| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' M Hamon, E Doucet, K Lef\\xc3\\xa8vre, M C Miquel, L Lanfumey, R Insausti, D Frechilla, J Del Rio, D Verg\\xc3\\xa. Antibodies and antisense oligonucleotide for probing the distribution and putative functions of central 5-HT6 receptors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 21. issue 2 Suppl. 1999-09-17. PMID:10432491.' |
immunocytochemistry at the light and electron microscope levels showed that 5-ht6 receptors are mainly confined to the dendritic compartment, suggesting that they could mediate 5-ht actions on neuronal firing. |
1999-09-17 |
2023-08-12 |
rat |
| Y W Yu, S J Tsai, C H Lin, C P Hsu, K H Yang, C J Hon. Serotonin-6 receptor variant (C267T) and clinical response to clozapine. Neuroreport. vol 10. issue 6. 1999-07-22. PMID:10363930. |
clozapine is an effective atypical antipsychotic that has high affinity for serotonin type 6 receptors (5ht6). |
1999-07-22 |
2023-08-12 |
Not clear |
| R P Ward, D M Dors. Molecular and behavioral effects mediated by Gs-coupled adenosine A2a, but not serotonin 5-Ht4 or 5-Ht6 receptors following antipsychotic administration. Neuroscience. vol 89. issue 3. 1999-07-07. PMID:10199625. |
molecular and behavioral effects mediated by gs-coupled adenosine a2a, but not serotonin 5-ht4 or 5-ht6 receptors following antipsychotic administration. |
1999-07-07 |
2023-08-12 |
rat |
| R P Ward, D M Dors. Molecular and behavioral effects mediated by Gs-coupled adenosine A2a, but not serotonin 5-Ht4 or 5-Ht6 receptors following antipsychotic administration. Neuroscience. vol 89. issue 3. 1999-07-07. PMID:10199625. |
we examined three striatal gs-coupled receptor systems (serotonin 5-ht4, serotonin 5-ht6 and adenosine a2a) to assess their potential involvement in the mechanism of action of the typical antipsychotic haloperidol. |
1999-07-07 |
2023-08-12 |
rat |
| M T Peña-Rangel, R Mercado, J Hernández-Rodrígue. Regulation of glial Na+/K+-ATPase by serotonin: identification of participating receptors. Neurochemical research. vol 24. issue 5. 1999-07-01. PMID:10344593. |
spiperone, a 5-ht1a antagonist, completely inhibited the response to 8-oh-dpat but had no effect on na+/k+-atpase activity in cerebellum where lsd, a 5-ht6 agonist, elicited a dose-dependent response similar to that of 5-ht. |
1999-07-01 |
2023-08-12 |
rat |
| C P Lawler, C Prioleau, M M Lewis, C Mak, D Jiang, J A Schetz, A M Gonzalez, D R Sibley, R B Mailma. Interactions of the novel antipsychotic aripiprazole (OPC-14597) with dopamine and serotonin receptor subtypes. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 20. issue 6. 1999-06-24. PMID:10327430. |
these studies characterized the molecular pharmacology of opc-14597, dm-1451 (its major rodent metabolite), and the related quinolinone derivative opc-4392 at each of the cloned dopamine receptors, and at serotonin 5ht6 and 5ht7 receptors. |
1999-06-24 |
2023-08-12 |
Not clear |
| A Menese. Physiological, pathophysiological and therapeutic roles of 5-HT systems in learning and memory. Reviews in the neurosciences. vol 9. issue 4. 1999-03-23. PMID:9886142. |
multiple 5-hydroxytryptamine (5-ht) receptors have been identified (5-ht1a/1b/1d/1e/1f, 5-ht2a/2b/2c, 5-ht3a/3b, 5-ht4a/4b, 5-ht5a/5b, 5-ht6 and 5-ht7a/7b/7c/7d) and extensive evidence suggests that 5-ht receptors have a role in learning and memory. |
1999-03-23 |
2023-08-12 |
Not clear |
