| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P De Deurwaerdère, M L'hirondel, N Bonhomme, G Lucas, A Cheramy, U Spampinat. Serotonin stimulation of 5-HT4 receptors indirectly enhances in vivo dopamine release in the rat striatum. Journal of neurochemistry. vol 68. issue 1. 1997-01-27. PMID:8978726. |
the 5-ht effect was partially reduced by 1 or 10 microm gr 125,487, a 5-ht4 antagonist, and by 100 microm dau 6285, a 5-ht3/4 antagonist, whereas the 5-ht1/2/6 antagonist methiothepin (50 microm) was ineffective. |
1997-01-27 |
2023-08-12 |
rat |
| P De Deurwaerdère, M L'hirondel, N Bonhomme, G Lucas, A Cheramy, U Spampinat. Serotonin stimulation of 5-HT4 receptors indirectly enhances in vivo dopamine release in the rat striatum. Journal of neurochemistry. vol 68. issue 1. 1997-01-27. PMID:8978726. |
in the presence of tetrodotoxin the effect of 1 microm 5-ht was not affected by 5-ht4 antagonists. |
1997-01-27 |
2023-08-12 |
rat |
| S Claeysen, M Sebben, L Journot, J Bockaert, A Dumui. Cloning, expression and pharmacology of the mouse 5-HT(4L) receptor. FEBS letters. vol 398. issue 1. 1997-01-22. PMID:8946946. |
in contrast to the previously described distribution, we found that mrna encoding for both the short (5-ht(4s))and the long form (5-ht(4l)) of 5-ht4 receptors are expressed in all mouse and rat brain areas. |
1997-01-22 |
2023-08-12 |
mouse |
| M Minami, T Endo, M Hirafuj. [Role of serotonin in emesis]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 108. issue 5. 1997-01-21. PMID:8974084. |
both 5-ht3 and 5-ht4 receptors may be involved in intestinal 5-ht release. |
1997-01-21 |
2023-08-12 |
Not clear |
| P G McLean, I M Coupa. Further investigation into the signal transduction mechanism of the 5-HT4-like receptor in the circular smooth muscle of human colon. British journal of pharmacology. vol 118. issue 4. 1997-01-17. PMID:8799582. |
the 5-ht4 receptor antagonist, gr 113808, inhibited cyclic amp formation and relaxation induced by 5-ht with -log ki values of 9.1 (cyclic amp) and 8.9 (relaxation) and apparent pa2 values of 9.2 (cyclic amp) and 9.5 (relaxation). |
1997-01-17 |
2023-08-12 |
human |
| M R Briejer, J A Schuurke. 5-HT3 and 5-HT4 receptors and cholinergic and tachykininergic neurotransmission in the guinea-pig proximal colon. European journal of pharmacology. vol 308. issue 2. 1997-01-15. PMID:8840129. |
in the presence of methysergide, 5-ht induced contractions, yielding a biphasic concentration-response curve that was changed into a monophasic curve in the presence of the 5-ht3 receptor antagonist, granisetron (1 microm) (low-affinity phase blocked), or the 5-ht4 receptor antagonist, sb 204070 ((1-butyl-4-piperidinyl methyl)-8-amino-7-chloro-1,4-benzodioxan-5-carboxylate) (10 nm) (high-affinity phase blocked) combination of the two antagonists abolished the contraction to 5-ht. |
1997-01-15 |
2023-08-12 |
Not clear |
| S A Jones-Humble, M J Durcan, D Lyerly, R M Norton, F L Tang, A V Russell, M J Watson, P J Gengo, P F Morgan, C M Wang, B R Cooper, R F Co. Preclinical neurochemical and electrophysiological profile of 1192U90, a potential antipsychotic. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 15. issue 3. 1997-01-15. PMID:8873105. |
it also bound to dopaminergic d1, serotonin 5-ht3, serotonin 5-ht4, and sigma sites, albeit with lower affinity. |
1997-01-15 |
2023-08-12 |
rat |
| Y Uchiyama-Tsuyuki, M Saitoh, M Muramats. Identification and characterization of the 5-HT4 receptor in the intestinal tract and striatum of the guinea pig. Life sciences. vol 59. issue 25-26. 1997-01-07. PMID:8950316. |
