| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Torr, M I Noble, J D Folt. Inhibition of acute platelet thrombosis formation in stenosed canine coronary arteries by specific serotonin 5HT2 receptor antagonist ritanserin. Cardiovascular research. vol 24. issue 6. 1990-09-27. PMID:2117499. |
inhibition of acute platelet thrombosis formation in stenosed canine coronary arteries by specific serotonin 5ht2 receptor antagonist ritanserin. |
1990-09-27 |
2023-08-11 |
Not clear |
| S Torr, M I Noble, J D Folt. Inhibition of acute platelet thrombosis formation in stenosed canine coronary arteries by specific serotonin 5HT2 receptor antagonist ritanserin. Cardiovascular research. vol 24. issue 6. 1990-09-27. PMID:2117499. |
the aim of the study was to test the hypothesis that platelet serotonin 5ht2 receptors are important in the genesis of thrombosis in stenosed coronary arteries. |
1990-09-27 |
2023-08-11 |
Not clear |
| L R Fitzpatrick, R M Lambert, C E Pendley, G E Martin, J S Bostwick, G W Gessner, J E Airey, R D Youssefyeh, R G Pendleton, D L Deckto. RG 12915: a potent 5-hydroxytryptamine-3 antagonist that is an orally effective inhibitor of cytotoxic drug-induced emesis in the ferret and dog. The Journal of pharmacology and experimental therapeutics. vol 254. issue 2. 1990-09-17. PMID:2166791. |
in radioligand binding assays, rg 12915 is a potent and selective displacer of binding of 5-hydroxytryptamine (5-ht)3 binding sites (ic50 value = 0.16 nm), whereas failing to displace binding of ligands for the alpha-1, alpha-2 and beta adrenergic, 5-ht1 or 5-ht2 or cholinergic-muscarinic sites with ic50 values less than 1 microm. |
1990-09-17 |
2023-08-11 |
dog |
| S Ahlenius, V Hillegaart, A Wijkströ. Increased dopamine turnover in the ventral striatum by 8-OH-DPAT administration in the rat. The Journal of pharmacy and pharmacology. vol 42. issue 4. 1990-09-12. PMID:1974300. |
both the 5-ht1a agonist flesinoxan (0.06-17.8 mumos kg-1 s.c. -50 min) and the mixed 5-ht1 and 5-ht2 agonist 5-meodmt (1.6-26.0 mumols kg-1 s.c.-50 min) produced a decrease in forebrain 5-htp accumulation (striatum and neocortex), following decarboxylase inhibition by means of nsd-1015 in reserpine treated rats, indicating stimulation of central 5-ht receptors by these two compounds. |
1990-09-12 |
2023-08-11 |
rat |
| D Lebrec, A Hadengue, C Gaudin, J C Levron, B Fraitag, P Berthelot, J P Benhamo. Pharmacokinetics of ketanserin in patients with cirrhosis. Clinical pharmacokinetics. vol 19. issue 2. 1990-09-10. PMID:2379381. |
the pharmacokinetics of ketanserin, a new serotonin s2 (5ht2) antagonist, were studied in 26 patients with cirrhosis. |
1990-09-10 |
2023-08-11 |
human |
| H Gozlan, G Daval, D Verge, U Spampinato, C M Fattaccini, M C Gallissot, S el Mestikawy, M Hamo. Aging associated changes in serotoninergic and dopaminergic pre- and postsynaptic neurochemical markers in the rat brain. Neurobiology of aging. vol 11. issue 4. 1990-09-10. PMID:2381503. |
of the three different classes of 5-ht receptors which were examined, 5-ht1b sites exhibited the largest age-dependent decrease in density, followed by 5-ht2 sites, while 5-ht1a sites remained practically unchanged during aging. |
1990-09-10 |
2023-08-11 |
rat |
| Y P Dragan, E F Elli. 5-Hydroxytryptamine and the metabolism of arachidonic acid by the lipoxygenase and cyclooxygenase of washed human platelets. Biochemical pharmacology. vol 40. issue 2. 1990-08-30. PMID:2142882. |
in addition, the 5-ht2 receptor antagonist ketanserin (10(-7) m) did not block the changes in co or lipoxygenase metabolism induced by 5-ht. |
1990-08-30 |
2023-08-11 |
human |
| Y P Dragan, E F Elli. 5-Hydroxytryptamine and the metabolism of arachidonic acid by the lipoxygenase and cyclooxygenase of washed human platelets. Biochemical pharmacology. vol 40. issue 2. 1990-08-30. PMID:2142882. |
since both doi and dpat stimulated 12-hete formation whereas ketanserin was unable to reverse the 5-ht-enhanced 12-hete formation, it seems unlikely that the stimulation of a 5-ht2 receptor is responsible for this action of 5-ht on platelets. |
1990-08-30 |
2023-08-11 |
human |
| Y P Dragan, E F Elli. 5-Hydroxytryptamine and the metabolism of arachidonic acid by the lipoxygenase and cyclooxygenase of washed human platelets. Biochemical pharmacology. vol 40. issue 2. 1990-08-30. PMID:2142882. |
we conclude that 5-ht depresses co product formation while increasing 12-hete formation through interaction with a platelet serotonergic binding site other than the 5-ht2 receptor. |
1990-08-30 |
2023-08-11 |
human |
| S R Snodgras. Myoclonus: analysis of monoamine, GABA, and other systems. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 4. issue 10. 1990-08-30. PMID:2165012. |
