| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J M Van Nueten, W De Ridder, P M Vanhoutt. Ketanserin and vascular contractions in response to cooling. European journal of pharmacology. vol 99. issue 4. 1984-08-07. PMID:6734731. |
5-hydroxytryptamine caused contractions which were enhanced by cooling from 37 to 29 degrees c. both the contractions induced by 5-hydroxytryptamine and their augmentation by cooling were inhibited by similar concentrations of the serotonergic 5-ht2 antagonist ketanserin. |
1984-08-07 |
2023-08-12 |
rabbit |
| J M Van Nueten, W De Ridder, P M Vanhoutt. Ketanserin and vascular contractions in response to cooling. European journal of pharmacology. vol 99. issue 4. 1984-08-07. PMID:6734731. |
these experiments demonstrate that cooling augments the responsiveness of peripheral arteries to 5-hydroxytryptamine and that the augmentation is mediated by 5-ht2 serotonergic receptors. |
1984-08-07 |
2023-08-12 |
rabbit |
| P Lidberg, A Dahlström, H Ahlma. Is 5-HT a mediator in the motor control of the feline pylorus? Scandinavian journal of gastroenterology. vol 19. issue 3. 1984-08-01. PMID:6377464. |
in this study in cats intra-arterial administration of 5-ht to the stomach evoked a dose-dependent pyloric contraction, which was efficiently antagonized by ketanserin, a peripheral 5-ht2 receptor antagonist. |
1984-08-01 |
2023-08-12 |
Not clear |
| H Affolter, P Erne, E Bürgisser, A Pletsche. Ca2+ as messenger of 5HT2-receptor stimulation in human blood platelets. Naunyn-Schmiedeberg's archives of pharmacology. vol 325. issue 4. 1984-07-18. PMID:6427633. |
ketanserin, an antagonist of 5ht2 -receptors, and 8-(n,n-diethyl-amino)octyl-3,4,5-trimethoxybenzoate (tmb-8), an intracellular ca2+-antagonist, counteracted the effects of 5ht much more than those of a23187, whereas acetylsalicylate and indomethacin did not influence the actions of either 5ht or a23187. |
1984-07-18 |
2023-08-12 |
human |
| G Engel, E Müller-Schweinitzer, J M Palacio. 2-[125Iodo]LSD, a new ligand for the characterisation and localisation of 5-HT2 receptors. Naunyn-Schmiedeberg's archives of pharmacology. vol 325. issue 4. 1984-07-18. PMID:6728042. |
it can be concluded that the sites labelled by 125iol have pharmacological properties in common with central 5ht2 receptors, which are identical with vascular postjunctional 5ht receptors. |
1984-07-18 |
2023-08-12 |
rat |
| E Glusa, F Markward. Inhibition of 5-hydroxytryptamine-potentiated aggregation of human blood platelets by 5-hydroxytryptamine receptor-blocking agents. Biomedica biochimica acta. vol 43. issue 2. 1984-07-18. PMID:6732757. |
our results indicate a certain similarity between the 5-ht receptors on platelets and the 5-ht receptors on serotonergic neurons and vascular smooth muscle which belong to the 5-ht2 receptor type. |
1984-07-18 |
2023-08-12 |
human |
| H Moritoki, M Takei, M Kotani, Y Kiso, Y Ishida, K Endo. Tripeptides acting on opioid receptors in rat colon. European journal of pharmacology. vol 100. issue 1. 1984-07-16. PMID:6202530. |
the actions of the tripeptides were inhibited by methysergide and methylergometrine, but not by the 5-ht2 antagonist ketanserin, and were not affected by 5-ht or substance p autodesensitization . |
1984-07-16 |
2023-08-12 |
rat |
| L Pawłowsk. Amitriptyline and femoxetine, but not clomipramine or citalopram, antagonize hyperthermia induced by directly acting 5-hydroxytryptamine-like drugs in heat adapted rats. The Journal of pharmacy and pharmacology. vol 36. issue 3. 1984-07-09. PMID:6144758. |
5-ht uptake inhibitors and pirenperone (a 5-ht2 receptor antagonist), which in previous experiments antagonized fenfluramine (5-ht releaser)-induced hyperthermia in heat adapted rats, were tested against hyperthermia induced by the directly acting 5-ht agonist--m-cpp and quipazine. |
1984-07-09 |
2023-08-12 |
rat |
| L Pawłowsk. Amitriptyline and femoxetine, but not clomipramine or citalopram, antagonize hyperthermia induced by directly acting 5-hydroxytryptamine-like drugs in heat adapted rats. The Journal of pharmacy and pharmacology. vol 36. issue 3. 1984-07-09. PMID:6144758. |
it is concluded that hyperthermia induced by 5-ht-like drugs in rats is due to the stimulation of the 5-ht2 receptor and that the antagonistic effect of citalopram and clomipramine against fenfluramine-induced hyperthermia might be connected with their effect on the uptake of 5-ht. |
1984-07-09 |
2023-08-12 |
rat |
| R W Prescott, P Kendall-Taylor, D R Weightman, M J Watson, W A Ratcliff. The effect of ketanserin, a specific serotonin antagonist on the PRL, GH, ACTH and cortisol responses to hypoglycaemia in normal subjects. Clinical endocrinology. vol 20. issue 2. 1984-06-20. PMID:6325044. |
the role of serotonin in the prolactin, growth hormone, acth and cortisol responses to hypoglycaemia has been investigated in normal subjects using a selective serotonin (5ht2) receptor antagonist, ketanserin. |
