| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C A Wilson, A J Hunte. Progesterone stimulates sexual behaviour in female rats by increasing 5-HT activity on 5-HT2 receptors. Brain research. vol 333. issue 2. 1985-07-23. PMID:2581660. |
it is suggested that 5-ht has a dual effect on female sexual receptivity acting via different systems, the inhibitory tract acting on 5-ht1 and the stimulatory tract on 5-ht2 receptors. |
1985-07-23 |
2023-08-11 |
rat |
| J M Lakoski, G K Aghajania. Effects of ketanserin on neuronal responses to serotonin in the prefrontal cortex, lateral geniculate and dorsal raphe nucleus. Neuropharmacology. vol 24. issue 4. 1985-07-09. PMID:3158835. |
the ability of the putative serotonin2 (5-ht2) antagonist ketanserin, to alter serotonin (5-ht)-induced responses in cell firing was examined in the prefrontal cortex, the lateral geniculate nucleus and the dorsal raphe nucleus of the rat by microiontophoretic extracellular single unit recording techniques. |
1985-07-09 |
2023-08-11 |
rat |
| J M Lakoski, G K Aghajania. Effects of ketanserin on neuronal responses to serotonin in the prefrontal cortex, lateral geniculate and dorsal raphe nucleus. Neuropharmacology. vol 24. issue 4. 1985-07-09. PMID:3158835. |
the observed potentiation by ketanserin of inhibitory responses to 5-ht but not those of gamma-aminobutyric acid, tryptamine or norepinephrine, recorded in the prefrontal cortex, may be consistent with the proposed interaction between ketanserin and a specific 5-ht2 binding site. |
1985-07-09 |
2023-08-11 |
rat |
| A Metz, G M Goodwin, A R Gree. The administration of baclofen to mice increases 5-HT2-mediated head-twitch behaviour and 5-HT2 receptor number in frontal cortex. Neuropharmacology. vol 24. issue 4. 1985-07-09. PMID:4000408. |
it is suggested that the enhanced 5-ht2 function, following longer-term administration of baclofen is the consequence of the drug inhibiting 5-ht release in vivo, as indicated by the observations after acute administration. |
1985-07-09 |
2023-08-11 |
mouse |
| D A Kendall, S R Nahorsk. 5-Hydroxytryptamine-stimulated inositol phospholipid hydrolysis in rat cerebral cortex slices: pharmacological characterization and effects of antidepressants. The Journal of pharmacology and experimental therapeutics. vol 233. issue 2. 1985-07-02. PMID:2987487. |
this response to 5-ht was blocked potently by ketanserin and other putative 5-ht2 antagonists but the overall pattern of apparent drug affinities was inconsistent with that seen at 5-ht2 sites labeled with [3h]ketanserin in cortical membranes. |
1985-07-02 |
2023-08-11 |
rat |
| V V Petkov, V D Petkov, T Grahovska, E Konstantinov. Age-related changes in rat brain dopaminergic receptors. Acta physiologica et pharmacologica Bulgarica. vol 10. issue 4. 1985-06-27. PMID:6535368. |
however, considering the fact that in the cerebral cortex [3h] spiroperidol labels a subclass of serotonin receptors (5-ht2) rather than da receptors, the present results, particularly those concerning the cerebral cortex, suggest an age-related decrease also in the number of 5-ht receptors in this cerebral structure. |
1985-06-27 |
2023-08-12 |
rat |
| G M Goodwin, A R Gree. A behavioural and biochemical study in mice and rats of putative selective agonists and antagonists for 5-HT1 and 5-HT2 receptors. British journal of pharmacology. vol 84. issue 3. 1985-06-20. PMID:2580582. |
radioligand binding techniques have demonstrated the existence of 5-hydroxytryptamine (5-ht) binding subtypes: 5-ht2, 5-ht1a and 5-ht1b. |
1985-06-20 |
2023-08-11 |
mouse |
| G M Goodwin, A R Gree. A behavioural and biochemical study in mice and rats of putative selective agonists and antagonists for 5-HT1 and 5-HT2 receptors. British journal of pharmacology. vol 84. issue 3. 1985-06-20. PMID:2580582. |
9 we suggest that 5-ht-induced head-twitch behaviour in mice is a useful 5-ht2 receptor model and the temperature change following 8-oh-dpat injection in rats may be a 5-ht,a model. |
1985-06-20 |
2023-08-11 |
mouse |
| S P Olese. A calcium-dependent reversible permeability increase in microvessels in frog brain, induced by serotonin. The Journal of physiology. vol 361. 1985-06-20. PMID:3157795. |
pre-treatment with the 5-ht2 receptor antagonist ketanserin blocked the serotonin response completely. |
1985-06-20 |
2023-08-11 |
Not clear |
| D Hoffmann, W Weseman. Characterization of 5-hydroxytryptamine binding sites in the plasma membrane of pig blood platelets. Journal of neural transmission. vol 61. issue 3-4. 1985-06-19. PMID:3157778. |
since ketanserin inhibited 5-ht induced aggregation of pig platelets (ic50 = 14.2 nm), the ketanserin binding sites can be classified as 5-ht2 receptors. |
1985-06-19 |
2023-08-11 |
rat |
