| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michael Sams, Rene Silye, Janett Göhring, Leila Muresan, Kurt Schilcher, Jaroslaw Jaca. Spatial cluster analysis of nanoscopically mapped serotonin receptors for classification of fixed brain tissue. Journal of biomedical optics. vol 19. issue 1. 2014-01-13. PMID:24297043. |
the localization microscopy allows nanoscopic mapping of serotonin 5-ht1a receptor groups within a two-dimensional image of a brain tissue slice. |
2014-01-13 |
2023-08-12 |
human |
| G Quesseveur, D J David, M C Gaillard, P Pla, M V Wu, H T Nguyen, V Nicolas, G Auregan, I David, A Dranovsky, P Hantraye, R Hen, A M Gardier, N Déglon, B P Guiar. BDNF overexpression in mouse hippocampal astrocytes promotes local neurogenesis and elicits anxiolytic-like activities. Translational psychiatry. vol 3. 2013-12-23. PMID:23632457. |
moreover, overexpressing bdnf revealed the anxiolytic-like activity of fluoxetine in the elevated plus maze while attenuating 5-ht neurotransmission in response to a blunted downregulation of the 5-ht1a autoreceptor. |
2013-12-23 |
2023-08-12 |
mouse |
| Cynthia L Bethea, Kenny Phu, Arubala P Reddy, Judy L Camero. The effect of short-term stress on serotonin gene expression in high and low resilient macaques. Progress in neuro-psychopharmacology & biological psychiatry. vol 44. 2013-12-18. PMID:23357537. |
tryptophan hydroxylase 2 (tph2), the serotonin reuptake transporter (sert), and the 5ht1a autoreceptor mrnas expression were determined at 4 morphological levels of the dorsal raphe nucleus with in situ hybridization (ish) using digoxigenin-incorporated riboprobes. |
2013-12-18 |
2023-08-12 |
monkey |
| Caroline Porto Leite Teixeira, Carla Thiciane Vasconcelos de Melo, Fernando Luiz Oliveira de Araújo, Allyne Mara Rodrigues de Carvalho, Maria Izabel Gomes Silva, José Maria Barbosa-Filho, Danielle Silveira Macêdo, Glauce Socorro de Barros Viana, Francisca Cléa Florenço de Sous. Antidepressant-like effect of riparin II from Aniba riparia in mice: evidence for the involvement of the monoaminergic system. Fundamental & clinical pharmacology. vol 27. issue 2. 2013-12-03. PMID:21854446. |
the pretreatment of mice with prazosin (1 mg/kg, i.p., an α1-adrenoceptor antagonist), sch23390 (15 μg/kg, i.p., a dopamine d1 receptor antagonist), sulpiride (50 mg/kg, i.p., a dopamine d2 receptor antagonist), p-chlorophenylalanine (100 mg/kg, an inhibitor of serotonin synthesis), or nan-190 (0.5 mg/kg, a serotonin 5-ht1a receptor antagonist) completely blocked the anti-immobility effects elicited by riparin ii (50 mg/kg, p.o.) |
2013-12-03 |
2023-08-12 |
mouse |
| Omer Ates, Nevin Karakus, Saime Sezer, Nihan Bozkur. Genetic association of 5-HT1A and 5-HT1B gene polymorphisms with migraine in a Turkish population. Journal of the neurological sciences. vol 326. issue 1-2. 2013-12-03. PMID:23375453. |
the present study was designed to explore the associations of polymorphisms of 5-hydroxytryptamine (serotonin) receptor 1a (5-ht1a) and 5-hydroxytryptamine receptor 1b (5-ht1b) genes in turkish migraine patients. |
2013-12-03 |
2023-08-12 |
human |
| Andrea Cappelli, Monica Manini, Salvatore Valenti, Federica Castriconi, Germano Giuliani, Maurizio Anzini, Simone Brogi, Stefania Butini, Sandra Gemma, Giuseppe Campiani, Gianluca Giorgi, Laura Mennuni, Marco Lanza, Antonio Giordani, Gianfranco Caselli, Ornella Letari, Francesco Makove. Synthesis and structure-activity relationship studies in serotonin 5-HT(1A) receptor agonists based on fused pyrrolidone scaffolds. European journal of medicinal chemistry. vol 63. 2013-11-27. PMID:23466604. |
a new class of serotonin 5-ht1a receptor ligands related to nan-190, buspirone and aripiprazole has been designed using our potent 5-ht3 receptor ligands as templates. |
2013-11-27 |
2023-08-12 |
Not clear |
