| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F De Clerck, J M van Nueten, R S Renema. Platelet-vessel wall interactions: implication of 5-hydroxytryptamine. A review. Agents and actions. vol 15. issue 5-6. 1985-05-08. PMID:6397984. |
by interacting with 5-ht2 serotonergic receptors, 5-ht, directly or through amplification, activates platelets, endothelial and vascular smooth muscle cells producing platelet aggregation, vascular permeability increase and large vessel constriction. |
1985-05-08 |
2023-08-12 |
Not clear |
| G Bartholin. GABA receptor agonists: pharmacological spectrum and therapeutic actions. Medicinal research reviews. vol 5. issue 1. 1985-04-29. PMID:2984490. |
gaba receptor agonists, by changing the firing rate of the corresponding neurons accelerate noradrenaline turnover without changes in postsynaptic receptor density and diminish serotonin liberation with an up-regulation of 5ht2 receptors. |
1985-04-29 |
2023-08-11 |
human |
| C Su, T Urun. Excitatory and inhibitory effects of 5-hydroxytryptamine in mesenteric arteries of spontaneously hypertensive rats. European journal of pharmacology. vol 106. issue 2. 1985-04-26. PMID:6529977. |
these results suggest that ketanserin-sensitive 5-ht2 receptors are involved in the potentiating effect of 5-ht in the rat mesenteric arteries, and that an increase in transmitter release by 5-ht may contribute to its potentiation of nerve stimulation-induced vasoconstriction in shr. |
1985-04-26 |
2023-08-12 |
rat |
| M L Cohen, K W Schenck, W Colbert, L Wittenaue. Role of 5-HT2 receptors in serotonin-induced contractions of nonvascular smooth muscle. The Journal of pharmacology and experimental therapeutics. vol 232. issue 3. 1985-04-25. PMID:3973826. |
vascular receptors responsible for serotonin-induced contractions are of the 5-ht2 subtype (site in brain cortical membranes that is preferentially radiolabeled by [3h]spiperone) whereas serotonin receptors mediating contraction in nonvascular smooth muscle have not been extensively studied. |
1985-04-25 |
2023-08-11 |
rat |
| M L Cohen, K W Schenck, W Colbert, L Wittenaue. Role of 5-HT2 receptors in serotonin-induced contractions of nonvascular smooth muscle. The Journal of pharmacology and experimental therapeutics. vol 232. issue 3. 1985-04-25. PMID:3973826. |
prazosin, but not the serotonin receptor antagonists, blocked serotonin-induced contractions in the rat vas deferens, indicating that alpha adrenergic and not 5-ht1 or 5-ht2 receptors mediate the contractile response to serotonin in this tissue. |
1985-04-25 |
2023-08-11 |
rat |
| M L Cohen, K W Schenck, W Colbert, L Wittenaue. Role of 5-HT2 receptors in serotonin-induced contractions of nonvascular smooth muscle. The Journal of pharmacology and experimental therapeutics. vol 232. issue 3. 1985-04-25. PMID:3973826. |
because selective 5-ht2 receptor antagonists did not block contractions to serotonin in the rat fundus or guinea-pig ileum, receptors in these gastrointestinal tissues are clearly not 5-ht2. |
1985-04-25 |
2023-08-11 |
rat |
| M B Emerit, H Gozlan, M D Hall, M Hamon, A Marque. Irreversible blockade of central 5-HT binding sites by 8-methoxy-2'-chloro-PAT. Biochemical pharmacology. vol 34. issue 6. 1985-04-17. PMID:3156602. |
although 8-methoxy-2'-chloro-pat bound irreversibly to different classes of 5-ht binding sites (5-ht1a, 5-ht1b, presynaptic sites), it can be considered a selective alkylating agent, since it exerted no action on 3h-spiperone binding to 5-ht2 sites, 3h-muscimol binding to gaba sites, or 3h-flunitrazepam binding to benzodiazepine sites. |
1985-04-17 |
2023-08-11 |
rat |
| J Arnt, J Hyttel, J J Larse. The citalopram/5-HTP-induced head shake syndrome is correlated to 5-HT2 receptor affinity and also influenced by other transmitters. Acta pharmacologica et toxicologica. vol 55. issue 5. 1985-04-15. PMID:6152104. |
this was blocked by a range of 5-ht antagonists, including the selective 5-ht2 antagonists, ketanserin and pirenperone and was also blocked by the alpha 1-adrenoceptor antagonists, prazosin and wb 4101, and the alpha 2-adrenoceptor agonist, clonidine. |
1985-04-15 |
2023-08-12 |
rat |
| J F Marwood, G S Stoke. Serotonin (5HT) and its antagonists: involvement in the cardiovascular system. Clinical and experimental pharmacology & physiology. vol 11. issue 5. 1985-03-27. PMID:6098391. |
biochemical studies in brain homogenates have delineated two sub-populations of serotonin receptors, named 5ht1 and 5ht2. |
1985-03-27 |
2023-08-12 |
Not clear |
