| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Fletcher, E A Forster, D J Bill, G Brown, I A Cliffe, J E Hartley, D E Jones, A McLenachan, K J Stanhope, D J Critchley, K J Childs, V C Middlefell, L Lanfumey, R Corradetti, A M Laporte, H Gozlan, M Hamon, C T Douris. Electrophysiological, biochemical, neurohormonal and behavioural studies with WAY-100635, a potent, selective and silent 5-HT1A receptor antagonist. Behavioural brain research. vol 73. issue 1-2. 1996-12-04. PMID:8788530. |
in vitro electrophysiological studies demonstrated that way-100635 had no 5-ht1a receptor agonist actions, but dose-dependently blocked the effects of agonists at both the postsynaptic 5-ht1a receptor in the ca1 region of the hippocampus, and the somatodendritic 5-ht1a receptor located on dorsal raphe 5-ht neurones. |
1996-12-04 |
2023-08-12 |
mouse |
| R K Raghupathi, D A Brousseau, P McGonigl. Time-course of recovery of 5-HT1A receptors and changes in 5-HT1A receptor mRNA after irreversible inactivation with EEDQ. Brain research. Molecular brain research. vol 38. issue 2. 1996-12-03. PMID:8793111. |
inactivation of 5-ht1a receptors ranged from 84% in the dorsal raphe to 97% in the cortex 12 h after administration of eedq. |
1996-12-03 |
2023-08-12 |
rat |
| J M Casanovas, F Artiga. Differential effects of ipsapirone on 5-hydroxytryptamine release in the dorsal and median raphe neuronal pathways. Journal of neurochemistry. vol 67. issue 5. 1996-12-02. PMID:8863499. |
recent results challenge previous evidence indicating a greater inhibition of dorsal raphe neurons after 5-hydroxytryptamine1a (5-ht1a) autoreceptor activation. |
1996-12-02 |
2023-08-12 |
Not clear |
| J M Casanovas, F Artiga. Differential effects of ipsapirone on 5-hydroxytryptamine release in the dorsal and median raphe neuronal pathways. Journal of neurochemistry. vol 67. issue 5. 1996-12-02. PMID:8863499. |
these results are consistent with a higher sensitivity of dorsal raphe neurons to 5-ht1a autoreceptor activation. |
1996-12-02 |
2023-08-12 |
Not clear |
| S M Remy, R Schreiber, M Dalmus, J De Vr. Somatodendritic 5-HT1A receptors are critically involved in the anxiolytic effects of 8-OH-DPAT. Psychopharmacology. vol 125. issue 1. 1996-11-27. PMID:8724453. |
in the rat shock-induced ultrasonic vocalization test, the anxiolytic effects of the 5-ht1a receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) obtained after systemic (ip) and intracerebral injection into the dorsal raphe nucleus (drn) were selectively abolished by pretreatment with the 5-ht1a receptor antagonist way-100635 [n-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-n-(2-pyridinyl) cyclo-hexane-carboxamide trihydrochloride]. |
1996-11-27 |
2023-08-12 |
rat |
| G Piñeyro, C de Montigny, M Weiss, P Blie. Autoregulatory properties of dorsal raphe 5-HT neurons: possible role of electrotonic coupling and 5-HT1D receptors in the rat brain. Synapse (New York, N.Y.). vol 22. issue 1. 1996-11-08. PMID:8822478. |
these results, in keeping with previous anatomical studies, suggest the existence of electrotonic coupling of 5-ht neurons and indicate that 5-ht release in the rat dorsal raphe nucleus may be controlled independently of firing-regulating 5-ht1a autoreceptors. |
1996-11-08 |
2023-08-12 |
rat |
| D D Mousseau, V L Rao, R F Butterwort. Alterations in serotonin parameters in brain of thiamine-deficient rats are evident prior to the appearance of neurological symptoms. Journal of neurochemistry. vol 67. issue 3. 1996-10-02. PMID:8752118. |