| Martyna Z Wróbel, Andrzej Chodkowski, Franciszek Herold, Anna Gomółka, Jerzy Kleps, Aleksander P Mazurek, Franciszek Pluciński, Andrzej Mazurek, Gabriel Nowak, Agata Siwek, Katarzyna Stachowicz, Anna Sławińska, Małgorzata Wolak, Bernadeta Szewczyk, Grzegorz Satała, Andrzej J Bojarski, Jadwiga Turł. Synthesis and biological evaluation of novel pyrrolidine-2,5-dione derivatives as potential antidepressant agents. Part 1. European journal of medicinal chemistry. vol 63. 2013-11-27. PMID:23524160. |
all tested compounds proved to be potent 5-ht1a receptor and serotonin transporter protein (sert) ligands. |
2013-11-27 |
2023-08-12 |
Not clear |
| Clara Naimi-Akbar, Markus Ritter, Sasika Demel, Husameldin El-Nour, Mari-Anne Hedblad, Efrain C Azmitia, Klas Nordlin. Different serotonergic expression in nevomelanocytic tumors. Cancers. vol 2. issue 2. 2013-11-27. PMID:24281111. |
for this purpose, paraffin-embedded biopsies of superficial spreading malignant melanoma (ssm), dysplastic compound nevi (dn) and benign compound nevi (bcn) were characterized with regard to their expression of 5-ht, the 5-ht1a and 5-ht2a receptors, and the serotonin transporter protein (sert), by immunohistochemical analysis. |
2013-11-27 |
2023-08-12 |
Not clear |
| Alvaro L García-García, Elisabet Venzala, Natalia Elizalde, M J Ramírez, Ahinoa Urbiola, Joaquin Del Rio, Laurence Lanfumey, Rosa M Torder. Regulation of serotonin (5-HT) function by a VGLUT1 dependent glutamate pathway. Neuropharmacology. vol 70. 2013-11-26. PMID:23168115. |
in addition to the inhibitory 5-ht1a autoreceptors, cortico-raphe glutamatergic descending pathways are suggested to modulate 5-ht activity in the drn. |
2013-11-26 |
2023-08-12 |
mouse |
| Judith R Homber. Serotonergic modulation of conditioned fear. Scientifica. vol 2012. 2013-11-26. PMID:24278743. |
the human and rodent studies i review here together reveal, amongst others, that acute selective serotonin reuptake inhibitor (ssri) treatment facilitates fear conditioning, reduces contextual fear, and increases cued fear, chronic ssri treatment reduces both contextual and cued fear, 5-ht1a receptors inhibit the acquisition and expression of contextual fear, 5-ht2a receptors facilitates the consolidation of cued and contextual fear, inactivation of 5-ht2c receptors facilitate the retrieval of cued fear memory, the 5-ht3 receptor mediates contextual fear, genetically induced increases in serotonin levels are associated with increased fear conditioning, impaired cued fear extinction, or impaired extinction recall, and that genetically induced 5-ht depletion increases fear conditioning and contextual fear. |
2013-11-26 |
2023-08-12 |
human |
| Cristian C Constantinescu, Evgueni Sevrioukov, Adriana Garcia, Min-Liang Pan, Jogeshwar Mukherje. Evaluation of [18F]Mefway biodistribution and dosimetry based on whole-body PET imaging of mice. Molecular imaging and biology. vol 15. issue 2. 2013-11-19. PMID:22833323. |
[(18)f]mefway is a novel radiotracer specific to the serotonin 5-ht1a receptor class. |
2013-11-19 |
2023-08-12 |
mouse |
| P Sowa, M Adamczyk-Sowa, K Zwirska-Korczala, G Namyslowski, M Misiolek, K Pierzchal. The role of serotonergic 5-HT1A receptors in central cardiovascular regulation in haemorrhagic shock in rats. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 64. issue 2. 2013-11-19. PMID:23756397. |
the aim of this study was to investigate the participation of central serotonin and, in particular, 5-ht1a receptors in cardiovascular regulation in haemorrhagic shock in rats. |
2013-11-19 |
2023-08-12 |
rat |
| Parichehr Yaghmaei, Shahrbanoo Oryan, Khadijeh Mohammadi, Jalal Solat. Role of serotonergic system on modulation of depressogenic-like effects of silymarine. Iranian journal of pharmaceutical research : IJPR. vol 11. issue 1. 2013-11-19. PMID:24250456. |
these results showed that the depressogenic effects of silymarin may be modulated via 5ht1a receptor of serotonin. |
2013-11-19 |
2023-08-12 |
rat |
