| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' F Radja, G Daval, M Hamon, D Verg\\xc3\\xa. Pharmacological and physicochemical properties of pre-versus postsynaptic 5-hydroxytryptamine1A receptor binding sites in the rat brain: a quantitative autoradiographic study. Journal of neurochemistry. vol 58. issue 4. 1992-04-17. PMID:1548468.' |
the potencies of 5'-guanylylimidodiphosphate to inhibit the specific binding of 125i-bolton-hunter-8-methoxy-2-(n-propyl-n-propylamino)tetralin (125i-bh-8-meo-n-pat) to 5-ht1a sites and of n-ethylmaleimide to block these sites irreversibly were identical in the dorsal raphe nucleus and the hippocampal areas in rat brain sections. |
1992-04-17 |
2023-08-11 |
rat |
| b' F Radja, G Daval, M Hamon, D Verg\\xc3\\xa. Pharmacological and physicochemical properties of pre-versus postsynaptic 5-hydroxytryptamine1A receptor binding sites in the rat brain: a quantitative autoradiographic study. Journal of neurochemistry. vol 58. issue 4. 1992-04-17. PMID:1548468.' |
however, in most cases, the observed variations were of greater amplitude between the ca1 area and the dentate gyrus, where 5-ht1a sites are located postsynaptically, than between any one of these areas and the dorsal raphe nucleus where they act as (presynaptic) somatodendritic autoreceptors. |
1992-04-17 |
2023-08-11 |
rat |
| J S Sprous. Inhibition of dorsal raphe cell firing by MDL 73005EF, a novel 5-HT1A receptor ligand. European journal of pharmacology. vol 201. issue 2-3. 1992-04-16. PMID:1839146. |
inhibition of dorsal raphe cell firing by mdl 73005ef, a novel 5-ht1a receptor ligand. |
1992-04-16 |
2023-08-11 |
rat |
| J S Sprous. Inhibition of dorsal raphe cell firing by MDL 73005EF, a novel 5-HT1A receptor ligand. European journal of pharmacology. vol 201. issue 2-3. 1992-04-16. PMID:1839146. |
the effect of a novel ligand for the 5-ht1a receptor subtype, mdl 73005ef, on the firing rate of serotonergic dorsal raphe neurons was assessed in rat midbrain slices maintained in vitro. |
1992-04-16 |
2023-08-11 |
rat |
| J S Sprous. Inhibition of dorsal raphe cell firing by MDL 73005EF, a novel 5-HT1A receptor ligand. European journal of pharmacology. vol 201. issue 2-3. 1992-04-16. PMID:1839146. |
taken together, these data suggest that mdl 73005ef is an agonist at the somatodendritic autoreceptor on dorsal raphe neurons, a 5-ht1a receptor which regulates in part the pacemaker activity of these cells. |
1992-04-16 |
2023-08-11 |
rat |
| J C Garratt, E J Kidd, I K Wright, C A Marsde. Inhibition of 5-hydroxytryptamine neuronal activity by the 5-HT agonist, DOI. European journal of pharmacology. vol 199. issue 3. 1991-11-15. PMID:1915582. |
the reduction of the firing rate of 5-ht neurons in the dorsal raphe and extracellular 5-ht concentration in the frontal cortex induced by systemic administration of doi could not be blocked by the 5-ht2 antagonist ketanserin, ritanserin (5-ht2/5-ht1c antagonist) or the putative 5-ht1a antagonist, pindolol. |
1991-11-15 |
2023-08-11 |
Not clear |
| H Tanaka, H Shimizu, Y Kumasaka, A Hirose, T Tatsuno, M Nakamur. Autoradiographic localization and pharmacological characterization of [3H]tandospirone binding sites in the rat brain. Brain research. vol 546. issue 2. 1991-08-22. PMID:1648988. |
