| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S M Evans, D Girdlestone, A Lopez, B Olivier, M H Robert. The actions of the novel anti-aggressive drug eltoprazine on central neurones in the anaesthetised rat. Neuropharmacology. vol 29. issue 10. 1991-01-24. PMID:1979428. |
cells in the brainstem have been shown previously to be excited by 5-ht, acting at a 5-ht2 receptor. |
1991-01-24 |
2023-08-11 |
rat |
| K Gradin, S Carlsson, T Hedner, B Persso. Cardiovascular effects of irindalone, a new S2-serotonergic antagonist, in the rat. Pharmacology & toxicology. vol 67. issue 3. 1991-01-24. PMID:2255675. |
irindalone is a new antihypertensive agent with affinity to serotonin (5-ht2) receptors and at higher concentrations also to alpha 1-adrenoceptors. |
1991-01-24 |
2023-08-11 |
rat |
| H Y Wang, E Friedma. Protein kinase C translocation in human blood platelets. Life sciences. vol 47. issue 16. 1991-01-16. PMID:2250559. |
serotonin (0.5-100 microm) and the specific 5-ht2 receptor agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (doi) (10-100 microm) but not the 5-ht1a or 5-ht1b agonists, (+/-) 8-hydroxy-dipropylamino-tetralin (8-oh-dpat) or 5-methoxy-3-3-(1,2,3,6-tetrahydro-4-pyridin) 1h-indole succinate (ru 24969) induced dose-dependent pkc translocations. |
1991-01-16 |
2023-08-11 |
human |
| G K Aghajanian, J S Sprouse, P Sheldon, K Rasmusse. Electrophysiology of the central serotonin system: receptor subtypes and transducer mechanisms. Annals of the New York Academy of Sciences. vol 600. 1991-01-14. PMID:2123618. |
based on the findings described in this review, the following pattern of central 5-ht electrophysiology is emerging: 1) inhibitory effects are mediated by 5-ht1 receptors linked to the opening of k channels via pertussis-toxin sensitive g proteins: 2) facilitatory effects are mediated by 5-ht2 receptors and involve the closing of k channels, an effect which appears to be negatively modulated by activation of the pi second messenger system: 3) fast excitations are mediated by 5-ht3 receptors, most likely involving a direct interaction with an ion channel rather than through coupling with a g protein or a second messenger. |
1991-01-14 |
2023-08-11 |
Not clear |
| D Hoyer, P Schoeffter, C Waeber, J M Palacio. Serotonin 5-HT1D receptors. Annals of the New York Academy of Sciences. vol 600. 1991-01-14. PMID:2252308. |
5-ht receptors are subdivided into 3 families, 5-ht1, 5-ht2, and 5-ht3, of which subtypes have been described. |
1991-01-14 |
2023-08-11 |
mouse |
| J E Leysen, P J Pauwel. 5-HT2 receptors, roles and regulation. Annals of the New York Academy of Sciences. vol 600. 1991-01-14. PMID:2252309. |
in vascular smooth muscle cells in culture kept for at least 24 h in a serotonin-free medium before treatment, the 5-ht2 receptor mediated 5-ht-induced inositol phosphate formation, was rapidly desensitized by agonist treatment: -20% after 15 min and -80% after 1 h incubation of the cells with 10(-5) m 5-ht or dom. |
1991-01-14 |
2023-08-11 |
rat |
| J J Mann, V Arango, M D Underwoo. Serotonin and suicidal behavior. Annals of the New York Academy of Sciences. vol 600. 1991-01-14. PMID:2252327. |
there also appears to be a region-specific increase in 5-ht2 receptors, which are post synaptic and may therefore be increased in number secondary to decreased serotonin levels. |
1991-01-14 |
2023-08-11 |
Not clear |
| D deBlois, J Bouthillier, F Marcea. Bacitracin U.S.P. contains a factor that stimulates receptors for 5-hydroxytryptamine on rabbit aortic strips. Life sciences. vol 47. issue 19. 1991-01-11. PMID:2250580. |
the use of several pharmacologic antagonists suggests that bac is a 5-hydroxytryptamine mimetic in aortic strips, since the antibiotic is competitively antagonized by methysergide and ketanserin with pa2 values compatible with an agonist action on the 5-ht2 receptors found in the aortic preparation. |
1991-01-11 |
2023-08-11 |
rabbit |
| N M Appel, W M Mitchell, R K Garlick, R A Glennon, M Teitler, E B De Souz. Autoradiographic characterization of (+-)-1-(2,5-dimethoxy-4-[125I] iodophenyl)-2-aminopropane ([125I]DOI) binding to 5-HT2 and 5-HT1c receptors in rat brain. The Journal of pharmacology and experimental therapeutics. vol 255. issue 2. 1990-12-31. PMID:2243353. |
the 5-ht2 (serotonin) receptor has traditionally been labeled with antagonist radioligands such as [3h]ketanserin and [3h]spiperone, which label both agonist high-affinity (guanyl nucleotide-sensitive) and agonist low-affinity (guanyl nucleotide-insensitive) states of this receptor. |
1990-12-31 |
2023-08-11 |
rat |
| T Branchek, N Adham, M Macchi, H T Kao, P R Harti. [3H]-DOB(4-bromo-2,5-dimethoxyphenylisopropylamine) and [3H] ketanserin label two affinity states of the cloned human 5-hydroxytryptamine2 receptor. Molecular pharmacology. vol 38. issue 5. 1990-12-19. PMID:2233697. |
