| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Fox, I K Morto. An examination of the 5-HT3 receptor mediating contraction and evoked [3H]-acetylcholine release in the guinea-pig ileum. British journal of pharmacology. vol 101. issue 3. 1991-04-22. PMID:2150179. |
the relative contributions of two classes of 5-hydroxytryptamine (5-ht) receptor (5-ht2 and 5-ht3) to the contractile action of 5-ht, 2-methyl-5-hydroxytryptamine (2-methyl-5-ht) and alpha-methyl-5-hydroxytryptamine (alpha-methyl-5-ht) were studied in the guinea-pig ileum longitudinal muscle-myenteric plexus strip (lmmp) preparation. |
1991-04-22 |
2023-08-11 |
Not clear |
| D Morin, S Hennequin, R Monteau, G Hilair. Serotonergic influences on central respiratory activity: an in vitro study in the newborn rat. Brain research. vol 535. issue 2. 1991-04-16. PMID:2073606. |
since 5-ht2 agonists (doi, alpha-methyl-5-ht) only evoked minor changes in frequency, the central action of 5-ht on the respiratory rhythm generator seems to depend on activation of 5-ht1 receptors. |
1991-04-16 |
2023-08-11 |
rat |
| D Morin, S Hennequin, R Monteau, G Hilair. Serotonergic influences on central respiratory activity: an in vitro study in the newborn rat. Brain research. vol 535. issue 2. 1991-04-16. PMID:2073606. |
tonic activity induced by 5-ht is: (1) antagonized by methysergide or ketanserine but not 5-ht3 antagonists; (2) induced by 5-ht2 but not 5-ht1 agonists; (3) still induced in the isolated spinal cord by 5-ht superfusion or 5-ht microinjection in the cervical ventral horn; and (4) sometimes replaced by rhythmic activity at a frequency different from that of respiration. |
1991-04-16 |
2023-08-11 |
rat |
| D Morin, S Hennequin, R Monteau, G Hilair. Serotonergic influences on central respiratory activity: an in vitro study in the newborn rat. Brain research. vol 535. issue 2. 1991-04-16. PMID:2073606. |
these results suggest that 5-ht exerts a facilitory modulation on the respiratory rhythm generator through 5-ht1 medullary receptors and on motoneurons through 5-ht2 spinal receptors. |
1991-04-16 |
2023-08-11 |
rat |
| D A Jackson, S R Whit. Receptor subtypes mediating facilitation by serotonin of excitability of spinal motoneurons. Neuropharmacology. vol 29. issue 9. 1991-04-09. PMID:2149874. |
other 5-ht agonists, with relatively selective affinity for 5-ht1b, 5-ht1c and 5-ht2 receptors, increased the excitability of spinal motoneurons when applied iontophoretically or intravenously. |
1991-04-09 |
2023-08-11 |
rat |
| D A Jackson, S R Whit. Receptor subtypes mediating facilitation by serotonin of excitability of spinal motoneurons. Neuropharmacology. vol 29. issue 9. 1991-04-09. PMID:2149874. |
the excitatory effect of iontophoretically applied 5-ht was antagonized by the nonselective 5-ht antagonist, methysergide and by ketanserin and ritanserin, which have relatively selective affinity for 5-ht1c and 5-ht2 receptors. |
1991-04-09 |
2023-08-11 |
rat |
| D A Jackson, S R Whit. Receptor subtypes mediating facilitation by serotonin of excitability of spinal motoneurons. Neuropharmacology. vol 29. issue 9. 1991-04-09. PMID:2149874. |
the iontophoretic results suggest that 5-ht1b, 5-ht1c and 5-ht2 receptors may all play a role in facilitation of the excitability of spinal motoneurons by locally applied 5-ht. |
1991-04-09 |
2023-08-11 |
rat |
| G Vanden Bussche, Y G Gelders, S L Heyle. [Development of new antipsychotic drugs]. Acta psiquiatrica y psicologica de America latina. vol 36. issue 1-2. 1991-04-08. PMID:2127339. |
pipamperone-based clinical studies evidenced that an antagonist combining serotonin 5-ht2, and dopamine d2 was successful in the treatment of schizophrenia--which could be clearly observed in (a) anti-autistic effects, (b) regulating disrupted sleep-wake rhythms, and (c) a lesser tendency to eps. |
1991-04-08 |
2023-08-11 |
Not clear |
| B Bjorvatn, R Ursi. Effects of zimeldine, a selective 5-HT reuptake inhibitor, combined with ritanserin, a selective 5-HT2 antagonist, on waking and sleep stages in rats. Behavioural brain research. vol 40. issue 3. 1991-03-27. PMID:2149499. |
effects of zimeldine, a selective 5-ht reuptake inhibitor, combined with ritanserin, a selective 5-ht2 antagonist, on waking and sleep stages in rats. |
1991-03-27 |
2023-08-11 |
rat |
| B Bjorvatn, R Ursi. Effects of zimeldine, a selective 5-HT reuptake inhibitor, combined with ritanserin, a selective 5-HT2 antagonist, on waking and sleep stages in rats. Behavioural brain research. vol 40. issue 3. 1991-03-27. PMID:2149499. |
