| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N Laaris, S Haj-Dahmane, M Hamon, L Lanfume. Glucocorticoid receptor-mediated inhibition by corticosterone of 5-HT1A autoreceptor functioning in the rat dorsal raphe nucleus. Neuropharmacology. vol 34. issue 9. 1996-01-26. PMID:8532191. |
complementary autoradiographic experiments showed that [3h]8-oh-dpat specific binding to 5-ht1a sites in the dorsal raphe nucleus (and the hippocampus) was not significantly altered following adrenalectomy and exposure of brain stem slices to corticosterone. |
1996-01-26 |
2023-08-12 |
rat |
| N Laaris, S Haj-Dahmane, M Hamon, L Lanfume. Glucocorticoid receptor-mediated inhibition by corticosterone of 5-HT1A autoreceptor functioning in the rat dorsal raphe nucleus. Neuropharmacology. vol 34. issue 9. 1996-01-26. PMID:8532191. |
these data suggest that gr are involved in the suppressive effects of high levels of corticosterone on the 5-ht1a receptor-dependent regulation of 5-ht neuronal activity in the rat dorsal raphe nucleus. |
1996-01-26 |
2023-08-12 |
rat |
| I Nevo, X Langlois, A M Laporte, M Kleven, W Koek, L Lima, C Maudhuit, M P Martres, M Hamo. Chronic alcoholization alters the expression of 5-HT1A and 5-HT1B receptor subtypes in rat brain. European journal of pharmacology. vol 281. issue 3. 1996-01-25. PMID:8521905. |
quantitative autoradiography indicated that the ethanol treatment provoked an increase (approximately +30%) in the labeling by [3h]8-hydroxy-2-(di-n-propylamino)tetralin ([3h]8-oh-dpat) and [3h]n-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-n-(2-pyridinyl) cyclohexane carboxamide ([3h]way-100635) of 5-ht1a autoreceptors in the dorsal raphe nucleus, accompanied by a concomitant decrease in the labeling of postsynaptic 5-ht1a receptors in the hippocampus (approximately -20%), anterior (approximately -30%) and posterior (approximately -32%) cortices. |
1996-01-25 |
2023-08-12 |
rat |
| E Le Poul, N Laaris, E Doucet, A M Laporte, M Hamon, L Lanfume. Early desensitization of somato-dendritic 5-HT1A autoreceptors in rats treated with fluoxetine or paroxetine. Naunyn-Schmiedeberg's archives of pharmacology. vol 352. issue 2. 1995-12-27. PMID:7477436. |
electrophysiological and autoradiographic approaches were used to assess possible changes in 5-hydroxytryptamine (serotonin) 5-ht1a receptors in the rat dorsal raphe nucleus after a subchronic treatment with fluoxetine or paroxetine, two specific serotonin reuptake inhibitors with antidepressant properties. |
1995-12-27 |
2023-08-12 |
rat |
| E Le Poul, N Laaris, E Doucet, A M Laporte, M Hamon, L Lanfume. Early desensitization of somato-dendritic 5-HT1A autoreceptors in rats treated with fluoxetine or paroxetine. Naunyn-Schmiedeberg's archives of pharmacology. vol 352. issue 2. 1995-12-27. PMID:7477436. |
electrophysiological recordings performed 24 h after the last injection showed that the potency of the 5-ht1a receptor agonist, 8-oh-dpat, to depress the firing of serotoninergic neurons in the dorsal raphe nucleus within brain stem slices was significantly reduced as early as after a 3-day treatment with either drug. |
1995-12-27 |
2023-08-12 |
rat |
| E Le Poul, N Laaris, E Doucet, A M Laporte, M Hamon, L Lanfume. Early desensitization of somato-dendritic 5-HT1A autoreceptors in rats treated with fluoxetine or paroxetine. Naunyn-Schmiedeberg's archives of pharmacology. vol 352. issue 2. 1995-12-27. PMID:7477436. |
at no time during the treatment, was the specific binding of [3h]8-oh-dpat (agonist radioligand) or [3h]way-100 635 (antagonist radioligand) to 5-ht1a receptors modified in the dorsal raphe nucleus or in other brain areas, suggesting that neither the density nor the coupling of these receptors to g-proteins were probably altered in rats injected with fluoxetine or paroxetine for up to 21 days. |
1995-12-27 |
2023-08-12 |
rat |
