| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G J Sange. 5-Hydroxytryptamine and functional bowel disorders. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 8. issue 4. 1997-03-14. PMID:8959736. |
5-ht4 and 5-ht3 receptors also mediate, respectively, sensitising and physiological actions of 5-ht on gastro-intestinal motor and secretory functions. |
1997-03-14 |
2023-08-12 |
Not clear |
| M R Budhoo, R P Harris, J M Kellu. The role of the 5-HT4 receptor in Cl- secretion in human jejunal mucosa. European journal of pharmacology. vol 314. issue 1-2. 1997-03-10. PMID:8957225. |
it was also antagonized by > or = 1 microm tropisetron (a 5-ht 3/5-ht4 receptor antagonist) and > or = 10 nm gr 113808 (a selective 5-ht4 receptor antagonist) with pa2 values of 6.5 and 7.9, respectively. |
1997-03-10 |
2023-08-12 |
human |
| M R Budhoo, R P Harris, J M Kellu. The role of the 5-HT4 receptor in Cl- secretion in human jejunal mucosa. European journal of pharmacology. vol 314. issue 1-2. 1997-03-10. PMID:8957225. |
another 5-ht4 receptor antagonist, sc 53606 (0.1 microm), antagonized the 5-ht-induced response with a pa2 of 7.3 5-ht1-like/5-ht2 (methysergide), 5-ht1p [n-acetyl-5-hydroxytryptophyl 5-hydroxytryptophan amide (5-ht-dp], 5-ht2a (ketanserin) and 5-ht3 (ondansetron) receptor antagonists and tetrodotoxin, had no significant effect on the ec50 for 5-ht. |
1997-03-10 |
2023-08-12 |
human |
| M R Budhoo, R P Harris, J M Kellu. The role of the 5-HT4 receptor in Cl- secretion in human jejunal mucosa. European journal of pharmacology. vol 314. issue 1-2. 1997-03-10. PMID:8957225. |
in conclusion, this study demonstrates that in the human muscle-stripped jejunum in vitro, 5-ht induced change in short circuit current is mediated by a 5-ht4 receptor via a non-neural pathway. |
1997-03-10 |
2023-08-12 |
human |
| M Tonin. Recent advances in the pharmacology of gastrointestinal prokinetics. Pharmacological research. vol 33. issue 4-5. 1997-02-27. PMID:8938012. |
furthermore, based on our improved knowledge of the role of 5-ht in emesis and gastrointestinal motility, the therapeutic potential of potent mixed 5-ht4 agonists--5-ht3 antagonists in the control of cytotoxic-drug-induced emesis and associated gut motor disturbances will be discussed. |
1997-02-27 |
2023-08-12 |
Not clear |
| S Kojima, Y Shim. Investigation into the 5-hydroxytryptamine-induced atropine-resistant neurogenic contraction of guinea-pig proximal colon. British journal of pharmacology. vol 117. issue 8. 1997-02-13. PMID:8732267. |
the 5-ht4 receptor stimulant, 5-methoxytryptamine (5-meot, 0.03-10 microm) also produced neurogenic contractions with similar maximum effect to those of 5-ht (pec50 = 6.89 +/- 0.16). |
1997-02-13 |
2023-08-12 |
Not clear |
| S Kojima, Y Shim. Investigation into the 5-hydroxytryptamine-induced atropine-resistant neurogenic contraction of guinea-pig proximal colon. British journal of pharmacology. vol 117. issue 8. 1997-02-13. PMID:8732267. |
the 5-ht4 receptor antagonist, dau 6285 (3 microm) shifted the concentration-response curves to both 5-ht and 5-meot to the right without significant depression of the maximum, but the 5-ht1/5-ht2 receptor antagonist, metitepine (0.1 microm) and the 5-ht3 receptor antagonist, ondansetron (0.3 microm) had no effect on the control curves to 5-ht and 5-meot. |
1997-02-13 |
2023-08-12 |
Not clear |
| B R Tuladhar, B Costall, R J Naylo. 5-HT3 and 5-HT4 receptor-mediated facilitation of the emptying phase of the peristaltic reflex in the marmoset isolated ileum. British journal of pharmacology. vol 117. issue 8. 1997-02-13. PMID:8732276. |
it is concluded that the facilitation of the peristaltic reflex in the marmoset intestine induced by 5-ht at submicromolar concentrations involves a 5-ht4 receptor stimulation with an additional 5-ht3 receptor activation at higher concentrations. |
1997-02-13 |
2023-08-12 |
marmoset |
| N Adham, C Gerald, L Schechter, P Vaysse, R Weinshank, T Branche. [3H]5-hydroxytryptamine labels the agonist high affinity state of the cloned rat 5-HT4 receptor. European journal of pharmacology. vol 304. issue 1-3. 1997-02-12. PMID:8813606. |
[3h]5-hydroxytryptamine labels the agonist high affinity state of the cloned rat 5-ht4 receptor. |
1997-02-12 |
2023-08-12 |
rat |
| N Adham, C Gerald, L Schechter, P Vaysse, R Weinshank, T Branche. [3H]5-hydroxytryptamine labels the agonist high affinity state of the cloned rat 5-HT4 receptor. European journal of pharmacology. vol 304. issue 1-3. 1997-02-12. PMID:8813606. |
we have used the cloned rat 5-ht4 receptor, and determined that the single protein product produced is able to bind both [3h]5-ht and [3h]gr113808 ([1-[(2-methyl sulphonyl) amino] ethyl-4-piperidinyl] methyl-1-methyl-1h-indole-3-carboxylate) with high affinity. |
