| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jessica J Walsh, Pierre Llorach, Daniel F Cardozo Pinto, Wendy Wenderski, Daniel J Christoffel, Juliana S Salgado, Boris D Heifets, Gerald R Crabtree, Robert C Malenk. Systemic enhancement of serotonin signaling reverses social deficits in multiple mouse models for ASD. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 11. 2021-09-16. PMID:34239048. |
these preclinical findings suggest that pharmacological enhancement of 5-ht release or direct 5-ht1b receptor activation may be therapeutically efficacious in ameliorating some of the core sociability deficits present across etiologically distinct presentations of asd. |
2021-09-16 |
2023-08-13 |
mouse |
| Daniela Adamo, Elena Calabria, Noemi Coppola, Giuseppe Pecoraro, Michele Davide Mignogn. Vortioxetine as a new frontier in the treatment of chronic neuropathic pain: a review and update. Therapeutic advances in psychopharmacology. vol 11. 2021-09-10. PMID:34497709. |
this drug inhibits the serotonin transporter with a high affinity, antagonises the 5-ht3, 5-ht1d and 5ht7 serotonin receptors, and activates the 5-ht1a and 5-ht1b receptors. |
2021-09-10 |
2023-08-13 |
Not clear |
| Anoosha Attaran, Arash Salahinejad, Mohammad Naderi, Adam L Crane, Douglas P Chivers, Som Niyog. Transgenerational effects of selenomethionine on behaviour, social cognition, and the expression of genes in the serotonergic pathway in zebrafish. Environmental pollution (Barking, Essex : 1987). vol 286. 2021-08-25. PMID:33971468. |
maternal exposure to high levels of se-met also led to dysregulation of the serotonergic system via changes in mrna expression of serotonin receptors, including the 5-ht1a, 5-ht1b, and 5-ht1d subtypes, the serotonin transporter, and monoamine oxidase (mao). |
2021-08-25 |
2023-08-13 |
human |
| Fatemeh Gharishvandi, Alireza Abdollahi, Hamed Shafaroodi, Razieh Mohammad Jafari, Parvin Pasalar, Ahmad Reza Dehpou. Involvement of 5-HT1B/1D receptors in the inflammatory response and oxidative stress in intestinal ischemia/reperfusion in rats. European journal of pharmacology. vol 882. 2021-05-13. PMID:32574671. |
5-hydroxytryptamine 1b (5-ht1b) and 5-ht1d receptors have anti-inflammatory and neuroprotective effects in different experimental studies. |
2021-05-13 |
2023-08-13 |
rat |
| Xi Xia, Mei Ding, Jin-Feng Xuan, Jia-Xin Xing, Hao Pang, Jun Yao, Xue Wu, Bao-Jie Wan. Effects of HTR1B 3' region polymorphisms and functional regions on gene expression regulation. BMC genetics. vol 21. issue 1. 2021-03-29. PMID:32689951. |
the htr1b gene encodes the 5-hydroxytryptamine (5-ht1b) receptor, which is involved in a variety of brain activities and mental disorders. |
2021-03-29 |
2023-08-13 |
Not clear |
| Silvia Vicenzi, Lisa Foa, Robert J Gasperin. Serotonin functions as a bidirectional guidance molecule regulating growth cone motility. Cellular and molecular life sciences : CMLS. vol 78. issue 5. 2021-03-29. PMID:32939562. |
extracellular gradients of 50 µm serotonin elicited attraction, mediated by the serotonin 5-ht2a receptor while 100 µm serotonin elicited repulsion mediated by the 5-ht1b receptor. |
2021-03-29 |
2023-08-13 |
Not clear |
| Craig K Docherty, Nina Denver, Simon Fisher, Margaret Nilsen, Dianne Hillyard, Rebecca L Openshaw, Hicham Labazi, Margaret R MacLea. Direct Delivery of MicroRNA96 to the Lungs Reduces Progression of Sugen/Hypoxia-Induced Pulmonary Hypertension in the Rat. Molecular therapy. Nucleic acids. vol 22. 2021-03-04. PMID:33230444. |
the 5ht1b receptor (5ht1br) contributes to the pathogenic effects of serotonin in pulmonary arterial hypertension. |
2021-03-04 |
2023-08-13 |
rat |
