| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Kagaya, M Mikuni, I Kusumi, H Yamamoto, K Takahash. Serotonin-induced acute desensitization of serotonin2 receptors in human platelets via a mechanism involving protein kinase C. The Journal of pharmacology and experimental therapeutics. vol 255. issue 1. 1990-11-21. PMID:2213562. |
serotonin-induced acute desensitization of serotonin2 receptors in human platelets via a mechanism involving protein kinase c. serotonin (5-ht)-induced changes in the levels of intracellular ca++ were analyzed in human platelets, using the ca+(+)-sensitive dye 1-(2-(5'-carboxyoxazol-2'-yl)-6-aminobenzofuran-5-oxy)-2-(2' -amino-5'- methylphenox)-ethane-n,n,n',n'-tetraacetic acid, pentaacetoxymethyl ester, to investigate the regulation of 5-ht2 receptor function. |
1990-11-21 |
2023-08-11 |
human |
| A Kagaya, M Mikuni, I Kusumi, H Yamamoto, K Takahash. Serotonin-induced acute desensitization of serotonin2 receptors in human platelets via a mechanism involving protein kinase C. The Journal of pharmacology and experimental therapeutics. vol 255. issue 1. 1990-11-21. PMID:2213562. |
ketanserin, a 5-ht2 antagonist, reversed the 5-ht (10 microm)-induced ca++ increase in a dose-dependent manner with an ic50 value of 2 nm. |
1990-11-21 |
2023-08-11 |
human |
| A Kagaya, M Mikuni, I Kusumi, H Yamamoto, K Takahash. Serotonin-induced acute desensitization of serotonin2 receptors in human platelets via a mechanism involving protein kinase C. The Journal of pharmacology and experimental therapeutics. vol 255. issue 1. 1990-11-21. PMID:2213562. |
an initial treatment with 10 microm 5-ht abolished the response to a second treatment with 100 microm 5-ht, suggesting that 5-ht evoked an acute desensitization of 5-ht2 receptors in human platelets. |
1990-11-21 |
2023-08-11 |
human |
| R A Glennon, C Chaurasia, M Titele. Binding of indolylalkylamines at 5-HT2 serotonin receptors: examination of a hydrophobic binding region. Journal of medicinal chemistry. vol 33. issue 10. 1990-11-20. PMID:2213830. |
binding of indolylalkylamines at 5-ht2 serotonin receptors: examination of a hydrophobic binding region. |
1990-11-20 |
2023-08-11 |
Not clear |
| R A Glennon, C Chaurasia, M Titele. Binding of indolylalkylamines at 5-HT2 serotonin receptors: examination of a hydrophobic binding region. Journal of medicinal chemistry. vol 33. issue 10. 1990-11-20. PMID:2213830. |
whereas tryptamine derivatives generally display little selectivity for the various populations of 5-ht receptors, n1-n-propyl-5-methoxy-alpha-methyltryptamine (3h) binds with significant affinity (ki = 12 nm) and selectivity at 5-ht2 receptors relative to 5-ht1a (ki = 7100 nm), 5-ht1b (ki = 5000 nm), 5-ht1c (ki = 120 nm), and 5-ht1d (ki greater than 10,000 nm) receptors. |
1990-11-20 |
2023-08-11 |
Not clear |
| L I Backus, T Sharp, D G Grahame-Smit. Behavioural evidence for a functional interaction between central 5-HT2 and 5-HT1A receptors. British journal of pharmacology. vol 100. issue 4. 1990-11-19. PMID:2145051. |
the possibility of 5-ht2 receptor modulation of central 5-ht1a receptor function has been examined using the 5-hydroxytryptamine (5-ht) behavioural syndrome induced by 5-ht1a receptor active drugs in rats. |
1990-11-19 |
2023-08-11 |
rat |
| M Cappelli-Bigazzi, K G Lamping, D W Nuno, D G Harriso. Leukocyte and platelet-derived factors augment canine coronary constriction to serotonin. The American journal of physiology. vol 259. issue 4 Pt 2. 1990-11-19. PMID:2171364. |
normalization of relaxation to serotonin in hypertensive vessels by ketanserin is likely due to inhibition of 5-hydroxytryptamine2 (5-ht2) receptors on platelet membranes. |
1990-11-19 |
2023-08-11 |
Not clear |
| N A Darmani, B R Martin, U Pandey, R A Glenno. Do functional relationships exist between 5-HT1A and 5-HT2 receptors? Pharmacology, biochemistry, and behavior. vol 36. issue 4. 1990-11-14. PMID:2145593. |
to investigate the possible functional relationship between 5-ht1 and 5-ht2 receptors, we studied the effects of a nonselective 5-ht agonist (5-meo dmt), a 5-ht1a-selective (8-oh-dpat) and a 5-ht1b/5-ht1c-selective (tfmpp) agonist on the head-twitch behavior induced by the putative 5-ht2-selective receptor agonist (+/-)-doi. |
1990-11-14 |
2023-08-11 |
mouse |
| M R Pranzatell. Evidence for involvement of 5-HT2 and 5-HT1C receptors in the behavioral effects of the 5-HT agonist 1-(2,5-dimethoxy-4-iodophenyl aminopropane)-2 (DOI). Neuroscience letters. vol 115. issue 1. 1990-11-14. PMID:2216059. |
evidence for involvement of 5-ht2 and 5-ht1c receptors in the behavioral effects of the 5-ht agonist 1-(2,5-dimethoxy-4-iodophenyl aminopropane)-2 (doi). |
1990-11-14 |
2023-08-11 |
rat |
| A M Mistry, J L Voog. Serotonin synthesis inhibition or receptor antagonism reduces pregnancy-induced nocturnal prolactin secretion. Life sciences. vol 47. issue 8. 1990-10-23. PMID:2144886. |
