| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P F Vonvoigtlander, R A Lewis, G L Neff, H J Triezenber. Involvement of biogenic amines with the mechanisms of novel analgesics. Progress in neuro-psychopharmacology & biological psychiatry. vol 7. issue 4-6. 1984-03-08. PMID:6141608. |
these results suggest that kappa analgesia requires serotonin acting through 5-ht2 receptors. |
1984-03-08 |
2023-08-12 |
Not clear |
| E Müller-Schweinitzer, G Enge. Evidence for mediation by 5-HT2 receptors of 5-hydroxytryptamine-induced contraction of canine basilar artery. Naunyn-Schmiedeberg's archives of pharmacology. vol 324. issue 4. 1984-03-08. PMID:6664382. |
there was a good correlation between the affinities of the antagonists for 5-ht2 binding sites labelled by both [125i]lsd and [3h]ketanserin and the affinity parameters calculated for inhibition of constrictor responses to 5-ht of canine basilar artery. |
1984-03-08 |
2023-08-12 |
rat |
| M Mikuni, H Y Meltze. Reduction of serotonin-2 receptors in rat cerebral cortex after subchronic administration of imipramine, chlorpromazine, and the combination thereof. Life sciences. vol 34. issue 1. 1984-03-07. PMID:6694512. |
the effects of subchronic administration of imipramine, chlorpromazine, or the combination, on serotonin 2 (5-ht2) receptors labeled by 3h-spiroperidol in rat cerebral cortex were studied to determine whether this synergism might be related to an effect on these receptors, which have been linked to the therapeutic action of antidepressants. |
1984-03-07 |
2023-08-12 |
rat |
| I Lucki, M S Nobler, A Fraze. Differential actions of serotonin antagonists on two behavioral models of serotonin receptor activation in the rat. The Journal of pharmacology and experimental therapeutics. vol 228. issue 1. 1984-02-29. PMID:6694097. |
ligand binding studies have identified certain serotonin (5-ht) antagonists with selective affinity for 5-ht2 receptors and other serotonin antagonists with affinity for both 5-ht1 and 5-ht2 receptors. |
1984-02-29 |
2023-08-12 |
rat |
| I Lucki, M S Nobler, A Fraze. Differential actions of serotonin antagonists on two behavioral models of serotonin receptor activation in the rat. The Journal of pharmacology and experimental therapeutics. vol 228. issue 1. 1984-02-29. PMID:6694097. |
this study compared the actions of ketanserin and pipamperone, selective 5-ht2 receptor antagonists, with metergoline and methysergide, nonselective 5-ht antagonists, on two behavioral responses in rats that are produced by the activation of 5-ht receptors: 1) the head shake response and 2) the 5-ht syndrome. |
1984-02-29 |
2023-08-12 |
rat |
| I Lucki, M S Nobler, A Fraze. Differential actions of serotonin antagonists on two behavioral models of serotonin receptor activation in the rat. The Journal of pharmacology and experimental therapeutics. vol 228. issue 1. 1984-02-29. PMID:6694097. |
in contrast, the symptoms of the 5-ht syndrome produced by 5-methoxy-n,n-dimethyltryptamine were blocked by pretreatment with the nonselective 5-ht receptor antagonists but not by the 5-ht2 receptor antagonists. |
1984-02-29 |
2023-08-12 |
rat |
| I Lucki, M S Nobler, A Fraze. Differential actions of serotonin antagonists on two behavioral models of serotonin receptor activation in the rat. The Journal of pharmacology and experimental therapeutics. vol 228. issue 1. 1984-02-29. PMID:6694097. |
in contrast, the ability of 5-ht antagonists with affinity for the 5-ht1 receptor to block the 5-ht syndrome and the inability of 5-ht2 receptor antagonists to block the syndrome suggests that this behavioral response probably involves the activation of 5-ht1 receptors. |
1984-02-29 |
2023-08-12 |
rat |
| M A Blackshear, R L Friedman, E Sanders-Bus. Acute and chronic effects of serotonin (5HT) antagonists on serotonin binding sites. Naunyn-Schmiedeberg's archives of pharmacology. vol 324. issue 2. 1984-01-07. PMID:6646240. |
therefore, these preliminary studies suggest that the loss of 5ht2 binding sites after in vivo treatment with cyproheptadine and with other 5ht antagonists may reflect an adaptive response. |
1984-01-07 |
2023-08-12 |
Not clear |
| M L Cohen, R W Fuller, K D Kur. LY53857, a selective and potent serotonergic (5-HT2) receptor antagonist, does not lower blood pressure in the spontaneously hypertensive rat. The Journal of pharmacology and experimental therapeutics. vol 227. issue 2. 1983-12-17. PMID:6313898. |
ly53857 was a potent antagonist of vascular contraction to serotonin, which is mediated by serotonergic (5-ht2) receptors, with a dissociation constant in vitro of 5.4 x 10(-11) m. unlike several other serotonin antagonists, ly53857 showed minimal affinity for vascular alpha adrenergic receptors (dissociation constant of 1.4 x 10(-5) m). |
1983-12-17 |
2023-08-12 |
rat |
| C Zoccali, J R Zabludowski, C G Isles, G D Murray, G C Inglis, J I Robertson, R Fraser, S G Bal. The effect of a 5-HT antagonist, ketanserin, on blood pressure, the renin-angiotensin system and sympathoadrenal function in normal man. British journal of clinical pharmacology. vol 16. issue 3. 1983-12-17. PMID:6626423. |
