| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L Romero, F Artiga. Preferential potentiation of the effects of serotonin uptake inhibitors by 5-HT1A receptor antagonists in the dorsal raphe pathway: role of somatodendritic autoreceptors. Journal of neurochemistry. vol 68. issue 6. 1997-06-17. PMID:9166757. |
therefore, potentiation by 5-ht1a antagonists occurs preferentially in forebrain areas innervated by serotonergic neurons of the dorsal raphe nucleus. |
1997-06-17 |
2023-08-12 |
Not clear |
| L Lanfumey, S Haj-Dahmane, A M Laporte, P Martin, M Hamon, H Gozla. Effects of chronic diazepam treatment on pre- and postsynaptic 5-HT1A receptors in the rat brain. European journal of pharmacology. vol 323. issue 2-3. 1997-06-16. PMID:9128832. |
in vitro binding and quantitative autoradiographic experiments with [3h]8-hydroxy-2-(di-n-propylamino)tetralin ([3h]8-oh-dpat) showed that the characteristics of 5-ht1a receptor binding sites in the hippocampus and the dorsal raphe nucleus were not significantly altered by the administration of diazepam under the treatment protocols a, b and c. furthermore, in vitro electrophysiological recordings of serotoninergic neurons in the dorsal raphe nucleus of brain stem slices revealed no modification in the sensitivity of somatodendritic 5-ht1a autoreceptors in rats treated with diazepam according to the protocols a and b. |
1997-06-16 |
2023-08-12 |
rat |
| J Katayama, T Yakushiji, N Akaik. Characterization of the K+ current mediated by 5-HT1A receptor in the acutely dissociated rat dorsal raphe neurons. Brain research. vol 745. issue 1-2. 1997-04-29. PMID:9037420. |
characterization of the k+ current mediated by 5-ht1a receptor in the acutely dissociated rat dorsal raphe neurons. |
1997-04-29 |
2023-08-12 |
rat |
| J Katayama, T Yakushiji, N Akaik. Characterization of the K+ current mediated by 5-HT1A receptor in the acutely dissociated rat dorsal raphe neurons. Brain research. vol 745. issue 1-2. 1997-04-29. PMID:9037420. |
the action of 5-hydroxytryptamine (5-ht) via the 5-ht1a receptor on dissociated rat dorsal raphe neurons was characterized under the whole-cell mode by using the nystatin-perforated patch-clamp technique. |
1997-04-29 |
2023-08-12 |
rat |
| J Katayama, T Yakushiji, N Akaik. Characterization of the K+ current mediated by 5-HT1A receptor in the acutely dissociated rat dorsal raphe neurons. Brain research. vol 745. issue 1-2. 1997-04-29. PMID:9037420. |
therefore, the k+ conductance activated via the 5-ht1a receptor of dorsal raphe neurons was thus characterized by the sensitivity to such k+ channel blockers as quinine, ba2+ and 4-aminopyridine. |
1997-04-29 |
2023-08-12 |
rat |
| F Lejeune, A Newman-Tancredi, V Audinot, M J Milla. Interactions of (+)- and (-)-8- and 7-hydroxy-2-(di-n-propylamino)tetralin at human (h)D3, hD2 and h serotonin1A receptors and their modulation of the activity of serotoninergic and dopaminergic neurones in rats. The Journal of pharmacology and experimental therapeutics. vol 280. issue 3. 1997-04-11. PMID:9067310. |
in our study, we evaluated the influence of their (+)- and (-) isomers on the electrical activity of serotoninergic neurones of the dorsal raphe nucleus (drn), which bear 5-ht1a autoreceptors, and of dopaminergic neurones of the ventral tegmental area (vta), which possess inhibitory d3 and d2 receptors. |
1997-04-11 |
2023-08-12 |
human |
| F F Matos, C Korpinen, F D Yocc. 5-HT1A receptor agonist effects of BMY-14802 on serotonin release in dorsal raphe and hippocampus. European journal of pharmacology. vol 317. issue 1. 1997-04-02. PMID:8982718. |
5-ht1a receptor agonist effects of bmy-14802 on serotonin release in dorsal raphe and hippocampus. |
1997-04-02 |
2023-08-12 |
rat |
| F F Matos, C Korpinen, F D Yocc. 5-HT1A receptor agonist effects of BMY-14802 on serotonin release in dorsal raphe and hippocampus. European journal of pharmacology. vol 317. issue 1. 1997-04-02. PMID:8982718. |
bmy-14802 also binds to 5-ht1a receptors and is able to inhibit the firing of dorsal raphe serotonergic neurons, suggesting that this compound has 5-ht1a receptor agonist properties in vivo. |
1997-04-02 |
2023-08-12 |
rat |
| F F Matos, C Korpinen, F D Yocc. 5-HT1A receptor agonist effects of BMY-14802 on serotonin release in dorsal raphe and hippocampus. European journal of pharmacology. vol 317. issue 1. 1997-04-02. PMID:8982718. |
the 5-ht decreases in dorsal raphe and hippocampus produced by bmy-14802 were completely antagonized by pretreatment with 1.0 mg/kg of the specific 5-ht1a antagonist, way-100635 (n-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-n-(2-pyridinyl) cyclohexanecarboxamide trihydrochloride). |
1997-04-02 |
2023-08-12 |
rat |
| F F Matos, C Korpinen, F D Yocc. 5-HT1A receptor agonist effects of BMY-14802 on serotonin release in dorsal raphe and hippocampus. European journal of pharmacology. vol 317. issue 1. 1997-04-02. PMID:8982718. |
