| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P D Verdouw, H M Jennewein, J Heiligers, D J Duncker, P R Saxen. Redistribution of carotid artery blood flow by 5-HT: effects of the 5-HT2 receptor antagonists ketanserin and Wal 1307. European journal of pharmacology. vol 102. issue 3-4. 1984-12-12. PMID:6548449. |
the major part of the constriction of arteriovenous anastomoses and arteriolar dilation elicited by 5-ht is, however, not mediated by 5-ht2 receptors. |
1984-12-12 |
2023-08-12 |
Not clear |
| A Pettersson, B Persson, M Henning, T Hedne. Antihypertensive effects of chronic 5-hydroxytryptamine (5-HT2) receptor blockade with ketanserin in the spontaneously hypertensive rat. Naunyn-Schmiedeberg's archives of pharmacology. vol 327. issue 1. 1984-12-05. PMID:6493349. |
antihypertensive effects of chronic 5-hydroxytryptamine (5-ht2) receptor blockade with ketanserin in the spontaneously hypertensive rat. |
1984-12-05 |
2023-08-12 |
rat |
| G M Goodwin, A R Green, P Johnso. 5-HT2 receptor characteristics in frontal cortex and 5-HT2 receptor-mediated head-twitch behaviour following antidepressant treatment to mice. British journal of pharmacology. vol 83. issue 1. 1984-11-28. PMID:6237705. |
the effects of repeated administration of antidepressant drugs or electroconvulsive shock on the binding of [3h]-spiperone to the 5-hydroxytryptamine 2 (5-ht2) receptor in mouse frontal cortex and the 5-ht-mediated head-twitch response have been examined. |
1984-11-28 |
2023-08-12 |
mouse |
| M T Nakada, C M Wieczorek, T C Rainbo. Localization and characterization by quantitative autoradiography of [125I]LSD binding sites in rat brain. Neuroscience letters. vol 49. issue 1-2. 1984-11-26. PMID:6493586. |
in agreement with the results of hartig and co-workers [5,6], [125i]lsd showed a high affinity for 5-ht2 serotonin receptors with some overlap with d-2 dopamine receptors. |
1984-11-26 |
2023-08-12 |
rat |
| J De Cree, J Leempoels, H Geukens, H Verhaege. Placebo-controlled double-blind trial of ketanserin in treatment of intermittent claudication. Lancet (London, England). vol 2. issue 8406. 1984-11-19. PMID:6148522. |
ketanserin, a selective serotonin (5-ht) antagonist at 5-ht2 receptors, was investigated in a 3-month, double-blind, placebo-controlled study in twenty patients with intermittent claudication. |
1984-11-19 |
2023-08-12 |
Not clear |
| S J Peroutka, M J Kuha. Autoradiographic localization of 5-HT1 receptors to human and canine basilar arteries. Brain research. vol 310. issue 1. 1984-11-19. PMID:6478239. |
5-ht1, but not 5-ht2, receptors could be localized to the medial layer of the vascular wall using both [3h]lsd and [3h]5-ht. |
1984-11-19 |
2023-08-12 |
human |
| J Traber, M A Davies, W U Dompert, T Glaser, T Schuurman, P R Seide. Brain serotonin receptors as a target for the putative anxiolytic TVX Q 7821. Brain research bulletin. vol 12. issue 6. 1984-11-19. PMID:6541079. |
since ketanserin (a putative 5-ht2 ligand) was equally weak in displacing labeled 5-ht or tvx q 7821, tvx q 7821 may preferentially bind to 5-ht1, receptors. |
1984-11-19 |
2023-08-12 |
Not clear |
| M Frenken, A J Kauman. Interaction of ketanserin and its metabolite ketanserinol with 5HT2 receptors in pulmonary and coronary arteries of calf. Naunyn-Schmiedeberg's archives of pharmacology. vol 326. issue 4. 1984-11-13. PMID:6482982. |
the evidence is consistent with the assumption that smooth muscle 5ht receptors of both pulmonary artery and large coronary artery are of the 5ht2 class. |
1984-11-13 |
2023-08-12 |
cattle |
| b' J Arnt, J Hyttel, K F Over\\xc3\\xb. Prolonged treatment with the specific 5-HT-uptake inhibitor citalopram: effect on dopaminergic and serotonergic functions. Polish journal of pharmacology and pharmacy. vol 36. issue 2-3. 1984-10-22. PMID:6591152.' |
the effect of prolonged administration of the clinically effective and specific serotonin (5-ht)-uptake-inhibitor, citalopram, has been studied in rats on behavioural measures of dopaminergic (da) and serotonergic activity and on da d-2, 5-ht2, alpha 1- and beta-adrenergic receptor number and affinity in vitro. |
1984-10-22 |
2023-08-12 |
rat |
| G Bartholin. Experimental basis for the antidepressant action of the GABA receptor agonist progabide. Neuroscience letters. vol 47. issue 3. 1984-10-15. PMID:6089056. |
also, these compounds, by changing the firing rate of the corresponding neurons, accelerate norepinephrine turnover (without changes in postsynaptic receptor density) and decrease 5-hydroxytryptamine (5-ht) liberation (with up-regulation of 5-ht2 receptors). |
1984-10-15 |
2023-08-12 |
Not clear |
| F De Clerck, B Xhonneux, J Leysen, P A Jansse. Evidence for functional 5-HT2 receptor sites on human blood platelets. Biochemical pharmacology. vol 33. issue 17. 1984-09-19. PMID:6466388. |