| Siamak Eyhani-Rad, Alireza Mohajjel Nayebi, Javad Mahmoudi, Morteza Samini, Vahab Babapou. Role of 5-Hydroxytryptamine 1A Receptors in 6-Hydroxydopmaine-induced Catalepsy-like Immobilization in Rats: a Therapeutic Approach for Treating Catalepsy of Parkinson's Disease. Iranian journal of pharmaceutical research : IJPR. vol 11. issue 4. 2013-11-19. PMID:24250551. |
we have shown that buspirone, a partial agonist of 5-hydroxytryptamine 1a (5-ht1a) receptors, improves motor dysfunctions induced by 6-hydroxydopamine (6-ohda) and haloperidol in rats. |
2013-11-19 |
2023-08-12 |
rat |
| In-Sun Choi, Jin-Hwa Cho, Il-Sung Jan. 5-Hydroxytryptamine 1A receptors inhibit glutamate release in rat medullary dorsal horn neurons. Neuroreport. vol 24. issue 8. 2013-11-14. PMID:23629688. |
we examined 5-hydroxytryptamine 1a (5-ht1a) receptor-mediated modulation of glutamatergic transmission in rat medullary dorsal horn neurons using a conventional whole-cell patch clamp technique. |
2013-11-14 |
2023-08-12 |
rat |
| Katerina Zavitsanou, Victoria S Dalton, Adam K Walker, Cynthia S Weickert, Luba Sominsky, Deborah M Hodgso. Neonatal lipopolysaccharide treatment has long-term effects on monoaminergic and cannabinoid receptors in the rat. Synapse (New York, N.Y.). vol 67. issue 6. 2013-10-29. PMID:23389966. |
dopamine d1, d2, serotonin 5ht1a, 5ht2a, and serotonin transporter and cannabinoid cb1 receptor binding across several brain regions were measured autoradiographically in adulthood (pnd 85). |
2013-10-29 |
2023-08-12 |
rat |
| Stephen M Stahl, Clara Lee-Zimmerman, Sylvia Cartwright, Debbi Ann Morrissett. Serotonergic drugs for depression and beyond. Current drug targets. vol 14. issue 5. 2013-10-29. PMID:23531115. |
the original trend to do this selectively (e.g., with ssris or selective serotonin reuptake inhibitors) has given way to combining various additional pharmacologic mechanisms with sert inhibition, including dual actions by single drugs (e.g., snris or serotonin norepinephrine reuptake inhibitors), or by augmenting ssris with a second drug of a different mechanism (e.g., bupropion with dopamine and norepinephrine reuptake inhibition; trazodone with 5ht2a antagonism; mirtazapine with 5ht2a/5ht2c/5ht3/alpha2 antagonism; buspirone or some atypical antipsychotics with 5ht1a partial agonism; other atypical antipsychotics with 5ht2c/5ht7 antagonism and other mechanisms). |
2013-10-29 |
2023-08-12 |
Not clear |
| Susan Schenk, Blaine Abraham, Dane Aronsen, Joyce Colussi-Mas, Jennifer D. Effects of repeated exposure to MDMA on 5HT1a autoreceptor function: behavioral and neurochemical responses to 8-OHDPAT. Psychopharmacology. vol 227. issue 2. 2013-10-28. PMID:23354536. |
the data suggest that the decrease in tissue levels of 5-ht produced by mdma is accompanied by a decrease in tryptophan hydroxylase activity but cannot be explained by supersensitivity of the 5-ht1a autoreceptor. |
2013-10-28 |
2023-08-12 |
Not clear |
| Takeshi Murai, Tomokazu Nakako, Masaru Ikejiri, Takeo Ishiyama, Mutsuo Taiji, Kazuhito Iked. Effects of lurasidone on executive function in common marmosets. Behavioural brain research. vol 246. 2013-10-28. PMID:23454675. |
lurasidone, a novel atypical antipsychotic agent with high binding affinity for dopamine d2, serotonin 5-ht7, 5-ht2a and 5-ht1a receptors has been reported to have superior efficacy in rodents' models of cognitive impairment. |
2013-10-28 |
2023-08-12 |
Not clear |
| Arne Mørk, Liliana P Montezinho, Silke Miller, Crista Trippodi-Murphy, Niels Plath, Yan Li, Maria Gulinello, Connie Sanche. Vortioxetine (Lu AA21004), a novel multimodal antidepressant, enhances memory in rats. Pharmacology, biochemistry, and behavior. vol 105. 2013-10-23. PMID:23380522. |
vortioxetine (lu aa21004) in development as a novel multimodal antidepressant is a 5-ht3, 5-ht7 and 5-ht1d receptor antagonist, a 5-ht1b receptor partial agonist, a 5-ht1a receptor agonist and a 5-ht transporter (5-htt) inhibitor in vitro. |
2013-10-23 |
2023-08-12 |
rat |