| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Hashimoto, N Nishino, H Nakai, C Tanak. Increase in serotonin 5-HT1A receptors in prefrontal and temporal cortices of brains from patients with chronic schizophrenia. Life sciences. vol 48. issue 4. 1991-03-05. PMID:1824956. |
the [3h]8-oh-dpat bindings to the prefrontal cortex and hippocampus were potently inhibited by serotonin (ic50 = 6.3 x 10(-9) m) and 5-ht1a agonists (ic50 = 5.0 x 10(-9) - 2.3 x 10(-7) m), while other neurotransmitters, 5-ht2 and 5-ht3 related compounds did not inhibit the binding (ic50 greater than 10(-5) m). |
1991-03-05 |
2023-08-11 |
human |
| A V Juorio, X M Li, A A Boulto. The effects of chronic trimipramine treatment on biogenic amine metabolism and on dopamine D2, 5-HT2 and tryptamine binding sites in rat brain. General pharmacology. vol 21. issue 5. 1991-03-01. PMID:2177438. |
the treatment also produced a reduction in dopamine d2 and 5-hydroxytryptamine 5-ht2 receptors but no change in tryptamine binding was observed. |
1991-03-01 |
2023-08-11 |
rat |
| R W Fuller, H D Snodd. Serotonin receptor subtypes involved in the elevation of serum corticosterone concentration in rats by direct- and indirect-acting serotonin agonists. Neuroendocrinology. vol 52. issue 2. 1991-02-28. PMID:2148812. |
the quipazine-induced increase in serum corticosterone was antagonized by 17 different serotonin antagonists; of these, mdl 11939, pirenperone, setoperone, mianserin, ly 281067, ketanserin, ritanserin and clozapine have relatively selective affinity for the 5-ht2 subtype of receptor. |
1991-02-28 |
2023-08-11 |
rat |
| A S Eison, M S Eison, J R Torrente, R N Wright, F D Yocc. Nefazodone: preclinical pharmacology of a new antidepressant. Psychopharmacology bulletin. vol 26. issue 3. 1991-02-26. PMID:2274630. |
in ex vivo studies, acute oral administration of nefazodone inhibits cortical serotonin uptake and occupies frontal cortical 5-ht2 receptor binding sites. |
1991-02-26 |
2023-08-11 |
rat |
| C A Ribeiro, M D Cotrim, M T Morgadinho, M I Ramos, E S Santos, T dos R de Maced. Migraine, serum serotonin and platelet 5-HT2 receptors. Cephalalgia : an international journal of headache. vol 10. issue 5. 1991-02-25. PMID:2272090. |
migraine, serum serotonin and platelet 5-ht2 receptors. |
1991-02-25 |
2023-08-11 |
Not clear |
| S S Navran, G Allain, H F Garcia, J C Allen, C L Seide. Serotonin-induced Na+/K+ pump stimulation in vascular smooth muscle cells. Evidence for coupling to multiple receptor mechanisms. The Journal of pharmacology and experimental therapeutics. vol 256. issue 1. 1991-02-22. PMID:1846420. |
second messengers generated by 5-ht2 receptor-mediated phosphoinositide hydrolysis, ins(1,4,5)p3 and diacylglycerol were implicated in the stimulatory action of 5-ht on the vascular na+/k+ pump. |
1991-02-22 |
2023-08-11 |
Not clear |
| C J Schmidt, V L Taylor, G M Abbate, T R Nieduza. 5-HT2 antagonists stereoselectively prevent the neurotoxicity of 3,4-methylenedioxymethamphetamine by blocking the acute stimulation of dopamine synthesis: reversal by L-dopa. The Journal of pharmacology and experimental therapeutics. vol 256. issue 1. 1991-02-22. PMID:1899117. |
the active and inactive stereoisomers of the serotonin (5-ht2) antagonist, mdl 11,939, were used to examine the relationship between the acute effects of 3,4-methylenedioxymethamphetamine (mdma) on the dopaminergic system and its long-term effects on the serotonergic system. |