1997-02-12 |
2023-08-12 |
rat |
| N Adham, C Gerald, L Schechter, P Vaysse, R Weinshank, T Branche. [3H]5-hydroxytryptamine labels the agonist high affinity state of the cloned rat 5-HT4 receptor. European journal of pharmacology. vol 304. issue 1-3. 1997-02-12. PMID:8813606. |
[3h]5-ht, at the concentration employed, therefore labels the agonist high affinity state of the 5-ht4 receptor in systems in which high densities of this receptor are found. |
1997-02-12 |
2023-08-12 |
rat |
| J A Terró. The relaxant 5-HT receptor in the dog coronary artery smooth muscle: pharmacological resemblance to the cloned 5-ht7 receptor subtype. British journal of pharmacology. vol 118. issue 6. 1997-02-06. PMID:8832067. |
the relaxant effect of 5-hydroxytryptamine (5-ht) in the dog isolated coronary artery deprived of endothelium is mediated by a receptor unrelated to the 5-ht1, 5-ht2, 5-ht3 or 5-ht4 types. |
1997-02-06 |
2023-08-12 |
dog |
| B R Tuladhar, B Costall, R J Naylo. Pharmacological characterization of the 5-hydroxytryptamine receptor mediating relaxation in the rat isolated ileum. British journal of pharmacology. vol 119. issue 2. 1997-02-06. PMID:8886413. |
6 the 5-ht4 receptor antagonists, tropisetron, sdz 205-557 and gr 113808 antagonized the relaxation response to 5-ht (in the presence of methysergide (1 or 10 microm) and atropine (0.1 microm)) with pkb values (95% cl) of 6.09 (5.94-6.24), 7.0 (6.9-7.09) and 8.95 (8.81-9.1) respectively. |
1997-02-06 |
2023-08-12 |
rat |
| B R Tuladhar, B Costall, R J Naylo. Pharmacological characterization of the 5-hydroxytryptamine receptor mediating relaxation in the rat isolated ileum. British journal of pharmacology. vol 119. issue 2. 1997-02-06. PMID:8886413. |
9 it is concluded that the relaxant response to 5-ht in the terminal region of the ileum is mediated directly at the smooth muscle; a ranked indole agonist potency and selective antagonism by 5-ht4 receptor antagonists tropisetron, sdz 205-557 and gr 113808 indicate a 5-ht4 receptor involvement in the relaxation response. |
1997-02-06 |
2023-08-12 |
rat |
| A P Albert, K M Spyer, P A Brook. The effect of 5-HT and selective 5-HT receptor agonists and antagonists on rat dorsal vagal preganglionic neurones in vitro. British journal of pharmacology. vol 119. issue 3. 1997-02-06. PMID:8894172. |
the effect of 5-ht was mimicked by the 5-ht2a/2c receptor agonist, alpha-methyl-5-ht (50 microm), the 5-ht1 receptor agonist, 5-carboxamidotryptamine (20 microm) and the putative 5-ht4 agonist, 5-methyoxytryptamine (5 microm). |
1997-02-06 |
2023-08-12 |
rat |
| A P Albert, K M Spyer, P A Brook. The effect of 5-HT and selective 5-HT receptor agonists and antagonists on rat dorsal vagal preganglionic neurones in vitro. British journal of pharmacology. vol 119. issue 3. 1997-02-06. PMID:8894172. |
the selective 5-ht4 receptor antagonist, gr113808, had no effect on the depolarizing effect of 5-ht or 5-meot on dvms. |
1997-02-06 |
2023-08-12 |
rat |
| R M Eglen, B Peelle, M T Pulido-Rios, E Leun. Functional interactions between muscarinic M2 receptors and 5-hydroxytryptamine (5-HT)4 receptors and beta 3-adrenoceptors in isolated oesophageal muscularis mucosae of the rat. British journal of pharmacology. vol 119. issue 3. 1997-02-06. PMID:8894184. |
relaxations of isolated oesophageal muscularis mucosae of rat are mediated by 5-hydroxytryptamine (5-ht), acting at 5-ht4 receptors, and isoprenaline, principally acting via beta 3-adrenoceptors. |
1997-02-06 |
2023-08-12 |
rat |
| M A Plaza, M P Arruebo, M D Murill. 5-Hydroxytryptamine induces forestomach hypomotility in sheep through 5-HT4 receptors. Experimental physiology. vol 81. issue 5. 1997-02-04. PMID:8889477. |
5-hydroxytryptamine induces forestomach hypomotility in sheep through 5-ht4 receptors. |
1997-02-04 |
2023-08-12 |
Not clear |
| M A Plaza, M P Arruebo, M D Murill. 5-Hydroxytryptamine induces forestomach hypomotility in sheep through 5-HT4 receptors. Experimental physiology. vol 81. issue 5. 1997-02-04. PMID:8889477. |
in conclusion, 5-ht induces inhibition of forestomach myoelectric activity through 5-ht4 receptors, these actions being mediated by cholinergic neural pathways involving muscarinic and nicotinic receptors. |
1997-02-04 |
2023-08-12 |
Not clear |
| P De Deurwaerdère, M L'hirondel, N Bonhomme, G Lucas, A Cheramy, U Spampinat. Serotonin stimulation of 5-HT4 receptors indirectly enhances in vivo dopamine release in the rat striatum. Journal of neurochemistry. vol 68. issue 1. 1997-01-27. PMID:8978726. |
serotonin stimulation of 5-ht4 receptors indirectly enhances in vivo dopamine release in the rat striatum. |
1997-01-27 |
2023-08-12 |
rat |