| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Ginefri-Gayet, J Gaye. Hypothermia induced by infusion of methionine sulfoximine into the dorsal raphe nucleus of the rat: involvement of 5-HT1A and GABAB receptors. European journal of pharmacology. vol 235. issue 2-3. 1993-07-13. PMID:8389714. |
hypothermia induced by infusion of methionine sulfoximine into the dorsal raphe nucleus of the rat: involvement of 5-ht1a and gabab receptors. |
1993-07-13 |
2023-08-12 |
rat |
| D Treit, A Robinson, S Rotzinger, C Pesol. Anxiolytic effects of serotonergic interventions in the shock-probe burying test and the elevated plus-maze test. Behavioural brain research. vol 54. issue 1. 1993-07-08. PMID:8504010. |
in the present experiments, serotonergic function was disrupted in rats, either by chemical depletion using the synthesis inhibitor p-cpa, by inhibitory autoreceptor activation using the selective 5-ht1a receptor ligand 8-oh-dpat, or by electrolytic lesions of the serotonin-containing, dorsal raphe nucleus. |
1993-07-08 |
2023-08-12 |
rat |
| F Radja, L Descarries, K M Dewar, T A Reade. Serotonin 5-HT1 and 5-HT2 receptors in adult rat brain after neonatal destruction of nigrostriatal dopamine neurons: a quantitative autoradiographic study. Brain research. vol 606. issue 2. 1993-06-14. PMID:8490720. |
5-ht1a binding, measured after 6 months, was unchanged in all regions examined including the dorsal raphe nucleus. |
1993-06-14 |
2023-08-12 |
rat |
| P Blier, A Lista, C De Montign. Differential properties of pre- and postsynaptic 5-hydroxytryptamine1A receptors in the dorsal raphe and hippocampus: II. Effect of pertussis and cholera toxins. The Journal of pharmacology and experimental therapeutics. vol 265. issue 1. 1993-05-18. PMID:8474003. |
the injection of 1 microgram of pertussis toxin, which inactivates gi/o proteins, in the rat dorsal raphe nearly abolished the responsiveness of serotonin (5-ht) neurons to microiontophoretic applications of 5-ht and selective 5-ht1a agonist 8-hydroxy-2-(di-n-propylamino)-tetralin (8-oh-dpat) without altering their responsiveness to of gamma-aminobutyric acid (gaba). |
1993-05-18 |
2023-08-12 |
rat |
| P Blier, A Lista, C De Montign. Differential properties of pre- and postsynaptic 5-hydroxytryptamine1A receptors in the dorsal raphe and hippocampus: I. Effect of spiperone. The Journal of pharmacology and experimental therapeutics. vol 265. issue 1. 1993-05-18. PMID:8474032. |
administration of the 5-hydroxytryptamine (5-ht)1a antagonist spiperone (1 mg/kg) antagonized the suppressant effect of microiontophoretic applications of 5-ht and of the selective 5-ht1a agonist 8-oh-dpat on the firing activity of the rat dorsal raphe 5-ht neurons. |
1993-05-18 |
2023-08-12 |
rat |
| C M Contreras, M L Marván, A Muñoz-Méndez, A Ramírez-Morale. Cortical and septal responses to dorsal raphe nucleus stimulation in the rat: long-term clomipramine actions. Boletin de estudios medicos y biologicos. vol 40. issue 1-4. 1993-04-28. PMID:1296670. |
from an electrophysiological point of view, it is concluded that the excitatory actions on firing rate elicited by dorsal raphe nucleus stimulation or clomipramine treatment are mediated by 5-ht2 receptor subtype activation which is likely to be acting as a 5-ht1a modulator in such places where both receptor subtypes coexist. |
1993-04-28 |
2023-08-11 |
rat |