1991-02-22 |
2023-08-11 |
Not clear |
| F M Lai, T Tanikella, P Cervon. Characterization of serotonin receptors in isolated rat intramyocardial coronary artery. The Journal of pharmacology and experimental therapeutics. vol 256. issue 1. 1991-02-22. PMID:1988655. |
in coronary artery with and without endothelium, only 5-ht and alpha-methylserotonin maleate (5-ht2 agonist) elicited equipotent concentration-dependent contractions. |
1991-02-22 |
2023-08-11 |
rat |
| F M Lai, T Tanikella, P Cervon. Characterization of serotonin receptors in isolated rat intramyocardial coronary artery. The Journal of pharmacology and experimental therapeutics. vol 256. issue 1. 1991-02-22. PMID:1988655. |
no relaxation was observed with 5-ht up to 1 x 10(-5) m. the contraction induced by 5-ht in artery both with and without endothelium was inhibited by ketanserin (5-ht2 antagonist) but not by l-propranolol (5-ht1 antagonist) nor by 3-tropanyl-indole-3,5-dichlorobenzoate (5-ht3 antagonist). |
1991-02-22 |
2023-08-11 |
rat |
| F M Lai, T Tanikella, P Cervon. Characterization of serotonin receptors in isolated rat intramyocardial coronary artery. The Journal of pharmacology and experimental therapeutics. vol 256. issue 1. 1991-02-22. PMID:1988655. |
ketanserin, the selective 5-ht2 antagonist, effectively antagonized 5-ht-induced contraction by shifting the 5-ht response curve to the right without inhibiting the maximal response in both endothelium-intact and -denuded arteries. |
1991-02-22 |
2023-08-11 |
rat |
| P Blandina, J Goldfarb, J Walcott, J P Gree. Serotonergic modulation of the release of endogenous norepinephrine from rat hypothalamic slices. The Journal of pharmacology and experimental therapeutics. vol 256. issue 1. 1991-02-22. PMID:1988665. |
serotonin (5-ht), 3 to 10 microm, in the presence of methylsergide or ritanserin (antagonists at 5-ht1-like and 5-ht2 receptors), caused a concentration-dependent decrease of k(+)-evoked ne release. |
1991-02-22 |
2023-08-11 |
rat |
| P J Pauwels, P Van Gompel, J E Leyse. Rapid desensitization and resensitization of 5-HT2 receptor mediated phosphatidyl inositol hydrolysis by serotonin agonists in quiescent calf aortic smooth muscle cells. Life sciences. vol 47. issue 22. 1991-02-22. PMID:2273941. |
rapid desensitization and resensitization of 5-ht2 receptor mediated phosphatidyl inositol hydrolysis by serotonin agonists in quiescent calf aortic smooth muscle cells. |
1991-02-22 |
2023-08-11 |
Not clear |
| P J Pauwels, P Van Gompel, J E Leyse. Rapid desensitization and resensitization of 5-HT2 receptor mediated phosphatidyl inositol hydrolysis by serotonin agonists in quiescent calf aortic smooth muscle cells. Life sciences. vol 47. issue 22. 1991-02-22. PMID:2273941. |
in these cells, 5-hydroxytryptamine (5-ht)-induced [3h]inositol phosphates accumulation showed the characteristics of a 5-ht2 receptor coupled transducing system according to the inhibition of the response by 5-ht2 antagonists at nanomolar concentrations. |
1991-02-22 |
2023-08-11 |
Not clear |
| P J Pauwels, P Van Gompel, J E Leyse. Rapid desensitization and resensitization of 5-HT2 receptor mediated phosphatidyl inositol hydrolysis by serotonin agonists in quiescent calf aortic smooth muscle cells. Life sciences. vol 47. issue 22. 1991-02-22. PMID:2273941. |
