| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sarah K Lawson, Andrew C Gray, Nancy S Woehrl. Effects of oxytocin on serotonin 1B agonist-induced autism-like behavior in mice. Behavioural brain research. vol 314. 2018-01-18. PMID:27439030. |
recently, serotonin 1b receptor (5-ht1b) agonist challenge in mice was shown to induce autism-like behaviors including perseveration, reduced prepulse inhibition, and delayed alternation deficits. |
2018-01-18 |
2023-08-13 |
mouse |
| Marc Fakhour. Revisiting the Serotonin Hypothesis: Implications for Major Depressive Disorders. Molecular neurobiology. vol 53. issue 5. 2017-12-22. PMID:25823514. |
the overarching goal of this review is to present recent findings from studies examining the serotonergic pathway in mdd, with a focus on sert and the serotonin 1a (5-ht1a), serotonin 1b (5-ht1b), and serotonin 2a (5-ht2a) receptors. |
2017-12-22 |
2023-08-13 |
mouse |
| Panayotis K Thanos, Lauren Malave, Foteini Delis, Paul Mangine, Katie Kane, Adam Grunseich, Melissa Vitale, Paul Greengard, Nora D Volko. Knockout of p11 attenuates the acquisition and reinstatement of cocaine conditioned place preference in male but not in female mice. Synapse (New York, N.Y.). vol 70. issue 7. 2017-12-22. PMID:26990537. |
here we examined the role of the protein p11, which recruits serotonin 5ht1b and 5ht4 receptors to the cell surface, in cocaine reward. |
2017-12-22 |
2023-08-13 |
mouse |
| Takuma Nishijo, Toshihiko Momiyam. Serotonin 5-HT1B receptor-mediated calcium influx-independent presynaptic inhibition of GABA release onto rat basal forebrain cholinergic neurons. The European journal of neuroscience. vol 44. issue 1. 2017-12-22. PMID:27177433. |
serotonin 5-ht1b receptor-mediated calcium influx-independent presynaptic inhibition of gaba release onto rat basal forebrain cholinergic neurons. |
2017-12-22 |
2023-08-13 |
rat |
| Celia Kjaerby, Jegath Athilingam, Sarah E Robinson, Jillian Iafrati, Vikaas S Soha. Serotonin 1B Receptors Regulate Prefrontal Function by Gating Callosal and Hippocampal Inputs. Cell reports. vol 17. issue 11. 2017-11-28. PMID:27974203. |
here, we use a combination of optogenetics and synaptic physiology to show that serotonin acts presynaptically via 5-ht1b receptors to selectively suppress inputs from the contralateral mpfc and ventral hippocampus (vhpc), while sparing those from mediodorsal thalamus. |
2017-11-28 |
2023-08-13 |
mouse |
| Andrea de Bartolomeis, Andrea Fagiolini, Giuseppe Main. [Vortioxetine in the treatment of major depression]. Rivista di psichiatria. vol 51. issue 6. 2017-11-20. PMID:27996982. |
vortioxetine is a multi-modal antidepressant that functions both as serotonin transporter (sert) inhibitor and as 5-ht3, 5-ht7 and 5-ht1d receptors antagonist, 5-ht1a receptor agonist and 5-ht1b receptor partial agonist. |
2017-11-20 |
2023-08-13 |
Not clear |
| Felix-Martin Werner, Rafael Covena. Serotonergic Drugs: Agonists/Antagonists at Specific Serotonergic Subreceptors for the Treatment of Cognitive, Depressant and Psychotic Symptoms in Alzheimer's Disease. Current pharmaceutical design. vol 22. issue 14. 2017-11-16. PMID:26818863. |
in post-mortem studies, serotonin levels and the number of specific serotonergic subreceptors, for example 5-ht1b receptors, decreased. |
2017-11-16 |
2023-08-13 |
Not clear |
