| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J A García-Pedraza, M García, M L Martín, A Rodríguez-Barbero, A Morá. 5-HT2 receptor blockade exhibits 5-HT vasodilator effects via nitric oxide, prostacyclin and ATP-sensitive potassium channels in rat renal vasculature. Vascular pharmacology. vol 79. 2016-12-13. PMID:26586311. |
our data suggest that 5-ht exerts renal vasodilator effect in the in situ autoperfused sarpogrelate-treated rat kidney, mediated by 5-ht1d, 5-ht1b and 5-ht7 receptors, involving cyclooxygenase-derived prostacyclin, nitric oxide synthesis/release and atp-sensitive k+ channels, respectively. |
2016-12-13 |
2023-08-13 |
rat |
| Jessica A Waller, Fenghua Chen, Connie Sánche. Vortioxetine promotes maturation of dendritic spines in vitro: A comparative study in hippocampal cultures. Neuropharmacology. vol 103. 2016-12-13. PMID:26702943. |
the multimodal-acting antidepressant vortioxetine is an antagonist at 5-ht3, 5-ht7, and 5-ht1d receptors, a partial agonist at 5-ht1b receptors, an agonist at 5-ht1a receptors, and an inhibitor of the serotonin (5-ht) transporter (sert) and has pro-cognitive properties. |
2016-12-13 |
2023-08-13 |
Not clear |
| D J David, L Tritschler, J-P Guilloux, A M Gardier, C Sanchez, R Gaillar. [Pharmacological properties of vortioxetine and its pre-clinical consequences]. L'Encephale. vol 42. issue 1 Suppl 1. 2016-12-13. PMID:26879252. |
compared to the ssris, vortioxetine is defined as a multimodal antidepressant drug since it is not only a serotonin reuptake inhibitor, but also a 5-ht1d, 5-ht3, 5-ht7 receptor antagonist, 5-ht1b receptor partial agonist and 5-ht1a receptor agonist. |
2016-12-13 |
2023-08-13 |
Not clear |
| Yi-Xiang Qi, Jia Huang, Meng-Qi Li, Ya-Su Wu, Ren-Ying Xia, Gong-Yin Y. Serotonin modulates insect hemocyte phagocytosis via two different serotonin receptors. eLife. vol 5. 2016-12-13. PMID:26974346. |
combined, these data demonstrate that 5-ht mediates hemocyte phagocytosis through 5-ht1b and 5-ht2b receptors and serotonergic signaling performs critical modulatory functions in immune systems of animals separated by 500 million years of evolution. |
2016-12-13 |
2023-08-13 |
drosophila_melanogaster |
| R Colle, E Corrubl. [Vortioxetine: a new antidepressant to treat depressive episodes]. L'Encephale. vol 42. issue 1. 2016-10-31. PMID:26358483. |
vortioxetine is a new antidepressant, which mechanism of action is multimodal, targeting the 5-ht1a, 5-ht1b, 5-ht1d, 5-ht3, 5-ht7 receptors and the serotonin transporter (5-htt). |
2016-10-31 |
2023-08-13 |
Not clear |
| Giovanna Paolone, Alberto Brugnoli, Ludovico Arcuri, Daniela Mercatelli, Michele Morar. Eltoprazine prevents levodopa-induced dyskinesias by reducing striatal glutamate and direct pathway activity. Movement disorders : official journal of the Movement Disorder Society. vol 30. issue 13. 2016-10-12. PMID:26207892. |
selective serotonin (5-hydroxytryptamine; 5-ht) 5-ht1a or 5-ht1b receptor agonists, and, very recently, the mixed 5-ht1a /5-ht1b receptor agonist, eltoprazine, proved effective in inhibiting l-dopa-induced dyskinesias in experimental animals and parkinsonian patients. |
2016-10-12 |
2023-08-13 |
Not clear |
| Danielle A Diniz, Júlia Alvarenga Petrocchi, Larissa Caldeira Navarro, Tâmara Cristina Souza, Marina G M Castor, Andrea C Perez, Igor D G Duarte, Thiago R L Romer. Serotonin induces peripheral mechanical antihyperalgesic effects in mice. European journal of pharmacology. vol 767. 2016-10-05. PMID:26460149. |