the 5-ht2 receptor coupled response became rapidly desensitized during continued incubation with 5-ht and 1-(2,5-dimethoxy-4-methylphenyl)-2- aminopropane (dom); nearly full desensitization was obtained in two hours with 10 microm 5-ht and dom pretreatment. |
1991-02-22 |
2023-08-11 |
Not clear |
| P A McBride, J J Mann, E Nimchinsky, M L Cohe. Inhibition of serotonin-amplified human platelet aggregation by ketanserin, ritanserin, and the ergoline 5HT2 receptor antagonists-LY53857, sergolexole, and LY237733. Life sciences. vol 47. issue 23. 1991-02-12. PMID:2125095. |
these data are consistent with the high potency of these ergolines as antagonists of 5ht2 receptors and further support the involvement of 5ht2 receptors on human platelets in the amplifying response to serotonin. |
1991-02-12 |
2023-08-11 |
human |
| E J Kidd, J E Leysen, C A Marsde. Chronic 5-HT2 receptor antagonist treatment alters 5-HT1A autoregulatory control of 5-HT release in rat brain in vivo. Journal of neuroscience methods. vol 34. issue 1-3. 1991-01-31. PMID:1701842. |
chronic 5-ht2 receptor antagonist treatment alters 5-ht1a autoregulatory control of 5-ht release in rat brain in vivo. |
1991-01-31 |
2023-08-11 |
rat |
| E J Kidd, J E Leysen, C A Marsde. Chronic 5-HT2 receptor antagonist treatment alters 5-HT1A autoregulatory control of 5-HT release in rat brain in vivo. Journal of neuroscience methods. vol 34. issue 1-3. 1991-01-31. PMID:1701842. |
neither acute nor chronic ritanserin treatment altered basal extracellular levels of 5-ht or 5-hiaa, suggesting that 5-ht2 receptors do not directly influence 5-ht release. |
1991-01-31 |
2023-08-11 |
rat |
| E J Kidd, J E Leysen, C A Marsde. Chronic 5-HT2 receptor antagonist treatment alters 5-HT1A autoregulatory control of 5-HT release in rat brain in vivo. Journal of neuroscience methods. vol 34. issue 1-3. 1991-01-31. PMID:1701842. |
these results suggest that chronic, but not acute, 5-ht2 receptor antagonist treatment attenuates the 5-ht1a receptor-mediated autoregulation of 5-ht release. |
1991-01-31 |
2023-08-11 |
rat |
| G J Chris. Determination of agonist dissociation constants in isolated vasculature: equivalence of estimates obtained by the method of partial irreversible receptor inactivation and a novel application of the operational model of pharmacological agonism. Life sciences. vol 47. issue 20. 1991-01-30. PMID:2175378. |
the observed nature of the ka estimates obtained with the furchgott method for phenylephrine (pe) and oxymetazoline (oxy) at the proportional 1-adrenergic receptor and for 5-hydroxytryptamine (5-ht) at the 5-ht2 receptor in isolated rat aorta, and for pe and 5-ht at the proportional 1-adrenergic and 5-ht2 receptors, respectively, in isolated rabbit aorta, was consistent with the hypothesis that the density of membrane receptors is greatly in excess of the density of transducer proteins (i.e., [ro] much greater than [to]) in these systems. |
1991-01-30 |
2023-08-11 |
rat |
| S Przedborski, M Wright, S Fahn, J L Cade. Quantitative autoradiographic changes in 5-[3H]HT-labeled 5-HT1 serotonin receptors in discrete regions of brain in the rat model of persistent dyskinesias induced by iminodipropionitrile (IDPN). Neuroscience letters. vol 116. issue 1-2. 1991-01-28. PMID:2259456. |
significant changes in 5-ht concentration and in 5-ht2 receptor density in several motor-related brain regions have been observed in idpn-treated rats. |
1991-01-28 |
2023-08-11 |
rat |