| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M L Barbaccia, O Gandolfi, D M Chuang, E Cost. Differences in the regulatory adaptation of the 5HT recognition sites labelled by 3H-mianserin or 3H-ketanserin. Neuropharmacology. vol 22. issue 1. 1983-06-23. PMID:6843781. |
in crude synaptic membranes prepared from rat brain the sites occupied by 3h-spiroperidol that are displaced by microm concentrations of serotonin (5ht) have been termed 5ht2 receptors (peroutka and snyder, 1980). |
1983-06-23 |
2023-08-12 |
rat |
| M L Barbaccia, O Gandolfi, D M Chuang, E Cost. Differences in the regulatory adaptation of the 5HT recognition sites labelled by 3H-mianserin or 3H-ketanserin. Neuropharmacology. vol 22. issue 1. 1983-06-23. PMID:6843781. |
since the 3h-spiroperidol displaced by 5ht is also displaced very effectively (ic50 in the nm range) by ketanserin and mianserin it was suggested that spiroperidol, mianserin and ketanserin are labelling 5ht2 receptors. |
1983-06-23 |
2023-08-12 |
rat |
| M L Cohen, N Mason, K S Wiley, R W Fulle. Further evidence that vascular serotonin receptors are of the 5HT2 type. Biochemical pharmacology. vol 32. issue 3. 1983-06-23. PMID:6847706. |
further evidence that vascular serotonin receptors are of the 5ht2 type. |
1983-06-23 |
2023-08-12 |
Not clear |
| F Cantalamessa, G de Caro, M Massi, L G Micoss. Ketanserin, a new selective 5-HT2 receptor blocking agent, inhibits the antidiuretic effect of 5-hydroxytryptamine (5-HT) in Wistar rats. Archives internationales de pharmacodynamie et de therapie. vol 261. issue 2. 1983-05-27. PMID:6838287. |
ketanserin, a new selective 5-ht2 receptor blocking agent, inhibits the antidiuretic effect of 5-hydroxytryptamine (5-ht) in wistar rats. |
1983-05-27 |
2023-08-12 |
rat |
| J M Liebman, R A Lovell, A Braunwalder, G Stone, P Bernard, B Barbaz, J Welch, H S Kim, J W Wasley, R D Robso. CGS 7525A, a new, centrally active alpha 2 adrenoceptor antagonist. Life sciences. vol 32. issue 4. 1983-04-15. PMID:6131367. |
although yohimbine resembled cgs 7525a in most respects, its activity at 5-ht2 binding sites was relatively low, cgs 7525a was not associated with any appreciable blockade of norepinephrine or serotonin uptake in vitro. |
1983-04-15 |
2023-08-12 |
Not clear |
| S J Peroutka, M Noguchi, D J Tolner, G S Alle. Serotonin-induced contraction of canine basilar artery: mediation by 5-HT1 receptors. Brain research. vol 259. issue 2. 1983-04-15. PMID:6824943. |
absolute potencies of both serotonin agonists and antagonists in chamber contraction studies significantly correlate (p less than 0.01) with their potencies for 5-ht1, but not 5-ht2, receptors as defined by central nervous system radioligand binding studies. |
1983-04-15 |
2023-08-12 |
Not clear |
| L P Niles, G M Brown, R K Mishr. A serotonergic component of [3H] N-acetylserotonin binding in mammalian brain. Progress in neuro-psychopharmacology & biological psychiatry. vol 6. issue 4-6. 1983-04-07. PMID:6891808. |
the 5-ht agonist, quipazine, and various 5-ht antagonists, including the 5-ht2 antagonist, ketanserine, also inhibited binding with moderate affinity in the frontal cortex. |
1983-04-07 |
2023-08-12 |
human |
| J M Van Nuete. 5-hydroxytryptamine and precapillary vessels. Federation proceedings. vol 42. issue 2. 1983-03-17. PMID:6295823. |
the interaction of 5-ht with 5-ht2 receptors is inhibited by specific antagonists such as ketanserin and methysergide. |
1983-03-17 |
2023-08-12 |
Not clear |
| S J Peroutka, S H Snyde. Multiple serotonin receptors and their physiological significance. Federation proceedings. vol 42. issue 2. 1983-03-17. PMID:6337063. |
5-ht1 sites are labeled preferentially by [3h]5-ht, whereas [3h]spiroperidol selectively labels 5-ht2 receptors. |
1983-03-17 |
2023-08-12 |
Not clear |
| S J Peroutka, S H Snyde. Multiple serotonin receptors and their physiological significance. Federation proceedings. vol 42. issue 2. 1983-03-17. PMID:6337063. |
5-ht and other agonists display 50-1000 times greater affinity for 5-ht1 than 5-ht2 sites, whereas most known 5-ht antagonists have 100-1000 times greater affinity for 5-ht2 than 5-ht1 receptors. |
1983-03-17 |