the 5-ht induced platelet reaction is inhibited in a concentration-dependent way by various serotonergic antagonists; the potency of these compounds in this respect correlates strongly with their potential to inhibit the specific binding of [3h] ketanserin, a selective label for 5-ht2 binding sites, to rat prefrontal cortex and striatum and to cat platelet membranes. |
1984-09-19 |
2023-08-12 |
human |
| M J Kadan, A M Krohn, M J Evans, R L Waltz, P R Harti. Characterization of 125I-lysergic acid diethylamide binding to serotonin receptors in rat frontal cortex. Journal of neurochemistry. vol 43. issue 3. 1984-09-13. PMID:6747625. |
this high specific activity, coupled with the selectivity of 125i-lsd for 5-ht2 sites, makes this ligand a sensitive new probe for 5-ht2 serotonin receptors. |
1984-09-13 |
2023-08-12 |
rat |
| A R Green, A P Guy, C R Gardne. The behavioural effects of RU 24969, a suggested 5-HT1 receptor agonist in rodents and the effect on the behaviour of treatment with antidepressants. Neuropharmacology. vol 23. issue 6. 1984-09-07. PMID:6462374. |
the results obtained are consistent with the view that administration of 5-ht agonists, such as quipazine and 5-methoxy-n,n-dimethyltryptamine, produces behaviour that results from stimulation of both 5-ht1 and 5-ht2 receptor populations. |
1984-09-07 |
2023-08-12 |
mouse |
| B P O'Malley, P E Jennings, N Cook, D B Barnett, F D Rosentha. The role of serotonin (5-HT) in the control of TSH and prolactin release in euthyroid subjects as assessed by the administration of ketanserin (5-HT2 antagonist) and zimelidine (5-HT re-uptake inhibitor). Psychoneuroendocrinology. vol 9. issue 1. 1984-08-22. PMID:6234610. |
the role of serotonin (5-ht) in the control of tsh and prolactin release in euthyroid subjects as assessed by the administration of ketanserin (5-ht2 antagonist) and zimelidine (5-ht re-uptake inhibitor). |
1984-08-22 |
2023-08-12 |
human |
| B P O'Malley, P E Jennings, N Cook, D B Barnett, F D Rosentha. The role of serotonin (5-HT) in the control of TSH and prolactin release in euthyroid subjects as assessed by the administration of ketanserin (5-HT2 antagonist) and zimelidine (5-HT re-uptake inhibitor). Psychoneuroendocrinology. vol 9. issue 1. 1984-08-22. PMID:6234610. |
we have studied the effects of ketanserin, a specific 5-ht2 antagonist, and zimelidine, a selective inhibitor of 5-ht re-uptake into central nervous system presynaptic terminals, upon basal and trh stimulated serum tsh and prolactin levels in euthyroid individuals. |
1984-08-22 |
2023-08-12 |
human |
| H F Lemberger, N Mason, M L Cohe. 5HT2 receptors in the rat portal vein: desensitization following cumulative serotonin addition. Life sciences. vol 35. issue 1. 1984-08-14. PMID:6738305. |
5ht2 receptors in the rat portal vein: desensitization following cumulative serotonin addition. |
1984-08-14 |
2023-08-12 |
rat |
| H F Lemberger, N Mason, M L Cohe. 5HT2 receptors in the rat portal vein: desensitization following cumulative serotonin addition. Life sciences. vol 35. issue 1. 1984-08-14. PMID:6738305. |
contractile responses to serotonin were examined in vitro in the longitudinal portal vein to determine whether such responses were mediated by the interaction of serotonin with 5ht1 receptors (those that preferentially bind [3h]serotonin) or 5ht2 receptors (those that preferentially bind [3h]spiperone). |
1984-08-14 |
2023-08-12 |
rat |
| H F Lemberger, N Mason, M L Cohe. 5HT2 receptors in the rat portal vein: desensitization following cumulative serotonin addition. Life sciences. vol 35. issue 1. 1984-08-14. PMID:6738305. |
using eight serotonin receptor antagonists (spiperone, metergoline, ly53857, ketanserin, trazodone, benzoctamine, 1-(1-naphthyl)piperazine, and 1-meta-methoxyphenylpiperazine), we found a significant correlation between the affinity for serotonin receptors in the rat portal vein and the ability to bind to 5ht2, but not 5ht1 receptors in rat frontal cortical membranes. |
1984-08-14 |
2023-08-12 |
rat |
| H F Lemberger, N Mason, M L Cohe. 5HT2 receptors in the rat portal vein: desensitization following cumulative serotonin addition. Life sciences. vol 35. issue 1. 1984-08-14. PMID:6738305. |
thus, 5ht2 receptor affinities of antagonists in the rat portal vein are best determined by the shift of non-cumulative responses to serotonin. |
1984-08-14 |
2023-08-12 |
rat |
| D E Mais, T R Bosi. A role for serotonin in alpha-naphthylthiourea-induced pulmonary edema. Toxicology and applied pharmacology. vol 74. issue 2. 1984-08-07. PMID:6429898. |
pretreatment with the selective 5-ht2 receptor antagonist, ketanserin, prevented the thrombocytopenia, the increase in lung content of 5-ht and 5-[3h]ht, and prevented the edematogenic response to antu by 70%. |
1984-08-07 |
2023-08-12 |
mouse |