| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aya Matsui, Veronica A Alvare. Cocaine Inhibition of Synaptic Transmission in the Ventral Pallidum Is Pathway-Specific and Mediated by Serotonin. Cell reports. vol 23. issue 13. 2019-12-10. PMID:29949769. |
the inhibition is independent of dopamine receptor activation, absent in 5-ht1b knockout mice, and mimicked by a serotonin transporter (sert) blocker. |
2019-12-10 |
2023-08-13 |
mouse |
| Kathryn Lanza, Christopher Bisho. Serotonergic targets for the treatment of L-DOPA-induced dyskinesia. Journal of neural transmission (Vienna, Austria : 1996). vol 125. issue 8. 2019-11-04. PMID:29305656. |
this review discusses the rationale for continued investigation of several potential anti-dyskinetic strategies including 5-ht stimulation of 5-ht1a and 5-ht1b receptors and blockade of 5-ht2a receptors and sert. |
2019-11-04 |
2023-08-13 |
Not clear |
| Maria A De Luca, Matthew W Buczynski, Gaetano Di Chiar. Loren Parsons' contribution to addiction neurobiology. Addiction biology. vol 23. issue 6. 2019-10-07. PMID:29949237. |
another larry's major contributions are the studies on 5-ht and 5-ht receptors' role in cocaine stimulant actions, which resulted in the identification of 5-ht1b receptors as a critical substrate of cocaine reinforcement. |
2019-10-07 |
2023-08-13 |
Not clear |
| Mina Khalilzadeh, Ghodratollah Panahi, Amir Rashidian, Mohammad Reza Hadian, Alireza Abdollahi, Khashayar Afshari, Saeed Shakiba, Abbas Norouzi-Javidan, Nastaran Rahimi, Majid Momeny, Ahmad Reza Dehpou. The protective effects of sumatriptan on vincristine - induced peripheral neuropathy in a rat model. Neurotoxicology. vol 67. 2019-04-08. PMID:29958920. |
sumatriptan, which is an anti-migraine agent is a specific agonist for 5-hydroxytryptamine 1b, 1d (5ht1b, 1d) receptors. |
2019-04-08 |
2023-08-13 |
rat |
| Meng-He Zhou, Fang-Fang Sun, Chang Xu, Hui-Bin Chen, Hui Qiao, Xiang Cai, Xin-Ming Ma, Shu-Cheng A. Modulation of Kalirin-7 expression by hippocampal CA1 5-HT Behavioural brain research. vol 356. 2019-03-22. PMID:29949735. |
modulation of kalirin-7 expression by hippocampal ca1 5-ht serotonin 5-ht1b receptors (5-ht1brs) are distributed in hippocampal ca1 and play a pivotal role in cognitive function. |
2019-03-22 |
2023-08-13 |
rat |
| Jessica J Walsh, Daniel J Christoffel, Boris D Heifets, Gabriel A Ben-Dor, Aslihan Selimbeyoglu, Lin W Hung, Karl Deisseroth, Robert C Malenk. 5-HT release in nucleus accumbens rescues social deficits in mouse autism model. Nature. vol 560. issue 7720. 2019-03-04. PMID:30089910. |
these sociability deficits can be rescued by optogenetic activation of dorsal raphe 5-ht neurons, an effect requiring and mimicked by activation of 5-ht1b receptors in the nucleus accumbens. |
2019-03-04 |
2023-08-13 |
mouse |
| Silvia Vincentiis, Juliana Alcantara, Patricia Rzezak, Daniel S Kerr, Wagner F Gattaz, Helio van der Linden, Bernardo Dos Santos, Sebastiao E Melo-Souza, Francisco Arruda, Paulo Ragazzo, Tiffany Chaim-Avancini, Mauricio H Serpa, Fernando Fernandes, Ricardo A Moreno, Geraldo Busatto, Ruda Alessi, Renata Demarque, Kette D Valent. Genetic polymorphisms of the 5HT receptors are not related with depression in temporal lobe epilepsy caused by hippocampal sclerosis. Epilepsy & behavior : E&B. vol 83. 2019-02-25. PMID:29709878. |
the primary goal of this study was to determine the possible association between polymorphisms of genes encoding the serotonin receptors 5ht1a (rs6295), 5ht1b (rs6296), and 5ht2c (rs6318) and the presence of mood disorders in patients with tle-hs. |
2019-02-25 |
2023-08-13 |
Not clear |
| Anna Rita Zuena, Daniela Maftei, Giovanni Sebastiano Alemà, Francesca Dal Moro, Roberta Lattanzi, Paola Casolini, Ferdinando Nicolett. Multimodal antidepressant vortioxetine causes analgesia in a mouse model of chronic neuropathic pain. Molecular pain. vol 14. 2019-02-20. PMID:30289053. |
