| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Laura A Stanquini, Leonardo B M Resstel, Fernando M A Corrêa, Sâmia R L Joca, América A Scopinh. Prelimbic cortex 5-HT1A and 5-HT2C receptors are involved in the hypophagic effects caused by fluoxetine in fasted rats. Pharmacology, biochemistry, and behavior. vol 136. 2016-05-17. PMID:26143050. |
independent groups of rats were pretreated with intra-pl antagonists of 5-ht receptors: 5-ht1a (way100635), 5-ht2c (sb242084) or 5-ht1b (sb216641). |
2016-05-17 |
2023-08-13 |
rat |
| Emma S Darios, Susan M Barman, Hakan S Orer, Shaun F Morrison, Robert P Davis, Bridget M Seitz, Robert Burnett, Stephanie W Watt. 5-Hydroxytryptamine does not reduce sympathetic nerve activity or neuroeffector function in the splanchnic circulation. European journal of pharmacology. vol 754. 2016-04-27. PMID:25732865. |
in superior mesenteric arterial rings prepared for electrical field stimulation, neither 5-ht (3, 10, 30nm), the 5-ht1b receptor agonist cp 93129 nor 5-ht1/7 receptor agonist 5-carboxamidotryptamine inhibited neurogenic contraction compared to vehicle. |
2016-04-27 |
2023-08-13 |
rat |
| Pia Baldinger, Christoph Kraus, Christina Rami-Mark, Gregor Gryglewski, Georg S Kranz, Daniela Haeusler, Andreas Hahn, Marie Spies, Wolfgang Wadsak, Markus Mitterhauser, Dan Rujescu, Siegfried Kasper, Rupert Lanzenberge. Interaction between 5-HTTLPR and 5-HT1B genotype status enhances cerebral 5-HT1A receptor binding. NeuroImage. vol 111. 2016-04-07. PMID:25652393. |
the serotonin transporter (sert), which is responsible for the reuptake of serotonin from the synaptic cleft into the neuron, as well as the serotonin-1a (5-ht1a) and -1b (5-ht1b) receptors, inhibitory auto-receptors in the raphe region and projection areas, respectively, are likely to determine serotonin release. |
2016-04-07 |
2023-08-13 |
human |
| Pia Baldinger, Christoph Kraus, Christina Rami-Mark, Gregor Gryglewski, Georg S Kranz, Daniela Haeusler, Andreas Hahn, Marie Spies, Wolfgang Wadsak, Markus Mitterhauser, Dan Rujescu, Siegfried Kasper, Rupert Lanzenberge. Interaction between 5-HTTLPR and 5-HT1B genotype status enhances cerebral 5-HT1A receptor binding. NeuroImage. vol 111. 2016-04-07. PMID:25652393. |
this finding suggests that the interaction between two major serotonergic structures involved in serotonin release, specifically the sert and 5-ht1b receptor, results in a modification of the inhibitory serotonergic tone mediated via 5-ht1a receptors. |
2016-04-07 |
2023-08-13 |
human |
| Yiting Liu, Jiangnan Luo, Mikael A Carlsson, Dick R Nässe. Serotonin and insulin-like peptides modulate leucokinin-producing neurons that affect feeding and water homeostasis in Drosophila. The Journal of comparative neurology. vol 523. issue 12. 2016-03-22. PMID:25732325. |
our results suggest that serotonin via 5-ht1b diminishes activity in the lk neurons and thereby modulates functions regulated by lk peptide, but the action of the dinr in these neurons remains less clear. |
2016-03-22 |
2023-08-13 |
drosophila_melanogaster |
| Y Liu, M A Kelly, T J Sexton, J F Neumaie. 5-HT1B autoreceptors differentially modulate the expression of conditioned fear in a circuit-specific manner. Neuroscience. vol 298. 2016-03-21. PMID:25907441. |
located in the nerve terminals of serotonergic neurons, 5-ht1b autoreceptors are poised to modulate synaptic 5-ht levels with precise temporal and spatial control, and play an important role in various emotional behaviors. |
2016-03-21 |
2023-08-13 |
mouse |
| José-Ángel García-Pedraza, Mónica García, María-Luisa Martín, Asunción Morá. Pharmacological evidence that 5-HT1D activation induces renal vasodilation by NO pathway in rats. Clinical and experimental pharmacology & physiology. vol 42. issue 6. 2016-02-29. PMID:25854421. |