receptors for 5-hydroxytryptamine (5-ht) of the 5-ht4 type were investigated in the intestinal tract and the striatum in guinea-pig, in binding studies using the 5-ht4 radioligand, [3h]gr113808. |
1997-01-07 |
2023-08-12 |
Not clear |
| Y Uchiyama-Tsuyuki, M Saitoh, M Muramats. Identification and characterization of the 5-HT4 receptor in the intestinal tract and striatum of the guinea pig. Life sciences. vol 59. issue 25-26. 1997-01-07. PMID:8950316. |
selective 5-ht4 receptor agonists and antagonists inhibited binding of [3h]gr113808 with high affinities in lmmps of the ilcum and which correlated well with their actions on the striatum (r = 0.98), as indicated by the rank order of displacement potencies: sdz205-557 > ly297524 > cisapride = bimu8 > 5-ht > mosapride > renzapride > 5-hydroxy-n-methyltryptamine(5-hmt) > (+/-) zacopride > alpha-methyl-5-hydroxytryptamine (alpha-m-5-ht) > 5-methyltryptamine(5-mt) > 5-carboxamidotryptamine (5-ct). |
1997-01-07 |
2023-08-12 |
Not clear |
| S M Candura, E Messori, G P Franceschetti, G D'Agostino, D Vicini, M Tagliani, M Tonin. Neural 5-HT4 receptors in the human isolated detrusor muscle: effects of indole, benzimidazolone and substituted benzamide agonists and antagonists. British journal of pharmacology. vol 118. issue 8. 1997-01-06. PMID:8864530. |
in strips of human isolated detrusor muscle, the 5-hydroxytryptamine (5-ht) receptor (5-ht4) that mediates facilitation of neuromuscular cholinergic transmission was further characterized by using 5-ht and a series of ligands known for their 5-ht4 agonist (5-methoxytryptamine: 5-meot, cisapride, (r,s)-zacopride, bimu 8) or antagonist (rs 23597, gr 125487, dau 6285) properties. |
1997-01-06 |
2023-08-12 |
human |
| S M Candura, E Messori, G P Franceschetti, G D'Agostino, D Vicini, M Tagliani, M Tonin. Neural 5-HT4 receptors in the human isolated detrusor muscle: effects of indole, benzimidazolone and substituted benzamide agonists and antagonists. British journal of pharmacology. vol 118. issue 8. 1997-01-06. PMID:8864530. |
in the presence of methysergide (1 microm) and ondansetron (3 microm) to isolate pharmacologically the 5-ht4 receptors, 5-ht (0.3 nm-1 microm), 5-meot (10 nm -30 microm), bimu 8 (10 nm-3 microm), cisapride (0.1-10 microm) and (r,s)-zacopride (0.1-30 microm) potentiated cholinergic contractions to electrical field stimulation in a concentration-dependent manner. |
1997-01-06 |
2023-08-12 |
human |
| S M Candura, E Messori, G P Franceschetti, G D'Agostino, D Vicini, M Tagliani, M Tonin. Neural 5-HT4 receptors in the human isolated detrusor muscle: effects of indole, benzimidazolone and substituted benzamide agonists and antagonists. British journal of pharmacology. vol 118. issue 8. 1997-01-06. PMID:8864530. |
the potentiation by 5-ht was competitively antagonized by the selective 5-ht4 receptor antagonist gr 125487 (0.3-3 nm) with a pa2 estimate of 9.75 (schild slope of 1.09), and by dau 6285 (1 microm; pk3 = 6.45). |
1997-01-06 |
2023-08-12 |
human |
| S M Candura, E Messori, G P Franceschetti, G D'Agostino, D Vicini, M Tagliani, M Tonin. Neural 5-HT4 receptors in the human isolated detrusor muscle: effects of indole, benzimidazolone and substituted benzamide agonists and antagonists. British journal of pharmacology. vol 118. issue 8. 1997-01-06. PMID:8864530. |
thus, in the human isolated detrusor muscle, the 5-ht4 receptors mediating facilitation of cholinergic neuromuscular transmission are activated by indoleamines (5-ht, 5-meot), substituted benzamide (cisapride, (r,s)-zacopride), benzoate (rs 23597) and benzimidazolone (bimu 8) derivatives. |