sleep and waking in rats were studied 8 h following administration of a selective 5-hydroxytryptamine (5-ht) reuptake inhibitor (zimeldine), a selective 5-ht2 antagonist (ritanserin) and a combination of ritanserin and zimeldine. |
1991-03-27 |
2023-08-11 |
rat |
| B Bjorvatn, R Ursi. Effects of zimeldine, a selective 5-HT reuptake inhibitor, combined with ritanserin, a selective 5-HT2 antagonist, on waking and sleep stages in rats. Behavioural brain research. vol 40. issue 3. 1991-03-27. PMID:2149499. |
this suggests that the increase in sws-2 seen after 5-ht reuptake inhibition and 5-ht2 blockade are independent phenomena. |
1991-03-27 |
2023-08-11 |
rat |
| D Lebre. Portal hypertension: serotonin and pathogenesis. Cardiovascular drugs and therapy. vol 4 Suppl 1. 1991-03-22. PMID:2285648. |
we observed that acute administration of ketanserin, an antagonist of serotonin at 5ht2 receptors, significantly decreased portal pressure and portal-systemic collateral blood flow in patients with cirrhosis, whereas hepatic blood flow was not modified. |
1991-03-22 |
2023-08-11 |
rat |
| D Lebre. Portal hypertension: serotonin and pathogenesis. Cardiovascular drugs and therapy. vol 4 Suppl 1. 1991-03-22. PMID:2285648. |
these studies confirm current evidence in favor of a role for the actions of serotonin via 5ht2 receptors in portal hypertension and add a new group of substances for its treatment. |
1991-03-22 |
2023-08-11 |
rat |
| C P Weine. The role of serotonin in the preeclampsia-eclampsia syndrome. Cardiovascular drugs and therapy. vol 4 Suppl 1. 1991-03-22. PMID:2285649. |
either inhibition of the delivery mechanism by a low, daily dose of aspirin, or inhibition of the peripheral serotonin type 2 (5ht2) receptor, effectively controls the hypertension. |
1991-03-22 |
2023-08-11 |
human |
| A Monopoli, A Conti, A Forlani, E Ongini, C Antona, P Bigliol. 5-Hydroxytryptamine induces contraction in isolated human mammary artery: effect of ketanserin. Cardiovascular drugs and therapy. vol 4 Suppl 1. 1991-03-22. PMID:2285652. |
5-hydroxytryptamine (5ht) treatment produced dose-related contractions in the human internal mammary artery with an ec50 value of 3.4 x 10(-7) m. the 5ht2 receptor antagonist ketanserin reversed the contractions evoked by 5ht in a competitive manner at a low concentration (10(-8) m), whereas a noncompetitive antagonism was apparent at higher concentrations (5 x 10(-8) m to 5 x 10(-7) m). |
1991-03-22 |
2023-08-11 |
human |
| A Monopoli, A Conti, A Forlani, E Ongini, C Antona, P Bigliol. 5-Hydroxytryptamine induces contraction in isolated human mammary artery: effect of ketanserin. Cardiovascular drugs and therapy. vol 4 Suppl 1. 1991-03-22. PMID:2285652. |
these findings indicate that the mammary artery is a vascular tissue sensitive to contractions induced by 5ht and that the drug ketanserin antagonizes this contractile response through the 5ht2 receptor subtype. |
1991-03-22 |
2023-08-11 |
human |
| G J Christ, M Jean-Jacque. Mutual-effect amplification of contractile responses elicited by simultaneous activation of alpha-1 adrenergic and 5-hydroxytryptamine2 receptors in isolated rat aorta. The Journal of pharmacology and experimental therapeutics. vol 256. issue 2. 1991-03-21. PMID:1847200. |
5-hydroxytryptamine (5-ht), and the selective alpha-1 agonists phenylephrine (pe) and oxymetazoline (oxy), were used to study the effects of simultaneous coactivation of the 5-ht2 and alpha-1 adrenergic receptors, respectively, on the contractile responses of isolated rat aortic rings. |
1991-03-21 |
2023-08-11 |
rat |
| G J Christ, M Jean-Jacque. Mutual-effect amplification of contractile responses elicited by simultaneous activation of alpha-1 adrenergic and 5-hydroxytryptamine2 receptors in isolated rat aorta. The Journal of pharmacology and experimental therapeutics. vol 256. issue 2. 1991-03-21. PMID:1847200. |
the ka values for pe and oxy at the alpha-1 receptor were 316 nm and 1.82 microm, respectively, while the ka for 5-ht at the 5-ht2 receptor was 478 nm. |
1991-03-21 |
2023-08-11 |
rat |
| A R Adolp. Pharmacological actions of peptides and indoleamines on turtle retinal ganglion cells. Visual neuroscience. vol 3. issue 5. 1991-03-13. PMID:2577268. |
lsd (lysergic acid diethylamide) and cyproheptadine, which act on 5-ht2 receptors, antagonize 5-ht actions in this retina. |
1991-03-13 |
2023-08-11 |
Not clear |
| Y Sugimoto, J Yamada, K Horisak. Activation of peripheral serotonin2 receptors induces hypothermia in mice. Life sciences. vol 48. issue 5. 1991-03-08. PMID:1992284. |
the hypothermic effects of 5-ht were strongly antagonized by the 5-ht1 and 5-ht2 receptor antagonist methysergide and the 5-ht2 receptor antagonist ketanserin. |
1991-03-08 |
2023-08-11 |
mouse |