in this investigation, a cdna clone encoding the serotonin 5-ht2 receptor was transiently transfected into monkey kidney cos-7 cells and stably transfected into mouse fibroblast l-m(tk-) cells. |
1990-12-19 |
2023-08-11 |
mouse |
| V Arango, P Ernsberger, P M Marzuk, J S Chen, H Tierney, M Stanley, D J Reis, J J Man. Autoradiographic demonstration of increased serotonin 5-HT2 and beta-adrenergic receptor binding sites in the brain of suicide victims. Archives of general psychiatry. vol 47. issue 11. 1990-12-13. PMID:2173513. |
autoradiographic demonstration of increased serotonin 5-ht2 and beta-adrenergic receptor binding sites in the brain of suicide victims. |
1990-12-13 |
2023-08-11 |
Not clear |
| V Arango, P Ernsberger, P M Marzuk, J S Chen, H Tierney, M Stanley, D J Reis, J J Man. Autoradiographic demonstration of increased serotonin 5-HT2 and beta-adrenergic receptor binding sites in the brain of suicide victims. Archives of general psychiatry. vol 47. issue 11. 1990-12-13. PMID:2173513. |
we determined the pattern of alteration in serotonin 5-ht2 (5-ht2) receptor binding sites in suicide victims in prefrontal cortex compared with temporal cortex using a matched-pairs design to study 11 suicide victims and 11 matched controls, by both membrane binding and quantitative receptor autoradiography. |
1990-12-13 |
2023-08-11 |
Not clear |
| H Beele, H Thierens, L de Ridde. Direct effects of serotonin, and 5-HT2, alpha 1 and H1 receptor-antagonists on embryonic chick skin in vitro: a morphological and functional study. Cell biology international reports. vol 14. issue 8. 1990-12-12. PMID:1977525. |
direct effects of serotonin, and 5-ht2, alpha 1 and h1 receptor-antagonists on embryonic chick skin in vitro: a morphological and functional study. |
1990-12-12 |
2023-08-11 |
chicken |
| A R Renzetti, D Barone, M Criscuol. High-affinity binding of mequitamium iodide (LG 30435) to muscarinic and histamine H1 receptors. European journal of pharmacology. vol 182. issue 3. 1990-12-12. PMID:2226618. |
lower affinity values (ki = 1-10 microm) were found for serotonin 5-ht2, platelet-activating factor (paf), verapamil and beta-adrenergic agents. |
1990-12-12 |
2023-08-11 |
rat |
| E C Twist, M J Brammer, J D Stephenson, T H Corn, I C Campbel. The effect of chronic ritanserin and clorgyline administration on 5-HT2 receptor linked inositol phospholipid hydrolysis. Biochemical pharmacology. vol 40. issue 9. 1990-12-10. PMID:2122900. |
we have previously shown that chronic administration of the 5-hydroxytryptamine (5-ht) receptor antagonist, ritanserin (10 mg/kg/day) or the monoamine oxidase type a inhibitor (maoi), clorgyline (2 mg/kg/day), results in a reduction in 5-ht2 receptor number in rat cerebral cortex. |
1990-12-10 |
2023-08-11 |
rat |
| M Sega. Serotonin attenuates a slow inhibitory postsynaptic potential in rat hippocampal neurons. Neuroscience. vol 36. issue 3. 1990-12-06. PMID:2234404. |
the effects of serotonin on the inhibitory postsynaptic potentials are blocked by the 5-ht1a antagonist spiperone, and not by mianserin, a 5-ht2 antagonist. |
1990-12-06 |
2023-08-11 |
rat |
| R A Baumgartner, M Wills-Karp, M J Kaufman, M Munakata, C Hirshma. Serotonin induces constriction and relaxation of the guinea pig airway. The Journal of pharmacology and experimental therapeutics. vol 255. issue 1. 1990-11-21. PMID:1976797. |
the 5-ht2 antagonist ketanserin shifted the bimodal 5-ht response-curve to the right (pa2 for ketanserin was 8.98). |
1990-11-21 |
2023-08-11 |
Not clear |
| R A Baumgartner, M Wills-Karp, M J Kaufman, M Munakata, C Hirshma. Serotonin induces constriction and relaxation of the guinea pig airway. The Journal of pharmacology and experimental therapeutics. vol 255. issue 1. 1990-11-21. PMID:1976797. |
the above findings suggest that 5-ht causes both constriction and relaxation of the guinea pig airway, and that both responses are antagonized by a 5-ht2 receptor blocker. |
1990-11-21 |
2023-08-11 |
Not clear |
| L B Zhang, D C Dye. Characterization of serotonergic receptors mediating contraction of ovine umbilical artery. The Journal of pharmacology and experimental therapeutics. vol 255. issue 1. 1990-11-21. PMID:2213559. |
variations in the sensitivity and potency of the agonists results primarily from the variation in the affinity for the 5-ht2 receptor and less so in the efficacy, alpha-methyl-5-ht was a full agonist compared to 5-ht. |
1990-11-21 |
2023-08-11 |
Not clear |
| L B Zhang, D C Dye. Characterization of serotonergic receptors mediating contraction of ovine umbilical artery. The Journal of pharmacology and experimental therapeutics. vol 255. issue 1. 1990-11-21. PMID:2213559. |
contractions to 5-ht and dom were antagonized by ketanserin with pa2 values being 9.4 and 9.1, respectively, suggesting that they act on the same receptor and that their responses are mediated by 5-ht2 receptors. |
1990-11-21 |
2023-08-11 |
Not clear |