| Maria Eliza Freitas, Susan H Fo. Nondopaminergic treatments for Parkinson's disease: current and future prospects. Neurodegenerative disease management. vol 6. issue 3. 2017-09-25. PMID:27230697. |
n-methyl-d-aspartate receptor antagonists and serotonin 5ht1b receptor agonists demonstrated benefit in levodopa-induced dyskinesia. |
2017-09-25 |
2023-08-13 |
Not clear |
| D J David, A M Gardie. [The pharmacological basis of the serotonin system: Application to antidepressant response]. L'Encephale. vol 42. issue 3. 2017-09-20. PMID:27112704. |
serotonin's homeostasis involves serotoninergic autoreceptor such as 5-ht1a, 5-ht1b, 5-ht1d, the enzymatic degradation of serotonin by monoamine oxidase a (mao-a), and a transporter (serotoninergic transporter [sert]). |
2017-09-20 |
2023-08-13 |
Not clear |
| D J David, A M Gardie. [The pharmacological basis of the serotonin system: Application to antidepressant response]. L'Encephale. vol 42. issue 3. 2017-09-20. PMID:27112704. |
among all the 5-ht receptors, 5-ht1a, 5-ht1b, 5-ht1d, 5-ht2b and 5-ht4 receptors activation would mediate antidepressant effects. |
2017-09-20 |
2023-08-13 |
Not clear |
| Lucian Medrihan, Yotam Sagi, Zintis Inde, Oleh Krupa, Chelsea Daniels, Adrien Peyrache, Paul Greengar. Initiation of Behavioral Response to Antidepressants by Cholecystokinin Neurons of the Dentate Gyrus. Neuron. vol 95. issue 3. 2017-09-14. PMID:28735749. |
here we show that serotonin 5-ht1b receptors in cholecystokinin (cck) inhibitory interneurons of the mammalian dentate gyrus (dg) initiate the therapeutic response to antidepressants. |
2017-09-14 |
2023-08-13 |
Not clear |
| Kristian Gaarn du Jardin, Heidi Kaastrup Müller, Betina Elfving, Elena Dale, Gregers Wegener, Connie Sanche. Potential involvement of serotonergic signaling in ketamine's antidepressant actions: A critical review. Progress in neuro-psychopharmacology & biological psychiatry. vol 71. 2017-08-30. PMID:27262695. |
recent imaging and behavioral data predominantly support a role for 5-ht1a or 5-ht1b receptors, but the full range of 5-ht receptors has currently not been systematically investigated in this context. |
2017-08-30 |
2023-08-13 |
rat |
| Laura Orsolini, Carmine Tomasetti, Alessandro Valchera, Felice Iasevoli, Elisabetta Filomena Buonaguro, Federica Vellante, Michele Fornaro, Annastasia Fiengo, Monica Mazza, Roberta Vecchiotti, Giampaolo Perna, Andrea de Bartolomeis, Giovanni Martinotti, Massimo Di Giannantonio, Domenico De Berardi. New advances in the treatment of generalized anxiety disorder: the multimodal antidepressant vortioxetine. Expert review of neurotherapeutics. vol 16. issue 5. 2017-06-27. PMID:27050932. |
vortioxetine (vrx) is a multimodal antidepressant with a unique mechanism of action, by acting as 5-ht3a, 5-ht1d and 5-ht7 receptor antagonist, partial agonist at the 5-ht1a and 5-ht1b receptors and inhibitor at the 5-ht transporter. |
2017-06-27 |
2023-08-13 |
Not clear |
| Katarina Varnäs, Anders Juréus, Peter Johnström, Charlotte Ahlgren, Pär Schött, Magnus Schou, Susanne Gruber, Eva Jerning, Jonas Malmborg, Christer Halldin, Lovisa Afzelius, Lars Fard. Integrated Strategy for Use of Positron Emission Tomography in Nonhuman Primates to Confirm Multitarget Occupancy of Novel Psychotropic Drugs: An Example with AZD3676. The Journal of pharmacology and experimental therapeutics. vol 358. issue 3. 2017-05-26. PMID:27402278. |
