neuronal firing in the guinea-pig dorsal raphe nucleus. Neuropharmacology. vol 33. issue 1. 1994-06-16. PMID:8183439. |
effect of the putative 5-ht1a antagonists way100135 and sdz 216-525 on 5-ht neuronal firing in the guinea-pig dorsal raphe nucleus. |
1994-06-16 |
2023-08-12 |
Not clear |
| M F Piercey, M W Smith, J T Lum-Raga. Excitation of noradrenergic cell firing by 5-hydroxytryptamine1A agonists correlates with dopamine antagonist properties. The Journal of pharmacology and experimental therapeutics. vol 268. issue 3. 1994-04-25. PMID:8138943. |
the 5-ht1a receptor agonists buspirone, 8-hydroxy-n,n-dipropyl-2-aminotetralin, gepirone and ipsapirone were evaluated for their receptor binding profiles and their effects on firing rates of 5-ht, dopamine (da) and noradrenaline (na) neurons in the dorsal raphe, substantia nigra pars compacta and the locus ceruleus, respectively. |
1994-04-25 |
2023-08-12 |
Not clear |