administration (0.00000125 to 0.1 μg/kg) of 5-ct or l-694,247 (5-ht1d agonist) mimicked 5-ht vasodilator effect, while other agonists (1-pbg, α-methyl-5-ht, as-19 (5-ht₇), 8-oh-dpat (5-ht1a) or cgs-12066b (5-ht1b)) did not alter baseline haemodynamic variables. |
2016-02-29 |
2023-08-13 |
rat |
| S E Cremer, N E Zois, S G Moesgaard, N Ravn, S Cirera, J L Honge, M H Smerup, J M Hasenkam, E Sloth, P S Leifsson, T Falk, M A Oyama, C Orton, T Martinussen, L H Olse. Serotonin markers show altered transcription levels in an experimental pig model of mitral regurgitation. Veterinary journal (London, England : 1997). vol 203. issue 2. 2016-02-22. PMID:25599900. |
serotonin (5-hydroxytryptamine, 5-ht) signalling is implicated in the pathogenesis of myxomatous mitral valve disease (mmvd) through 5-ht1b receptor (r), 5-ht2ar and 5-ht2br-induced myxomatous pathology. |
2016-02-22 |
2023-08-13 |
Not clear |
| Andrea Varrone, Per Svenningsson, Petter Marklund, Helena Fatouros-Bergman, Anton Forsberg, Christer Halldin, Lars-Göran Nilsson, Lars Fard. 5-HT1B receptor imaging and cognition: a positron emission tomography study in control subjects and Parkinson's disease patients. Synapse (New York, N.Y.). vol 69. issue 7. 2016-02-12. PMID:25914348. |
the serotonin 5-ht1b receptor subtype is involved in the modulation of serotonin release and is a target of interest for neuroreceptor imaging. |
2016-02-12 |
2023-08-13 |
human |
| John D McCorvy, Bryan L Rot. Structure and function of serotonin G protein-coupled receptors. Pharmacology & therapeutics. vol 150. 2016-02-08. PMID:25601315. |
currently, two gpcr crystal structures exist for the serotonin family, the 5-ht1b and 5-ht2b receptor, with the antimigraine and valvulopathic drug ergotamine bound. |
2016-02-08 |
2023-08-13 |
Not clear |
| Frank Scott Hall, Ichiro Sora, René Hen, George R Uh. Serotonin/dopamine interactions in a hyperactive mouse: reduced serotonin receptor 1B activity reverses effects of dopamine transporter knockout. PloS one. vol 9. issue 12. 2016-02-04. PMID:25514162. |
these findings of complementation of the locomotor effects of dat ko by reducing 5-ht1b receptor activity underscore roles for interactions between specific 5-ht receptors and dopamine (da) systems in basal and cocaine-stimulated locomotion and support evaluation of 5-ht1b antagonists as potential, non-stimulant adhd therapeutics. |
2016-02-04 |
2023-08-13 |
mouse |
| Mostafa El Mansari, Maurice Lecours, Pierre Blie. Effects of acute and sustained administration of vortioxetine on the serotonin system in the hippocampus: electrophysiological studies in the rat brain. Psychopharmacology. vol 232. issue 13. 2016-02-02. PMID:25665528. |
vortioxetine is a novel multimodal antidepressant that is a 5-ht1b receptor partial agonist, a 5-ht1a receptor agonist, an inhibitor of the serotonin (5-ht) transporter, and a 5-ht1d, 5-ht3, and 5-ht7 receptor antagonist in vitro. |
2016-02-02 |
2023-08-13 |
rat |
| Cécile Bétry, Adeline Etiévant, Alan Pehrson, Connie Sánchez, Nasser Haddjer. Effect of the multimodal acting antidepressant vortioxetine on rat hippocampal plasticity and recognition memory. Progress in neuro-psychopharmacology & biological psychiatry. vol 58. 2016-01-05. PMID:25524057. |
vortioxetine is a multimodal acting antidepressant that functions as a 5-ht3 and 5-ht7 and 5-ht1d receptor antagonist, 5-ht1b receptor partial agonist, 5-ht1a receptor agonist and inhibitor of the 5-ht transporter. |
2016-01-05 |
2023-08-13 |
human |