| D McDonald, G M Stancel, S J Enn. Binding and function of serotonin 2 receptors following chronic administration of imipramine. Neuropharmacology. vol 23. issue 11. 1985-03-25. PMID:6098843. |
experiments were undertaken to determine whether alterations in the binding of 5-ht2 receptors in the cerebral cortex of rat brain, induced by antidepressant drugs, are related to behavioral changes observed in response to the administration of a precursor of serotonin. |
1985-03-25 |
2023-08-12 |
rat |
| D McDonald, G M Stancel, S J Enn. Binding and function of serotonin 2 receptors following chronic administration of imipramine. Neuropharmacology. vol 23. issue 11. 1985-03-25. PMID:6098843. |
these results suggest a lack of correlation between the drug-induced change in 5-ht2 binding in frontal cortex and the function of serotonin 2 receptors. |
1985-03-25 |
2023-08-12 |
rat |
| J M Van Nueten, J E Leysen, F de Clerck, P M Vanhoutt. Serotonergic receptor subtypes and vascular reactivity. Journal of cardiovascular pharmacology. vol 6 Suppl 4. 1985-02-15. PMID:6210424. |
two distinct binding sites for serotonin have been identified in brain tissue and labeled 5-ht1 and 5-ht2 binding sites. |
1985-02-15 |
2023-08-12 |
Not clear |
| J M Van Nueten, J E Leysen, F de Clerck, P M Vanhoutt. Serotonergic receptor subtypes and vascular reactivity. Journal of cardiovascular pharmacology. vol 6 Suppl 4. 1985-02-15. PMID:6210424. |
the other peripheral actions of serotonin, in particular its vasodilator effects and its excitatory effects on gastrointestinal smooth muscle, do not involve 5-ht2 serotonergic receptors. |
1985-02-15 |
2023-08-12 |
Not clear |
| J A Thompson, E P Wei, H A Konto. Inhibition by ketanserin of serotonin induced cerebral arteriolar constriction. Stroke. vol 15. issue 6. 1985-01-23. PMID:6506113. |
ketanserin, a specific 5-ht2 inhibitor, completely blocked the vascular response of serotonin. |
1985-01-23 |
2023-08-12 |
Not clear |
| J A Thompson, E P Wei, H A Konto. Inhibition by ketanserin of serotonin induced cerebral arteriolar constriction. Stroke. vol 15. issue 6. 1985-01-23. PMID:6506113. |
we conclude that serotonin causes generalized cerebral arteriolar constriction that is due to the stimulation of 5-ht2 receptor. |
1985-01-23 |
2023-08-12 |
Not clear |
| R W Fuller, H D Snodd. Central serotonin antagonist activity of ketanserin. Research communications in chemical pathology and pharmacology. vol 46. issue 1. 1985-01-15. PMID:6505385. |
the relatively low ed50 value of ketanserin (0.9 mg/kg) supports other literature data showing that ketanserin is selective for the 5ht2 subtype of serotonin receptors, the data also suggest that 5ht2 receptors are involved in the elevation of serum corticosterone by the serotonin agonist, quipazine. |
1985-01-15 |
2023-08-12 |
rat |
| H Koop, R Arnol. Serotoninergic control of somatostatin and gastrin release from the isolated rat stomach. Regulatory peptides. vol 9. issue 1-2. 1985-01-03. PMID:6150515. |
changes in hormone secretion in response to serotonin were reversed by combined blockade of 5-ht1 and 5-ht2 receptors by methysergide and blockade of 5-ht2 receptors by ketanserin (10(-5) and 10(-6) m, respectively), and of cholinoreceptors by atropine (10(-5) m). |
1985-01-03 |
2023-08-12 |
rat |
| W Buczko, M C Gambino, G De Gaetan. Prolongation of rat tail bleeding time by ketanserin: mechanisms of action. European journal of pharmacology. vol 103. issue 3-4. 1984-12-12. PMID:6237923. |
ketanserin is a recently developed selective 5-ht2 receptor antagonist, reportedly effective against both platelet and vascular 5-ht activation. |
1984-12-12 |
2023-08-12 |
rat |
| P D Verdouw, H M Jennewein, J Heiligers, D J Duncker, P R Saxen. Redistribution of carotid artery blood flow by 5-HT: effects of the 5-HT2 receptor antagonists ketanserin and Wal 1307. European journal of pharmacology. vol 102. issue 3-4. 1984-12-12. PMID:6548449. |
redistribution of carotid artery blood flow by 5-ht: effects of the 5-ht2 receptor antagonists ketanserin and wal 1307. |
1984-12-12 |
2023-08-12 |
Not clear |
| P D Verdouw, H M Jennewein, J Heiligers, D J Duncker, P R Saxen. Redistribution of carotid artery blood flow by 5-HT: effects of the 5-HT2 receptor antagonists ketanserin and Wal 1307. European journal of pharmacology. vol 102. issue 3-4. 1984-12-12. PMID:6548449. |
the study concerned effects of ketanserin and a new 5-ht2 receptor antagonist, wal 1307, on the responses to 5-hydroxytryptamine (5-ht) in the porcine common carotid vascular bed. |
1984-12-12 |
2023-08-12 |
Not clear |