| E Le Poul, N Laaris, E Doucet, A M Laporte, M Hamon, L Lanfume. Early desensitization of somato-dendritic 5-HT1A autoreceptors in rats treated with fluoxetine or paroxetine. Naunyn-Schmiedeberg's archives of pharmacology. vol 352. issue 2. 1995-12-27. PMID:7477436. |
these results show that adaptive desensitization of somatodendritic 5-ht1a autoreceptors within the dorsal raphe nucleus can already be detected after a 3-day treatment with selective serotonin reuptake inhibitors. |
1995-12-27 |
2023-08-12 |
rat |
| L Arborelius, G G Nomikos, P Grillner, P Hertel, B B Höök, U Hacksell, T H Svensso. 5-HT1A receptor antagonists increase the activity of serotonergic cells in the dorsal raphe nucleus in rats treated acutely or chronically with citalopram. Naunyn-Schmiedeberg's archives of pharmacology. vol 352. issue 2. 1995-12-27. PMID:7477438. |
5-ht1a receptor antagonists increase the activity of serotonergic cells in the dorsal raphe nucleus in rats treated acutely or chronically with citalopram. |
1995-12-27 |
2023-08-12 |
rat |
| L Arborelius, G G Nomikos, P Grillner, P Hertel, B B Höök, U Hacksell, T H Svensso. 5-HT1A receptor antagonists increase the activity of serotonergic cells in the dorsal raphe nucleus in rats treated acutely or chronically with citalopram. Naunyn-Schmiedeberg's archives of pharmacology. vol 352. issue 2. 1995-12-27. PMID:7477438. |
in this study we have examined the acute effects of systemic administration of the selective serotonin reuptake inhibitor (ssri), citalopram, in combination with either of the two selective 5-ht1a receptor antagonists, [(s)-5-fluoro-8-hydroxy-2-(dipropylamino)-tetralin [(s)-uh-301] or (+)-n-tertbutyl 3-(4-(2-methoxyphenyl)piperazin-1-yl)-2-phenyl-propionamide dihydrochloride [(+)-way100135], on the activity of single 5-ht neurons in the dorsal raphe nucleus (drn) of anesthetized rats using extracellular recording techniques. |
1995-12-27 |
2023-08-12 |
rat |
| P M Larkman, J S Kell. The use of brain slices and dissociated neurones to explore the multiplicity of actions of 5-HT in the central nervous system. Journal of neuroscience methods. vol 59. issue 1. 1995-11-24. PMID:7475248. |
patch-clamp recordings from acutely dissociated adult rat dorsal raphe neurones confirm data obtained using conventional slice preparations that 5-ht activates an inwardly rectifying potassium channel through a 5-ht1a receptor leading to hyperpolarization of the cell. |
1995-11-24 |
2023-08-12 |
rat |
| N Haddjeri, P Blie. Pre- and post-synaptic effects of the 5-HT3 agonist 2-methyl-5-HT on the 5-HT system in the rat brain. Synapse (New York, N.Y.). vol 20. issue 1. 1995-08-31. PMID:7624830. |
the firing activity of dorsal raphe 5-ht neurons was also reduced by 5-ht, 2-methyl-5-ht and the 5-ht1a agonist 8-oh-dpat applied by microiontophoresis. |
1995-08-31 |
2023-08-12 |
rat |
| N Haddjeri, P Blie. Pre- and post-synaptic effects of the 5-HT3 agonist 2-methyl-5-HT on the 5-HT system in the rat brain. Synapse (New York, N.Y.). vol 20. issue 1. 1995-08-31. PMID:7624830. |
these findings suggest that, in vivo, the suppressant effect of 2-methyl-5-ht on the firing activity of dorsal hippocampus pyramidal, somatosensory cortical, and dorsal raphe 5-ht neurons is not mediated by 5-ht3 receptors, but rather by 5-ht1a receptors. |
1995-08-31 |
2023-08-12 |
rat |
| X Khawaj. Quantitative autoradiographic characterisation of the binding of [3H]WAY-100635, a selective 5-HT1A receptor antagonist. Brain research. vol 673. issue 2. 1995-08-17. PMID:7606435. |
the affinity of [3h]way-100635 for the 5-ht1a binding site tended to be higher in the dorsal raphe n. and entorhinal cortex compared with that of the hippocampal formation. |
1995-08-17 |
2023-08-12 |
rat |
| N Bonhomme, M Cador, L Stinus, M Le Moal, U Spampinat. Short and long-term changes in dopamine and serotonin receptor binding sites in amphetamine-sensitized rats: a quantitative autoradiographic study. Brain research. vol 675. issue 1-2. 1995-08-03. PMID:7796132. |