1997-01-06 |
2023-08-12 |
human |
| E Leung, M T Pulido-Rios, D W Bonhaus, L A Pekins, K D Zeitung, S A Hsu, R D Clark, E H Wong, R M Egle. Comparison of 5-HT4 receptors in guinea-pig colon and rat oesophagus: effects of novel agonists and antagonists. Naunyn-Schmiedeberg's archives of pharmacology. vol 354. issue 2. 1996-12-19. PMID:8857591. |
5-ht4 receptor agonists of other structural classes, including benzimidazolones (bimu 1 and bimu 8), and benzamides ((s)-zacopride, (r)-zacopride, renzapride, sc 49518) were partial agonists with intrinsic activities less than that of 5-ht. |
1996-12-19 |
2023-08-12 |
rat |
| C Ullmer, H G Boddeke, K Schmuck, H Lübber. 5-HT2B receptor-mediated calcium release from ryanodine-sensitive intracellular stores in human pulmonary artery endothelial cells. British journal of pharmacology. vol 117. issue 6. 1996-12-11. PMID:8882600. |
using rt-pcr we show, that of all cloned g-protein coupled 5-ht receptors, these cells express only 5-ht1d beta, 5-ht2b and little 5-ht4 receptor mrna. |
1996-12-11 |
2023-08-12 |
human |
| H Giles, S J Lansdell, M L Bolofo, H L Wilson, G R Marti. Characterization of a 5-HT1B receptor on CHO cells: functional responses in the absence of radioligand binding. British journal of pharmacology. vol 117. issue 6. 1996-12-11. PMID:8882605. |
8-oh-dpat (1 microm) and renzapride (3 microm) were without effect on forskolin-stimulated cyclic amp production and ketanserin (0.3 microm) did not antagonize the inhibition produced by 5-ht, thus excluding the involvement of 5-ht1a, 5-ht4, and 5-ht2 receptors. |
1996-12-11 |
2023-08-12 |
Not clear |
| Y Nishimur. Characterization of 5-hydroxytryptamine receptors mediating contractions in basilar arteries from stroke-prone spontaneously hypertensive rats. British journal of pharmacology. vol 117. issue 6. 1996-12-11. PMID:8882632. |
the contractile effects of 5-ht in wky and shrsp arteries were not affected by mdl 72222 (1 microm, 5-ht3) and sdz 205-557 (1 microm, 5-ht4). |
1996-12-11 |
2023-08-12 |
rat |
| J R Grider, J F Kuemmerle, J G Ji. 5-HT released by mucosal stimuli initiates peristalsis by activating 5-HT4/5-HT1p receptors on sensory CGRP neurons. The American journal of physiology. vol 270. issue 5 Pt 1. 1996-12-06. PMID:8967488. |
release of cgrp induced by exogenous 5-ht or mucosal stimulation was inhibited by selective 5-ht4 and 5-ht1p antagonists but was not affected by 5-ht1a, 5-ht2, and 5-ht3 antagonists. |
1996-12-06 |
2023-08-12 |
rat |
| K Racké, A Reimann, H Schwörer, H Kilbinge. Regulation of 5-HT release from enterochromaffin cells. Behavioural brain research. vol 73. issue 1-2. 1996-12-04. PMID:8788482. |
stimulatory receptors (beta-adrenoceptors, muscarine, nicotine and 5-ht3 receptors) and inhibitory receptors (alpha 2-adrenoceptors, histamine h3, gabaa- and gabab-, a2 and p2y alpha purine and 5-ht4 receptors as well as receptors for vasoactive intestinal polypeptide (vip), pituitary adenylate cyclase stimulating peptide (pacap) and somatostatin) have been shown to be involved in the control of 5-ht release from the ecs. |
1996-12-04 |
2023-08-12 |
Not clear |
| D R Brow. Mucosal protection through active intestinal secretion: neural and paracrine modulation by 5-hydroxytryptamine. Behavioural brain research. vol 73. issue 1-2. 1996-12-04. PMID:8788501. |
in addition, 5-ht appears to interact with 5-ht3 or 5-ht4 receptors on submucosal neurons to elicit neuronal depolarization and an associated increase in intestinal secretion. |
1996-12-04 |
2023-08-12 |
Not clear |