| Hager Tabka, Amani Cheikh, Sonia Maatoug, Mohamed El Ayeb, Saïd Bendahhou, Rym Benkhalif. First Evidence of Kv3.1b Potassium Channel Subtype Expression during Neuronal Serotonergic 1C11 Cell Line Development. International journal of molecular sciences. vol 21. issue 19. 2021-03-01. PMID:33003279. |
serotonin dosage shows that fluoxetine at 10 nm blocks serotonin reuptake in 1c11nd but slows down its release when cells are differentiated through a decrease of 5ht1b receptors density. |
2021-03-01 |
2023-08-13 |
Not clear |
| Xi Xia, Mei Ding, Jin-Feng Xuan, Jia-Xin Xing, Jun Yao, Xue Wu, Bao-Jie Wan. Functional polymorphisms and transcriptional analysis in the 5' region of the human serotonin receptor 1B gene (HTR1B) and their associations with psychiatric disorders. BMC psychiatry. vol 20. issue 1. 2021-02-10. PMID:33036580. |
the 5-hydroxytryptamine 1b receptor (5-ht1b) plays an essential role in the serotonin (5-ht) system and is widely involved in a variety of brain activities. |
2021-02-10 |
2023-08-13 |
human |
| Fernando E Padovan-Neto, Santanna Patterson, Nivea M F Voelkner, Feras Altwal, Joel A Beverley, Anthony R West, Heinz Steine. Selective Regulation of 5-HT1B Serotonin Receptor Expression in the Striatum by Dopamine Depletion and Repeated L-DOPA Treatment: Relationship to L-DOPA-Induced Dyskinesias. Molecular neurobiology. vol 57. issue 2. 2020-11-05. PMID:31468338. |
these interactions include 5-ht receptor-mediated facilitation of dopamine receptor-induced gene regulation in striatal output pathways, which involves the 5-ht1b receptor and others. |
2020-11-05 |
2023-08-13 |
Not clear |
| Fernando E Padovan-Neto, Santanna Patterson, Nivea M F Voelkner, Feras Altwal, Joel A Beverley, Anthony R West, Heinz Steine. Selective Regulation of 5-HT1B Serotonin Receptor Expression in the Striatum by Dopamine Depletion and Repeated L-DOPA Treatment: Relationship to L-DOPA-Induced Dyskinesias. Molecular neurobiology. vol 57. issue 2. 2020-11-05. PMID:31468338. |
to further investigate the effects of dopamine and agonists on 5-ht receptors, we assessed the expression of 5-ht1b and other serotonin receptor subtypes in the striatum after unilateral dopamine depletion by 6-ohda and subsequent treatment with l-dopa (5 mg/kg; 4 weeks). |
2020-11-05 |
2023-08-13 |
Not clear |
| Meiju Zhu, Hongzhu Zhu, Xiaomin Ding, Shaosheng Liu, Yuanhua Zo. Analysis of the anti-fatigue activity of polysaccharides from Spirulina platensis: role of central 5-hydroxytryptamine mechanisms. Food & function. vol 11. issue 2. 2020-10-19. PMID:32057057. |
this study evaluated the effects of polysaccharides from spirulina platensis (psp) on endurance during treadmill exercise; levels of some biochemical indicators including hemoglobin (hb), lactic acid (la), creatine kinase (ck), and blood urea nitrogen (bun); concentrations of 5-hydroxytryptamine (5-ht); and expressions of second isoforms of tryptophan hydroxylase (tph2) and serotonergic type 1b inhibitory autoreceptor (5-ht1b) in the caudate putamen of exercising rats. |
2020-10-19 |
2023-08-13 |
rat |
| Meiju Zhu, Hongzhu Zhu, Xiaomin Ding, Shaosheng Liu, Yuanhua Zo. Analysis of the anti-fatigue activity of polysaccharides from Spirulina platensis: role of central 5-hydroxytryptamine mechanisms. Food & function. vol 11. issue 2. 2020-10-19. PMID:32057057. |
the results demonstrated that psp prolonged the time to exhaustion during the treadmill exercise; increased hb levels; decreased la, bun, and ck levels in the blood; suppressed the exercise-induced increase of 5-ht concentrations and tph2 expression; and prevented the exercise-induced decrease of 5-ht1b expression in the caudate putamen. |
2020-10-19 |
2023-08-13 |
rat |
| Meiju Zhu, Hongzhu Zhu, Xiaomin Ding, Shaosheng Liu, Yuanhua Zo. Analysis of the anti-fatigue activity of polysaccharides from Spirulina platensis: role of central 5-hydroxytryptamine mechanisms. Food & function. vol 11. issue 2. 2020-10-19. PMID:32057057. |
