| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ming-lian Zhang, Guo-zhen Yuan, Jian-jun Yao, Yong-chao Qian, Xia Zhang, Yin-ping Huang, Rui-chun Tang, Qing Ji, San-duo Jian. [Associations between six functional genes and schizophrenia]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics. vol 20. issue 1. 2003-09-02. PMID:12579508. |
to assess the associations between schizophrenia and six functional genes: dopamine d2 receptor gene (drd2), dopamine d4 receptor gene (drd4), 5-hydroxytryptamine 2a receptor gene (5-ht2a), 5-ht6 receptor gene (5-ht6), catechol-o-methyltransferase gene (comt) and dopamine transporter gene (dat1). |
2003-09-02 |
2023-08-12 |
Not clear |
| Wha Bin Im, Christopher L Chio, Glen L Alberts, Dac M Din. Positive allosteric modulator of the human 5-HT2C receptor. Molecular pharmacology. vol 64. issue 1. 2003-07-22. PMID:12815163. |
these actions of pnu-69176e were observed with the human 5-ht2c receptor expressed in several mammalian cell lines (human embryonic kidney 293, nih3t3, and sh-ep) at variable receptor densities (6 to 45 pmol/mg of protein), but not with analogous 5-ht and dopamine receptors (human 5-ht2a, 5-ht2b, 5-ht6, 5-ht7, and dopamine d2-long and d3 receptors). |
2003-07-22 |
2023-08-12 |
human |
| Anna Wesołowsk. In the search for selective ligands of 5-HT5, 5-HT6 and 5-HT7 serotonin receptors. Polish journal of pharmacology. vol 54. issue 4. 2003-06-03. PMID:12523486. |
in the search for selective ligands of 5-ht5, 5-ht6 and 5-ht7 serotonin receptors. |
2003-06-03 |
2023-08-12 |
Not clear |
| Lydia C Harris, S Olubusayo Awe, Catherine A Opere, Angela M LeDay, Sunny E Ohia, Najam A Shari. Pharmacology of serotonin receptors modulating electrically-induced [3h]-norepinephrine release from isolated mammalian iris-ciliary bodies. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. vol 18. issue 4. 2003-03-20. PMID:12222764. |
to further confirm the nature of the prejunctional 5-ht heteroreceptors regulating [3h]ne release, effects of 5-ht3, 5-ht6 and 5-ht7 receptor antagonists were examined on a standard response to 5-ht. |
2003-03-20 |
2023-08-12 |
human |
| Anil Purohit, Katharine Herrick-Davis, Milt Teitle. Creation, expression, and characterization of a constitutively active mutant of the human serotonin 5-HT6 receptor. Synapse (New York, N.Y.). vol 47. issue 3. 2003-02-04. PMID:12494404. |
creation, expression, and characterization of a constitutively active mutant of the human serotonin 5-ht6 receptor. |
2003-02-04 |
2023-08-12 |
human |
| N H Prins, L M Akkermans, R A Lefebvre, J A Schuurke. Characterization of the receptors involved in the 5-HT-induced excitation of canine antral longitudinal muscle. British journal of pharmacology. vol 134. issue 6. 2002-03-15. PMID:11704657. |
there were non-significant trends of the selective 5-ht3 receptor antagonist granisetron (1 microm), and methysergide (1 microm; preventing interactions of 5-ht with 5-ht1, 5-ht2, 5-ht5, 5-ht6 and 5-ht7 receptors) to increase the response to 5-ht. |
2002-03-15 |
2023-08-12 |
dog |
| M Gobbi, M Moia, L Pirona, P Morizzoni, T Mennin. In vitro binding studies with two hypericum perforatum extracts--hyperforin, hypericin and biapigenin--on 5-HT6, 5-HT7, GABA(A)/benzodiazepine, sigma, NPY-Y1/Y2 receptors and dopamine transporters. Pharmacopsychiatry. vol 34 Suppl 1. 2002-02-19. PMID:11518075. |
the two extracts, tested at 10 microg/ml, did not inhibit ligand binding at the following receptors: serotonin 5-ht6 and 5-ht7, benzodiazepine, sigma and neuropeptide y (npy) y1 and y2 receptors. |
2002-02-19 |
2023-08-12 |
Not clear |
| L D Dinh, U Simmen, K B Bueter, B Bueter, K Lundstrom, W Schaffne. Interaction of various Piper methysticum cultivars with CNS receptors in vitro. Planta medica. vol 67. issue 4. 2001-08-09. PMID:11458444. |
cultivars, mahakea, nene, purple moi and png, were tested on binding affinities to cns receptors including gabaa (gaba and benzodiazepine binding site), dopamine d2, opioid (mu and delta), serotonin (5-ht6 and 5-ht7) and histamine (h1 and h2). |
2001-08-09 |
2023-08-12 |
human |
| L D Dinh, U Simmen, K B Bueter, B Bueter, K Lundstrom, W Schaffne. Interaction of various Piper methysticum cultivars with CNS receptors in vitro. Planta medica. vol 67. issue 4. 2001-08-09. PMID:11458444. |
binding to serotonin (5-ht6 and 5-ht7) and benzodiazepine receptors was only weakly inhibited by both root and leaf extracts of all four cultivars. |
2001-08-09 |
2023-08-12 |
human |
| H J Chiu, Y C Wang, J H Liou, C H Chao, H Lee, K Y Tsai, W C Li. Serotonin 6 receptor polymorphism in schizophrenia: frequency, age at onset and cognitive function. Neuropsychobiology. vol 43. issue 3. 2001-07-12. PMID:11287786. |
the relative abundance of serotonin 6 receptor (5ht6) in some limbic regions and the high affinity of some antipsychotics for 5ht6 suggest that the 5ht6 gene might play a role in the pathogenesis of schizophrenic disorders. |