| F G Boess, F J Monsma, A J Sleigh. Identification of residues in transmembrane regions III and VI that contribute to the ligand binding site of the serotonin 5-HT6 receptor. Journal of neurochemistry. vol 71. issue 5. 1998-11-30. PMID:9798944. |
identification of residues in transmembrane regions iii and vi that contribute to the ligand binding site of the serotonin 5-ht6 receptor. |
1998-11-30 |
2023-08-12 |
Not clear |
| F G Boess, F J Monsma, A J Sleigh. Identification of residues in transmembrane regions III and VI that contribute to the ligand binding site of the serotonin 5-HT6 receptor. Journal of neurochemistry. vol 71. issue 5. 1998-11-30. PMID:9798944. |
we have examined the ligand binding site of the serotonin 5-ht6 receptor using site-directed mutagenesis. |
1998-11-30 |
2023-08-12 |
Not clear |
| F G Boess, C Riemer, M Bös, J Bentley, A Bourson, A J Sleigh. The 5-hydroxytryptamine6 receptor-selective radioligand [3H]Ro 63-0563 labels 5-hydroxytryptamine receptor binding sites in rat and porcine striatum. Molecular pharmacology. vol 54. issue 3. 1998-10-05. PMID:9730917. |
the pharmacological profile of the rat 5-ht6 receptor labeled with [3h]ro 63-0563 (methiothepin > d-lysergic acid diethylamide > clozapine approximately ro 63-0563 > lisuride > ergotamine approximately ro 04-6790 > 5-ht > amitriptyline approximately metergoline approximately mianserin approximately ritanserin > methysergide > mesulergine) was similar to that obtained by using either [3h]d-lysergic acide diethylamide or [3h]5-ht as radioligand. |
1998-10-05 |
2023-08-12 |
human |
| L P Baker, M D Nielsen, S Impey, M A Metcalf, S W Poser, G Chan, K Obrietan, M W Hamblin, D R Stor. Stimulation of type 1 and type 8 Ca2+/calmodulin-sensitive adenylyl cyclases by the Gs-coupled 5-hydroxytryptamine subtype 5-HT7A receptor. The Journal of biological chemistry. vol 273. issue 28. 1998-08-06. PMID:9651336. |
to better understand how serotonin might control camp levels in the brain, we coexpressed 5-ht6 or 5-ht7a receptors with specific isoforms of adenylyl cyclase in hek 293 cells. |
1998-08-06 |
2023-08-12 |
Not clear |
| B Grimaldi, A Bonnin, M P Fillion, M Ruat, E Traiffort, G Fillio. Characterization of 5-ht6 receptor and expression of 5-ht6 mRNA in the rat brain during ontogenetic development. Naunyn-Schmiedeberg's archives of pharmacology. vol 357. issue 4. 1998-07-24. PMID:9606024. |
the pharmacological analysis of the [3h]5-ht binding in stably transfected cho cells expressing rat 5-ht6 receptors revealed the presence of a single class of high affinity saturable binding sites for 5-ht corresponding to an affinity constant: kd=27.2+/-3.4 nm. |
1998-07-24 |
2023-08-12 |
rat |
| J T Callaghan, B J Cerimele, K J Kassahun, E H Nyhart, P J Hoyes-Beehler, G V Kondrask. Olanzapine: interaction study with imipramine. Journal of clinical pharmacology. vol 37. issue 10. 1998-03-30. PMID:9505989. |
olanzapine is an "atypical" antipsychotic agent with a high affinity for serotonin 5ht2a/c, 5ht3, 5ht6, and dopamine d1, d2, d3, d4 receptors. |
1998-03-30 |
2023-08-12 |
Not clear |
| F G Boess, F J Monsma, V Meyer, C Zwingelstein, A J Sleigh. Interaction of tryptamine and ergoline compounds with threonine 196 in the ligand binding site of the 5-hydroxytryptamine6 receptor. Molecular pharmacology. vol 52. issue 3. 1997-10-02. PMID:9284367. |