using quantitative receptor autoradiography, the binding of 8-hydroxy-2-(di-n-[3h]propylamino) tetralin, a ligand used to label the somatodendritic 5-ht1a autoreceptor of the dorsal raphe nucleus, was found to be unaffected in this region, suggesting that the structural integrity of the 5-ht cell bodies is maintained throughout the course of pyrithiamine treatment. |
1996-10-02 |
2023-08-12 |
rat |
| R Corradetti, E Le Poul, N Laaris, M Hamon, L Lanfume. Electrophysiological effects of N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl) cyclohexane carboxamide (WAY 100635) on dorsal raphe serotonergic neurons and CA1 hippocampal pyramidal cells in vitro. The Journal of pharmacology and experimental therapeutics. vol 278. issue 2. 1996-09-18. PMID:8768719. |
the aim of the present study was to examine the effects of n-(2-(4-2-methoxphenyl)-1-piperazinyl)ethyl)-n-(2-pyridnyl) cyclohexane carboxamide (way 100635) on 5-ht1a receptor-mediated responses in the dorsal raphe nucleus (drn) and the ca1 hippocampal region. |
1996-09-18 |
2023-08-12 |
Not clear |
| C A Fornal, C W Metzler, R A Gallegos, S C Veasey, A C McCreary, B L Jacob. WAY-100635, a potent and selective 5-hydroxytryptamine1A antagonist, increases serotonergic neuronal activity in behaving cats: comparison with (S)-WAY-100135. The Journal of pharmacology and experimental therapeutics. vol 278. issue 2. 1996-09-18. PMID:8768728. |
the present study examined the effects of systemic administration of two reportedly selective 5-ht1a receptor antagonists, (s)-way-100135 {n-tert-butyl-3-[4-(2-methoxyphenyl) piperazin-1-yl]-2-phenylpropanamide} and its more potent analog way-100635 {n-[2-[4-(2-methoxyphenyl)-1-piperazinyl] ethyl]-n-(2-pyridinyl)cyclohexanecarboxamide}, on the single-unit activity of serotonergic neurons in the dorsal raphe nucleus of freely moving cats. |
1996-09-18 |
2023-08-12 |
Not clear |
| W P Clarke, F D Yocca, S Maayan. Lack of 5-hydroxytryptamine1A-mediated inhibition of adenylyl cyclase in dorsal raphe of male and female rats. The Journal of pharmacology and experimental therapeutics. vol 277. issue 3. 1996-08-06. PMID:8667186. |
in the dorsal raphe, 5-ht1a receptors also open k+ channels; however, coupling to adenylyl cyclase has not been demonstrated. |
1996-08-06 |
2023-08-12 |
rat |
| M K Mundey, A Fletcher, C A Marsde. Effects of 8-OHDPAT and 5-HT1A antagonists WAY100135 and WAY100635, on guinea-pig behaviour and dorsal raphe 5-HT neurone firing. British journal of pharmacology. vol 117. issue 4. 1996-07-24. PMID:8646424. |
effects of 8-ohdpat and 5-ht1a antagonists way100135 and way100635, on guinea-pig behaviour and dorsal raphe 5-ht neurone firing. |
1996-07-24 |
2023-08-12 |
Not clear |
| M K Mundey, A Fletcher, C A Marsde. Effects of 8-OHDPAT and 5-HT1A antagonists WAY100135 and WAY100635, on guinea-pig behaviour and dorsal raphe 5-HT neurone firing. British journal of pharmacology. vol 117. issue 4. 1996-07-24. PMID:8646424. |
the effects of 5-ht1a antagonists on guinea-pig behaviour and dorsal raphe neuronal activity were investigated. |
1996-07-24 |
2023-08-12 |
Not clear |
| M K Mundey, A Fletcher, C A Marsde. Effects of 8-OHDPAT and 5-HT1A antagonists WAY100135 and WAY100635, on guinea-pig behaviour and dorsal raphe 5-HT neurone firing. British journal of pharmacology. vol 117. issue 4. 1996-07-24. PMID:8646424. |