we used selective antagonists of serotonin receptors (isamoltan 5-ht1b, brl 15572 5-ht1d, ketanserin 5-ht2a, ondansetron 5-ht3 and sb-269970 5-ht7). |
2016-10-05 |
2023-08-13 |
mouse |
| Danielle A Diniz, Júlia Alvarenga Petrocchi, Larissa Caldeira Navarro, Tâmara Cristina Souza, Marina G M Castor, Andrea C Perez, Igor D G Duarte, Thiago R L Romer. Serotonin induces peripheral mechanical antihyperalgesic effects in mice. European journal of pharmacology. vol 767. 2016-10-05. PMID:26460149. |
selective antagonists for 5-ht1b, 5-ht2a, 5-ht3 receptors at doses of 0.1, 1 and 10 µg, reversed the antihyperalgesic effect induced by 250 ng serotonin. |
2016-10-05 |
2023-08-13 |
mouse |
| Danielle A Diniz, Júlia Alvarenga Petrocchi, Larissa Caldeira Navarro, Tâmara Cristina Souza, Marina G M Castor, Andrea C Perez, Igor D G Duarte, Thiago R L Romer. Serotonin induces peripheral mechanical antihyperalgesic effects in mice. European journal of pharmacology. vol 767. 2016-10-05. PMID:26460149. |
these results demonstrated for the first time, the peripheral mechanical antihyperalgesic effect of serotonin, and participation of 5-ht1b, 5-ht2a and 5-ht3 receptors in this event. |
2016-10-05 |
2023-08-13 |
mouse |
| Keytam S Awad, James D West, Vinicio de Jesus Perez, Margaret MacLea. Novel signaling pathways in pulmonary arterial hypertension (2015 Grover Conference Series). Pulmonary circulation. vol 6. issue 3. 2016-09-29. PMID:27683605. |
in females, decreased mir96 enhances serotonin's effect by upregulating the 5-hydroxytryptamine 1b (5ht1b) receptor. |
2016-09-29 |
2023-08-13 |
Not clear |
| Gitte M Knudsen, Peter S Jensen, David Erritzoe, William F C Baaré, Anders Ettrup, Patrick M Fisher, Nic Gillings, Hanne D Hansen, Lars Kai Hansen, Steen G Hasselbalch, Susanne Henningsson, Matthias M Herth, Klaus K Holst, Pernille Iversen, Lars V Kessing, Julian Macoveanu, Kathrine Skak Madsen, Erik L Mortensen, Finn Årup Nielsen, Olaf B Paulson, Hartwig R Siebner, Dea S Stenbæk, Claus Svarer, Terry L Jernigan, Stephen C Strother, Vibe G Frokjae. The Center for Integrated Molecular Brain Imaging (Cimbi) database. NeuroImage. vol 124. issue Pt B. 2016-09-06. PMID:25891375. |
the data is of particular relevance for neurobiological research questions related to the serotonergic transmitter system with its normative data on the serotonergic subtype receptors 5-ht1a, 5-ht1b, 5-ht2a, and 5-ht4 and the 5-ht transporter (5-htt), but can easily serve other purposes. |
2016-09-06 |
2023-08-13 |
human |
| Nicolas Morin, Marc Morissette, Laurent Grégoire, Alex Rajput, Ali H Rajput, Thérèse Di Paol. Contribution of brain serotonin subtype 1B receptors in levodopa-induced motor complications. Neuropharmacology. vol 99. 2016-08-30. PMID:26254863. |
serotonin receptors are implicated in the development of lid and modulation of basal ganglia 5-ht1b receptors is a potential therapeutic alternative in parkinson's disease. |
2016-08-30 |
2023-08-13 |
human |
| K Nonogaki, T Kaj. Pharmacological stimulation of serotonin 5-HT1B receptors enhances increases in plasma active glucagon-like peptide-1 levels induced by dipeptidyl peptidase-4 inhibition independently of feeding in mice. Diabetes & metabolism. vol 41. issue 5. 2016-08-25. PMID:26234524. |
pharmacological stimulation of serotonin 5-ht1b receptors enhances increases in plasma active glucagon-like peptide-1 levels induced by dipeptidyl peptidase-4 inhibition independently of feeding in mice. |