2023-08-12 |
Not clear |
| S J Peroutka, S H Snyde. Multiple serotonin receptors and their physiological significance. Federation proceedings. vol 42. issue 2. 1983-03-17. PMID:6337063. |
drug potencies in blocking 5-ht behavioral effects in rodents and in antagonizing vascular effects of 5-ht in several blood vessel systems correlate best with influences on 5-ht2 receptors. |
1983-03-17 |
2023-08-12 |
Not clear |
| b' M K Krsti\\xc4\\x87, Z S Katusi\\xc4\\x8. Divergent effects of cyproheptadine and R 50 656, a 5-HT2 antagonist, on the cardiovascular response to 5-hydroxytryptamine in rats. European journal of pharmacology. vol 85. issue 2. 1983-03-11. PMID:6129985.' |
divergent effects of cyproheptadine and r 50 656, a 5-ht2 antagonist, on the cardiovascular response to 5-hydroxytryptamine in rats. |
1983-03-11 |
2023-08-12 |
rat |
| b' M K Krsti\\xc4\\x87, Z S Katusi\\xc4\\x8. Divergent effects of cyproheptadine and R 50 656, a 5-HT2 antagonist, on the cardiovascular response to 5-hydroxytryptamine in rats. European journal of pharmacology. vol 85. issue 2. 1983-03-11. PMID:6129985.' |
cyproheptadine and r 50 656, a novel 5-ht2 antagonist, produced a dose-dependent suppression of the pressor response to 5-hydroxytryptamine (5-ht), but did not affect the depressor response. |
1983-03-11 |
2023-08-12 |
rat |
| C S Cascio, K J Kella. Tetrahydro-beta-carbolines: affinities for tryptamine and serotonergic binding sites. Neuropharmacology. vol 21. issue 11. 1983-02-25. PMID:7177348. |
the affinities of four tetrahydro-beta-carbolines at [3h]tryptamine, [3h]5-ht (5-ht1), and [3h]spiperone (5-ht2) binding sites in rat cerebral cortex were investigated. |
1983-02-25 |
2023-08-12 |
rat |
| F De Clerck, L Van Gorp, B Xhonneux, Y Somers, L Wouter. Enhanced platelet turnover and prostaglandin production in spontaneously hypertensive rats. Thrombosis research. vol 27. issue 3. 1982-12-21. PMID:7135358. |
the anti-hypertensive effect of ketanserin, a selective 5-ht2 antagonist, both in experimental and human pathology (1,2) could implicate the blood platelets as a source for peripherally available 5-hydroxytryptamine (5-ht), acting to increase peripheral vascular resistance (3). |
1982-12-21 |
2023-08-12 |
human |
| M Qui. Presence of an endogenous factor which inhibits binding of alpha-bungarotoxin 2.2 to its receptor. Brain research. vol 245. issue 1. 1982-12-02. PMID:7116193. |
specificity of the supernatant for the alpha-bungarotoxin site was demonstrated; a supernatant fraction could be prepared which inhibited alpha-bungarotoxin binding by 50% but had no effect on [3h]spiroperidol (da2 and 5-ht2), [3h]prazosin (alpha 1-adrenergic, [3h]5-hydroxytryptamine (5-ht1) and [3h]quinuclidinylbenzilate (muscarinic cholinergic) binding. |
1982-12-02 |
2023-08-12 |
rat |
| S Clements-Jewery, P A Robso. Intact 5HT neuroterminals are not required for 5HT2 receptor down-regulation by amitriptyline. Neuropharmacology. vol 21. issue 7. 1982-12-02. PMID:7121743. |
intact 5ht neuroterminals are not required for 5ht2 receptor down-regulation by amitriptyline. |
1982-12-02 |
2023-08-12 |
rat |
| D A Kendall, G M Stancel, S J Enn. The influence of sex hormones on antidepressant-induced alterations in neurotransmitter receptor binding. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 2. issue 3. 1982-05-27. PMID:7062114. |
long term (21-day) treatment with antidepressants induces a decrease in beta-adrenergic and serotonin 2 (5-ht2) receptor binding in rat brain frontal cortex. |
1982-05-27 |
2023-08-12 |
rat |
| L L Martin, R L Bouchal, D J Smit. Ketamine inhibits serotonin uptake in vivo. Neuropharmacology. vol 21. issue 2. 1982-05-21. PMID:6460944. |
ketamine only weakly affected either [3h]5-ht or [3h]spiroperidol binding to 5-ht1 and 5-ht2 receptors respectively even at concentrations as high as 1 mm. |
1982-05-21 |
2023-08-12 |
Not clear |
| M A Blackshear, L R Steranka, E Sanders-Bus. Multiple serotonin receptors: regional distribution and effect of Raphe lesions. European journal of pharmacology. vol 76. issue 4. 1982-04-12. PMID:7327207. |
these sites are referred to as 5ht, and 5ht2, respectively. |
1982-04-12 |
2023-08-12 |
rat |