vortioxetine is a multimodal antidepressant that potently antagonizes 5-ht3 serotonin receptors, inhibits the high-affinity serotonin transporter, activates 5-ht1a and 5-ht1b receptors, and antagonizes 5-ht1d and 5-ht7 receptors. |
2019-02-20 |
2023-08-13 |
mouse |
| Elske N de Haas, Jerine A J van der Eij. Where in the serotonergic system does it go wrong? Unravelling the route by which the serotonergic system affects feather pecking in chickens. Neuroscience and biobehavioral reviews. vol 95. 2019-02-11. PMID:30055196. |
genetic associations exist between fp, 5-ht1a and 5-ht1b receptor functioning and metabolism of 5-ht and da. |
2019-02-11 |
2023-08-13 |
Not clear |
| Alireza Mohammadi, Ehsan Rashidi, Vahid Ghasem Amooeia. Brain, blood, cerebrospinal fluid, and serum biomarkers in schizophrenia. Psychiatry research. vol 265. 2019-01-16. PMID:29680514. |
the levels of dopamine, tyrosine hydroxylase (th), serotonin or 5-hydroxytryptamine (5-ht) receptor 1a and b (5-htr1a and 5-htr1b), and 5-ht1b were significantly increased in scz patients, while the levels of gamma-aminobutyric acid (gaba), 5-ht transporter (5-htt), and 5-ht receptor 2a (5-htr2a) were decreased. |
2019-01-16 |
2023-08-13 |
human |
| F Jiménez-Trejo, I Coronado-Mares, M Boeta, I González-Santoyo, R Vigueras-Villaseñor, C Arriaga-Canon, L A Herrera, M Tapia-Rodrígue. Identification of serotoninergic system components in stallion sperm. Histology and histopathology. vol 33. issue 9. 2019-01-10. PMID:29658099. |
therefore, using both immunofluorescence and western blot techniques, we searched for and found some serotonin markers such as 5-ht, 5-ht1b, 5-ht2a, 5-ht₃ receptors, both tph1 and maoa enzymes, and serotonin transporter (5-htt) in stallion sperm. |
2019-01-10 |
2023-08-13 |
Not clear |
| Emily M Allen, Elizabeth F Hughes, Carl J Anderson, Nancy S Woehrl. N-acetylcysteine blocks serotonin 1B agonist-induced OCD-related behavior in mice. Behavioral neuroscience. vol 132. issue 4. 2018-12-11. PMID:29985009. |
mice were tested in the delayed alternation task (dat) and open field test following acute serotonin 1b receptor (5-ht1b) agonist challenge to induce ocd-related behavior. |
2018-12-11 |
2023-08-13 |
mouse |
| Miriam A Snider, David L Harmon, James L Klot. Pharmacologic assessment of bovine ruminal and mesenteric vascular serotonin receptor populations. Journal of animal science. vol 96. issue 4. 2018-10-09. PMID:29471490. |
to determine what 5-ht receptors are involved in vasoconstriction of gut vasculature, contractility of ruminal and mesenteric arteries and veins collected from cattle was evaluated in the presence of agonists selective for 5-ht1b (cp 93129), 5-ht1d (l-694, 247), 5-ht2a (tcb-2), 5-ht2b (bw 723c86), 5-ht4 (bimu-8), and 5-ht7 (lp 44) receptors. |
2018-10-09 |
2023-08-13 |
cattle |
| Lauren Hatherall, Connie Sánchez, David A Morila. Chronic Vortioxetine Treatment Reduces Exaggerated Expression of Conditioned Fear Memory and Restores Active Coping Behavior in Chronically Stressed Rats. The international journal of neuropsychopharmacology. vol 20. issue 4. 2018-05-18. PMID:27927740. |
vortioxetine, a novel multimodal antidepressant, is a serotonin transporter inhibitor; 5-ht3, 5-ht7, and 5-ht1d receptor antagonist; 5-ht1b partial agonist; and 5-ht1a agonist. |
2018-05-18 |
2023-08-13 |
rat |
| Rebecca L Brindley, Mary Beth Bauer, Randy D Blakely, Kevin P M Curri. An interplay between the serotonin transporter (SERT) and 5-HT receptors controls stimulus-secretion coupling in sympathoadrenal chromaffin cells. Neuropharmacology. vol 110. issue Pt A. 2018-02-22. PMID:27544824. |
the 5-ht1a receptor antagonist way100635 blocked the inhibition by 5-ht which was mimicked by the 5-ht1a agonist 8-oh-dpat but not the 5-ht1b agonist cp93129. |