in addition, there was no significant difference in the dissociation constant of [3h]tandospirone binding between the dentate gyrus, ca1 area, dorsal raphe nucleus, lateral septum and entorhinal cortex (about 10 nm) suggesting that [3h]tandospirone binds to 5-ht1a receptors with same affinities in these brain structures. |
1991-08-22 |
2023-08-11 |
rat |
| G A Higgins, P J Elliot. Differential behavioural activation following intra-raphe infusion of 5-HT1A receptor agonists. European journal of pharmacology. vol 193. issue 3. 1991-07-31. PMID:1675996. |
microinfusion of the selective 5-ht1a receptor agonist, 8-hydroxy-(di-n-propylamino)tetralin (8-ohdpat), into the dorsal raphe nucleus (drn) produced a marked behavioural hypoactivity and flat body posture. |
1991-07-31 |
2023-08-11 |
rat |
| S Hjorth, T Shar. Effect of the 5-HT1A receptor agonist 8-OH-DPAT on the release of 5-HT in dorsal and median raphe-innervated rat brain regions as measured by in vivo microdialysis. Life sciences. vol 48. issue 18. 1991-05-30. PMID:1826937. |
recent electrophysiological studies, measurements of 5-ht synthesis and in vivo voltammetry recordings of 5-ht metabolism have suggested that serotoninergic neurones in the median raphe (mr) are less sensitive to 5-ht1a autoreceptor stimulation relative to those in the dorsal raphe (dr). |
1991-05-30 |
2023-08-11 |
rat |
| L E Schechter, F J Bolaños, H Gozlan, L Lanfumey, S Haj-Dahmane, A M Laporte, C M Fattaccini, M Hamo. Alterations of central serotoninergic and dopaminergic neurotransmission in rats chronically treated with ipsapirone: biochemical and electrophysiological studies. The Journal of pharmacology and experimental therapeutics. vol 255. issue 3. 1991-02-07. PMID:1702155. |
for 14 days did not alter the characteristics of 5-ht1a sites in the hippocampus, septum and dorsal raphe nucleus. |
1991-02-07 |
2023-08-11 |
rat |
| T Sharp, S Hjort. Application of brain microdialysis to study the pharmacology of the 5-HT1A autoreceptor. Journal of neuroscience methods. vol 34. issue 1-3. 1991-01-31. PMID:2259248. |
we have observed that a range of 5-ht1a agonists, including 8-hydroxy-2-(di-n-propylamino) tetralin (8-oh-dpat), inhibit 5-ht release in hippocampus, most probably by acting on somatodendritic 5-ht1a autoreceptors in the dorsal raphe nucleus. |
1991-01-31 |
2023-08-11 |
rat |
| H E Connor, G A Higgin. Cardiovascular effects of 5-HT1A receptor agonists injected into the dorsal raphe nucleus of conscious rats. European journal of pharmacology. vol 182. issue 1. 1990-10-19. PMID:2144824. |
cardiovascular effects of 5-ht1a receptor agonists injected into the dorsal raphe nucleus of conscious rats. |
1990-10-19 |
2023-08-11 |
rat |
| H E Connor, G A Higgin. Cardiovascular effects of 5-HT1A receptor agonists injected into the dorsal raphe nucleus of conscious rats. European journal of pharmacology. vol 182. issue 1. 1990-10-19. PMID:2144824. |
the aim of this study was to investigate the cardiovascular effects of the 5-ht1a receptor agonists, 8-oh-dpat (8-hydroxy-2-(di-n-propylamino)tetralin), flesinoxan and 5-carboxamidotryptamine (5-ct) following injection into the dorsal raphe nucleus of conscious rats. |
1990-10-19 |
2023-08-11 |
rat |
| H E Connor, G A Higgin. Cardiovascular effects of 5-HT1A receptor agonists injected into the dorsal raphe nucleus of conscious rats. European journal of pharmacology. vol 182. issue 1. 1990-10-19. PMID:2144824. |
the results suggest that 8-oh-dpat activates 5-ht1a receptors in the dorsal raphe nucleus to cause hypotension and bradycardia. |