2016-08-25 |
2023-08-13 |
mouse |
| Meiju Zhu, Hongzhu Zhu, Ninghua Tan, Hui Wang, Hongbiao Chu, Chonglin Zhan. Central anti-fatigue activity of verbascoside. Neuroscience letters. vol 616. 2016-08-04. PMID:26827721. |
in this study, the effects of verbascoside on treadmill exercise endurance, 5-hydroxytryptamine (5-ht) concentrations, the second isoforms of tryptophan hydroxylase (tph2) and serotonergic type 1b inhibitory autoreceptors (5-ht1b) protein expression in the caudate putamen of exercised rats were investigated. |
2016-08-04 |
2023-08-13 |
rat |
| Meiju Zhu, Hongzhu Zhu, Ninghua Tan, Hui Wang, Hongbiao Chu, Chonglin Zhan. Central anti-fatigue activity of verbascoside. Neuroscience letters. vol 616. 2016-08-04. PMID:26827721. |
we found that verbascoside could prolong the time to exhaustion in treadmill exercise and suppress the exercise-induced increase of 5-ht synthesis and tph2 protein expression, and prevent the exercise-induced decrease of 5-ht1b protein expression in the caudate putamen. |
2016-08-04 |
2023-08-13 |
rat |
| Meiju Zhu, Hongzhu Zhu, Ninghua Tan, Hui Wang, Hongbiao Chu, Chonglin Zhan. Central anti-fatigue activity of verbascoside. Neuroscience letters. vol 616. 2016-08-04. PMID:26827721. |
the mechanism of verbascoside' s anti-fatigue activity might be related to the inhibition of the exercise-induced synthesis of 5-ht and tph2 expression, and to the increase of the 5-ht1b expression in the caudate putamen of exercised rats. |
2016-08-04 |
2023-08-13 |
rat |
| Víctor Rovira, Emilio Geijo-Barriento. Intra- and Interhemispheric Propagation of Electrophysiological Synchronous Activity and Its Modulation by Serotonin in the Cingulate Cortex of Juvenile Mice. PloS one. vol 11. issue 3. 2016-08-02. PMID:26930051. |
these actions of serotonin were mimicked by the activation of either 5-ht1b or 5-ht2a receptors, but not by the activation of the 5-ht1a subtype. |
2016-08-02 |
2023-08-13 |
mouse |
| Priyoneel Basu, Naomi Ie, Adrienne L Wensel, Joelle D Baskerville, Victoria M Smith, Michael C Antl. Triptans attenuate circadian responses to light. The European journal of neuroscience. vol 42. issue 7. 2016-07-20. PMID:26228801. |
these responses to light can be modified by serotonergic drugs, such as serotonin 5ht1b receptor agonists. |
2016-07-20 |
2023-08-13 |
Not clear |
| Martin Reznitsky, Per Plenge, Anders Hay-Schmid. Serotonergic projections from the raphe nuclei to the subthalamic nucleus; a retrograde- and anterograde neuronal tracing study. Neuroscience letters. vol 612. 2016-06-28. PMID:26683905. |
autoradiography showed that serotonin receptors 5-ht1b and 5-ht2c and the serotonin transporter were present in stn, whereas the 5-ht1a and 5-ht2a not were present. |
2016-06-28 |
2023-08-13 |
rat |
| Steven C Leiser, Deborah Iglesias-Bregna, Ligia Westrich, Alan L Pehrson, Connie Sanche. Differentiated effects of the multimodal antidepressant vortioxetine on sleep architecture: Part 2, pharmacological interactions in rodents suggest a role of serotonin-3 receptor antagonism. Journal of psychopharmacology (Oxford, England). vol 29. issue 10. 2016-06-23. PMID:26174134. |
vortioxetine, a multimodal antidepressant acting through serotonin (5-ht) transporter (sert) inhibition, 5-ht3, 5-ht7 and 5-ht1d receptor antagonism, 5-ht1b receptor partial agonism, and 5-ht1a receptor agonism, had fewer incidences of sleep-related adverse events reported in depressed patients. |
2016-06-23 |
2023-08-13 |
human |