but did not affect the maximum inhibition induced by 8-ohdpat indicating competitive antagonism between 8-ohdpat and way100635 at the 5-ht1a somato-dendritic autoreceptor in the dorsal raphe nucleus of the guinea-pig. |
1996-07-24 |
2023-08-12 |
Not clear |
| R H McAllister-Williams, J S Kell. The modulation of calcium channel currents recorded from adult rat dorsal raphe neurones by 5-HT1A receptor or direct G-protein activation. Neuropharmacology. vol 34. issue 11. 1996-05-20. PMID:8606796. |
the modulation of calcium channel currents recorded from adult rat dorsal raphe neurones by 5-ht1a receptor or direct g-protein activation. |
1996-05-20 |
2023-08-12 |
rat |
| N Aguirre, J L Galbete, B Lasheras, J Del Rí. Methylenedioxymethamphetamine induces opposite changes in central pre- and postsynaptic 5-HT1A receptors in rats. European journal of pharmacology. vol 281. issue 1. 1996-03-06. PMID:8566108. |
[3h]8-hydroxy-2-(di-n-propylamino)tetralin ([3h]8-oh-dpat) was used to label 5-ht1a receptors in the brain stem region containing the dorsal raphe nucleus and in the frontal cortex. |
1996-03-06 |
2023-08-12 |
rat |
| Y Wang, J F Jones, A G Ramage, D Jorda. Effects of 5-HT and 5-HT1A receptor agonists and antagonists on dorsal vagal preganglionic neurones in anaesthetized rats: an ionophoretic study. British journal of pharmacology. vol 116. issue 4. 1996-03-05. PMID:8564262. |
effects of ionophoretic administration of 5-hydroxytryptamine (5-ht) and selective 5-ht1a receptor agonists and antagonists on identified dorsal vagal preganglionic and dorsal raphe neurones were studied in pentobarbitone sodium or chloral hydrate-anaesthetized rats, respectively. |
1996-03-05 |
2023-08-12 |
rat |
| V Hadrava, P Blier, T Dennis, C Ortemann, C de Montign. Characterization of 5-hydroxytryptamine1A properties of flesinoxan: in vivo electrophysiology and hypothermia study. Neuropharmacology. vol 34. issue 10. 1996-03-04. PMID:8570029. |
while the coapplication of flesinoxan antagonized the suppressant effect of 5-ht on ca3 pyramidal neurons, it failed to do so on dorsal raphe 5-ht neurons, indicating that flesinoxan acts as a partial agonist at postsynaptic and as a full agonist at presynaptic 5-ht1a receptors. |
1996-03-04 |
2023-08-12 |
rat |
| N Laaris, S Haj-Dahmane, M Hamon, L Lanfume. Glucocorticoid receptor-mediated inhibition by corticosterone of 5-HT1A autoreceptor functioning in the rat dorsal raphe nucleus. Neuropharmacology. vol 34. issue 9. 1996-01-26. PMID:8532191. |
glucocorticoid receptor-mediated inhibition by corticosterone of 5-ht1a autoreceptor functioning in the rat dorsal raphe nucleus. |
1996-01-26 |
2023-08-12 |
rat |
| N Laaris, S Haj-Dahmane, M Hamon, L Lanfume. Glucocorticoid receptor-mediated inhibition by corticosterone of 5-HT1A autoreceptor functioning in the rat dorsal raphe nucleus. Neuropharmacology. vol 34. issue 9. 1996-01-26. PMID:8532191. |
in the rat brain, the dorsal raphe nucleus contains a large proportion of serotoninergic neurons, which are mostly regulated by somato-dendritic 5-ht1a autoreceptors. |
1996-01-26 |
2023-08-12 |
rat |
| N Laaris, S Haj-Dahmane, M Hamon, L Lanfume. Glucocorticoid receptor-mediated inhibition by corticosterone of 5-HT1A autoreceptor functioning in the rat dorsal raphe nucleus. Neuropharmacology. vol 34. issue 9. 1996-01-26. PMID:8532191. |
control by corticosteroids of 5-ht1a receptor-mediated inhibitory control of the firing of serotoninergic neurons in the dorsal raphe nucleus was investigated using an in vitro electrophysiological approach. |
1996-01-26 |
2023-08-12 |
rat |