a significant increase of [3h]sch 23390 binding to d1 da receptors was observed in the substantia nigra pars reticulata 1 day but not 15 days after the cessation of amph treatment, whereas [3h]8-oh-dpat binding to 5-ht1a sites was found to be significantly enhanced in the dorsal raphe nucleus at both time points. |
1995-08-03 |
2023-08-12 |
rat |
| A Gobert, F Lejeune, J M Rivet, V Audinot, A Newman-Tancredi, M J Milla. Modulation of the activity of central serotoninergic neurons by novel serotonin1A receptor agonists and antagonists: a comparison to adrenergic and dopaminergic neurons in rats. The Journal of pharmacology and experimental therapeutics. vol 273. issue 3. 1995-07-21. PMID:7791073. |
the novel, high efficacy, 5-ht1a agonists, wy 48,723 (an arylpiperazine), (+)-flesinoxan (a benzodioxane) and s 14671 and s 14506 (methoxynaphtylpiperazines) mimicked the aminotetralin, 8-hydroxy-2-(di-n-propylamino)tetralin hydrobromide (8-oh-dpat), in inhibiting the firing of dorsal raphe nucleus (drn) neurons. |
1995-07-21 |
2023-08-12 |
rat |
| E Le Poul, L Lima, A M Laporte, C Even, E Doucet, C M Fattaccini, N Laaris, M Hamon, L Lanfume. [Central serotonin receptors and chronic treatment with selective serotonin reuptake inhibitors in the rat: comparative effects of fluoxetine and paroxetine]. L'Encephale. vol 21. issue 2. 1995-07-20. PMID:7781583. |
nevertheless, in vitro electrophysiological recordings of serotonergic neurons in the dorsal raphe nucleus allowed the demonstration of a clearcut functional desensitization of somatodendritic 5-ht1a autoreceptors. |
1995-07-20 |
2023-08-12 |
rat |
| C Davidson, J A Stamfor. The effect of paroxetine on 5-HT efflux in the rat dorsal raphe nucleus is potentiated by both 5-HT1A and 5-HT1B/D receptor antagonists. Neuroscience letters. vol 188. issue 1. 1995-07-20. PMID:7783975. |
the effect of paroxetine on 5-ht efflux in the rat dorsal raphe nucleus is potentiated by both 5-ht1a and 5-ht1b/d receptor antagonists. |
1995-07-20 |
2023-08-12 |
rat |
| R Craven, D Grahame-Smith, N Newberr. WAY-100635 and GR127935: effects on 5-hydroxytryptamine-containing neurones. European journal of pharmacology. vol 271. issue 1. 1995-05-04. PMID:7698189. |
n-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-n-(2- pyridinyl)cyclohexanecarboxamide trihydrochloride (way-100635) is a potent and selective 5-ht1a receptor antagonist in a slice preparation of the guinea pig dorsal raphe nucleus: the inhibitory actions on 5-ht neuronal firing of 5-hydroxytryptamine (5-ht, serotonin), 5-carboxamidotryptamine (5-ct) and 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat), but not those of baclofen, were abolished by 30 nm way-100635. |
1995-05-04 |
2023-08-12 |
Not clear |
| L G Iben, C D Mahle, F D Yocc. Differential sensitivity of 3H-agonist binding to pre- and postsynaptic 5-HT1A receptors in bovine brain. British journal of pharmacology. vol 113. issue 4. 1995-04-19. PMID:7889298. |
the full and weak partial 5-ht1a agonist ligands [3h]-8-oh-dpat and [3h]-bmy-7378 were used to characterize the binding parameters of pre- and postsynaptic 5-ht1a binding sites in bovine dorsal raphe and hippocampal membranes, respectively. |
1995-04-19 |
2023-08-12 |
cattle |
| L Romero, P Celada, F Artiga. Reduction of in vivo striatal 5-hydroxytryptamine release by 8-OH-DPAT after inactivation of Gi/G(o) proteins in dorsal raphe nucleus. European journal of pharmacology. vol 265. issue 1-2. 1995-04-10. PMID:7883021. |
we have examined the effects of 8-hydroxy-2-(di-n- propylamino)tetralin (8-oh-dpat, 0.1 mg/kg s.c.) on in vivo striatal 5-ht release in conscious rats with somatodendritic 5-ht1a receptors inactivated by the application of pertussis toxin in the dorsal raphe nucleus. |
1995-04-10 |
2023-08-12 |
rat |