in the 5-ht6 receptor, one of these residues is a threonine (thr196), whereas in most other mammalian 5-ht receptors, the corresponding residue is alanine. |
1997-10-02 |
2023-08-12 |
human |
| F G Boess, F J Monsma, V Meyer, C Zwingelstein, A J Sleigh. Interaction of tryptamine and ergoline compounds with threonine 196 in the ligand binding site of the 5-hydroxytryptamine6 receptor. Molecular pharmacology. vol 52. issue 3. 1997-10-02. PMID:9284367. |
when the corresponding residue of the 5-ht6 receptor (ala154) was converted to serine, no change in the affinity of twelve 5-ht6 receptor ligands or in the potency of 5-ht and lsd could be detected, suggesting that this position does not contribute to the ligand binding site of the 5-ht6 receptor. |
1997-10-02 |
2023-08-12 |
human |
| M Volonté, E Monferini, M Cerutti, F Fodritto, F Borsin. BIMG 80, a novel potential antipsychotic drug: evidence for multireceptor actions and preferential release of dopamine in prefrontal cortex. Journal of neurochemistry. vol 69. issue 1. 1997-07-24. PMID:9202309. |
in radioligand binding studies, bimg 80, a new putative antipsychotic, displayed good affinity at certain serotonin (5-ht1a, 5-ht2a, 5-ht6), dopamine (d1, d2l, d4), and noradrenergic (alpha1) receptors. |
1997-07-24 |
2023-08-12 |
rat |
| C Gérard, M P Martres, K Lefèvre, M C Miquel, D Vergé, L Lanfumey, E Doucet, M Hamon, S el Mestikaw. Immuno-localization of serotonin 5-HT6 receptor-like material in the rat central nervous system. Brain research. vol 746. issue 1-2. 1997-04-28. PMID:9037500. |
immuno-localization of serotonin 5-ht6 receptor-like material in the rat central nervous system. |
1997-04-28 |
2023-08-12 |
rat |
| C Gérard, M P Martres, K Lefèvre, M C Miquel, D Vergé, L Lanfumey, E Doucet, M Hamon, S el Mestikaw. Immuno-localization of serotonin 5-HT6 receptor-like material in the rat central nervous system. Brain research. vol 746. issue 1-2. 1997-04-28. PMID:9037500. |
in order to map the recently cloned serotonin 5-ht6 receptor in the rat brain and spinal cord, polyclonal antibodies were raised against a synthetic octadecapeptide corresponding to a specific portion (leu398-val415) of the c-terminal domain of this receptor. |
1997-04-28 |
2023-08-12 |
rat |
| C Gérard, S el Mestikawy, C Lebrand, J Adrien, M Ruat, E Traiffort, M Hamon, M P Martre. Quantitative RT-PCR distribution of serotonin 5-HT6 receptor mRNA in the central nervous system of control or 5,7-dihydroxytryptamine-treated rats. Synapse (New York, N.Y.). vol 23. issue 3. 1997-03-24. PMID:8807744. |
quantitative rt-pcr distribution of serotonin 5-ht6 receptor mrna in the central nervous system of control or 5,7-dihydroxytryptamine-treated rats. |
1997-03-24 |
2023-08-12 |
rat |
| C Gérard, S el Mestikawy, C Lebrand, J Adrien, M Ruat, E Traiffort, M Hamon, M P Martre. Quantitative RT-PCR distribution of serotonin 5-HT6 receptor mRNA in the central nervous system of control or 5,7-dihydroxytryptamine-treated rats. Synapse (New York, N.Y.). vol 23. issue 3. 1997-03-24. PMID:8807744. |
possible adaptive changes of the recently cloned serotonin 5-ht6 receptor after the selective lesion of serotoninergic neurons by an intracerebral administration of 5,7-dihydroxytryptamine were investigated using competitive rt-pcr (reverse transcription followed by polymerase chain reaction) for the measurement of 5-ht6-mrna in various areas of the rat central nervous system. |
1997-03-24 |
2023-08-12 |
rat |