1984-06-20 |
2023-08-12 |
human |
| R W Prescott, P Kendall-Taylor, D R Weightman, M J Watson, W A Ratcliff. The effect of ketanserin, a specific serotonin antagonist on the PRL, GH, ACTH and cortisol responses to hypoglycaemia in normal subjects. Clinical endocrinology. vol 20. issue 2. 1984-06-20. PMID:6325044. |
these findings suggest that serotonin, probably acting through 5ht2 receptors, is involved in the stimulation of prolactin and acth release but not in the release of growth hormone, during insulin induced hypoglycaemia. |
1984-06-20 |
2023-08-12 |
human |
| b' M K Krsti\\xc4\\x87, Z S Katusi\\xc4\\x8. Divergent effects of pirenperone, a 5-HT2 antagonist, on the pressor and tachycardic responses to 5-HT in guinea-pigs. Archives internationales de physiologie et de biochimie. vol 91. issue 4. 1984-05-30. PMID:6202264.' |
divergent effects of pirenperone, a 5-ht2 antagonist, on the pressor and tachycardic responses to 5-ht in guinea-pigs. |
1984-05-30 |
2023-08-12 |
Not clear |
| b' M K Krsti\\xc4\\x87, Z S Katusi\\xc4\\x8. Divergent effects of pirenperone, a 5-HT2 antagonist, on the pressor and tachycardic responses to 5-HT in guinea-pigs. Archives internationales de physiologie et de biochimie. vol 91. issue 4. 1984-05-30. PMID:6202264.' |
it is concluded that not only the 5-ht receptors in arterial smooth muscle but also the 5-ht receptors in sympathetic ganglia and the adrenal medulla responsible for the pressor response to 5-ht are sensitive to the 5-ht antagonists and probably analogous to the central 5-ht2 receptors. |
1984-05-30 |
2023-08-12 |
Not clear |
| G Skolnik, U Bagge, A Dahlström, H Ahlma. The importance of 5-HT for tumor cell lodgement in the liver. International journal of cancer. vol 33. issue 4. 1984-05-18. PMID:6368410. |
to test the importance of 5-ht released from platelets, thrombocytopenia was induced with anti-platelet serum in one experimental group, while animals in another group were treated with ketanserin (a selective 5-ht2 receptor blocking agent). |
1984-05-18 |
2023-08-12 |
rat |
| R L Friedman, R J Barrett, E Sanders-Bus. Discriminative stimulus properties of quipazine: mediation by serotonin2 binding sites. The Journal of pharmacology and experimental therapeutics. vol 228. issue 3. 1984-05-02. PMID:6707913. |
the relative abilities of putative serotonin (5-ht) antagonists to block the quipazine discriminative cue were compared with their relative potencies to compete for the 5-ht1 and 5-ht2 binding sites in the brain. |
1984-05-02 |
2023-08-12 |
rat |
| R L Friedman, R J Barrett, E Sanders-Bus. Discriminative stimulus properties of quipazine: mediation by serotonin2 binding sites. The Journal of pharmacology and experimental therapeutics. vol 228. issue 3. 1984-05-02. PMID:6707913. |
the id50 values for the blockade of the quipazine discrimination by the 5-ht antagonists correlated significantly with their affinities for the 5-ht2 binding site (r = 0.87). |
1984-05-02 |
2023-08-12 |
rat |
| F De Clerck, B Xhonneux, J Leysen, P A Jansse. The involvement of 5-HT2-receptor sites in the activation of cat platelets. Thrombosis research. vol 33. issue 3. 1984-05-02. PMID:6710435. |
5-hydroxytryptamine (5-ht) induces a concentration-dependent aggregation/release of/by cat platelets (km = 6.2 x 10(-7) m); this activation is inhibited (ki = 5.24 x 10(-9) m) or reversed by ketanserin, a selective 5-ht2 receptor antagonist. |
1984-05-02 |
2023-08-12 |
rat |
| F De Clerck, B Xhonneux, J Leysen, P A Jansse. The involvement of 5-HT2-receptor sites in the activation of cat platelets. Thrombosis research. vol 33. issue 3. 1984-05-02. PMID:6710435. |
this study demonstrates a functional role for the 5-ht2 receptors in the primary activation of the platelets by 5-ht and in the secondary aggregation induced by other agonists, especially in platelets superreactive to 5-ht2 receptor activation. |
1984-05-02 |
2023-08-12 |
rat |
| M Ansseau, A Doumont, D Thiry, Y Gelder. Pilot study of a specific serotonergic antagonist, pirenperone, in the treatment of anxiety disorders. Acta psychiatrica Belgica. vol 83. issue 5. 1984-04-13. PMID:6670580. |
pirenperone (r 47465) is the prototype of a new class of psychotropic drugs, selective serotonin 5-ht2 receptor blocking agents. |
1984-04-13 |
2023-08-12 |
Not clear |
| A Vaccari, R Biassoni, P S Timira. Effects of neonatal dysthyroidism on serotonin type 1 and type 2 receptors in rat brain. European journal of pharmacology. vol 95. issue 1-2. 1984-03-29. PMID:6667715. |
severe hypothyroidism in both strains of rats markedly increased the density of serotonin type 1 (5-ht1) and type 2 (5-ht2) receptors in the brain (less cerebellum, corpus striatum and olfactory bulbs) at 31-32 days of age. |
1984-03-29 |
2023-08-12 |
rat |