2018-02-22 |
2023-08-13 |
mouse |
| Laura Orsolini, Carmine Tomasetti, Alessandro Valchera, Felice Iasevoli, Elisabetta Filomena Buonaguro, Michele Fornaro, Annastasia L C Fiengo, Giovanni Martinotti, Federica Vellante, Ilaria Matarazzo, Roberta Vecchiotti, Giampaolo Perna, Marco Di Nicola, Alessandro Carano, Andrea Di Bartolomeis, Massimo De Giannantonio, Domenico De Berardi. Current and Future Perspectives on the Major Depressive Disorder: Focus on the New Multimodal Antidepressant Vortioxetine. CNS & neurological disorders drug targets. vol 16. issue 1. 2018-02-09. PMID:27781949. |
vortioxetine (vrx) is a multimodal antidepressant that acts as serotonin (5ht) transporter inhibitor as well as 5ht3a and 5ht7 receptors antagonist, 5ht1a and 5ht1b receptors partial agonist. |
2018-02-09 |
2023-08-13 |
Not clear |
| Walid Tajeddinn, Torbjörn Persson, Javier Calvo-Garrido, Mohammed Seed Ahmed, Silvia Maioli, Swetha Vijayaraghavan, Mehmet Selim Kazokoglu, Cristina Parrado-Fernández, Takashi Yoshitake, Jan Kehr, Paul Francis, Bengt Winblad, Kina Höglund, Angel Cedazo-Minguez, Dag Aarslan. Pharmacological Modulations of the Serotonergic System in a Cell-Model of Familial Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 53. issue 1. 2018-01-29. PMID:27163814. |
the 5-ht homeostasis is regulated by many factors, including serotonin transporter (sert), monoamine oxidase enzyme (mao), and several 5-ht receptors, including the 5-ht1b. |
2018-01-29 |
2023-08-13 |
Not clear |
| Walid Tajeddinn, Torbjörn Persson, Javier Calvo-Garrido, Mohammed Seed Ahmed, Silvia Maioli, Swetha Vijayaraghavan, Mehmet Selim Kazokoglu, Cristina Parrado-Fernández, Takashi Yoshitake, Jan Kehr, Paul Francis, Bengt Winblad, Kina Höglund, Angel Cedazo-Minguez, Dag Aarslan. Pharmacological Modulations of the Serotonergic System in a Cell-Model of Familial Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 53. issue 1. 2018-01-29. PMID:27163814. |
sh-sy5y neuroblastoma cells transfected with the amyloid precursor protein (app) gene containing the swedish mutations causing familial ad (appswe), were used as a model to explore the effect of aβ pathology on 5-ht1b and related molecules including the receptor adaptor protein (p11), sert and maoa gene expression, and maoa activity after treatment with selective serotonin reuptake inhibitor (ssri) (sertraline), and a 5-ht1b receptor antagonist. |
2018-01-29 |
2023-08-13 |
Not clear |
| Walid Tajeddinn, Torbjörn Persson, Javier Calvo-Garrido, Mohammed Seed Ahmed, Silvia Maioli, Swetha Vijayaraghavan, Mehmet Selim Kazokoglu, Cristina Parrado-Fernández, Takashi Yoshitake, Jan Kehr, Paul Francis, Bengt Winblad, Kina Höglund, Angel Cedazo-Minguez, Dag Aarslan. Pharmacological Modulations of the Serotonergic System in a Cell-Model of Familial Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 53. issue 1. 2018-01-29. PMID:27163814. |
sertraline led more than 70 fold increase of 5-ht1b gene expression (p < 0.001), an increased serotonin turnover in both appswe and control cells and reduced intracellular serotonin levels by 75% in appswe cells but not in controls (p > 0.05). |
2018-01-29 |
2023-08-13 |
Not clear |
| Walid Tajeddinn, Torbjörn Persson, Javier Calvo-Garrido, Mohammed Seed Ahmed, Silvia Maioli, Swetha Vijayaraghavan, Mehmet Selim Kazokoglu, Cristina Parrado-Fernández, Takashi Yoshitake, Jan Kehr, Paul Francis, Bengt Winblad, Kina Höglund, Angel Cedazo-Minguez, Dag Aarslan. Pharmacological Modulations of the Serotonergic System in a Cell-Model of Familial Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 53. issue 1. 2018-01-29. PMID:27163814. |
5-ht and 5-ht1b antagonist treatment resulted in different p11 expression patterns in appswe cells compared to controls. |
2018-01-29 |
2023-08-13 |
Not clear |