2001-07-12 |
2023-08-12 |
human |
| M Masellis, V S Basile, H Y Meltzer, J A Lieberman, S Sevy, D A Goldman, M W Hamblin, F M Macciardi, J L Kenned. Lack of association between the T-->C 267 serotonin 5-HT6 receptor gene (HTR6) polymorphism and prediction of response to clozapine in schizophrenia. Schizophrenia research. vol 47. issue 1. 2001-04-26. PMID:11163544. |
lack of association between the t-->c 267 serotonin 5-ht6 receptor gene (htr6) polymorphism and prediction of response to clozapine in schizophrenia. |
2001-04-26 |
2023-08-12 |
Not clear |
| Y Tsai, M Dukat, A Slassi, N MacLean, L Demchyshyn, J E Savage, B L Roth, S Hufesein, M Lee, R A Glenno. N1-(Benzenesulfonyl)tryptamines as novel 5-HT6 antagonists. Bioorganic & medicinal chemistry letters. vol 10. issue 20. 2001-02-22. PMID:11055342. |
n-benzenesulfonyl-5-methoxy-n,n-dimethyltryptamine (bs/5-ome dmt; 5) was shown to bind at human 5-ht6 serotonin receptors with high affinity (ki = 2.3 nm) relative to serotonin (ki = 78 nm). |
2001-02-22 |
2023-08-12 |
human |
| M Matsumoto, M Yoshiok. [Possible involvement of serotonin receptors in anxiety disorders]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 115. issue 1. 2000-09-28. PMID:10876814. |
inactivation of mrna encoding 5-ht6 receptors using antisense oligonucleotide produced decreases in cortical 5-ht release enhanced by anxiety. |
2000-09-28 |
2023-08-12 |
mouse |
| I R Vogt, D Shimron-Abarbanell, H Neidt, J Erdmann, S Cichon, T G Schulze, D J Müller, W Maier, M Albus, M Borrmann-Hassenbach, M Knapp, M Rietschel, P Propping, M M Nöthe. Investigation of the human serotonin 6 [5-HT6] receptor gene in bipolar affective disorder and schizophrenia. American journal of medical genetics. vol 96. issue 2. 2000-09-06. PMID:10893499. |
investigation of the human serotonin 6 [5-ht6] receptor gene in bipolar affective disorder and schizophrenia. |
2000-09-06 |
2023-08-12 |
human |
| T A Branchek, T P Blackbur. 5-ht6 receptors as emerging targets for drug discovery. Annual review of pharmacology and toxicology. vol 40. 2000-08-17. PMID:10836139. |
5-ht6 receptors are the latest serotonin receptors to be identified by molecular cloning. |
2000-08-17 |
2023-08-12 |
mouse |
| S J Tsai, H C Liu, T Y Liu, Y C Wang, C J Hon. Association analysis of the 5-HT6 receptor polymorphism C267T in Alzheimer's disease. Neuroscience letters. vol 276. issue 2. 2000-02-15. PMID:10624811. |
this association study explores whether the serotonin 6 receptor (5-ht6) polymorphism (c267t) is a susceptibility factor for ad. |
2000-02-15 |
2023-08-12 |
Not clear |
| S J Tsai, H J Chiu, Y C Wang, C J Hon. Association study of serotonin-6 receptor variant (C267T) with schizophrenia and aggressive behavior. Neuroscience letters. vol 271. issue 2. 2000-01-21. PMID:10477121. |
the relative abundance of serotonin type 6 receptors (5-ht6) in some limbic regions and the high affinity of some antipsychotics to 5-ht6 receptors suggest that they might be involved in the pathogenesis of schizophrenic disorders. |
2000-01-21 |
2023-08-12 |
human |
| P Z Tan, R M Baldwin, C H Van Dyck, M Al-Tikriti, B Roth, N Khan, D S Charney, R B Inni. Characterization of radioactive metabolites of 5-HT2A receptor PET ligand [18F]altanserin in human and rodent. Nuclear medicine and biology. vol 26. issue 6. 1999-12-30. PMID:10587097. |
displacement binding of altanserin to cloned serotonin 5-ht2a, 5-ht2c, 5-ht6, and 5-ht7 receptors showed ki values of 0.3, 6.0, 1,756, and 15 nm; the binding of fbp and altanserinol to these four 5-ht subtypes was negligible. |
1999-12-30 |
2023-08-12 |
human |
| D J Healy, J H Meador-Woodruf. Ionotropic glutamate receptor modulation of 5-HT6 and 5-HT7 mRNA expression in rat brain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 21. issue 3. 1999-10-19. PMID:10457531. |
in particular, the regulation of extracellular serotonin levels in the striatum and hippocampal formation by glutamate receptors led us to examine the effects of systemic ionotropic glutamate receptor modulator treatment on 5-ht6 and 5-ht7 receptor expression in these regions. |
1999-10-19 |
2023-08-12 |
rat |
| b' M Hamon, E Doucet, K Lef\\xc3\\xa8vre, M C Miquel, L Lanfumey, R Insausti, D Frechilla, J Del Rio, D Verg\\xc3\\xa. Antibodies and antisense oligonucleotide for probing the distribution and putative functions of central 5-HT6 receptors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 21. issue 2 Suppl. 1999-09-17. PMID:10432491.' |
among the recently cloned serotonin (5-hydroxytryptamine, 5-ht) receptors, the 5-ht6 subtype is of special interest for at least two reasons: 1) it is abundant in limbic areas which participate in the control of mood and emotion; and 2) some antidepressants and antipsychotics are potent 5-ht6 receptor antagonists. |
1999-09-17 |
2023-08-12 |
rat |