among 5-ht receptors, 5-ht1a receptors are related to some forms of myoclonus, although 5-ht2 receptors are also implicated. |
1990-08-30 |
2023-08-11 |
human |
| A E Dusser, S J Peroutk. Neurotransmitter receptors in adult tottering (tg/tg) mice. Epilepsia. vol 31. issue 4. 1990-08-21. PMID:2164468. |
the amount of radioligand binding to 5-hydroxytryptamine 1a (5-ht1a), non-5-ht1a, 5-ht2, dopamine d2, and benzodiazepine receptors was also identical in tottering and control mice. |
1990-08-21 |
2023-08-11 |
mouse |
| b' M Toivonen, P T M\\xc3\\xa4nnist\\xc3\\xb. Complex actions of serotonergic agonists on cold-stimulated TSH secretion in male rats. European journal of pharmacology. vol 180. issue 1. 1990-08-13. PMID:2142094.' |
in conclusion, stimulation of both 5-ht1 and 5-ht2 receptors may inhibit tsh secretion, but the exact mechanism underlying the site-dependent action of 5-ht and 8-oh-dpat on tsh secretion remains to be identified. |
1990-08-13 |
2023-08-11 |
rat |
| A J Gaw, R M Wadsworth, P P Humphre. Pharmacological characterisation of postjunctional 5-HT receptors in cerebral arteries from the sheep. European journal of pharmacology. vol 179. issue 1-2. 1990-08-13. PMID:2163850. |
5-ht therefore appears to cause contraction by stimulation of a mixed receptor population of 5-ht1-like and 5-ht2 receptors. |
1990-08-13 |
2023-08-11 |
Not clear |
| S M Todorovic, E G Anderso. Pharmacological characterization of 5-hydroxytryptamine2 and 5-hydroxytryptamine3 receptors in rat dorsal root ganglion cells. The Journal of pharmacology and experimental therapeutics. vol 254. issue 1. 1990-08-13. PMID:2366178. |
when 5-ht increased the rin, the response was mimicked by the 5-ht2 agonists alpha-methyl-5-ht, (+/-)-1-(2,5-dimethoxy-4 iodophenyl)-2-aminopropane hcl, quipazine and mk 212 (6-chloro-1-[1-piperazinyl]-pyrazine), but not by 2-methyl-5-ht or carboxamidotryptamine. |
1990-08-13 |
2023-08-11 |
rat |
| D I Lewis, J H Coot. The influence of 5-hydroxytryptamine agonists and antagonists on identified sympathetic preganglionic neurones in the rat, in vivo. British journal of pharmacology. vol 99. issue 4. 1990-08-08. PMID:2361167. |
it was concluded that the excitatory responses evoked by 5-ht are mediated by a receptor that is neither 5-ht2 or 5-ht3, but shows similarities to the 5-ht1-like receptor profile. |
1990-08-08 |
2023-08-11 |
rat |
| D I Lewis, J H Coot. The influence of 5-hydroxytryptamine agonists and antagonists on identified sympathetic preganglionic neurones in the rat, in vivo. British journal of pharmacology. vol 99. issue 4. 1990-08-08. PMID:2361167. |
the inhibitory actions of 5-ht are mimicked by 2-me-5-ht, but the receptor is not 5-ht3, or 5-ht1-like or 5-ht2. |
1990-08-08 |
2023-08-11 |
rat |
| J R Lever, U A Scheffel, M Stathis, J L Musachio, H N Wagne. In vitro and in vivo binding of (E)- and (Z)-N-(iodoallyl)spiperone to dopamine D2 and serotonin 5-HT2 neuroreceptors. Life sciences. vol 46. issue 26. 1990-08-07. PMID:2362552. |
in vitro and in vivo binding of (e)- and (z)-n-(iodoallyl)spiperone to dopamine d2 and serotonin 5-ht2 neuroreceptors. |
1990-08-07 |
2023-08-11 |
mouse |
| J R Lever, U A Scheffel, M Stathis, J L Musachio, H N Wagne. In vitro and in vivo binding of (E)- and (Z)-N-(iodoallyl)spiperone to dopamine D2 and serotonin 5-HT2 neuroreceptors. Life sciences. vol 46. issue 26. 1990-08-07. PMID:2362552. |
apparent affinities (ki) of (e)- and (z)-n-(iodoallyl)spiperone [e)- and (z)-niasp) for dopamine d2 and serotonin 5-ht2 receptors were determined in competition binding assays. |
1990-08-07 |
2023-08-11 |
mouse |
| J R Lever, U A Scheffel, M Stathis, J L Musachio, H N Wagne. In vitro and in vivo binding of (E)- and (Z)-N-(iodoallyl)spiperone to dopamine D2 and serotonin 5-HT2 neuroreceptors. Life sciences. vol 46. issue 26. 1990-08-07. PMID:2362552. |
stereoselective, dose-dependent blockade of (e)-[125i]-niasp uptake was found for drugs binding to dopamine d2 sites, while drugs selective for serotonin 5-ht2, alpha 1-adrenergic and dopamine d1 receptors did not inhibit radioligand binding 2 hr postinjection. |
1990-08-07 |
2023-08-11 |
mouse |
| C F Saller, M J Czupryna, A I Salam. 5-HT2 receptor blockade by ICI 169,369 and other 5-HT2 antagonists modulates the effects of D-2 dopamine receptor blockade. The Journal of pharmacology and experimental therapeutics. vol 253. issue 3. 1990-07-31. PMID:2141636. |
the effects of d-2 dopamine (da) receptor blockade were modulated by ici 169,369, a selective 5-hydroxytryptamine (5-ht)2 receptor antagonist, and by other 5-ht2 antagonists. |
1990-07-31 |
2023-08-11 |
rat |