these data indicate that bmy-14802 decreases dorsal raphe and hippocampal release of 5-ht by interaction with somatodendritic 5-ht1a receptors in the raphe nuclei and suggest that this compound is a potential anxiolytic. |
1997-04-02 |
2023-08-12 |
rat |
| L Romero, N Bel, J M Casanovas, F Artiga. Two actions are better than one: avoiding self-inhibition of serotonergic neurones enhances the effects of serotonin uptake inhibitors. International clinical psychopharmacology. vol 11 Suppl 4. 1997-03-19. PMID:8923121. |
this effect is maximal in forebrain areas innervated by the dorsal raphe nucleus and can be prevented by the administration of non-selective [(-)pindolol, (-)tertatolol] and selective (way-100635) 5-ht1a antagonists. |
1997-03-19 |
2023-08-12 |
Not clear |
| J C Compaan, L Groenink, J van der Gugten, R A Maes, B Olivie. 5-HT1A receptor agonist flesinoxan enhances Fos immunoreactivity in rat central amygdala, bed nucleus of the stria terminalis and hypothalamus. The European journal of neuroscience. vol 8. issue 11. 1997-03-17. PMID:8950098. |
typically, 5-ht1a receptor-containing brain areas, such as the dorsal raphe nuclei, hippocampus, septum, diagonal band and the cortical and basomedial amygdala, do not show fos-ir. |
1997-03-17 |
2023-08-12 |
rat |
| b' H K Kia, M J Brisorgueil, M Hamon, A Calas, D Verg\\xc3\\xa. Ultrastructural localization of 5-hydroxytryptamine1A receptors in the rat brain. Journal of neuroscience research. vol 46. issue 6. 1997-03-17. PMID:8978504.' |
5-hydroxytryptamine1a (5-ht1a) receptors have been visualized at the electron microscopic level in selected areas (dorsal raphe nucleus, hippocampus, septum) of the rat brain using specific anti-peptide antibodies. |
1997-03-17 |
2023-08-12 |
rat |
| Y Chen, N J Peningto. Differential effects of protein kinase C activation on 5-HT1A receptor coupling to Ca2+ and K+ currents in rat serotonergic neurones. The Journal of physiology. vol 496 ( Pt 1). 1997-03-14. PMID:8910201. |
we have studied the effect of pkc activation on 5-ht1a receptor coupling of ca2+ currents and 5-ht-induced k+ current (ik,5-ht) in acutely isolated adult rat dorsal raphe neurones. |
1997-03-14 |
2023-08-12 |
rat |
| L Romero, N Bel, F Artigas, C de Montigny, P Blie. Effect of pindolol on the function of pre- and postsynaptic 5-HT1A receptors: in vivo microdialysis and electrophysiological studies in the rat brain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 15. issue 4. 1997-03-06. PMID:8887989. |
in microdialysis studies, somatodendritic 5-ht1a receptors in the dorsal raphe nucleus (drn) were activated by the local infusion of 50 microm citalopram, a selective 5-ht reuptake inhibitor (ssri). |
1997-03-06 |
2023-08-12 |
rat |
| S M Korte, O C Meijer, E R de Kloet, B Buwalda, J Keijser, F Sluyter, G van Oortmerssen, B Bohu. Enhanced 5-HT1A receptor expression in forebrain regions of aggressive house mice. Brain research. vol 736. issue 1-2. 1997-02-26. PMID:8930340. |
no difference in ligand binding was found for the 5-ht1a autoreceptor on cell bodies in the dorsal raphe nucleus. |
1997-02-26 |
2023-08-12 |
mouse |
| R G Johnson, C M Severin, R A Rabi. Serotonergic binding in the rat dorsal raphe nucleus: critical role of MAO inhibition. Journal of pharmacological and toxicological methods. vol 36. issue 2. 1997-02-13. PMID:8912226. |
the biochemical properties of the 5-ht1a receptor in dorsal raphe nucleus (drn) were investigated using a micropunch procedure. |
1997-02-13 |
2023-08-12 |
rat |
| S A Jones-Humble, M J Durcan, D Lyerly, R M Norton, F L Tang, A V Russell, M J Watson, P J Gengo, P F Morgan, C M Wang, B R Cooper, R F Co. Preclinical neurochemical and electrophysiological profile of 1192U90, a potential antipsychotic. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 15. issue 3. 1997-01-15. PMID:8873105. |
intravenous injection or iontophoretic application of 1192u90 or the 5-ht1a agonist (+/-)8-oh-dpat inhibited the firing rates of dorsal raphe nucleus (drn) neurons in rats, and the effects of both compounds were blocked by iontophoretically applied s(-) propranolol, a 5-ht1a antagonist. |
1997-01-15 |
2023-08-12 |
rat |
| L D Van de Ka. Forebrain pathways mediating stress-induced renin secretion. Clinical and experimental pharmacology & physiology. vol 23. issue 2. 1996-12-10. PMID:8819647. |
activation of serotonin1a (5ht1a) receptors with the anti-anxiety drugs buspirone and ipsapirone reduces the firing rate of serotonergic neurons in the dorsal raphe nucleus in the midbrain and decreases the effect of stress on plasma renin concentrations. |
1996-12-10 |
2023-08-12 |
rat |
| W P Paré, S M Tejani-But. Effect of stress on the behavior and 5-HT system in Sprague-Dawley and Wistar Kyoto rat strains. Integrative physiological and behavioral science : the official journal of the Pavlovian Society. vol 31. issue 2. 1996-12-06. PMID:8809595. |
stress did not appear to alter the binding of 3h-dpat to 5-ht1a sites in the dorsal raphe or median raphe in either strains. |
1996-12-06 |
2023-08-12 |
rat |