| M J Millan, J M Rivet, H Canton, F Lejeune, A Gobert, P Widdowson, K Bervoets, M Brocco, J L Peglio. S 15535: a highly selective benzodioxopiperazine 5-HT1A receptor ligand which acts as an agonist and an antagonist at presynaptic and postsynaptic sites respectively. European journal of pharmacology. vol 230. issue 1. 1993-03-09. PMID:8381359. |
at presynaptic 5-ht1a receptors, s 15535 acted as an agonist in inhibiting striatal accumulation of 5-hydroxytryptophan (0.04-0.63 mg/kg s.c.) and in spiperone reversibly reducing electrical activity of the dorsal raphe nucleus (0.004-0.031 mg/kg i.v.). |
1993-03-09 |
2023-08-12 |
Not clear |
| K Yoshimoto, W J McBrid. Regulation of nucleus accumbens dopamine release by the dorsal raphe nucleus in the rat. Neurochemical research. vol 17. issue 5. 1992-10-22. PMID:1356241. |
the effects of microinfusing l-glutamate, serotonin (5-ht), (+-)-8-hydroxy-2-(di-n-propylamino) tetralin (8-oh dpat; a 5-ht1a agonist), and muscimol (a gabaa agonist) into the dorsal raphe nucleus on the extracellular levels of 5-ht, dopamine (da) and their metabolites in the nucleus accumbens were studied in unanesthetized, freely moving, adult male wistar rats, using the technique of microdialysis coupled with small-bore hplc. |
1992-10-22 |
2023-08-11 |
rat |
| K Yoshimoto, W J McBrid. Regulation of nucleus accumbens dopamine release by the dorsal raphe nucleus in the rat. Neurochemical research. vol 17. issue 5. 1992-10-22. PMID:1356241. |
the data indicate that (a) the 5-ht neurons projecting to the nucleus accumbens from the dorsal raphe nucleus can be activated by excitatory amino acid receptors and inhibited by stimulation of 5-ht1a autoreceptors, and (b) the dorsal raphe nucleus 5-ht neuronal system may regulate the ventral tegmental area da projection to the nucleus accumbens. |
1992-10-22 |
2023-08-11 |
rat |
| M C Miquel, E Doucet, M Riad, J Adrien, D Vergé, M Hamo. Effect of the selective lesion of serotoninergic neurons on the regional distribution of 5-HT1A receptor mRNA in the rat brain. Brain research. Molecular brain research. vol 14. issue 4. 1992-10-19. PMID:1326699. |
twenty one days after the treatment, the 5-ht1a receptor protein was no longer detected within the dorsal raphe nucleus but was still present in the hippocampus and entorhinal cortex. |
1992-10-19 |
2023-08-11 |
rat |
| M C Miquel, E Doucet, M Riad, J Adrien, D Vergé, M Hamo. Effect of the selective lesion of serotoninergic neurons on the regional distribution of 5-HT1A receptor mRNA in the rat brain. Brain research. Molecular brain research. vol 14. issue 4. 1992-10-19. PMID:1326699. |
quantitative in situ hybridization showed an 85% decrease in the levels of 5-ht1a receptor mrna within the dorsal raphe nucleus, but no significant change in the hippocampus, interpeduncular nucleus and entorhinal cortex of 5,7-dihydroxytryptamine-treated rats. |
1992-10-19 |
2023-08-11 |
rat |
| M C Miquel, E Doucet, M Riad, J Adrien, D Vergé, M Hamo. Effect of the selective lesion of serotoninergic neurons on the regional distribution of 5-HT1A receptor mRNA in the rat brain. Brain research. Molecular brain research. vol 14. issue 4. 1992-10-19. PMID:1326699. |
these data demonstrate that 5-ht1a receptors are synthesized by serotoninergic neurons in the dorsal raphe nucleus, and by neurons located postsynaptically with regard to serotoninergic projections in other areas. |
1992-10-19 |
2023-08-11 |
rat |