5-ht may be important in the control of blood pressure in man and specific 5-ht2 receptor antagonists could be a useful new class of antihypertensive agents. |
1983-12-17 |
2023-08-12 |
human |
| H Y Meltzer, M Simonovic, G A Gudelsk. Effects of pirenperone and ketanserin on rat prolactin secretion in vivo and in vitro. European journal of pharmacology. vol 92. issue 1-2. 1983-12-17. PMID:6628538. |
ketanserin, also a purported selective 5-ht2 receptor blocker, has no effect on rat prl secretion in vivo or in vitro, but at high doses, it inhibits the increase in serum prl levels produced by the two 5-ht agonists, quipazine and 5-methoxy-n,n-dimethyl-tryptamine (5-meodmt). |
1983-12-17 |
2023-08-12 |
rat |
| M L Cohen, R W Fuller, K D Kur. Evidence that blood pressure reduction by serotonin antagonists is related to alpha receptor blockade in spontaneously hypertensive rats. Hypertension (Dallas, Tex. : 1979). vol 5. issue 5. 1983-11-23. PMID:6311738. |
in vitro affinity for vascular 5ht2 and alpha receptors was determined for several compounds (spiperone, ketanserin, mianserin, trazodone, mepiprazole, benzoctamine, m-trifluoro-methylphenylpiperazine, m-chlorophenylpiperazine, and 1-(1-naphthyl)piperazine) known to interact with serotonin receptors. |
1983-11-23 |
2023-08-12 |
rat |
| M L Cohen, R W Fuller, K D Kur. Evidence that blood pressure reduction by serotonin antagonists is related to alpha receptor blockade in spontaneously hypertensive rats. Hypertension (Dallas, Tex. : 1979). vol 5. issue 5. 1983-11-23. PMID:6311738. |
a similar order of potency toward both 5ht2 and alpha receptors was found in pithed shr based on antagonism of the pressor response to serotonin and methoxamine, respectively. |
1983-11-23 |
2023-08-12 |
rat |
| F C Colpaert, P A Jansse. The head-twitch response to intraperitoneal injection of 5-hydroxytryptophan in the rat: antagonist effects of purported 5-hydroxytryptamine antagonists and of pirenperone, an LSD antagonist. Neuropharmacology. vol 22. issue 8. 1983-11-23. PMID:6604885. |
the antagonist effects of pirenperone, and the first phase of the curve of the putative 5-ht antagonists, may reflect antagonist activity at 5-ht2 receptors. |
1983-11-23 |
2023-08-12 |
rat |
| R A Glennon, R Young, J A Rosecran. Antagonism of the effects of the hallucinogen DOM and the purported 5-HT agonist quipazine by 5-HT2 antagonists. European journal of pharmacology. vol 91. issue 2-3. 1983-11-23. PMID:6617740. |
antagonism of the effects of the hallucinogen dom and the purported 5-ht agonist quipazine by 5-ht2 antagonists. |
1983-11-23 |
2023-08-12 |
rat |
| H Gozlan, S El Mestikawy, L Pichat, J Glowinski, M Hamo. Identification of presynaptic serotonin autoreceptors using a new ligand: 3H-PAT. Nature. vol 305. issue 5930. 1983-10-21. PMID:6225026. |
binding studies with appropriate labelled ligands have revealed the existence of two types of serotonin (5-ht) receptor, 5-ht1 and 5-ht2, in the central nervous system of mammals. |
1983-10-21 |
2023-08-12 |
rat |
| J Bevan, S Heptinstal. Effects of ketanserin and mepyramine on platelet aggregation and on the uptake of 5-hydroxytryptamine into platelets. Thrombosis research. vol 30. issue 5. 1983-10-21. PMID:6612677. |
we have determined the effects of ketanserin, a 5ht2 antagonist, and of mepyramine, a histamine h1 antagonist, on the aggregation induced in platelet rich plasma by 5-hydroxytryptamine (5ht), adenosine diphosphate (adp), and by combinations of 5ht and adp. |
1983-10-21 |
2023-08-12 |
Not clear |
| J Bevan, S Heptinstal. Effects of ketanserin and mepyramine on platelet aggregation and on the uptake of 5-hydroxytryptamine into platelets. Thrombosis research. vol 30. issue 5. 1983-10-21. PMID:6612677. |
the results suggest that 5ht2 receptors are involved in 5ht-induced aggregation and that the platelets' endogenous 5ht may contribute to the second phase of adp-induced aggregation. |
1983-10-21 |
2023-08-12 |
Not clear |
| A R Green, P Johnson, V L Nimgaonka. Interactions of beta-adrenoceptor agonists and antagonists with the 5-hydroxytryptamine2 (5-HT2) receptor. Neuropharmacology. vol 22. issue 5. 1983-09-20. PMID:6136009. |
methysergide and the putative 5-ht2 antagonist, pirenperone, had ic50 values in the low nanomolar range whilst 5-ht and quipazine had micromolar ic50 values. |
1983-09-20 |
2023-08-12 |
rat |
| E C Degli Uberti, G Trasforini, A R Margutti, C A Rotola, M Bianconi, P Pansin. Effect of ketanserin, an inhibitor of 5-HT2 receptors, on the aldosterone-stimulating action of metoclopramide. Hormone research. vol 17. issue 3. 1983-07-15. PMID:6343215. |
to estimate the possible involvement of a peripheral serotonergic pathway in the mechanism of the aldosterone-stimulating effect of metoclopramide (m) the plasma aldosterone (pa), renin activity (pra) and prolactin (prl) response to m was studied in 6 normal subjects before and after administration of ketanserin (k), a pure, specific, and selective blocking agent of 5-hydroxytryptamine type 2 (5-ht2) receptors. |
1983-07-15 |
2023-08-12 |
human |