| N S Buckholtz, D X Freedman, L D Middaug. Daily LSD administration selectively decreases serotonin2 receptor binding in rat brain. European journal of pharmacology. vol 109. issue 3. 1985-06-19. PMID:3987809. |
[3h]lsd (3.0 nm) was used with either 30.0 nm 5-ht or 70.0 nm cinanserin to estimate 5-ht1 and 5-ht2 receptors, respectively. |
1985-06-19 |
2023-08-11 |
rat |
| C J Garlan. Endothelial cells and the electrical and mechanical responses of the rabbit coronary artery to 5-hydroxytryptamine. The Journal of pharmacology and experimental therapeutics. vol 233. issue 1. 1985-05-23. PMID:3981453. |
hyperpolarization to 5-ht was not observed, even with 1 microm ketanserin (a 5-ht2 receptor antagonist) present to reduce its direct action on the smooth muscle. |
1985-05-23 |
2023-08-11 |
rabbit |
| M L Cohen, L A Wittenaue. Relationship between serotonin and tryptamine receptors in the rat stomach fundus. The Journal of pharmacology and experimental therapeutics. vol 233. issue 1. 1985-05-23. PMID:3981465. |
tryptamine and serotonin (5-ht) are relatively potent contractile agonists in the rat fundus, a tissue in which contraction to 5-ht is not mediated by interaction with 5-ht1 or 5-ht2 receptors. |
1985-05-23 |
2023-08-11 |
rat |
| R A Locock, G B Baker, R T Coutts, W G Dewhurs. Displacement of serotonin from binding sites in rat cortex: the effects of biogenic "trace" amines. Progress in neuro-psychopharmacology & biological psychiatry. vol 8. issue 4-6. 1985-05-17. PMID:6531441. |
the concentrations for 50 percent inhibition of binding (ic50's) to specific in vitro serotonin binding sites (5-ht1 and 5-ht2) of rat cerebral cortex were determined for the trace amines 2-phenylethylamine, m- and p-tyramine, tryptamine, and (+)- and (-)- alpha-methyltryptamine. |
1985-05-17 |
2023-08-12 |
rat |
| R A Locock, G B Baker, R T Coutts, W G Dewhurs. Displacement of serotonin from binding sites in rat cortex: the effects of biogenic "trace" amines. Progress in neuro-psychopharmacology & biological psychiatry. vol 8. issue 4-6. 1985-05-17. PMID:6531441. |
the trace amines may have different functional roles as evidenced by their different degrees of displacement of serotonin at 5-ht1 and 5-ht2 binding sites in the brain. |
1985-05-17 |
2023-08-12 |
rat |
| J L Blackshear, C Orlandi, J D Garnic, N K Hollenber. Differential large and small vessel responses to serotonin in the dog hindlimb in vivo: role of the 5HT2 receptor. Journal of cardiovascular pharmacology. vol 7. issue 1. 1985-05-16. PMID:2580149. |
differential large and small vessel responses to serotonin in the dog hindlimb in vivo: role of the 5ht2 receptor. |
1985-05-16 |
2023-08-11 |
dog |
| J L Blackshear, C Orlandi, J D Garnic, N K Hollenber. Differential large and small vessel responses to serotonin in the dog hindlimb in vivo: role of the 5HT2 receptor. Journal of cardiovascular pharmacology. vol 7. issue 1. 1985-05-16. PMID:2580149. |
failure of ne to constrict large arteries in vivo and ketanserin antagonism of constriction produced by 5ht suggest the response to 5ht involves the 5ht2 receptor. |
1985-05-16 |
2023-08-11 |
dog |
| M Frenken, A J Kauman. Ketanserin causes surmountable antagonism of 5-hydroxytryptamine-induced contractions of large coronary arteries of dog. Naunyn-Schmiedeberg's archives of pharmacology. vol 328. issue 3. 1985-05-15. PMID:3157065. |
we conclude that large coronary arteries of dog are contracted by 5-ht mainly through 5-ht2-receptors and to a smaller extent through receptors different from 5-ht2. |
1985-05-15 |
2023-08-11 |
dog |
| P D Verdouw, H M Jennewein, J Mierau, P R Saxen. N-(3-acetylaminophenyl)piperazine hydrochloride (BEA 1654), a putative 5-HT1 agonist, causes constriction of arteriovenous anastomoses and dilatation of arterioles. European journal of pharmacology. vol 107. issue 3. 1985-05-10. PMID:3156750. |
the compound had a ki value of 32 nm (5-ht: 8 nm) on 5-ht1 but no or very weak affinity for 5-ht2, alpha 1- and alpha 2-adrenoceptor sites in rat cerebral cortex homogenates. |
1985-05-10 |
2023-08-11 |
rat |
| P D Verdouw, H M Jennewein, J Mierau, P R Saxen. N-(3-acetylaminophenyl)piperazine hydrochloride (BEA 1654), a putative 5-HT1 agonist, causes constriction of arteriovenous anastomoses and dilatation of arterioles. European journal of pharmacology. vol 107. issue 3. 1985-05-10. PMID:3156750. |
in view of the high and selective affinity of bea 1654 to 5-ht1 binding sites, the similarity of pharmacological responses between 5-ht and bea 1654, and the ineffectiveness of antagonists of 5-ht2 and alpha-adrenergic receptors to block the ava constriction and arteriolar dilatation caused by both 5-ht and bea 1654, we conclude that these effects are mediated by 5-ht1 receptors. |
1985-05-10 |
2023-08-11 |
rat |