| Patricia J Sollars, Michael J Weiser, Andrea E Kudwa, Jayne R Bramley, Malcolm D Ogilvie, Robert L Spencer, Robert J Handa, Gary E Pickar. Altered entrainment to the day/night cycle attenuates the daily rise in circulating corticosterone in the mouse. PloS one. vol 9. issue 11. 2015-11-25. PMID:25365210. |
serotonin (5-ht) afferents to the scn modulate retinal signals via activation of 5-ht1b receptors, decreasing responsiveness to light. |
2015-11-25 |
2023-08-13 |
mouse |
| Jian-Pu Zheng, Xuemei Zhang, Hao Wang, Yunman Wang, Zhuoan Cheng, Peihao Yin, Wen Pen. Vasomotor dysfunction in the mesenteric artery after organ culture with cyclosporin A. Basic & clinical pharmacology & toxicology. vol 113. issue 6. 2015-11-09. PMID:23809336. |
the results showed that csa increased the mrna expression and contractile function of several g-protein-coupled receptors (gpcrs), such as endothelin receptor type b (etb ), 5-hydroxytryptamine type 1b (5-ht1b ) and 1d (5-ht1d ), in vascular smooth muscle cells. |
2015-11-09 |
2023-08-12 |
rat |
| Meiju Zhu, Hongzhu Zhu, Ninghua Tan, Guangzhi Zeng, Zhigang Zeng, Hongbiao Chu, Hui Wang, Zhi Xia, Renle W. The effects of Acorus tatarinowii Schott on 5-HT concentrations, TPH2 and 5-HT1B expression in the dorsal raphe of exercised rats. Journal of ethnopharmacology. vol 158 Pt A. 2015-09-25. PMID:25456438. |
the effects of acorus tatarinowii schott on 5-ht concentrations, tph2 and 5-ht1b expression in the dorsal raphe of exercised rats. |
2015-09-25 |
2023-08-13 |
rat |
| Meiju Zhu, Hongzhu Zhu, Ninghua Tan, Guangzhi Zeng, Zhigang Zeng, Hongbiao Chu, Hui Wang, Zhi Xia, Renle W. The effects of Acorus tatarinowii Schott on 5-HT concentrations, TPH2 and 5-HT1B expression in the dorsal raphe of exercised rats. Journal of ethnopharmacology. vol 158 Pt A. 2015-09-25. PMID:25456438. |
in this study, the effects of acorus tatarinowii schott on treadmill running endurance, 5-ht concentrations, tph2, 5-ht1b expression in the dorsal raphe of exercised rats were investigated. |
2015-09-25 |
2023-08-13 |
rat |
| Stephen M Stah. Modes and nodes explain the mechanism of action of vortioxetine, a multimodal agent (MMA): enhancing serotonin release by combining serotonin (5HT) transporter inhibition with actions at 5HT receptors (5HT1A, 5HT1B, 5HT1D, 5HT7 receptors). CNS spectrums. vol 20. issue 2. 2015-09-15. PMID:25831967. |
modes and nodes explain the mechanism of action of vortioxetine, a multimodal agent (mma): enhancing serotonin release by combining serotonin (5ht) transporter inhibition with actions at 5ht receptors (5ht1a, 5ht1b, 5ht1d, 5ht7 receptors). |
2015-09-15 |
2023-08-13 |
Not clear |
| Walid Tajeddinn, Torbjörn Persson, Silvia Maioli, Javier Calvo-Garrido, Cristina Parrado-Fernandez, Takashi Yoshitake, Jan Kehr, Paul Francis, Bengt Winblad, Kina Höglund, Angel Cedazo-Minguez, Dag Aarslan. 5-HT1B and other related serotonergic proteins are altered in APPswe mutation. Neuroscience letters. vol 594. 2015-09-14. PMID:25841787. |
serotonin 1b receptors (5-ht1b), along with serotonin transporter (sert) are among the regulators of extracellular 5-ht levels. |
2015-09-14 |
2023-08-13 |
mouse |
| Walid Tajeddinn, Torbjörn Persson, Silvia Maioli, Javier Calvo-Garrido, Cristina Parrado-Fernandez, Takashi Yoshitake, Jan Kehr, Paul Francis, Bengt Winblad, Kina Höglund, Angel Cedazo-Minguez, Dag Aarslan. 5-HT1B and other related serotonergic proteins are altered in APPswe mutation. Neuroscience letters. vol 594. 2015-09-14. PMID:25841787. |
we investigated the effect of the familial ad app (amyloid precursor protein) k670n/m671l double mutation, app swedish mutation (appswe), on the expression of 5-ht1b, sert, maoa, p11 and 5-ht and its metabolite 5-hiaa in sh-sy5y human neuroblastoma cell line stably transfected with appswe mutation. |
2015-09-14 |
2023-08-13 |
mouse |