1990-10-19 |
2023-08-11 |
rat |
| P Blier, C de Montign. Differential effect of gepirone on presynaptic and postsynaptic serotonin receptors: single-cell recording studies. Journal of clinical psychopharmacology. vol 10. issue 3 Suppl. 1990-09-05. PMID:1973935. |
the sustained administration of the serotonin (5-hydroxytryptamine1a, 5-ht1a) agonist gepirone (15 mg/kg/day subcutaneously) in the rat produced an initial decrease of the firing activity of dorsal raphe 5-ht neurons, which was followed by a progressive recovery to normal after 14 days of treatment. |
1990-09-05 |
2023-08-11 |
rat |
| P Blier, C de Montign. Differential effect of gepirone on presynaptic and postsynaptic serotonin receptors: single-cell recording studies. Journal of clinical psychopharmacology. vol 10. issue 3 Suppl. 1990-09-05. PMID:1973935. |
the concurrent microiontophoretic application of gepirone readily blocked the effect of 5-ht on dorsal hippocampus pyramidal neurons, but not on dorsal raphe 5-ht neurons, thus indicating that gepirone is a partial agonist at postsynaptic 5-ht1a receptors and a full agonist at somatodendritic 5-ht1a receptors. |
1990-09-05 |
2023-08-11 |
rat |
| F D Yocc. Neurochemistry and neurophysiology of buspirone and gepirone: interactions at presynaptic and postsynaptic 5-HT1A receptors. Journal of clinical psychopharmacology. vol 10. issue 3 Suppl. 1990-09-05. PMID:1973941. |
preclinical neurochemical studies indicate that buspirone and gepirone bind selectively to presynaptic (dorsal raphe) and postsynaptic (hippocampus, cortex) 5-hydroxytryptamine1a (5-ht1a) receptor binding sites. |
1990-09-05 |
2023-08-11 |
Not clear |
| F D Yocc. Neurochemistry and neurophysiology of buspirone and gepirone: interactions at presynaptic and postsynaptic 5-HT1A receptors. Journal of clinical psychopharmacology. vol 10. issue 3 Suppl. 1990-09-05. PMID:1973941. |
through their action at presynaptic 5-ht1a receptors, these agents have been shown to dose-dependently inhibit cortical and hippocampal 5-ht synthesis while inhibiting the firing of 5-ht--containing dorsal raphe neurons, both in vitro and in vivo. |
1990-09-05 |
2023-08-11 |
Not clear |
| A Hirose, M Sasa, A Akaike, S Takaor. Inhibition of hippocampal CA1 neurons by 5-hydroxytryptamine, derived from the dorsal raphe nucleus and the 5-hydroxytryptamine1A agonist SM-3997. Neuropharmacology. vol 29. issue 2. 1990-05-30. PMID:1970426. |
in the short-latency neurons, the stimulation-induced spikes of the medial septal nucleus were inhibited by conditioning stimuli applied to the dorsal raphe nucleus and iontophoretic application of 5-ht and the 5-ht1a agonists, sm-3997 (3 a alpha,4 beta,7 beta,7a alpha-hexahydro-2-(4-(4-(2-pyrimidinyl)-1- piperazinyl)-butyl)-4,7-methano-1h-isoindole-1,3(2h)-dione dihydrogen citrate) and 8-oh-dpat (8-hydroxy-2-(di-n-propylamino)tetralin). |
1990-05-30 |
2023-08-11 |
rat |
| P Blier, A Serrano, B Scatto. Differential responsiveness of the rat dorsal and median raphe 5-HT systems to 5-HT1 receptor agonists and p-chloroamphetamine. Synapse (New York, N.Y.). vol 5. issue 2. 1990-04-09. PMID:2137943. |
the selective 5-ht1a agonist 8-oh-dpat produced a gradual decrease in the height of the 300 mv oxidation peak in the dorsal raphe and in the frontal cortex, reaching a maximum of 60% 3 h after the i.v. |
1990-04-09 |
2023-08-11 |
rat |