| K A Cunningham, J M Paris, N E Goeder. Chronic cocaine enhances serotonin autoregulation and serotonin uptake binding. Synapse (New York, N.Y.). vol 11. issue 2. 1992-08-10. PMID:1385662. |
the inhibitory response of single 5-ht neurons in the dorsal raphe (dr) to (-)-cocaine, the 5-ht uptake inhibitor fluoxetine or the 5-ht1a agonist 8-hydroxy-2-[di-n-propylamino]tetralin (8-ohdpat) was significantly enhanced in cocaine-treated rats. |
1992-08-10 |
2023-08-11 |
rat |
| K C Corley, V B Singh, T H Phan, M C Boadle-Bibe. Effect of gepirone on increases in tryptophan hydroxylase in response to sound stress. European journal of pharmacology. vol 213. issue 3. 1992-08-06. PMID:1377631. |
gepirone may block the sound stress-induced biochemical increases by its inhibition of serotonergic neuronal firing in the dorsal raphe nucleus that is mediated by its agonist action at the somatodendritic (5-ht1a) autoreceptors. |
1992-08-06 |
2023-08-11 |
rat |
| P Blier, C Bouchar. Effect of repeated electroconvulsive shocks on serotonergic neurons. European journal of pharmacology. vol 211. issue 3. 1992-08-06. PMID:1535597. |
these results thus indicate that repeated ecs attenuates the 8-oh-dpat-induced hypothermia in rats, as previously reported, but does not affect the firing activity of 5-ht neurons and the sensitivity of their somatodendritic 5-ht1a autoreceptors in the dorsal raphe. |
1992-08-06 |
2023-08-11 |
rat |
| J M Greuel, T Glase. The putative 5-HT1A receptor antagonists NAN-190 and BMY 7378 are partial agonists in the rat dorsal raphe nucleus in vitro. European journal of pharmacology. vol 211. issue 2. 1992-07-28. PMID:1535319. |
the putative 5-ht1a receptor antagonists nan-190 and bmy 7378 are partial agonists in the rat dorsal raphe nucleus in vitro. |
1992-07-28 |
2023-08-11 |
rat |
| J M Greuel, T Glase. The putative 5-HT1A receptor antagonists NAN-190 and BMY 7378 are partial agonists in the rat dorsal raphe nucleus in vitro. European journal of pharmacology. vol 211. issue 2. 1992-07-28. PMID:1535319. |
the present electrophysiological study examined the actions of the putative 5-ht1a receptor antagonists nan-190 (1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl]piperazine) and bmy 7378 (8-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4,5]- decane-7,9-dione dihydrochloride) in the rat dorsal raphe nucleus in vitro. |
1992-07-28 |
2023-08-11 |
rat |
| M A Critchley, K Njung'e, S L Handle. Actions and some interactions of 5-HT1A ligands in the elevated X-maze and effects of dorsal raphe lesions. Psychopharmacology. vol 106. issue 4. 1992-06-10. PMID:1533721. |
actions and some interactions of 5-ht1a ligands in the elevated x-maze and effects of dorsal raphe lesions. |
1992-06-10 |
2023-08-11 |
Not clear |
| G A Higgins, B J Jones, N R Oakle. Effect of 5-HT1A receptor agonists in two models of anxiety after dorsal raphe injection. Psychopharmacology. vol 106. issue 2. 1992-04-22. PMID:1347954. |
effect of 5-ht1a receptor agonists in two models of anxiety after dorsal raphe injection. |
1992-04-22 |
2023-08-11 |
rat |
| G A Higgins, B J Jones, N R Oakle. Effect of 5-HT1A receptor agonists in two models of anxiety after dorsal raphe injection. Psychopharmacology. vol 106. issue 2. 1992-04-22. PMID:1347954. |
firstly, to present a more comprehensive analysis of the disinhibitory effects of 5-ht1a receptor agonists after discrete dorsal raphe (drn) injections (higgins et al. |
1992-04-22 |
2023-08-11 |
rat |