its role in the n surge remained inconclusive due to the contradictory results obtained with the 5-ht synthesis inhibitor parachlorophenylalanine (pcpa) and 5-ht2 receptor antagonists. |
1990-10-23 |
2023-08-11 |
rat |
| J Sawynok, A Rei. Supersensitivity to intrathecal 5-hydroxytryptamine, but not noradrenaline, following depletion of spinal 5-hydroxytryptamine by 5,7-dihydroxytryptamine administered into various sites. Naunyn-Schmiedeberg's archives of pharmacology. vol 342. issue 1. 1990-10-23. PMID:2402297. |
thus, the 5ht behavioural syndrome (presumably mediated by 5ht1a receptors) more readily reflects the development of supersensitivity than the tail flick test (presumably mediated by 5ht2 receptors), while the hot plate test (uncharacterized subtype) shows an intermediate development of supersensitivity. |
1990-10-23 |
2023-08-11 |
Not clear |
| R Gross-Isseroff, D Salama, M Israeli, A Biego. Autoradiographic analysis of age-dependent changes in serotonin 5-HT2 receptors of the human brain postmortem. Brain research. vol 519. issue 1-2. 1990-10-16. PMID:2397409. |
autoradiographic analysis of age-dependent changes in serotonin 5-ht2 receptors of the human brain postmortem. |
1990-10-16 |
2023-08-11 |
human |
| M Bodelsson, B Arneklo-Nobin, K Törnebrand. Cooling augments contractile response to 5-hydroxytryptamine via an endothelium-dependent mechanism. Blood vessels. vol 26. issue 6. 1990-10-16. PMID:2641924. |
5-ht at concentrations of more than 10(-8) m induced a contraction in all vessels at 37 degrees c mediated via a 5-ht2 receptor. |
1990-10-16 |
2023-08-11 |
rat |
| J A Den Boer, H G Westenber. Serotonin function in panic disorder: a double blind placebo controlled study with fluvoxamine and ritanserin. Psychopharmacology. vol 102. issue 1. 1990-10-04. PMID:1697419. |
in order to evaluate serotonin (5-ht) function in panic disorder, a double blind placebo controlled study was conducted with ritanserin, a specific 5-ht2 receptor antagonist, and fluvoxamine, a selective 5-ht reuptake inhibitor, in 60 patients with panic disorder. |
1990-10-04 |
2023-08-11 |
Not clear |
| W Löscher, U Witte, G Fredow, M Ganter, K Bickhard. Pharmacodynamic effects of serotonin (5-HT) receptor ligands in pigs: stimulation of 5-HT2 receptors induces malignant hyperthermia. Naunyn-Schmiedeberg's archives of pharmacology. vol 341. issue 6. 1990-10-04. PMID:2118235. |
pharmacodynamic effects of serotonin (5-ht) receptor ligands in pigs: stimulation of 5-ht2 receptors induces malignant hyperthermia. |
1990-10-04 |
2023-08-11 |
Not clear |
| A Biegon, N Essar, M Israeli, A Elizur, S Bruch, A A Bar-Natha. Serotonin 5-HT2 receptor binding on blood platelets as a state dependent marker in major affective disorder. Psychopharmacology. vol 102. issue 1. 1990-10-04. PMID:2392511. |
serotonin 5-ht2 receptor binding on blood platelets as a state dependent marker in major affective disorder. |
1990-10-04 |
2023-08-11 |
Not clear |
| A Biegon, N Essar, M Israeli, A Elizur, S Bruch, A A Bar-Natha. Serotonin 5-HT2 receptor binding on blood platelets as a state dependent marker in major affective disorder. Psychopharmacology. vol 102. issue 1. 1990-10-04. PMID:2392511. |
serotonin receptors of the 5-ht2 type were studied on platelet membranes from 15 patients suffering from major depression. |
1990-10-04 |
2023-08-11 |
Not clear |
| T M Aune, K A Kelley, G E Ranges, M P Bombar. Serotonin-activated signal transduction via serotonin receptors on Jurkat cells. Journal of immunology (Baltimore, Md. : 1950). vol 145. issue 6. 1990-10-03. PMID:2144010. |
binding of serotonin to the 5ht1 family results in inhibition of adenylate cyclase whereas binding to the 5ht2 family results in stimulation of phosphatidylinositol turnover and mobilization of intracellular ca2+. |
1990-10-03 |
2023-08-11 |
human |
| T M Aune, K A Kelley, G E Ranges, M P Bombar. Serotonin-activated signal transduction via serotonin receptors on Jurkat cells. Journal of immunology (Baltimore, Md. : 1950). vol 145. issue 6. 1990-10-03. PMID:2144010. |
these results link the 5ht receptor on jurkat cells to the 5ht2 family; however, studies with 5ht receptor agonists and antagonists failed to clearly classify the 5ht receptor on jurkat cells as a known member of the 5ht2 family. |
1990-10-03 |
2023-08-11 |
human |
| C J Schmidt, C K Black, V L Taylo. Antagonism of the neurotoxicity due to a single administration of methylenedioxymethamphetamine. European journal of pharmacology. vol 181. issue 1-2. 1990-09-27. PMID:1974858. |
although these results strongly implicate dopamine release in the long-term neurochemical effects of mdma, protection was also provided by selective 5-ht2 antagonists indicating that the neurotoxicity is dependent upon the release of both dopamine and 5-ht. |
1990-09-27 |
2023-08-11 |
Not clear |