these results suggest that the mechanism of promotion of physical performance by psp might be related to increase in hb levels; decrease in la, bun, and ck levels in the blood; inhibition of the exercise-induced 5-ht and tph2 expressions; and the increase in the 5-ht1b expression in the caudate putamen of exercised rats. |
2020-10-19 |
2023-08-13 |
rat |
| Jane Khalife, Clinton G Lauritsen, John Liang, Syed O Sha. DHE-Induced Peripheral Arterial Vasospasm in Primary Raynaud Phenomenon: Case Report. The Neurohospitalist. vol 9. issue 2. 2020-10-01. PMID:30915191. |
dihydroergotamine (dhe) is primarily a serotonin 5ht1b and 5ht1d receptor agonist used for acute migraine treatment. |
2020-10-01 |
2023-08-13 |
Not clear |
| Margaret Mandy R MacLea. The serotonin hypothesis in pulmonary hypertension revisited: targets for novel therapies (2017 Grover Conference Series). Pulmonary circulation. vol 8. issue 2. 2020-09-30. PMID:29468941. |
pulmonary endothelial serotonin synthesis via tryptophan hydroxlase 1 (tph1) is increased in patients with pah and serotonin can act in a paracrine fashion on underlying pulmonary arterial smooth muscle cells (pasmcs), in humans, serotonin can enter pasmcs via the serotonin transporter (sert) or activate the 5-ht1b receptor; 5-ht1b activation and sert activity cooperate to induce pasmc contraction and proliferation via activation of downstream proliferative and contractile signaling pathways. |
2020-09-30 |
2023-08-13 |
Not clear |
| Chunyuan Li, Yi Ma, Fei Fei, Minying Zheng, Zugui Li, Qi Zhao, Jiaxing Du, Kai Liu, Rui Lu, Shiwu Zhan. Critical role and its underlying molecular events of the plasminogen receptor, S100A10 in malignant tumor and non-tumor diseases. Journal of Cancer. vol 11. issue 4. 2020-09-30. PMID:31949486. |
in non-tumor diseases, the distribution of s100a10 in the brain and its interaction with 5-hydroxytryptamine 1b (5-ht1b) receptor, an important mediator in the central nervous system that maintains a dynamic balance of the neurotransmitters, correlates with depression-like behavior. |
2020-09-30 |
2023-08-13 |
Not clear |
| Dubravka Svob Strac, Gordana Nedic Erjavec, Matea Nikolac Perkovic, Korona Nenadic-Sviglin, Marcela Konjevod, Mirko Grubor, Nela Piva. The association between Neuropsychiatric disease and treatment. vol 15. 2020-09-29. PMID:30774345. |
serotonergic changes have been associated with alcoholism, while serotonin receptors type 1b (5-ht1b) play an important role in regulating serotonergic neurotransmission. |
2020-09-29 |
2023-08-13 |
Not clear |
| Minxuan Cai, Liangliang Zhou, Jun Liao, Qiaoling Huang, Zhenjiang Xia, Jing Shan. IFN-γ inhibits 5-HT-induced melanin biosynthesis via downregulation of 5-HT receptors in vivo/in vitro. Journal of pharmacological sciences. vol 141. issue 1. 2020-03-11. PMID:31519333. |
in addition, we found that ifn-γ decreased serum serotonin levels as well as the cutaneous expression of tryptophan hydroxylase 1 (tph1), 5-ht1a receptor (5-ht1ar) and 5-ht1b receptor (5-ht1br) in c57bl/6 mice. |
2020-03-11 |
2023-08-13 |
mouse |
| Jiqiang Guo, Huaxia Ding, Zhuangwei Lv, Junna Jiao, Hui Wang, Yanhong J. Down-regulation effects of IFN-α on p11, 5-htr1b and 5-HTR4 protein levels were affected by NH Journal of biosciences. vol 44. issue 4. 2020-01-30. PMID:31502579. |
down-regulation effects of ifn-α on p11, 5-htr1b and 5-htr4 protein levels were affected by nh in previous studies, we found interferon-α (ifn-α) could reduce protein levels of p11, 5-hydroxytryptamine receptor 1b (5-ht1b) and 5-hydroxytryptamine receptor 4 (5-ht4), but does not influence their messenger rna levels in sh-sy5y cells. |
2020-01-30 |
2023-08-13 |
Not clear |