azd3676 [n,n-dimethyl-7-(4-(2-(pyridin-2-yl)ethyl)piperazin-1-yl) benzofuran-2-carboxamide] is a novel combined serotonin (5-hydroxytryptamine) 5-ht1a and 5-ht1b receptor antagonist that was developed for the treatment of cognitive impairment in alzheimer's disease. |
2017-05-26 |
2023-08-13 |
monkey |
| M Wierucka-Rybak, M Wolak, M Juszczak, J Drobnik, E Bojanowsk. The inhibitory effect of combination treatment with leptin and cannabinoid CB1 receptor agonist on food intake and body weight gain is mediated by serotonin 1B and 2C receptors. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 67. issue 3. 2017-05-09. PMID:27512006. |
these results suggest that serotonin mediates the leptin- and am 251-dependent regulation of feeding behavior in rats via the 5-ht1b and 5-ht2c receptors. |
2017-05-09 |
2023-08-13 |
rat |
| Dioneia Araldi, Luiz F Ferrari, Jon D Levin. Gi-protein-coupled 5-HT1B/D receptor agonist sumatriptan induces type I hyperalgesic priming. Pain. vol 157. issue 8. 2017-03-13. PMID:27075428. |
the prolongation of pge2 hyperalgesia induced by sumatriptan was partially prevented by coinjection of antagonists for the 5-ht1b and 5-ht1d, but not 5-ht7, serotonin receptors and completely prevented by coadministration of a combination of the 5-ht1b and 5-ht1d antagonists. |
2017-03-13 |
2023-08-13 |
rat |
| E Studer, J Näslund, A Westman, A Carlsson, E Eriksso. The effects of the dopamine stabilizer (-)-OSU6162 on aggressive and sexual behavior in rodents. Translational psychiatry. vol 6. 2017-02-06. PMID:27003188. |
the effect was observed also in serotonin-depleted animals and is hence probably not caused by the antagonism of serotonin receptors displayed by the drug; refuting the possibility that it is due to 5-ht1b activation, it was also not counteracted by isamoltane. |
2017-02-06 |
2023-08-13 |
mouse |
| Gennady N Smagin, Dekun Song, David P Budac, Jessica A Waller, Yan Li, Alan L Pehrson, Connie Sánche. Histamine may contribute to vortioxetine's procognitive effects; possibly through an orexigenic mechanism. Progress in neuro-psychopharmacology & biological psychiatry. vol 68. 2017-01-02. PMID:26945513. |
vortioxetine is a novel multimodal antidepressant that acts as a serotonin (5-ht)3, 5-ht7, and 5-ht1d receptor antagonist; 5-ht1b receptor partial agonist; 5-ht1a receptor agonist; and 5-ht transporter inhibitor in vitro. |
2017-01-02 |
2023-08-13 |
rat |
| J A García-Pedraza, M García, M L Martín, A Rodríguez-Barbero, A Morá. 5-HT2 receptor blockade exhibits 5-HT vasodilator effects via nitric oxide, prostacyclin and ATP-sensitive potassium channels in rat renal vasculature. Vascular pharmacology. vol 79. 2016-12-13. PMID:26586311. |
agonists 5-ct (5-ht1/7), cgs-12066b (5-ht1b), l-694,247 (5-ht1d) or as-19 (5-ht7) mimicked renal 5-ht vasodilator effect. |
2016-12-13 |
2023-08-13 |
rat |
| J A García-Pedraza, M García, M L Martín, A Rodríguez-Barbero, A Morá. 5-HT2 receptor blockade exhibits 5-HT vasodilator effects via nitric oxide, prostacyclin and ATP-sensitive potassium channels in rat renal vasculature. Vascular pharmacology. vol 79. 2016-12-13. PMID:26586311. |
our data suggest that 5-ht exerts renal vasodilator effect in the in situ autoperfused sarpogrelate-treated rat kidney, mediated by 5-ht1d, 5-ht1b and 5-ht7 receptors, involving cyclooxygenase-derived prostacyclin, nitric oxide synthesis/release and atp-sensitive k+ channels, respectively. |
2016-12-13 |
2023-08-13 |
rat |